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The map label for this gene is mmsB [H]

Identifier: 167624787

GI number: 167624787

Start: 3493047

End: 3493976

Strand: Reverse

Name: mmsB [H]

Synonym: Shal_2873

Alternate gene names: 167624787

Gene position: 3493976-3493047 (Counterclockwise)

Preceding gene: 167624788

Following gene: 167624786

Centisome position: 66.85

GC content: 48.92

Gene sequence:

>930_bases
ATGAGTACTGTTGCATTTATTGGTTTAGGAAACATGGGCGGCCCAATGGCGGCCAATCTGATTAAGGCGGGTTTTACCGT
TAAAGTATTTGATCTGGTGCCCGCGGCGATGCAGACATTAGCCGAGCAAGGCGCGCTTACTGCAACAAGTGCCTGCGGCG
CAGCAGCGGGTGCCGACATAGTGGTAACCATGTTACCTGCGGGTAAGCATGTGCGTAGTCTTTATGTGACTAATGCTACA
AGCAGCGATGCAACAAAAGGGCTTATTGATGTAGTCGCACCGGGAACTTTACTTATCGACTGCTCAACCATAGATGCAGA
CAGTGCGCGCTTTGTGGCAGAGCAAGCGGCCAGCAAGGGCTTAGAGTTTATCGATGCGCCGGTATCTGGCGGCACAGCAG
GGGCCGCTGCGGGCACGTTAACCTTTATTTGTGGCGGTAGTGATAACGCTTTTGAACAGGCACAAGGTGTATTAAATGCT
ATGGGGGGGAATATCTTCCACGCAGGCGGTCCCGGTGCTGGGCAAGTGGCTAAAATATGTAATAATATGCTGCTTTCGGT
CTTAATGGTTGCCACATCAGAGTCATTGCAGATGGGAGTCGATCATGGTCTCGACCCAAAAGTGCTTTCCGATATTATGA
AAGTCAGCAGTGGTGGTAATTGGACGTTAGAGAAATACAATCCTTGTCCAGATGTGATGGAGTCGGTTCCATCTTCAAAC
GGTTACCAAGGCGGCTTTATGGTCGACTTGATGGTGAAGGATTTAGGACTATCTCAAGAGGCGGCGCTGTTATCAAATTC
AAGCACGCCAATGGGCGCATTAGCGCGTAGTCTCTATGTGAATCATGCGAAACAAGGTAACGGTAAGCGAGATTTTTCGA
GTATTTTTGAGCTGTTTGCTCAGTCAGAACAGATAAAAAACAAAGGGTGA

Upstream 100 bases:

>100_bases
GTTCATCAGCTTTAACAGAAGATAAACGCGAGCGGTGAGTCATATTGGCCGCTAAAGGGATTAAGTCGCAAACACTCACA
AAAGTGAGCCGGAGCAAATA

Downstream 100 bases:

>100_bases
CCCAATGGATTTAAAAGATAAGGTTGTTGTTATTACTGGTGGTGCAGGTGGACTAGGTTACGCCATGGCGGAGAATTTAG
CGGCTGCAGGTGCCAAGCTA

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MSTVAFIGLGNMGGPMAANLIKAGFTVKVFDLVPAAMQTLAEQGALTATSACGAAAGADIVVTMLPAGKHVRSLYVTNAT
SSDATKGLIDVVAPGTLLIDCSTIDADSARFVAEQAASKGLEFIDAPVSGGTAGAAAGTLTFICGGSDNAFEQAQGVLNA
MGGNIFHAGGPGAGQVAKICNNMLLSVLMVATSESLQMGVDHGLDPKVLSDIMKVSSGGNWTLEKYNPCPDVMESVPSSN
GYQGGFMVDLMVKDLGLSQEAALLSNSSTPMGALARSLYVNHAKQGNGKRDFSSIFELFAQSEQIKNKG

Sequences:

>Translated_309_residues
MSTVAFIGLGNMGGPMAANLIKAGFTVKVFDLVPAAMQTLAEQGALTATSACGAAAGADIVVTMLPAGKHVRSLYVTNAT
SSDATKGLIDVVAPGTLLIDCSTIDADSARFVAEQAASKGLEFIDAPVSGGTAGAAAGTLTFICGGSDNAFEQAQGVLNA
MGGNIFHAGGPGAGQVAKICNNMLLSVLMVATSESLQMGVDHGLDPKVLSDIMKVSSGGNWTLEKYNPCPDVMESVPSSN
GYQGGFMVDLMVKDLGLSQEAALLSNSSTPMGALARSLYVNHAKQGNGKRDFSSIFELFAQSEQIKNKG
>Mature_308_residues
STVAFIGLGNMGGPMAANLIKAGFTVKVFDLVPAAMQTLAEQGALTATSACGAAAGADIVVTMLPAGKHVRSLYVTNATS
SDATKGLIDVVAPGTLLIDCSTIDADSARFVAEQAASKGLEFIDAPVSGGTAGAAAGTLTFICGGSDNAFEQAQGVLNAM
GGNIFHAGGPGAGQVAKICNNMLLSVLMVATSESLQMGVDHGLDPKVLSDIMKVSSGGNWTLEKYNPCPDVMESVPSSNG
YQGGFMVDLMVKDLGLSQEAALLSNSSTPMGALARSLYVNHAKQGNGKRDFSSIFELFAQSEQIKNKG

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=302, Percent_Identity=42.7152317880795, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI40556376, Length=296, Percent_Identity=24.3243243243243, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI145693186, Length=303, Percent_Identity=32.3432343234323, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1790315, Length=298, Percent_Identity=32.5503355704698, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1786719, Length=295, Percent_Identity=29.4915254237288, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1789092, Length=299, Percent_Identity=30.1003344481605, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17557316, Length=303, Percent_Identity=42.9042904290429, Blast_Score=233, Evalue=6e-62,
Organism=Drosophila melanogaster, GI24655230, Length=300, Percent_Identity=40.6666666666667, Blast_Score=225, Evalue=3e-59,
Organism=Drosophila melanogaster, GI19922568, Length=300, Percent_Identity=40.6666666666667, Blast_Score=225, Evalue=3e-59,
Organism=Drosophila melanogaster, GI28574115, Length=303, Percent_Identity=22.4422442244224, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 31507; Mature: 31376

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVAFIGLGNMGGPMAANLIKAGFTVKVFDLVPAAMQTLAEQGALTATSACGAAAGADI
CCEEEEEEECCCCCHHHHHHHHCCCEEEHHHHHHHHHHHHHHCCCCEEHHHCCCCCCCCE
VVTMLPAGKHVRSLYVTNATSSDATKGLIDVVAPGTLLIDCSTIDADSARFVAEQAASKG
EEEECCCCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCC
LEFIDAPVSGGTAGAAAGTLTFICGGSDNAFEQAQGVLNAMGGNIFHAGGPGAGQVAKIC
CEEEECCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEECCCCCHHHHHHHH
NNMLLSVLMVATSESLQMGVDHGLDPKVLSDIMKVSSGGNWTLEKYNPCPDVMESVPSSN
HHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHCCCCC
GYQGGFMVDLMVKDLGLSQEAALLSNSSTPMGALARSLYVNHAKQGNGKRDFSSIFELFA
CCCCCEEEEEHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
QSEQIKNKG
HHHHHCCCC
>Mature Secondary Structure 
STVAFIGLGNMGGPMAANLIKAGFTVKVFDLVPAAMQTLAEQGALTATSACGAAAGADI
CEEEEEEECCCCCHHHHHHHHCCCEEEHHHHHHHHHHHHHHCCCCEEHHHCCCCCCCCE
VVTMLPAGKHVRSLYVTNATSSDATKGLIDVVAPGTLLIDCSTIDADSARFVAEQAASKG
EEEECCCCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCC
LEFIDAPVSGGTAGAAAGTLTFICGGSDNAFEQAQGVLNAMGGNIFHAGGPGAGQVAKIC
CEEEECCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEECCCCCHHHHHHHH
NNMLLSVLMVATSESLQMGVDHGLDPKVLSDIMKVSSGGNWTLEKYNPCPDVMESVPSSN
HHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHCCCCC
GYQGGFMVDLMVKDLGLSQEAALLSNSSTPMGALARSLYVNHAKQGNGKRDFSSIFELFA
CCCCCEEEEEHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
QSEQIKNKG
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339433; 10984043 [H]