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The map label for this gene is mprB [H]

Identifier: 169628172

GI number: 169628172

Start: 1090384

End: 1091946

Strand: Direct

Name: mprB [H]

Synonym: MAB_1077

Alternate gene names: 169628172

Gene position: 1090384-1091946 (Clockwise)

Preceding gene: 169628171

Following gene: 169628173

Centisome position: 21.52

GC content: 65.2

Gene sequence:

>1563_bases
ATGTCGACACTACGGATGCCGAGGCGGATGCGAGACTCCAGCACGGCCATATTTACTCCACTGCGGGCAACCAGCTCATC
GGTATCGCTGCGCTGGCGCGTGATGCTGCTCGCAATGTCCATGGTGGCGATGGTCGTGGTGCTCATGGCCGTCGCTTCGT
ACCTGCTGGTGTCCACCGCGTTGTATCGCGATGTTGACAAGCAGCTCAACGATCGCGCCAACCTGCTGATCGGCAGTGGG
TTGCTCTCGGTCGATCCACGCCGCGCCATCGAAGGCACCGCATATTCGGCCGACGTCAACGCCAAGCTGATCTTCCCGGG
GCTCATCACCTTCTCGGCGACGCAGCAGGGTCAAACCATTCCCTACGGCACACCCGAGCAGGCGGTAACCCGGGGCGATC
TGCAGCAGTCGCTGCGTACCGTCAATCACCAACGCGTGCTTGCTCTTCGTCTCGACAACGGCAGCACGCTGATCATGGCC
AAATCGCTCGATCCCACCGACACGGTGCTGCGGCGGCTGGGCTGGGTGCTGCTGATCGTCGGTGGCGTGGGTGTCGCGGT
GGCAGCCGCGGCCGGGGCCATGGTGGCCGGCACCGGGCTACGTCCTGTGGCGAGGCTCACCGATGCCGCCGAACGCGTGG
CCAGAACCGATGACCTGCGCCCTATCGCCGTCACCGGCAGCGACGAGCTGGCGCGGCTCACTATCAGTTTCAACACGATG
CTGCGCGCCCTGGCCGAGTCTCGGGACCGCCAGGCGCGATTGGTGACCGACGCCGGCCACGAGCTGCGTACCCCGCTCAC
ATCGCTGCGCACCAACACCGAGCTGCTGATGGCCGCCATGCAGCCGGGTGCTCCCAGGCTGCCTGACGAAGAAATGCAGG
CGCTGCAGCAAGATGTGATCGCCCAAATCGAGGAATTGTCCACGCTGGTGGGCGATCTGGTCGATCTGGCACGGGGAGAC
GGCGCCGACATCGTGCACGAGCCAGTCGACATGGTTGAGGTGGTGGAGGGCACACTCGAGCGAGTTCGTCGCCGCCGCAA
CGATATTGAATTCGATGTCGTGATGCAGCCCTGGCAGGTGTACGGCGATGCGGCGGGACTGTCGCGGGCCGTCCTCAATT
TGCTCGACAACGCGGCCAAATGGAGCCCCTCGGGAACCGCGGTGTCGGTGCGGCTGGCGCAGGTTGATGCCGCCCATGCC
GAACTCGTCATTTCCGACCACGGCCCGGGAATCCCGCCGGCCGAACGCGACCTGGTCTTCGAGCGGTTCTACCGGGCCAC
CCCGGCGCGGGGAATGCCCGGCTCCGGCTTGGGGTTGGCCATCGTTAAGCAGGTAGTGCTCAAACATGGTGGCGCCATTA
AGGTTGAAGAGACTGATCCCGGTGCAGTGATCGACGGTGAACCGGCCCCCGGGACATCCATGCACGTGCTTCTGCCGGGC
AGGCCCGGACCCATTGTTCGGCCGAACATGGGCGATACGGCCGGCCGCCGGAACTCTGGGCCGAACGCGAGGGAGATCTC
AGTGGATTCTCAGTCCGTTCCGGCAGCGTGGCGCCCAAGCTAG

Upstream 100 bases:

>100_bases
GCTACCTACGACGCAAGACCGAGGCCGAAGGGGAGCTCCGGCTCATTCATACCGTTCGCGGTGTCGGCTACGTGCTGCGG
GAGACCCCTCCGTAATCCCC

Downstream 100 bases:

>100_bases
ATGATCCCGAACGCCTATGAAGGACTGGTGAGGAAGCAGCTATGACCAACGACCCGCACGGCAGCTGGGCATACCGGCCG
TCCGGCTCCTACTCGGGGCA

Product: two component sensor kinase MprB

Products: NA

Alternate protein names: Mycobacterial persistence regulator B [H]

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MSTLRMPRRMRDSSTAIFTPLRATSSSVSLRWRVMLLAMSMVAMVVVLMAVASYLLVSTALYRDVDKQLNDRANLLIGSG
LLSVDPRRAIEGTAYSADVNAKLIFPGLITFSATQQGQTIPYGTPEQAVTRGDLQQSLRTVNHQRVLALRLDNGSTLIMA
KSLDPTDTVLRRLGWVLLIVGGVGVAVAAAAGAMVAGTGLRPVARLTDAAERVARTDDLRPIAVTGSDELARLTISFNTM
LRALAESRDRQARLVTDAGHELRTPLTSLRTNTELLMAAMQPGAPRLPDEEMQALQQDVIAQIEELSTLVGDLVDLARGD
GADIVHEPVDMVEVVEGTLERVRRRRNDIEFDVVMQPWQVYGDAAGLSRAVLNLLDNAAKWSPSGTAVSVRLAQVDAAHA
ELVISDHGPGIPPAERDLVFERFYRATPARGMPGSGLGLAIVKQVVLKHGGAIKVEETDPGAVIDGEPAPGTSMHVLLPG
RPGPIVRPNMGDTAGRRNSGPNAREISVDSQSVPAAWRPS

Sequences:

>Translated_520_residues
MSTLRMPRRMRDSSTAIFTPLRATSSSVSLRWRVMLLAMSMVAMVVVLMAVASYLLVSTALYRDVDKQLNDRANLLIGSG
LLSVDPRRAIEGTAYSADVNAKLIFPGLITFSATQQGQTIPYGTPEQAVTRGDLQQSLRTVNHQRVLALRLDNGSTLIMA
KSLDPTDTVLRRLGWVLLIVGGVGVAVAAAAGAMVAGTGLRPVARLTDAAERVARTDDLRPIAVTGSDELARLTISFNTM
LRALAESRDRQARLVTDAGHELRTPLTSLRTNTELLMAAMQPGAPRLPDEEMQALQQDVIAQIEELSTLVGDLVDLARGD
GADIVHEPVDMVEVVEGTLERVRRRRNDIEFDVVMQPWQVYGDAAGLSRAVLNLLDNAAKWSPSGTAVSVRLAQVDAAHA
ELVISDHGPGIPPAERDLVFERFYRATPARGMPGSGLGLAIVKQVVLKHGGAIKVEETDPGAVIDGEPAPGTSMHVLLPG
RPGPIVRPNMGDTAGRRNSGPNAREISVDSQSVPAAWRPS
>Mature_519_residues
STLRMPRRMRDSSTAIFTPLRATSSSVSLRWRVMLLAMSMVAMVVVLMAVASYLLVSTALYRDVDKQLNDRANLLIGSGL
LSVDPRRAIEGTAYSADVNAKLIFPGLITFSATQQGQTIPYGTPEQAVTRGDLQQSLRTVNHQRVLALRLDNGSTLIMAK
SLDPTDTVLRRLGWVLLIVGGVGVAVAAAAGAMVAGTGLRPVARLTDAAERVARTDDLRPIAVTGSDELARLTISFNTML
RALAESRDRQARLVTDAGHELRTPLTSLRTNTELLMAAMQPGAPRLPDEEMQALQQDVIAQIEELSTLVGDLVDLARGDG
ADIVHEPVDMVEVVEGTLERVRRRRNDIEFDVVMQPWQVYGDAAGLSRAVLNLLDNAAKWSPSGTAVSVRLAQVDAAHAE
LVISDHGPGIPPAERDLVFERFYRATPARGMPGSGLGLAIVKQVVLKHGGAIKVEETDPGAVIDGEPAPGTSMHVLLPGR
PGPIVRPNMGDTAGRRNSGPNAREISVDSQSVPAAWRPS

