Click here to switch to the map view.

The map label for this gene is fklB [H]

Identifier: 167625076

GI number: 167625076

Start: 3863774

End: 3864391

Strand: Reverse

Name: fklB [H]

Synonym: Shal_3164

Alternate gene names: 167625076

Gene position: 3864391-3863774 (Counterclockwise)

Preceding gene: 167625077

Following gene: 167625075

Centisome position: 73.93

GC content: 44.17

Gene sequence:

>618_bases
ATGTCTGAGAAGTTCAGTACAATTGAAGCGCAAGCAAGCTACGGTGTTGGTCGTCAACTAGGTGAGCAACTAGCTGCTAA
CTCGTTTGAAGGTATCGATATTTCTGCTGTTCAATTGGGTCTATCTGACGCTTTCGAAGGTAAAGAAAGTGTTGTATCTA
TGCAAGATATGCAAATTGCATTCACTGAAATCAGCCAGCGTATCCAGAAAGTTCAAGAAGCTGCTGCTGCTGCTGCATCA
GAAGTAGGTGAAAAATTCCTTGCTGATAATGGTGCTCGTGAAGGCGTTGTGACTTTGGACTCTGGTCTACAGTACGAAAT
TATTACTGAAGGTAACGGTGACAAGCCTAGTTACGACTCTACAGTACGTACTCACTATCACGGTACTTTCATCTCTGGTG
ATGTATTTGATAGCTCTGTTGCTCGTGGTGAGCCAGCTGAATTCCCAGTTTCTGGCGTTATTGCTGGCTGGACAGAAGCA
CTACAACTTATGCCTACAGGTTCTAAGTGGAGACTATTTGTACCACAACACCTAGCATACGGTGAGCGCGGCGCAGGTGC
TGCAATCCCACCATATTCAACTTTGGTATTCGAAGTTGAATTGTTAGACATTATCTAA

Upstream 100 bases:

>100_bases
GCCAAAGACCAAAATAGCTACGGTTTTTAGGGCAACATCACAGAAATTATGATAAAGTTGCGCGCGAAAATTCATTTGAA
TCATTGAGAGTACAATCATT

Downstream 100 bases:

>100_bases
GTTAGACAATAAGCCTAAGTTAATACTTAGGCTTTTTTTTGACATTTTGCAGGGAGTACTGAGATGACTGAACGCGTAAG
AGTGGCAATAACAGGCGGCA

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: FKBP22; PPIase; Rotamase [H]

Number of amino acids: Translated: 205; Mature: 204

Protein sequence:

>205_residues
MSEKFSTIEAQASYGVGRQLGEQLAANSFEGIDISAVQLGLSDAFEGKESVVSMQDMQIAFTEISQRIQKVQEAAAAAAS
EVGEKFLADNGAREGVVTLDSGLQYEIITEGNGDKPSYDSTVRTHYHGTFISGDVFDSSVARGEPAEFPVSGVIAGWTEA
LQLMPTGSKWRLFVPQHLAYGERGAGAAIPPYSTLVFEVELLDII

Sequences:

>Translated_205_residues
MSEKFSTIEAQASYGVGRQLGEQLAANSFEGIDISAVQLGLSDAFEGKESVVSMQDMQIAFTEISQRIQKVQEAAAAAAS
EVGEKFLADNGAREGVVTLDSGLQYEIITEGNGDKPSYDSTVRTHYHGTFISGDVFDSSVARGEPAEFPVSGVIAGWTEA
LQLMPTGSKWRLFVPQHLAYGERGAGAAIPPYSTLVFEVELLDII
>Mature_204_residues
SEKFSTIEAQASYGVGRQLGEQLAANSFEGIDISAVQLGLSDAFEGKESVVSMQDMQIAFTEISQRIQKVQEAAAAAASE
VGEKFLADNGAREGVVTLDSGLQYEIITEGNGDKPSYDSTVRTHYHGTFISGDVFDSSVARGEPAEFPVSGVIAGWTEAL
QLMPTGSKWRLFVPQHLAYGERGAGAAIPPYSTLVFEVELLDII

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm. Periplasm. Note=According to PubMed:7610040 it is periplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=106, Percent_Identity=39.622641509434, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI4503725, Length=106, Percent_Identity=39.622641509434, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI206725530, Length=85, Percent_Identity=45.8823529411765, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI17149844, Length=85, Percent_Identity=45.8823529411765, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI17149842, Length=85, Percent_Identity=45.8823529411765, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=36.7924528301887, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI192448443, Length=85, Percent_Identity=40, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI87082390, Length=201, Percent_Identity=55.2238805970149, Blast_Score=224, Evalue=2e-60,
Organism=Escherichia coli, GI1789745, Length=218, Percent_Identity=37.1559633027523, Blast_Score=119, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=41.5094339622642, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17540882, Length=85, Percent_Identity=44.7058823529412, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320727, Length=109, Percent_Identity=43.1192660550459, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324194, Length=109, Percent_Identity=41.2844036697248, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281363946, Length=96, Percent_Identity=42.7083333333333, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI17352457, Length=96, Percent_Identity=42.7083333333333, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24583150, Length=106, Percent_Identity=39.622641509434, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=39.622641509434, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24647110, Length=93, Percent_Identity=39.7849462365591, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21944; Mature: 21812

Theoretical pI: Translated: 4.14; Mature: 4.14

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKFSTIEAQASYGVGRQLGEQLAANSFEGIDISAVQLGLSDAFEGKESVVSMQDMQIA
CCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCEEHHEEECCHHHCCCHHHHHHHHHHHHH
FTEISQRIQKVQEAAAAAASEVGEKFLADNGAREGVVTLDSGLQYEIITEGNGDKPSYDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEECCCCCCCCCCC
TVRTHYHGTFISGDVFDSSVARGEPAEFPVSGVIAGWTEALQLMPTGSKWRLFVPQHLAY
EEEEEECCEEEECCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHCC
GERGAGAAIPPYSTLVFEVELLDII
CCCCCCCCCCCCCEEEEEEEEEECC
>Mature Secondary Structure 
SEKFSTIEAQASYGVGRQLGEQLAANSFEGIDISAVQLGLSDAFEGKESVVSMQDMQIA
CCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCEEHHEEECCHHHCCCHHHHHHHHHHHHH
FTEISQRIQKVQEAAAAAASEVGEKFLADNGAREGVVTLDSGLQYEIITEGNGDKPSYDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEECCCCCCCCCCC
TVRTHYHGTFISGDVFDSSVARGEPAEFPVSGVIAGWTEALQLMPTGSKWRLFVPQHLAY
EEEEEECCEEEECCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHCC
GERGAGAAIPPYSTLVFEVELLDII
CCCCCCCCCCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 8703024; 9298646 [H]