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The map label for this gene is hisC [H]

Identifier: 167625649

GI number: 167625649

Start: 4543018

End: 4544178

Strand: Reverse

Name: hisC [H]

Synonym: Shal_3744

Alternate gene names: 167625649

Gene position: 4544178-4543018 (Counterclockwise)

Preceding gene: 167625650

Following gene: 167625648

Centisome position: 86.94

GC content: 50.04

Gene sequence:

>1161_bases
ATGCAAAACTCTTCTTTCAAGTTAAGTCGTCGTCAATTCTTATATGCAGGTGCCGCCGCATCAAGTTTAGCGACCTTAGG
TTGCAGCTCAACCTCAATCTCTACTGCAGCAAGTTCGTTAGCATCGGCCTCGATGAGTACGGATGAGCCGATCCCGCTTA
ATTTTAATGAGAACCCACTCGGCTTGGCACCTAAAGCCCAGCAAGCAGTTACCGATGCGTTGCCCAATGCTTGGCGTTAC
CCCGATGCGGCCCGAAGTGAGCTGATGGCGAGTATTGCTGGCAATTTGGGGCTTATAGAGTCGCAGTTAATCTATGGTAA
TGGCTCCTCTGAAGTGCTTAAGATGGCGCTTGATGCCCTCGCGCAAAGCAATAGCCAGTTGGTGATGCCAGATCCAAGTT
ATGGGGTGATAATCGATTACGCCATGGCGCGTGGAATCCCTGTGGTCAAGGTCAAGCTCGATGGTGACTGGCAAACCGAT
TTAGCCCAGATGCAAGCAAAAGTGGCTCAGCATAATGGCCCGTCGATTGTGTACCTGTGTAACCCTAATAATCCAACGGG
ATTAGTATTACCACAGAGTGAGCTGAATCAGTGGTTAGATAAGGCATCGAGTCAACTAAGCTTTATCATTGATGAGGCCT
ATGTGGAGTATGTCGCTCAAGCTGGGTTTGTGTCTGCGGTTGAACGGGTGAAGCAAGGTCAGTCACATATTGTGGTGTGT
CGAACCTTCTCAAAAATCTACGCCCTTGCTGGGCTACGTGTCGGTTACGGCGTGGCGCATAGCGAGCTCATTAAGGCGAT
GCAGGCGCAGGCAAGTATCGATAATGCCAATCTAATCGGCTGCGTCGCGGCTAAGGCTAGCCTCGAGAGTTCACAGTGGC
TAGGGTTGAGTTTGCAATCAAACAGTCAAGCCAAAGCCTTGGTATATCAGCAGCTAAGCGAGCTTGGTTTAGATTATCTA
CCGAGCGAGACTAACTTTATCTTTCACAAAGTTAATGGCGATAGCGGGCTGTATATGCAACGCATGGCAAAGGCAGGCAT
TTTGGTCGGCCGCCCATTTAACCATGGTGAAGGCTGGAACCGTCTCTCTATCGGCACACCCGCGCAGATGCAATACTTCT
GTAAGACCTTGGCAAAGTTTCGCGAGTTGGGCTGGGTGTAA

Upstream 100 bases:

>100_bases
AGTGTGATCTTGGCTACAAATCTAGTCTGCTAGACTAGCGATAGTGAGTCGTTAATAAGAATATCTAGTGTATATATTAA
TTCAATAATAATAACTAAGT

Downstream 100 bases:

>100_bases
TTAACGGTTGGGGGTCGATAGCTAATCTTAGCGAGTTAATCAGTATTGCGGCAAAGCAATACTGATCCTCAGTTAACTGA
AGTATCATGGAGCCACAGGT

Product: class I/II aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MQNSSFKLSRRQFLYAGAAASSLATLGCSSTSISTAASSLASASMSTDEPIPLNFNENPLGLAPKAQQAVTDALPNAWRY
PDAARSELMASIAGNLGLIESQLIYGNGSSEVLKMALDALAQSNSQLVMPDPSYGVIIDYAMARGIPVVKVKLDGDWQTD
LAQMQAKVAQHNGPSIVYLCNPNNPTGLVLPQSELNQWLDKASSQLSFIIDEAYVEYVAQAGFVSAVERVKQGQSHIVVC
RTFSKIYALAGLRVGYGVAHSELIKAMQAQASIDNANLIGCVAAKASLESSQWLGLSLQSNSQAKALVYQQLSELGLDYL
PSETNFIFHKVNGDSGLYMQRMAKAGILVGRPFNHGEGWNRLSIGTPAQMQYFCKTLAKFRELGWV

Sequences:

>Translated_386_residues
MQNSSFKLSRRQFLYAGAAASSLATLGCSSTSISTAASSLASASMSTDEPIPLNFNENPLGLAPKAQQAVTDALPNAWRY
PDAARSELMASIAGNLGLIESQLIYGNGSSEVLKMALDALAQSNSQLVMPDPSYGVIIDYAMARGIPVVKVKLDGDWQTD
LAQMQAKVAQHNGPSIVYLCNPNNPTGLVLPQSELNQWLDKASSQLSFIIDEAYVEYVAQAGFVSAVERVKQGQSHIVVC
RTFSKIYALAGLRVGYGVAHSELIKAMQAQASIDNANLIGCVAAKASLESSQWLGLSLQSNSQAKALVYQQLSELGLDYL
PSETNFIFHKVNGDSGLYMQRMAKAGILVGRPFNHGEGWNRLSIGTPAQMQYFCKTLAKFRELGWV
>Mature_386_residues
MQNSSFKLSRRQFLYAGAAASSLATLGCSSTSISTAASSLASASMSTDEPIPLNFNENPLGLAPKAQQAVTDALPNAWRY
PDAARSELMASIAGNLGLIESQLIYGNGSSEVLKMALDALAQSNSQLVMPDPSYGVIIDYAMARGIPVVKVKLDGDWQTD
LAQMQAKVAQHNGPSIVYLCNPNNPTGLVLPQSELNQWLDKASSQLSFIIDEAYVEYVAQAGFVSAVERVKQGQSHIVVC
RTFSKIYALAGLRVGYGVAHSELIKAMQAQASIDNANLIGCVAAKASLESSQWLGLSLQSNSQAKALVYQQLSELGLDYL
PSETNFIFHKVNGDSGLYMQRMAKAGILVGRPFNHGEGWNRLSIGTPAQMQYFCKTLAKFRELGWV

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=331, Percent_Identity=25.6797583081571, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322075, Length=371, Percent_Identity=24.7978436657682, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41555; Mature: 41555

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNSSFKLSRRQFLYAGAAASSLATLGCSSTSISTAASSLASASMSTDEPIPLNFNENPL
CCCCCCCHHHHHHEEECHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GLAPKAQQAVTDALPNAWRYPDAARSELMASIAGNLGLIESQLIYGNGSSEVLKMALDAL
CCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEECEEEECCCHHHHHHHHHHHH
AQSNSQLVMPDPSYGVIIDYAMARGIPVVKVKLDGDWQTDLAQMQAKVAQHNGPSIVYLC
HCCCCEEEECCCCCCEEEEEHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEE
NPNNPTGLVLPQSELNQWLDKASSQLSFIIDEAYVEYVAQAGFVSAVERVKQGQSHIVVC
CCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
RTFSKIYALAGLRVGYGVAHSELIKAMQAQASIDNANLIGCVAAKASLESSQWLGLSLQS
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCCCEEEEEECC
NSQAKALVYQQLSELGLDYLPSETNFIFHKVNGDSGLYMQRMAKAGILVGRPFNHGEGWN
CCCHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCEEEECCCCCCCCCC
RLSIGTPAQMQYFCKTLAKFRELGWV
EEECCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQNSSFKLSRRQFLYAGAAASSLATLGCSSTSISTAASSLASASMSTDEPIPLNFNENPL
CCCCCCCHHHHHHEEECHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GLAPKAQQAVTDALPNAWRYPDAARSELMASIAGNLGLIESQLIYGNGSSEVLKMALDAL
CCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEECEEEECCCHHHHHHHHHHHH
AQSNSQLVMPDPSYGVIIDYAMARGIPVVKVKLDGDWQTDLAQMQAKVAQHNGPSIVYLC
HCCCCEEEECCCCCCEEEEEHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEE
NPNNPTGLVLPQSELNQWLDKASSQLSFIIDEAYVEYVAQAGFVSAVERVKQGQSHIVVC
CCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
RTFSKIYALAGLRVGYGVAHSELIKAMQAQASIDNANLIGCVAAKASLESSQWLGLSLQS
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCCCEEEEEECC
NSQAKALVYQQLSELGLDYLPSETNFIFHKVNGDSGLYMQRMAKAGILVGRPFNHGEGWN
CCCHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCEEEECCCCCCCCCC
RLSIGTPAQMQYFCKTLAKFRELGWV
EEECCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA