Click here to switch to the map view.

The map label for this gene is ilvC [H]

Identifier: 167625850

GI number: 167625850

Start: 4810862

End: 4812343

Strand: Reverse

Name: ilvC [H]

Synonym: Shal_3945

Alternate gene names: 167625850

Gene position: 4812343-4810862 (Counterclockwise)

Preceding gene: 167625853

Following gene: 167625849

Centisome position: 92.07

GC content: 47.17

Gene sequence:

>1482_bases
ATGGCTAACTATTTTAACTCTCTGAATTTGCGTCAACAATTACAGCAGCTGGCACAATGCCGCTTTATGGATCGTAGTGA
GTTTAGTGAAGGCTGTAACTTCATCAAGGGCTGGAATATCGTCATTCTTGGTTGTGGCGCTCAAGGCCTTAACCAAGGCT
TGAATATGCGTGACTCGGGCCTAAATATCTCTTTTGCACTGCGTGAGCAGGCGATTACTGACAAGCGTGACTCTTACCAG
AAAGCGACAGGCAACGGTTTCCGCGTAGGCACTATCGAAGAGCTTATTCCTGATGCAGATCTGGTTCTAAACTTGACGCC
AGACAAGCAGCACACTAACGCTGTGAACACGGTAATGCCGTTGATGAAGCAAGGTGCAACCTTGTCTTATTCTCACGGTT
TCAACATTGTTGAAGAGGGCATGCAAGTTCGCCCTGATATCACGGTAATCATGGTAGCACCTAAGTGCCCAGGTACTGAA
GTTCGTGAAGAGTACAAGCGTGGCTTTGGTGTACCAACACTGATTGCGGTTCACCCAGAGAATGACCATAAGGGTGAAGG
TTTCGATATCGCTAAGGCTTACGCAAGTGCAACCGGTGGCGATCGCGCTGGTGTACTACATTCATCTTTCATTGCGGAAG
TGAAGTCTGATCTGATGGGTGAGCAAACCATCCTTTGTGGCATGCTGCAAACCGGTGCAATTTTAGGTTATGAGAAGATG
GTTGCCGACGGTATTGAGCCTGGTTACGCGGCCAAGCTTATTCAGCAAGGCTGGGAAACCACCACTGAAGCACTGAAGCA
CGGCGGCATCACTCATATGATGGACCGACTATCAAACCCAGCCAAGATCAAGGCATTTGATATGGCTGAAGAGTTGAAAG
TTATTCTTAAGCCGCTGTTTGAAAAGCATATGGACGACATCATCGGTGGCGAATTCTCTAAGACCATGATGGCTGACTGG
GCAAACGATGATGCGAATCTACTGAAGTGGCGCAGCGAAACTAACGACACTGGCTTTGAGAATGCACCGACTTGCGATGA
GTATATCGATGAGCAGGCTTATTTCGATAAAGGCATCTTCTTGGTGGCGATGATCAAAGCGGGTGTAGAGCTTGCTTTCG
ATACCATGGTTGCGGCTGGCATCATCGAAGAGTCGGCTTACTATGAATCACTACATGAGACGCCACTTATCGCGAACACC
ATTGCACGTAAGCGTTTATACGAAATGAACGTAGTGATTTCAGATACGGCAGAATACGGCTGTTACCTATTTAACCATGC
AGCGCTACCGCTACTAAAAGACTATGTTGCTAATATGTCTGCCGAGTACCTAGGTGGTGGCTTGCAAGATACAAGTAATG
GAGTCGATAACCAGCGTTTAATTGAAGTTAACGCGGCGATTCGTTACACCGCAGTTGAAGAAATTGGCGCCGAACTTCGC
GGATATATGACTGAAATGAAGCGCATTGTAGAAGAAAGCTAA

Upstream 100 bases:

>100_bases
TTTAAGCAATGAAATGCTTGCGCTATAGTGAATTCAATTACAGCGTGACTCGCTATCGAGTCAGCCCGTTTAACTGTCCA
GAATCAAGGTGGTATATCAG

Downstream 100 bases:

>100_bases
TCGCTTTTTAGCCAGAGTCTTCGCCATGATTAGCGCAGGCTCTGGCTGTCTAAAATTGAAATTAGAGATAAAAGTCATTT
AGACAAATCATTAACGATTA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MANYFNSLNLRQQLQQLAQCRFMDRSEFSEGCNFIKGWNIVILGCGAQGLNQGLNMRDSGLNISFALREQAITDKRDSYQ
KATGNGFRVGTIEELIPDADLVLNLTPDKQHTNAVNTVMPLMKQGATLSYSHGFNIVEEGMQVRPDITVIMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDHKGEGFDIAKAYASATGGDRAGVLHSSFIAEVKSDLMGEQTILCGMLQTGAILGYEKM
VADGIEPGYAAKLIQQGWETTTEALKHGGITHMMDRLSNPAKIKAFDMAEELKVILKPLFEKHMDDIIGGEFSKTMMADW
ANDDANLLKWRSETNDTGFENAPTCDEYIDEQAYFDKGIFLVAMIKAGVELAFDTMVAAGIIEESAYYESLHETPLIANT
IARKRLYEMNVVISDTAEYGCYLFNHAALPLLKDYVANMSAEYLGGGLQDTSNGVDNQRLIEVNAAIRYTAVEEIGAELR
GYMTEMKRIVEES

Sequences:

>Translated_493_residues
MANYFNSLNLRQQLQQLAQCRFMDRSEFSEGCNFIKGWNIVILGCGAQGLNQGLNMRDSGLNISFALREQAITDKRDSYQ
KATGNGFRVGTIEELIPDADLVLNLTPDKQHTNAVNTVMPLMKQGATLSYSHGFNIVEEGMQVRPDITVIMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDHKGEGFDIAKAYASATGGDRAGVLHSSFIAEVKSDLMGEQTILCGMLQTGAILGYEKM
VADGIEPGYAAKLIQQGWETTTEALKHGGITHMMDRLSNPAKIKAFDMAEELKVILKPLFEKHMDDIIGGEFSKTMMADW
ANDDANLLKWRSETNDTGFENAPTCDEYIDEQAYFDKGIFLVAMIKAGVELAFDTMVAAGIIEESAYYESLHETPLIANT
IARKRLYEMNVVISDTAEYGCYLFNHAALPLLKDYVANMSAEYLGGGLQDTSNGVDNQRLIEVNAAIRYTAVEEIGAELR
GYMTEMKRIVEES
>Mature_492_residues
ANYFNSLNLRQQLQQLAQCRFMDRSEFSEGCNFIKGWNIVILGCGAQGLNQGLNMRDSGLNISFALREQAITDKRDSYQK
ATGNGFRVGTIEELIPDADLVLNLTPDKQHTNAVNTVMPLMKQGATLSYSHGFNIVEEGMQVRPDITVIMVAPKCPGTEV
REEYKRGFGVPTLIAVHPENDHKGEGFDIAKAYASATGGDRAGVLHSSFIAEVKSDLMGEQTILCGMLQTGAILGYEKMV
ADGIEPGYAAKLIQQGWETTTEALKHGGITHMMDRLSNPAKIKAFDMAEELKVILKPLFEKHMDDIIGGEFSKTMMADWA
NDDANLLKWRSETNDTGFENAPTCDEYIDEQAYFDKGIFLVAMIKAGVELAFDTMVAAGIIEESAYYESLHETPLIANTI
ARKRLYEMNVVISDTAEYGCYLFNHAALPLLKDYVANMSAEYLGGGLQDTSNGVDNQRLIEVNAAIRYTAVEEIGAELRG
YMTEMKRIVEES

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=489, Percent_Identity=70.7566462167689, Blast_Score=715, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323387, Length=269, Percent_Identity=30.8550185873606, Blast_Score=108, Evalue=1e-24,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- InterPro:   IPR014359
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 54525; Mature: 54393

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANYFNSLNLRQQLQQLAQCRFMDRSEFSEGCNFIKGWNIVILGCGAQGLNQGLNMRDSG
CCCCHHCCCHHHHHHHHHHHHCCCHHHHHHCCCEECCCCEEEEECCCHHHHCCCCCCCCC
LNISFALREQAITDKRDSYQKATGNGFRVGTIEELIPDADLVLNLTPDKQHTNAVNTVMP
CCEEEEEHHHHHHCHHHHHHHHCCCCEEECCHHHHCCCCCEEEEECCCCHHHHHHHHHHH
LMKQGATLSYSHGFNIVEEGMQVRPDITVIMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCEEEECCCCHHHHCCCEECCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEECCC
NDHKGEGFDIAKAYASATGGDRAGVLHSSFIAEVKSDLMGEQTILCGMLQTGAILGYEKM
CCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHH
VADGIEPGYAAKLIQQGWETTTEALKHGGITHMMDRLSNPAKIKAFDMAEELKVILKPLF
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHH
EKHMDDIIGGEFSKTMMADWANDDANLLKWRSETNDTGFENAPTCDEYIDEQAYFDKGIF
HHHHHHHHCCCHHHHHHHHCCCCCHHHHEECCCCCCCCCCCCCCHHHHHHHHHHHCCCHH
LVAMIKAGVELAFDTMVAAGIIEESAYYESLHETPLIANTIARKRLYEMNVVISDTAEYG
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEECCHHHC
CYLFNHAALPLLKDYVANMSAEYLGGGLQDTSNGVDNQRLIEVNAAIRYTAVEEIGAELR
HHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHH
GYMTEMKRIVEES
HHHHHHHHHHHCC
>Mature Secondary Structure 
ANYFNSLNLRQQLQQLAQCRFMDRSEFSEGCNFIKGWNIVILGCGAQGLNQGLNMRDSG
CCCHHCCCHHHHHHHHHHHHCCCHHHHHHCCCEECCCCEEEEECCCHHHHCCCCCCCCC
LNISFALREQAITDKRDSYQKATGNGFRVGTIEELIPDADLVLNLTPDKQHTNAVNTVMP
CCEEEEEHHHHHHCHHHHHHHHCCCCEEECCHHHHCCCCCEEEEECCCCHHHHHHHHHHH
LMKQGATLSYSHGFNIVEEGMQVRPDITVIMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCEEEECCCCHHHHCCCEECCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEECCC
NDHKGEGFDIAKAYASATGGDRAGVLHSSFIAEVKSDLMGEQTILCGMLQTGAILGYEKM
CCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHH
VADGIEPGYAAKLIQQGWETTTEALKHGGITHMMDRLSNPAKIKAFDMAEELKVILKPLF
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHH
EKHMDDIIGGEFSKTMMADWANDDANLLKWRSETNDTGFENAPTCDEYIDEQAYFDKGIF
HHHHHHHHCCCHHHHHHHHCCCCCHHHHEECCCCCCCCCCCCCCHHHHHHHHHHHCCCHH
LVAMIKAGVELAFDTMVAAGIIEESAYYESLHETPLIANTIARKRLYEMNVVISDTAEYG
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEECCHHHC
CYLFNHAALPLLKDYVANMSAEYLGGGLQDTSNGVDNQRLIEVNAAIRYTAVEEIGAELR
HHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHH
GYMTEMKRIVEES
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA