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The map label for this gene is htrA [H]

Identifier: 169628173

GI number: 169628173

Start: 1091988

End: 1093301

Strand: Direct

Name: htrA [H]

Synonym: MAB_1078

Alternate gene names: 169628173

Gene position: 1091988-1093301 (Clockwise)

Preceding gene: 169628172

Following gene: 169628174

Centisome position: 21.55

GC content: 66.89

Gene sequence:

>1314_bases
ATGACCAACGACCCGCACGGCAGCTGGGCATACCGGCCGTCCGGCTCCTACTCGGGGCAACATGGGCATCATCAGGCGCC
GAACCATCACGCCCAGTCCAGCCACCATTACCAGGGGCAGTCGTACGGATACCCGTCGCAGCAGCCACAGCAGCGTCCGG
CTCAGCAGCCGCAGCGGCAGGCGCAGCCCAAGGGGCGGAGTAGCGGCGGGCTCGTGGTGGGCGCCGTTGTCCTGGCCCTG
GTTTCAGGCGGTCTGGGAGGAACGGTCGGTGCCGTTGTCGCCGATCGTCAGCACAAGGCACCCGTCGTCACCAGCAGCAG
CACCGGGCTGACCCCCATCGCGCCGGGCCGTCCGCCCGCTGCTCAGCCGGTCGCCTCGCTACCGGCCGGATCGGTGGAAC
AGGTTGCGGCCAAAGTGCTTCCGAGCGTCGTCAAGCTGGAAACCATCATGGGCCGGTCGAGTGAAGAGGGATCCGGAGTG
ATTCTCTCCGCCGACGGATTGGTGCTCACCAACGCCCACGTGGTGCAGGCGGCGGGGGATCCCGGCGCCAAGACCACCGC
CACCATCGCTGGCGGAAAGACCTCCCCATTCACCGTGGTCGGAATCGATCCCGGCACCGATATCGCGGTGGTTCGCATCA
CCGGGGCCTCGGGTCTCACCCCGATAGCATTGGGTTCCTCCGCGAATTTGGTTGTGGGCCAATCGGTTGTTGCGATCGGA
TCTCCGCTGGGTCTCGACGGCACCGTCACCACCGGCATCGTCAGCTCACTGAACCGTCCGGTGTTCACCGCGGGGCAGGC
CGGTAATCAGGACACCGTGCTGGACGCCATCCAGACGGATGCCGCGATCAACCCGGGTAACTCCGGGGGCGCGCTGGTCA
ATCTGAACGGCGAGCTGGTGGGGATCAACTCCGCGATCGCAACCATGGGCGGAGACTCCAGCGGCGAAACGCAGGGCGGA
TCTATCGGCCTCGGCTTTGCGATTCCGGTCGACCAGGCCAAACGTGTCGCCGATCAGCTGATCACCAACGGCCGCGCCAC
CCACGCCTCGCTCGGTGTCCGGGTAGGCAATGACAAGGAGGTCCAGGGCGCCCGGATCGTCGAGGTGGTCGCCGGCGGCG
CCGCAGAGAAGGCCGGCATCCCCAATGGGGCGGTCGTCACGAAGGTCGACAACCGCCCTGTGAACAGCGCCGATGGACTC
GTGGCAGCGGTGCGGTCCAAAGCGCCCGGCGACAAGGTGACATTGACGTATACCGATGGCAACGGCGGCCAGGAGAAGAC
CGCCGACGTGACACTGGGTGAGGTCGCCCGATGA

Upstream 100 bases:

>100_bases
ACGCGAGGGAGATCTCAGTGGATTCTCAGTCCGTTCCGGCAGCGTGGCGCCCAAGCTAGATGATCCCGAACGCCTATGAA
GGACTGGTGAGGAAGCAGCT

Downstream 100 bases:

>100_bases
CCTCCATGTCCCCGCGAACGGTTACGGTTGCTTCCATGGCAGAGCTTGAGGCAGGACCGGTTGGGCGATCTCTGGTCGTC
ATCGTCAACGACAGGACAGC

Product: putative serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MTNDPHGSWAYRPSGSYSGQHGHHQAPNHHAQSSHHYQGQSYGYPSQQPQQRPAQQPQRQAQPKGRSSGGLVVGAVVLAL
VSGGLGGTVGAVVADRQHKAPVVTSSSTGLTPIAPGRPPAAQPVASLPAGSVEQVAAKVLPSVVKLETIMGRSSEEGSGV
ILSADGLVLTNAHVVQAAGDPGAKTTATIAGGKTSPFTVVGIDPGTDIAVVRITGASGLTPIALGSSANLVVGQSVVAIG
SPLGLDGTVTTGIVSSLNRPVFTAGQAGNQDTVLDAIQTDAAINPGNSGGALVNLNGELVGINSAIATMGGDSSGETQGG
SIGLGFAIPVDQAKRVADQLITNGRATHASLGVRVGNDKEVQGARIVEVVAGGAAEKAGIPNGAVVTKVDNRPVNSADGL
VAAVRSKAPGDKVTLTYTDGNGGQEKTADVTLGEVAR

Sequences:

