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The map label for this gene is ilvG [H]

Identifier: 167625849

GI number: 167625849

Start: 4808626

End: 4810320

Strand: Reverse

Name: ilvG [H]

Synonym: Shal_3944

Alternate gene names: 167625849

Gene position: 4810320-4808626 (Counterclockwise)

Preceding gene: 167625850

Following gene: 167625848

Centisome position: 92.03

GC content: 51.86

Gene sequence:

>1695_bases
ATGGAACAAGGGAAGATGGAGCAAGGACAAATGATAAGAGGCGCAGATGCAGTCATCAAGGCGATTGCCGCACACGGTGT
AACAACGGTGTTTGGTTATCCCGGTGGGGCGATTATGCCCATCTATGATGCGCTCTATGGTAGCCCTGTCGAGCACCTGC
TAAGCCGTCATGAGCAAGGCGCGGCATTTGCCGCTGTCGGCTACGCCAGAGCCAGCGGCCAAACCGGGGTTTGCTTTGCC
ACTTCAGGCCCTGGTGCCACAAATCTCGTGACATCACTTGCCGACGCTCTGCTAGATTCGGTGCCAGTCGTTGCCATCAC
GGGTCAAGTTTCTACCGCGGTTATTGGCACCGATGCCTTTCAAGAAATTGATGTCTTAGGTATGTCACTGTCATGCACTA
AACATAGCTTTATGGTGACCCATGTCGATGAGCTTGTTCCTACTCTGTACAAAGCGTTTGAGATCGCCGCCTCTGGTCGC
CCTGGTCCTGTGTTAGTCGATATCCCTAAAGATGTGCAGATCGCCATGCTTGAATACAAGACGCCACTGCAAGCGGTTAG
CGTTGAACCTGAGCACACTGCCGAGCAGCTTAATGAGGCAAATCAGCTTATTGAGCAAGCTAAGCGACCAATGCTTTATG
TGGGTGGGGGGGTAGGCATGGCAAGCGCTGTCGAGCAACTCGCTGATTTCATCAAGGTCACCGGGATTCCATCGGTTGCC
ACCCTAAAGGGCTTAGGCGCTATCAATCCAAATACTCCCGGCTACTTGGGTATGCTCGGTATGCACGGATCTAAAGCGGC
CAATTTAGCGGTACAAGAGTGTGACTTGTTGATTGTGGTGGGGGCTCGTTTTGACGATAGGGTGACCGGACGCTTAGCCA
GCTTTGCTGAAAATGCCAAGGTGATCCATCTGGATATCGACGCTGCCGAGCTAGGTAAGTTACGTCTTCCTGAAGTGGCT
ATTGCTGGCGATTTGCGCCAAATTCTTCCTGCACTAACTCAAAACCTAGGTGAGCAATTTGCCCCATGGCAAGCCAAGGT
GGCCCAGATGAAGCATGAGCATCAATGGCGTTATGACCGTCCGAGTGAGCTTATCTACGCACCTGCAATGCTCAATCGTC
TTGCGCATAAGTTGCCACAAGACAGCGTGGTGTCCTGTGATGTCGGTCAGCATCAGATGTGGGTAGCGCAGCACATGTTC
TTTAATCGCCCAGAAGATCACCTGTCGAGTGCCGGGCTTGGCACTATGGGCTTTGGCTTGCCTGCGGCCATTGGCGCTAA
AGTGGCGCGTCCCGATGCTATGGTAGTCGCAGTCTCGGGGGATGGCTCTTTTATGATGAATGTTCAGGAGCTGACCACCA
TCAAGCGTAGGCGCCTACCCGTTAAAATCTTGCTTATCGATAACCAAAAGCTAGGCATGGTTAAGCAGTGGCAGCAGCTG
TTTTTTGAAGAGCGCTACAGCGAAACCGACCTGTCTGACAACCCTGATTTCGTTAAGATGGCATCGGCATTCGATATCCC
AGGACGCACTATCTCTAAGACGAGTGAAGTCGAAGCCGGACTCGATGAACTCCTCAATAGTGAAGGTCCCTTTTTACTGC
ATGTGTCGATAGATGATGTCCATAACGTCTGGCCATTAGTGCCGCCAGGGGCTTCAAACCAAGAGATGATGGAAGAGATG
GATAAGCAAACTTAA

Upstream 100 bases:

>100_bases
GGGGGTTTTTTCGTTTAAGGGCTTAGGTGAAATAAAAGGTAAAGTAAAACTTCTATCTAAGCTCTTAATAAAAAAGTTAA
TTGTAGCGGAGCGCTGATTT

Downstream 100 bases:

>100_bases
GCTGCAGAAATCGGCGAGTTTGAGTCTGAATAAGAAGATTAGAAAGAGCGATAAAACGAGATGGAGAGCAAGGATATGAA
TAATTACTCATTAGCGTTAA

Product: acetolactate synthase 2 catalytic subunit

Products: NA

Alternate protein names: AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit [H]

Number of amino acids: Translated: 564; Mature: 564

Protein sequence:

>564_residues
MEQGKMEQGQMIRGADAVIKAIAAHGVTTVFGYPGGAIMPIYDALYGSPVEHLLSRHEQGAAFAAVGYARASGQTGVCFA
TSGPGATNLVTSLADALLDSVPVVAITGQVSTAVIGTDAFQEIDVLGMSLSCTKHSFMVTHVDELVPTLYKAFEIAASGR
PGPVLVDIPKDVQIAMLEYKTPLQAVSVEPEHTAEQLNEANQLIEQAKRPMLYVGGGVGMASAVEQLADFIKVTGIPSVA
TLKGLGAINPNTPGYLGMLGMHGSKAANLAVQECDLLIVVGARFDDRVTGRLASFAENAKVIHLDIDAAELGKLRLPEVA
IAGDLRQILPALTQNLGEQFAPWQAKVAQMKHEHQWRYDRPSELIYAPAMLNRLAHKLPQDSVVSCDVGQHQMWVAQHMF
FNRPEDHLSSAGLGTMGFGLPAAIGAKVARPDAMVVAVSGDGSFMMNVQELTTIKRRRLPVKILLIDNQKLGMVKQWQQL
FFEERYSETDLSDNPDFVKMASAFDIPGRTISKTSEVEAGLDELLNSEGPFLLHVSIDDVHNVWPLVPPGASNQEMMEEM
DKQT

Sequences:

>Translated_564_residues
MEQGKMEQGQMIRGADAVIKAIAAHGVTTVFGYPGGAIMPIYDALYGSPVEHLLSRHEQGAAFAAVGYARASGQTGVCFA
TSGPGATNLVTSLADALLDSVPVVAITGQVSTAVIGTDAFQEIDVLGMSLSCTKHSFMVTHVDELVPTLYKAFEIAASGR
PGPVLVDIPKDVQIAMLEYKTPLQAVSVEPEHTAEQLNEANQLIEQAKRPMLYVGGGVGMASAVEQLADFIKVTGIPSVA
TLKGLGAINPNTPGYLGMLGMHGSKAANLAVQECDLLIVVGARFDDRVTGRLASFAENAKVIHLDIDAAELGKLRLPEVA
IAGDLRQILPALTQNLGEQFAPWQAKVAQMKHEHQWRYDRPSELIYAPAMLNRLAHKLPQDSVVSCDVGQHQMWVAQHMF
FNRPEDHLSSAGLGTMGFGLPAAIGAKVARPDAMVVAVSGDGSFMMNVQELTTIKRRRLPVKILLIDNQKLGMVKQWQQL
FFEERYSETDLSDNPDFVKMASAFDIPGRTISKTSEVEAGLDELLNSEGPFLLHVSIDDVHNVWPLVPPGASNQEMMEEM
DKQT
>Mature_564_residues
MEQGKMEQGQMIRGADAVIKAIAAHGVTTVFGYPGGAIMPIYDALYGSPVEHLLSRHEQGAAFAAVGYARASGQTGVCFA
TSGPGATNLVTSLADALLDSVPVVAITGQVSTAVIGTDAFQEIDVLGMSLSCTKHSFMVTHVDELVPTLYKAFEIAASGR
PGPVLVDIPKDVQIAMLEYKTPLQAVSVEPEHTAEQLNEANQLIEQAKRPMLYVGGGVGMASAVEQLADFIKVTGIPSVA
TLKGLGAINPNTPGYLGMLGMHGSKAANLAVQECDLLIVVGARFDDRVTGRLASFAENAKVIHLDIDAAELGKLRLPEVA
IAGDLRQILPALTQNLGEQFAPWQAKVAQMKHEHQWRYDRPSELIYAPAMLNRLAHKLPQDSVVSCDVGQHQMWVAQHMF
FNRPEDHLSSAGLGTMGFGLPAAIGAKVARPDAMVVAVSGDGSFMMNVQELTTIKRRRLPVKILLIDNQKLGMVKQWQQL
FFEERYSETDLSDNPDFVKMASAFDIPGRTISKTSEVEAGLDELLNSEGPFLLHVSIDDVHNVWPLVPPGASNQEMMEEM
DKQT

