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The map label for this gene is seqA [H]

Identifier: 167624163

GI number: 167624163

Start: 2716127

End: 2716747

Strand: Reverse

Name: seqA [H]

Synonym: Shal_2239

Alternate gene names: 167624163

Gene position: 2716747-2716127 (Counterclockwise)

Preceding gene: 167624173

Following gene: 167624162

Centisome position: 51.98

GC content: 41.22

Gene sequence:

>621_bases
ATGCGATCTTTTGCATTTAAGAACACCGATCCGCTTTTCTACTTAAGGAAGATAACCGTTATGAAATATATCGAAGTTGA
TGAAGAGCTTTATCGACACATCGCCAGCAAGACTGAACATATTGGTGAGAGCGCTTCGGATATTTTGCGCCGTATATTGG
GATTACAAGTTGAATCAGTGGTTCAAGATGCACCTGAAGAGATCAGTCATCCTAGCCTTGAACGAGTTTCACCTAAGCCA
GTTAAAGTCGCTAAAGTGATAACTAAGATGACATCTACGGCTGTTTCTGATTTTACAAGTTTAATCGATGCCGATGTATT
GGCAGCCCAAAAGGGCGCTGTAGGCCGTTTTCTATTTATTCTCGATACGGTTCATAGAGCATCACCTGTTCAGTTTGAGC
AAGTGTTACAAATTCAAGGACGTGACCGCTTATACTTTGCGACGTCAAAAGACGCACTGTTAAAAGCCAGTAAGTCAGCG
AATCCTAAAGAGATTGGCCAAAGTGGTTTTTGGGTAACGACAAACAACAACACCGCTAAAAAACGCACCATACTTTCAGA
AGTTTTGCTGCAGTTTGGTACTGATGAAGCACAAGTTACCGATATCATAGAGAAAATCTAA

Upstream 100 bases:

>100_bases
AGTAAATAGGATCTTTCTTCTCTGGATCGCAGTTTTCATTTAATGACGCTTTATCAAGGCTCTAAACCTCGCTACACTGA
GCGGATAATTCGGGACAGTT

Downstream 100 bases:

>100_bases
CGCCGTATCGCGTTAATGTAAAACATTTAAACTTGCCGTGCTTAACGTCATCACGGCAATAAAAGGAGAAGGAACTTGGC
TACACACAAGAGAGCTGGAT

Product: replication initiation regulator SeqA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MRSFAFKNTDPLFYLRKITVMKYIEVDEELYRHIASKTEHIGESASDILRRILGLQVESVVQDAPEEISHPSLERVSPKP
VKVAKVITKMTSTAVSDFTSLIDADVLAAQKGAVGRFLFILDTVHRASPVQFEQVLQIQGRDRLYFATSKDALLKASKSA
NPKEIGQSGFWVTTNNNTAKKRTILSEVLLQFGTDEAQVTDIIEKI

Sequences:

>Translated_206_residues
MRSFAFKNTDPLFYLRKITVMKYIEVDEELYRHIASKTEHIGESASDILRRILGLQVESVVQDAPEEISHPSLERVSPKP
VKVAKVITKMTSTAVSDFTSLIDADVLAAQKGAVGRFLFILDTVHRASPVQFEQVLQIQGRDRLYFATSKDALLKASKSA
NPKEIGQSGFWVTTNNNTAKKRTILSEVLLQFGTDEAQVTDIIEKI
>Mature_206_residues
MRSFAFKNTDPLFYLRKITVMKYIEVDEELYRHIASKTEHIGESASDILRRILGLQVESVVQDAPEEISHPSLERVSPKP
VKVAKVITKMTSTAVSDFTSLIDADVLAAQKGAVGRFLFILDTVHRASPVQFEQVLQIQGRDRLYFATSKDALLKASKSA
NPKEIGQSGFWVTTNNNTAKKRTILSEVLLQFGTDEAQVTDIIEKI

Specific function: Negative regulator of replication initiation. Required for sequestration, a process that blocks secondary initiation events. Could block the allosteric transition of dnaA from an inactive form to an active form [H]

COG id: COG3057

COG function: function code L; Negative regulator of replication initiationR

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786903, Length=191, Percent_Identity=38.2198952879581, Blast_Score=112, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005621
- InterPro:   IPR010985 [H]

Pfam domain/function: PF03925 SeqA [H]

EC number: NA

Molecular weight: Translated: 23054; Mature: 23054

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSFAFKNTDPLFYLRKITVMKYIEVDEELYRHIASKTEHIGESASDILRRILGLQVESV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHH
VQDAPEEISHPSLERVSPKPVKVAKVITKMTSTAVSDFTSLIDADVLAAQKGAVGRFLFI
HHCCHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LDTVHRASPVQFEQVLQIQGRDRLYFATSKDALLKASKSANPKEIGQSGFWVTTNNNTAK
HHHHHHCCCCCHHHHHHHCCCCEEEEECCHHHHHHHCCCCCHHHHCCCCCEEEECCCCHH
KRTILSEVLLQFGTDEAQVTDIIEKI
HHHHHHHHHHHHCCCHHHHHHHHHHC
>Mature Secondary Structure
MRSFAFKNTDPLFYLRKITVMKYIEVDEELYRHIASKTEHIGESASDILRRILGLQVESV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHH
VQDAPEEISHPSLERVSPKPVKVAKVITKMTSTAVSDFTSLIDADVLAAQKGAVGRFLFI
HHCCHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LDTVHRASPVQFEQVLQIQGRDRLYFATSKDALLKASKSANPKEIGQSGFWVTTNNNTAK
HHHHHHCCCCCHHHHHHHCCCCEEEEECCHHHHHHHCCCCCHHHHCCCCCEEEECCCCHH
KRTILSEVLLQFGTDEAQVTDIIEKI
HHHHHHHHHHHHCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]