>Translated_437_residues
MTNDPHGSWAYRPSGSYSGQHGHHQAPNHHAQSSHHYQGQSYGYPSQQPQQRPAQQPQRQAQPKGRSSGGLVVGAVVLAL
VSGGLGGTVGAVVADRQHKAPVVTSSSTGLTPIAPGRPPAAQPVASLPAGSVEQVAAKVLPSVVKLETIMGRSSEEGSGV
ILSADGLVLTNAHVVQAAGDPGAKTTATIAGGKTSPFTVVGIDPGTDIAVVRITGASGLTPIALGSSANLVVGQSVVAIG
SPLGLDGTVTTGIVSSLNRPVFTAGQAGNQDTVLDAIQTDAAINPGNSGGALVNLNGELVGINSAIATMGGDSSGETQGG
SIGLGFAIPVDQAKRVADQLITNGRATHASLGVRVGNDKEVQGARIVEVVAGGAAEKAGIPNGAVVTKVDNRPVNSADGL
VAAVRSKAPGDKVTLTYTDGNGGQEKTADVTLGEVAR
>Mature_436_residues
TNDPHGSWAYRPSGSYSGQHGHHQAPNHHAQSSHHYQGQSYGYPSQQPQQRPAQQPQRQAQPKGRSSGGLVVGAVVLALV
SGGLGGTVGAVVADRQHKAPVVTSSSTGLTPIAPGRPPAAQPVASLPAGSVEQVAAKVLPSVVKLETIMGRSSEEGSGVI
LSADGLVLTNAHVVQAAGDPGAKTTATIAGGKTSPFTVVGIDPGTDIAVVRITGASGLTPIALGSSANLVVGQSVVAIGS
PLGLDGTVTTGIVSSLNRPVFTAGQAGNQDTVLDAIQTDAAINPGNSGGALVNLNGELVGINSAIATMGGDSSGETQGGS
IGLGFAIPVDQAKRVADQLITNGRATHASLGVRVGNDKEVQGARIVEVVAGGAAEKAGIPNGAVVTKVDNRPVNSADGLV
AAVRSKAPGDKVTLTYTDGNGGQEKTADVTLGEVAR

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=305, Percent_Identity=34.4262295081967, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI7019477, Length=306, Percent_Identity=33.9869281045752, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI4506141, Length=305, Percent_Identity=33.1147540983607, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI24308541, Length=303, Percent_Identity=31.3531353135314, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1789629, Length=270, Percent_Identity=40.7407407407407, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1786356, Length=270, Percent_Identity=41.1111111111111, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1789630, Length=290, Percent_Identity=34.8275862068965, Blast_Score=121, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24646839, Length=261, Percent_Identity=34.0996168582375, Blast_Score=131, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 43428; Mature: 43297

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNDPHGSWAYRPSGSYSGQHGHHQAPNHHAQSSHHYQGQSYGYPSQQPQQRPAQQPQRQ
CCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCHHHCHHHH
AQPKGRSSGGLVVGAVVLALVSGGLGGTVGAVVADRQHKAPVVTSSSTGLTPIAPGRPPA
CCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHEEECCCCCCCEEECCCCCCCCCCCCCCCC
AQPVASLPAGSVEQVAAKVLPSVVKLETIMGRSSEEGSGVILSADGLVLTNAHVVQAAGD
CCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEECCEEEEECCC
PGAKTTATIAGGKTSPFTVVGIDPGTDIAVVRITGASGLTPIALGSSANLVVGQSVVAIG
CCCCEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEECCCCCEEECCEEEEEC
SPLGLDGTVTTGIVSSLNRPVFTAGQAGNQDTVLDAIQTDAAINPGNSGGALVNLNGELV
CCCCCCCHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEECCCEE
GINSAIATMGGDSSGETQGGSIGLGFAIPVDQAKRVADQLITNGRATHASLGVRVGNDKE
ECCHHEEECCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCC
VQGARIVEVVAGGAAEKAGIPNGAVVTKVDNRPVNSADGLVAAVRSKAPGDKVTLTYTDG
CCCCEEEEEEECCCHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHCCCCCCEEEEEEECC
NGGQEKTADVTLGEVAR
CCCCCCCCCCCHHHHCC
>Mature Secondary Structure 
TNDPHGSWAYRPSGSYSGQHGHHQAPNHHAQSSHHYQGQSYGYPSQQPQQRPAQQPQRQ
CCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCHHHCHHHH
AQPKGRSSGGLVVGAVVLALVSGGLGGTVGAVVADRQHKAPVVTSSSTGLTPIAPGRPPA
CCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHEEECCCCCCCEEECCCCCCCCCCCCCCCC
AQPVASLPAGSVEQVAAKVLPSVVKLETIMGRSSEEGSGVILSADGLVLTNAHVVQAAGD
CCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEECCEEEEECCC
PGAKTTATIAGGKTSPFTVVGIDPGTDIAVVRITGASGLTPIALGSSANLVVGQSVVAIG
CCCCEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEECCCCCEEECCEEEEEC
SPLGLDGTVTTGIVSSLNRPVFTAGQAGNQDTVLDAIQTDAAINPGNSGGALVNLNGELV
CCCCCCCHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEECCCEE
GINSAIATMGGDSSGETQGGSIGLGFAIPVDQAKRVADQLITNGRATHASLGVRVGNDKE
ECCHHEEECCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCC
VQGARIVEVVAGGAAEKAGIPNGAVVTKVDNRPVNSADGLVAAVRSKAPGDKVTLTYTDG
CCCCEEEEEEECCCHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHCCCCCCEEEEEEECC
NGGQEKTADVTLGEVAR
CCCCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]