Specific function: Catalyzes the first step in the biosynthesis of branched-chain amino acids [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=528, Percent_Identity=26.7045454545455, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI93004078, Length=558, Percent_Identity=24.910394265233, Blast_Score=153, Evalue=4e-37,
Organism=Escherichia coli, GI1790104, Length=561, Percent_Identity=45.632798573975, Blast_Score=487, Evalue=1e-139,
Organism=Escherichia coli, GI87081685, Length=573, Percent_Identity=41.3612565445026, Blast_Score=439, Evalue=1e-124,
Organism=Escherichia coli, GI1786717, Length=566, Percent_Identity=29.5053003533569, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI1787096, Length=538, Percent_Identity=28.4386617100372, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI1788716, Length=553, Percent_Identity=26.0397830018083, Blast_Score=155, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17531299, Length=562, Percent_Identity=26.3345195729537, Blast_Score=152, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17531301, Length=562, Percent_Identity=26.3345195729537, Blast_Score=152, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17542570, Length=531, Percent_Identity=25.6120527306968, Blast_Score=136, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6323755, Length=592, Percent_Identity=42.5675675675676, Blast_Score=453, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6320816, Length=475, Percent_Identity=23.3684210526316, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321524, Length=478, Percent_Identity=24.0585774058577, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6323163, Length=479, Percent_Identity=23.7995824634656, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6320123, Length=501, Percent_Identity=21.7564870259481, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323073, Length=480, Percent_Identity=24.1666666666667, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19922626, Length=504, Percent_Identity=25.9920634920635, Blast_Score=164, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 60786; Mature: 60786

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQGKMEQGQMIRGADAVIKAIAAHGVTTVFGYPGGAIMPIYDALYGSPVEHLLSRHEQG
CCCCCCCCCCEECHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCHHHHHHHCCCCC
AAFAAVGYARASGQTGVCFATSGPGATNLVTSLADALLDSVPVVAITGQVSTAVIGTDAF
CEEEEEHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCHHH
QEIDVLGMSLSCTKHSFMVTHVDELVPTLYKAFEIAASGRPGPVLVDIPKDVQIAMLEYK
HHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEECC
TPLQAVSVEPEHTAEQLNEANQLIEQAKRPMLYVGGGVGMASAVEQLADFIKVTGIPSVA
CCCCEEECCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCHH
TLKGLGAINPNTPGYLGMLGMHGSKAANLAVQECDLLIVVGARFDDRVTGRLASFAENAK
HHHCCCCCCCCCCCCEEEECCCCCCHHHEEHCCCCEEEEECCCCCCHHHHHHHHHHCCCE
VIHLDIDAAELGKLRLPEVAIAGDLRQILPALTQNLGEQFAPWQAKVAQMKHEHQWRYDR
EEEEECCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
PSELIYAPAMLNRLAHKLPQDSVVSCDVGQHQMWVAQHMFFNRPEDHLSSAGLGTMGFGL
CCCEEEHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCC
PAAIGAKVARPDAMVVAVSGDGSFMMNVQELTTIKRRRLPVKILLIDNQKLGMVKQWQQL
HHHHCCHHCCCCEEEEEEECCCCEEEEHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHH
FFEERYSETDLSDNPDFVKMASAFDIPGRTISKTSEVEAGLDELLNSEGPFLLHVSIDDV
HHHHHCCCCCCCCCCCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCH
HNVWPLVPPGASNQEMMEEMDKQT
HCCCCCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MEQGKMEQGQMIRGADAVIKAIAAHGVTTVFGYPGGAIMPIYDALYGSPVEHLLSRHEQG
CCCCCCCCCCEECHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCHHHHHHHCCCCC
AAFAAVGYARASGQTGVCFATSGPGATNLVTSLADALLDSVPVVAITGQVSTAVIGTDAF
CEEEEEHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCHHH
QEIDVLGMSLSCTKHSFMVTHVDELVPTLYKAFEIAASGRPGPVLVDIPKDVQIAMLEYK
HHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEECC
TPLQAVSVEPEHTAEQLNEANQLIEQAKRPMLYVGGGVGMASAVEQLADFIKVTGIPSVA
CCCCEEECCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCHH
TLKGLGAINPNTPGYLGMLGMHGSKAANLAVQECDLLIVVGARFDDRVTGRLASFAENAK
HHHCCCCCCCCCCCCEEEECCCCCCHHHEEHCCCCEEEEECCCCCCHHHHHHHHHHCCCE
VIHLDIDAAELGKLRLPEVAIAGDLRQILPALTQNLGEQFAPWQAKVAQMKHEHQWRYDR
EEEEECCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
PSELIYAPAMLNRLAHKLPQDSVVSCDVGQHQMWVAQHMFFNRPEDHLSSAGLGTMGFGL
CCCEEEHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCC
PAAIGAKVARPDAMVVAVSGDGSFMMNVQELTTIKRRRLPVKILLIDNQKLGMVKQWQQL
HHHHCCHHCCCCEEEEEEECCCCEEEEHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHH
FFEERYSETDLSDNPDFVKMASAFDIPGRTISKTSEVEAGLDELLNSEGPFLLHVSIDDV
HHHHHCCCCCCCCCCCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCH
HNVWPLVPPGASNQEMMEEMDKQT
HCCCCCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3550695; 1379743; 9278503; 1995430; 6154938; 7015336; 3897211 [H]