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to en

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=308, Percent_Identity=28.8961038961039, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788393, Length=288, Percent_Identity=31.9444444444444, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI1790346, Length=272, Percent_Identity=30.8823529411765, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1788279, Length=301, Percent_Identity=25.2491694352159, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1789808, Length=263, Percent_Identity=27.7566539923954, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790861, Length=302, Percent_Identity=29.1390728476821, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786600, Length=212, Percent_Identity=33.0188679245283, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1786912, Length=263, Percent_Identity=27.7566539923954, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1787894, Length=288, Percent_Identity=28.8194444444444, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1789403, Length=277, Percent_Identity=28.8808664259928, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1787374, Length=232, Percent_Identity=27.1551724137931, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1790551, Length=267, Percent_Identity=27.3408239700375, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI48994928, Length=224, Percent_Identity=26.7857142857143, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI145693157, Length=262, Percent_Identity=27.0992366412214, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788713, Length=239, Percent_Identity=23.8493723849372, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI87082128, Length=291, Percent_Identity=23.7113402061856, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1789149, Length=278, Percent_Identity=24.4604316546763, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55797; Mature: 55666

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLRMPRRMRDSSTAIFTPLRATSSSVSLRWRVMLLAMSMVAMVVVLMAVASYLLVSTA
CCCCCCCHHHCCCCCEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYRDVDKQLNDRANLLIGSGLLSVDPRRAIEGTAYSADVNAKLIFPGLITFSATQQGQTI
HHHHHHHHHCCCCCEEEECCCCCCCCHHHHCCCEEECCCCEEEEECCEEEEECCCCCCCC
PYGTPEQAVTRGDLQQSLRTVNHQRVLALRLDNGSTLIMAKSLDPTDTVLRRLGWVLLIV
CCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHH
GGVGVAVAAAAGAMVAGTGLRPVARLTDAAERVARTDDLRPIAVTGSDELARLTISFNTM
HHHHHHHHHHHCHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEEHHHH
LRALAESRDRQARLVTDAGHELRTPLTSLRTNTELLMAAMQPGAPRLPDEEMQALQQDVI
HHHHHHCCCCCEEEECCCCHHHHCCHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHH
AQIEELSTLVGDLVDLARGDGADIVHEPVDMVEVVEGTLERVRRRRNDIEFDVVMQPWQV
HHHHHHHHHHHHHHHHHCCCCCCHHHCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHH
YGDAAGLSRAVLNLLDNAAKWSPSGTAVSVRLAQVDAAHAELVISDHGPGIPPAERDLVF
HCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCHHHHHH
ERFYRATPARGMPGSGLGLAIVKQVVLKHGGAIKVEETDPGAVIDGEPAPGTSMHVLLPG
HHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCEECCCCCCCCEEEEEECC
RPGPIVRPNMGDTAGRRNSGPNAREISVDSQSVPAAWRPS
CCCCEECCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
STLRMPRRMRDSSTAIFTPLRATSSSVSLRWRVMLLAMSMVAMVVVLMAVASYLLVSTA
CCCCCCHHHCCCCCEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYRDVDKQLNDRANLLIGSGLLSVDPRRAIEGTAYSADVNAKLIFPGLITFSATQQGQTI
HHHHHHHHHCCCCCEEEECCCCCCCCHHHHCCCEEECCCCEEEEECCEEEEECCCCCCCC
PYGTPEQAVTRGDLQQSLRTVNHQRVLALRLDNGSTLIMAKSLDPTDTVLRRLGWVLLIV
CCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHH
GGVGVAVAAAAGAMVAGTGLRPVARLTDAAERVARTDDLRPIAVTGSDELARLTISFNTM
HHHHHHHHHHHCHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEEHHHH
LRALAESRDRQARLVTDAGHELRTPLTSLRTNTELLMAAMQPGAPRLPDEEMQALQQDVI
HHHHHHCCCCCEEEECCCCHHHHCCHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHH
AQIEELSTLVGDLVDLARGDGADIVHEPVDMVEVVEGTLERVRRRRNDIEFDVVMQPWQV
HHHHHHHHHHHHHHHHHCCCCCCHHHCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHH
YGDAAGLSRAVLNLLDNAAKWSPSGTAVSVRLAQVDAAHAELVISDHGPGIPPAERDLVF
HCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCHHHHHH
ERFYRATPARGMPGSGLGLAIVKQVVLKHGGAIKVEETDPGAVIDGEPAPGTSMHVLLPG
HHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCEECCCCCCCCEEEEEECC
RPGPIVRPNMGDTAGRRNSGPNAREISVDSQSVPAAWRPS
CCCCEECCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA