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The map label for this gene is mprA [H]

Identifier: 169628171

GI number: 169628171

Start: 1089686

End: 1090378

Strand: Direct

Name: mprA [H]

Synonym: MAB_1076

Alternate gene names: 169628171

Gene position: 1089686-1090378 (Clockwise)

Preceding gene: 169628170

Following gene: 169628172

Centisome position: 21.5

GC content: 64.07

Gene sequence:

>693_bases
GTGCCTGTGCGAATTCTTGTAGTCGACGACGATCGTGCTGTGCGCGAGTCGTTGCGGCGTTCCTTGTCCTTCAATGGGTA
CTCGGTCGATCTGGCCGAGGACGGTGTCGATGCGCTGAACGTGATCGCCAATGATCGCCCCGACGCATTGGTGCTCGACG
TGATGATGCCCAAGCTTGACGGCCTTGAGGTGTGTCGTCGCCTGCGCAGCACGGGGGATGATCTGCCGATCCTGGTCCTT
ACCGCTCGCGATTCGGTCTCGGAGCGGGTGGCCGGGCTGGATGCGGGCGCCGACGACTACCTGCCCAAGCCCTTTGCGCT
GGAGGAGCTGCTGGCCCGGATGCGCGCGCTGCTGCGCCGCACCACGATCGATGAATCGGCCGATGCCGCCACGCTCAGCT
TCGGCGACCTGACACTGGACCCCGTCACACGTGAGGTGCATCGAGGCACCCGGTCGATCAGTCTGACGCGCACGGAATTT
GCGCTGCTTGAAATGCTCATGGCTAATCCCCGGCGGGTGCTCACCCGCAGCCGCATCCTCGAAGAGGTATGGGGGTTCGA
CTTCCCGACGTCCGGTAATGCCCTCGAGGTGTACGTCGGCTACCTACGACGCAAGACCGAGGCCGAAGGGGAGCTCCGGC
TCATTCATACCGTTCGCGGTGTCGGCTACGTGCTGCGGGAGACCCCTCCGTAA

Upstream 100 bases:

>100_bases
GGCTGCCCGCCTCGGGCTCATCGACCTCGACCGTCGCTGATCGCTGATCGAGCCGATTCTCAGGCTTCCTCAGTAATATC
TCAGCCGCACGGTTAACACT

Downstream 100 bases:

>100_bases
TCCCCATGTCGACACTACGGATGCCGAGGCGGATGCGAGACTCCAGCACGGCCATATTTACTCCACTGCGGGCAACCAGC
TCATCGGTATCGCTGCGCTG

Product: two component response transcriptional regulatory protein MprA

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MPVRILVVDDDRAVRESLRRSLSFNGYSVDLAEDGVDALNVIANDRPDALVLDVMMPKLDGLEVCRRLRSTGDDLPILVL
TARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTTIDESADAATLSFGDLTLDPVTREVHRGTRSISLTRTEF
ALLEMLMANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEAEGELRLIHTVRGVGYVLRETPP

Sequences:

>Translated_230_residues
MPVRILVVDDDRAVRESLRRSLSFNGYSVDLAEDGVDALNVIANDRPDALVLDVMMPKLDGLEVCRRLRSTGDDLPILVL
TARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTTIDESADAATLSFGDLTLDPVTREVHRGTRSISLTRTEF
ALLEMLMANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEAEGELRLIHTVRGVGYVLRETPP
>Mature_229_residues
PVRILVVDDDRAVRESLRRSLSFNGYSVDLAEDGVDALNVIANDRPDALVLDVMMPKLDGLEVCRRLRSTGDDLPILVLT
ARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTTIDESADAATLSFGDLTLDPVTREVHRGTRSISLTRTEFA
LLEMLMANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEAEGELRLIHTVRGVGYVLRETPP

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=42.7947598253275, Blast_Score=174, Evalue=6e-45,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=40.2714932126697, Blast_Score=163, Evalue=9e-42,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=41.7777777777778, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=38.3259911894273, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=37.7777777777778, Blast_Score=153, Evalue=9e-39,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=40, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=39.9103139013453, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=35.8744394618834, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=34.5291479820628, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=38.5964912280702, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=31.6964285714286, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=27.7533039647577, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787229, Length=234, Percent_Identity=30.3418803418803, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788550, Length=161, Percent_Identity=32.9192546583851, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=29.4372294372294, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=36.1111111111111, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=40.8695652173913, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI145693157, Length=104, Percent_Identity=40.3846153846154, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=35.6435643564356, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790437, Length=146, Percent_Identity=34.2465753424658, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788191, Length=123, Percent_Identity=34.9593495934959, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788905, Length=103, Percent_Identity=32.0388349514563, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25695; Mature: 25564

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVRILVVDDDRAVRESLRRSLSFNGYSVDLAEDGVDALNVIANDRPDALVLDVMMPKLD
CCEEEEEECCCHHHHHHHHHHHCCCCEEEEHHHCCHHHHHHHCCCCCCEEEEEHHHCCCC
GLEVCRRLRSTGDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRR
HHHHHHHHHCCCCCCCEEEEECCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
TTIDESADAATLSFGDLTLDPVTREVHRGTRSISLTRTEFALLEMLMANPRRVLTRSRIL
HCCCCCCCEEEEEECCEECCHHHHHHHCCCCEEEEHHHHHHHHHHHHCCHHHHHHHHHHH
EEVWGFDFPTSGNALEVYVGYLRRKTEAEGELRLIHTVRGVGYVLRETPP
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHCCCCCC
>Mature Secondary Structure 
PVRILVVDDDRAVRESLRRSLSFNGYSVDLAEDGVDALNVIANDRPDALVLDVMMPKLD
CEEEEEECCCHHHHHHHHHHHCCCCEEEEHHHCCHHHHHHHCCCCCCEEEEEHHHCCCC
GLEVCRRLRSTGDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRR
HHHHHHHHHCCCCCCCEEEEECCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
TTIDESADAATLSFGDLTLDPVTREVHRGTRSISLTRTEFALLEMLMANPRRVLTRSRIL
HCCCCCCCEEEEEECCEECCHHHHHHHCCCCEEEEHHHHHHHHHHHHCCHHHHHHHHHHH
EEVWGFDFPTSGNALEVYVGYLRRKTEAEGELRLIHTVRGVGYVLRETPP
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA