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The map label for this gene is cbs [H]

Identifier: 167625648

GI number: 167625648

Start: 4541765

End: 4542856

Strand: Reverse

Name: cbs [H]

Synonym: Shal_3743

Alternate gene names: 167625648

Gene position: 4542856-4541765 (Counterclockwise)

Preceding gene: 167625649

Following gene: 167625647

Centisome position: 86.91

GC content: 49.08

Gene sequence:

>1092_bases
ATGTCATCTTCCGCTGTAAATGATAACGACTCTTCCCCTGTAAAATCAGGGATCTCAGGTAATATTACTGAACTCATCGG
CAATACTGATCTGTTACGAATCAACAGTCTGAGTGAGTTGAGTGGCTGTGAGATATTGCTTAAATGCGAACAGCAAAACC
CCGGTGGTTCAATTAAAGATCGCGCCGCCCTGCAGATGGTCCAAGATGCCATTGCCAGCGGAAAGCTAACCCCCGGCATG
ACTATCGTTGAAGGCACGGCTGGAAATACTGGAATAGGCCTGGCGTTGGTCGCAAAAGCGTTAGGCTTTAAGATGCTGGT
GGTGATGCCAAGAGGTCAGGCGCACGAAAAAGAGCGAATGATCTCCCTGTACGATGCTGAGCTTAAGTTAGTGGATGCCT
GTCCCTTTGCTAATCCAGATCATTTCTATCATACGGCTAAGCGTCTTGGTGAGGCTAACAGCGATTATTGGTGGGCGGAT
CAATTTGAAAATACCAGCAATAGCAAGGCTCACTTTATTCATACTGGGCCTGAGATCTGGCGTCAAACTCATGGAAAAAT
CGATGCTCTGGTGTCTGTCGCCGGCACCGGCGGCACCATTGCGGGTAATTCTCGTTACTTATCGACCAAGAATAGACAGT
TGCAGACTTGGCTGGTGGATCCCGATGGTTCCGGGATCTATAACTATTTAAAAACCGGCGAATATGTTTCTAGTGGAACT
TCCTTTACCGAAGGGATAGGCATCATGCGCAGCGTCGAAAACTTTCGACAGGCAAAGATTGATAAAGCCATTACCCTGCC
GGATCTCGACCTAGTCGCCATCGCGCGTCATGTAAGAGAGCATGATGGCATCGTACTCGGTAGCAGTGCGGCGCTTAATG
TGGCGGGCGCCCTTTATGCGGCGGCTAAGATGGGGCCGGGCAATACCATAGTCACTTTCTATTGCGATCAGCCTGAGCGC
TCCTCCTCTAAGCTCTACAACGAACACTTTCTATTAGATAATGGCTTTAGTGGTGAGAGTGAGCCTGCTCTGACGATGTT
TAGTCGCTATCAAAAACAGCCATTATCGGCCGTAGTGGAGGTACGAGGGTAA

Upstream 100 bases:

>100_bases
CTGATCCTCAGTTAACTGAAGTATCATGGAGCCACAGGTTTGGCTTATAGGTGAACTGTGCCTAATATTGAATGAGAGCC
AATAACTGAGATAGCCATCT

Downstream 100 bases:

>100_bases
TCGAGAGCTCGTAATCGCTTTAGATTGAGAGCTGAGTTTTATTTTCACTGCGTCTTTATTGATTATTAGCTTATGGCATT
AGATAGTTCACTAAAGTAGT

Product: cysteine synthase A

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MSSSAVNDNDSSPVKSGISGNITELIGNTDLLRINSLSELSGCEILLKCEQQNPGGSIKDRAALQMVQDAIASGKLTPGM
TIVEGTAGNTGIGLALVAKALGFKMLVVMPRGQAHEKERMISLYDAELKLVDACPFANPDHFYHTAKRLGEANSDYWWAD
QFENTSNSKAHFIHTGPEIWRQTHGKIDALVSVAGTGGTIAGNSRYLSTKNRQLQTWLVDPDGSGIYNYLKTGEYVSSGT
SFTEGIGIMRSVENFRQAKIDKAITLPDLDLVAIARHVREHDGIVLGSSAALNVAGALYAAAKMGPGNTIVTFYCDQPER
SSSKLYNEHFLLDNGFSGESEPALTMFSRYQKQPLSAVVEVRG

Sequences:

>Translated_363_residues
MSSSAVNDNDSSPVKSGISGNITELIGNTDLLRINSLSELSGCEILLKCEQQNPGGSIKDRAALQMVQDAIASGKLTPGM
TIVEGTAGNTGIGLALVAKALGFKMLVVMPRGQAHEKERMISLYDAELKLVDACPFANPDHFYHTAKRLGEANSDYWWAD
QFENTSNSKAHFIHTGPEIWRQTHGKIDALVSVAGTGGTIAGNSRYLSTKNRQLQTWLVDPDGSGIYNYLKTGEYVSSGT
SFTEGIGIMRSVENFRQAKIDKAITLPDLDLVAIARHVREHDGIVLGSSAALNVAGALYAAAKMGPGNTIVTFYCDQPER
SSSKLYNEHFLLDNGFSGESEPALTMFSRYQKQPLSAVVEVRG
>Mature_362_residues
SSSAVNDNDSSPVKSGISGNITELIGNTDLLRINSLSELSGCEILLKCEQQNPGGSIKDRAALQMVQDAIASGKLTPGMT
IVEGTAGNTGIGLALVAKALGFKMLVVMPRGQAHEKERMISLYDAELKLVDACPFANPDHFYHTAKRLGEANSDYWWADQ
FENTSNSKAHFIHTGPEIWRQTHGKIDALVSVAGTGGTIAGNSRYLSTKNRQLQTWLVDPDGSGIYNYLKTGEYVSSGTS
FTEGIGIMRSVENFRQAKIDKAITLPDLDLVAIARHVREHDGIVLGSSAALNVAGALYAAAKMGPGNTIVTFYCDQPERS
SSKLYNEHFLLDNGFSGESEPALTMFSRYQKQPLSAVVEVRG

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=335, Percent_Identity=35.5223880597015, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI295821200, Length=335, Percent_Identity=35.5223880597015, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI4557415, Length=335, Percent_Identity=35.5223880597015, Blast_Score=177, Evalue=1e-44,
Organism=Escherichia coli, GI2367138, Length=314, Percent_Identity=34.7133757961783, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1788754, Length=276, Percent_Identity=34.7826086956522, Blast_Score=134, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17535051, Length=314, Percent_Identity=34.7133757961783, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17562970, Length=306, Percent_Identity=33.6601307189542, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI32566674, Length=297, Percent_Identity=34.006734006734, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI115535073, Length=319, Percent_Identity=34.4827586206897, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17561720, Length=305, Percent_Identity=33.1147540983607, Blast_Score=137, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17534315, Length=338, Percent_Identity=31.9526627218935, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI25147552, Length=306, Percent_Identity=33.0065359477124, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI32566672, Length=222, Percent_Identity=29.7297297297297, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321449, Length=340, Percent_Identity=35.8823529411765, Blast_Score=176, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6321594, Length=313, Percent_Identity=33.8658146964856, Blast_Score=139, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24643623, Length=327, Percent_Identity=32.1100917431193, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI20129101, Length=327, Percent_Identity=32.1100917431193, Blast_Score=153, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 39165; Mature: 39033

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00144 ASN_GLN_ASE_1 ; PS00165 DEHYDRATASE_SER_THR ; PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSAVNDNDSSPVKSGISGNITELIGNTDLLRINSLSELSGCEILLKCEQQNPGGSIKD
CCCCCCCCCCCCHHHCCCCCCHHHHHCCCCEEEECCCCCCCCCEEEEEEECCCCCCCCHH
RAALQMVQDAIASGKLTPGMTIVEGTAGNTGIGLALVAKALGFKMLVVMPRGQAHEKERM
HHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCEEEEEECCCCCHHHHHH
ISLYDAELKLVDACPFANPDHFYHTAKRLGEANSDYWWADQFENTSNSKAHFIHTGPEIW
HHHCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCEECCCCCCCCCCCEEEEECCHHHH
RQTHGKIDALVSVAGTGGTIAGNSRYLSTKNRQLQTWLVDPDGSGIYNYLKTGEYVSSGT
HHHCCCEEEEEEECCCCCEECCCCEEEECCCCEEEEEEECCCCCCHHHHHHCCCHHHCCC
SFTEGIGIMRSVENFRQAKIDKAITLPDLDLVAIARHVREHDGIVLGSSAALNVAGALYA
CHHHHHHHHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHCCEEEECCCHHHHHHHHHH
AAKMGPGNTIVTFYCDQPERSSSKLYNEHFLLDNGFSGESEPALTMFSRYQKQPLSAVVE
HHCCCCCCEEEEEEECCCCCCHHHHHHCEEEEECCCCCCCCHHHHHHHHHHHCCCHHHEE
VRG
ECC
>Mature Secondary Structure 
SSSAVNDNDSSPVKSGISGNITELIGNTDLLRINSLSELSGCEILLKCEQQNPGGSIKD
CCCCCCCCCCCHHHCCCCCCHHHHHCCCCEEEECCCCCCCCCEEEEEEECCCCCCCCHH
RAALQMVQDAIASGKLTPGMTIVEGTAGNTGIGLALVAKALGFKMLVVMPRGQAHEKERM
HHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCEEEEEECCCCCHHHHHH
ISLYDAELKLVDACPFANPDHFYHTAKRLGEANSDYWWADQFENTSNSKAHFIHTGPEIW
HHHCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCEECCCCCCCCCCCEEEEECCHHHH
RQTHGKIDALVSVAGTGGTIAGNSRYLSTKNRQLQTWLVDPDGSGIYNYLKTGEYVSSGT
HHHCCCEEEEEEECCCCCEECCCCEEEECCCCEEEEEEECCCCCCHHHHHHCCCHHHCCC
SFTEGIGIMRSVENFRQAKIDKAITLPDLDLVAIARHVREHDGIVLGSSAALNVAGALYA
CHHHHHHHHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHCCEEEECCCHHHHHHHHHH
AAKMGPGNTIVTFYCDQPERSSSKLYNEHFLLDNGFSGESEPALTMFSRYQKQPLSAVVE
HHCCCCCCEEEEEEECCCCCCHHHHHHCEEEEECCCCCCCCHHHHHHHHHHHCCCHHHEE
VRG
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]