Click here to switch to the map view.

The map label for this gene is yngI [H]

Identifier: 167624020

GI number: 167624020

Start: 2522944

End: 2524644

Strand: Direct

Name: yngI [H]

Synonym: Shal_2096

Alternate gene names: 167624020

Gene position: 2522944-2524644 (Clockwise)

Preceding gene: 167624019

Following gene: 167624021

Centisome position: 48.27

GC content: 42.03

Gene sequence:

>1701_bases
ATGGATATTATGGATCATGCGCAAGAGGTAAAAGCACAACTGACAGCCGTAGGAGCCCCTTTTGAATTAGTACAACTTGA
TCAAGGTGAAATAAGTGTACCAGTTTACCTTAACGCACCTAAGGATCTGTCTGAAGTCATAGAAGCATCGCGACGTGATG
ATGAAAGTACTTTCCTTGTTTATCAAGATGATGTTTACAGCTATCGCCGGTTTTATTCTGAAGTAGATGCGCTTGCCATT
TGGTTCCATGAACAAGGAGTCGTTCAAGGGACTCGGGTGGCTATTGCGCTACGTAATCGTCCTGAATGGGCAGTATCATT
TGCAGCCATTGCAAAGCTTGGTGCAGTACCTGTACCGTTAAATAGTCTGGGGCAGCCAAAAGAGTTATGGTCAGCAATTG
ATGAGGTCATGCCAAAGATCTTGGTATGTGACAAGGCTCGTTGGAATAAGCTAGATACTCAGGTAAGCAACAATATATTT
AAAGTGTTGGTTGTAGATGATAACGATAAAATTACAGCAGAAGTGAGCCATTATGAAGACGCCATAGTAGAAGCCAATAC
CAAAACTTCTTTACCTCGTCTGAATATTTTGCCAGAAGATACGGCGTTGATCCTATTTACCTCTGGAGCATCAAGTAACG
CTAAAGCTGTTATCTCGACCCAAAGAGCAGTTTGCCAAGCGCTATATAATATTGATTATATCTCTGCAATATCGGCGATG
ACGTCGCCAAAAATTGTAGCGAGAATAATGGCAAATGCAAAACCTCCTATGTTATTGACCGCAGTACCTTTATTCCATGT
AAGTGGTTTACATGCGCAATTGCTTACCGCGCTTCGTAGCGGTCGTGGAATGGTAATGATGCATCGTTGGGATCCCACTG
AAGCAGTAAAAATGATCAAGCAGCACAATATTACACAGTTTAATGGTGCTCCTTCGATGGTTATGCAGTTACTTAGGGAG
CCTGGATTTTTATCAACTTCTATTCTTGATAATATGGCTGGACTCGGTTTCGGCGGCTCCGGTTTACCAGAAGTATTAGT
CGAGCTTGTATTAAAGGAAATGCCAAACCATATGGTTGGTAGCGGTTTTGGTATGACAGAATCTAATGGTGTCGGCTCTT
CTTCATCAGGAGAGTTGTTTAGAGTTAGCCCTAAAAGTTCAGGTATGTTATCGCCATTAGTTAAGATTAAAGTTTGTGAT
CCTATAGGTGATGAGCTTTCAGAAGGGGAAATCGGCGAAATTTGTATTCAGTCAGTTACTGTAATGCGTGAGTATCTGAA
TAATCATGCGGGTACACAAGAAGCCATTCGTAACGGCTGGTTGCATACTGGAGATATTGGTTATTTAGACCATAATGGAT
TCTTATTTATTGTCGATAGACTCAAAAATGTCATTATCAGAAATGGTGAAAATATTGCCTCTGTAGAGGTTGAGTCTAGC
TTGATGCTACATAATGCAGTTAAAGAGGCTGCGGTATTTGGAGTTGCTGATGAAATGGTGGGCGAAAGTGTTGTGGCCGT
TATCTCCCTTAAAAATGGGCACTCAACCGATGAAGAGGCGCTAAAGTTGCACGTTGCAGGGCAACTTGCCAGTTACAAGG
TGCCAAGTACCATTCATATTATTGATGATGATCTACCACGCAATCCAGCGGGTAAGTTACAGCACAATCAACTAAAGGCC
GCCTATAGCGCCAATCAATAA

Upstream 100 bases:

>100_bases
CGAGAACCCTTTGCAATAAAAGCGATAAATTTATATATAACAATAAGCTGAAATAGCTTAGGGATTATAGTTAACGAGAA
AAGGATAACAGGAGAAAGTT

Downstream 100 bases:

>100_bases
AACATGAGCAATAAGGCAGCGTCAACTAATGATTTTGACGTTGCTTTTTAATAGTTAAGTCATTGTTTATTAGTTGTTAT
TAACACTTCTCTAGAGCATG

Product: AMP-dependent synthetase and ligase

Products: AMP; diphosphate; acyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 566; Mature: 566

Protein sequence:

>566_residues
MDIMDHAQEVKAQLTAVGAPFELVQLDQGEISVPVYLNAPKDLSEVIEASRRDDESTFLVYQDDVYSYRRFYSEVDALAI
WFHEQGVVQGTRVAIALRNRPEWAVSFAAIAKLGAVPVPLNSLGQPKELWSAIDEVMPKILVCDKARWNKLDTQVSNNIF
KVLVVDDNDKITAEVSHYEDAIVEANTKTSLPRLNILPEDTALILFTSGASSNAKAVISTQRAVCQALYNIDYISAISAM
TSPKIVARIMANAKPPMLLTAVPLFHVSGLHAQLLTALRSGRGMVMMHRWDPTEAVKMIKQHNITQFNGAPSMVMQLLRE
PGFLSTSILDNMAGLGFGGSGLPEVLVELVLKEMPNHMVGSGFGMTESNGVGSSSSGELFRVSPKSSGMLSPLVKIKVCD
PIGDELSEGEIGEICIQSVTVMREYLNNHAGTQEAIRNGWLHTGDIGYLDHNGFLFIVDRLKNVIIRNGENIASVEVESS
LMLHNAVKEAAVFGVADEMVGESVVAVISLKNGHSTDEEALKLHVAGQLASYKVPSTIHIIDDDLPRNPAGKLQHNQLKA
AYSANQ

Sequences:

>Translated_566_residues
MDIMDHAQEVKAQLTAVGAPFELVQLDQGEISVPVYLNAPKDLSEVIEASRRDDESTFLVYQDDVYSYRRFYSEVDALAI
WFHEQGVVQGTRVAIALRNRPEWAVSFAAIAKLGAVPVPLNSLGQPKELWSAIDEVMPKILVCDKARWNKLDTQVSNNIF
KVLVVDDNDKITAEVSHYEDAIVEANTKTSLPRLNILPEDTALILFTSGASSNAKAVISTQRAVCQALYNIDYISAISAM
TSPKIVARIMANAKPPMLLTAVPLFHVSGLHAQLLTALRSGRGMVMMHRWDPTEAVKMIKQHNITQFNGAPSMVMQLLRE
PGFLSTSILDNMAGLGFGGSGLPEVLVELVLKEMPNHMVGSGFGMTESNGVGSSSSGELFRVSPKSSGMLSPLVKIKVCD
PIGDELSEGEIGEICIQSVTVMREYLNNHAGTQEAIRNGWLHTGDIGYLDHNGFLFIVDRLKNVIIRNGENIASVEVESS
LMLHNAVKEAAVFGVADEMVGESVVAVISLKNGHSTDEEALKLHVAGQLASYKVPSTIHIIDDDLPRNPAGKLQHNQLKA
AYSANQ
>Mature_566_residues
MDIMDHAQEVKAQLTAVGAPFELVQLDQGEISVPVYLNAPKDLSEVIEASRRDDESTFLVYQDDVYSYRRFYSEVDALAI
WFHEQGVVQGTRVAIALRNRPEWAVSFAAIAKLGAVPVPLNSLGQPKELWSAIDEVMPKILVCDKARWNKLDTQVSNNIF
KVLVVDDNDKITAEVSHYEDAIVEANTKTSLPRLNILPEDTALILFTSGASSNAKAVISTQRAVCQALYNIDYISAISAM
TSPKIVARIMANAKPPMLLTAVPLFHVSGLHAQLLTALRSGRGMVMMHRWDPTEAVKMIKQHNITQFNGAPSMVMQLLRE
PGFLSTSILDNMAGLGFGGSGLPEVLVELVLKEMPNHMVGSGFGMTESNGVGSSSSGELFRVSPKSSGMLSPLVKIKVCD
PIGDELSEGEIGEICIQSVTVMREYLNNHAGTQEAIRNGWLHTGDIGYLDHNGFLFIVDRLKNVIIRNGENIASVEVESS
LMLHNAVKEAAVFGVADEMVGESVVAVISLKNGHSTDEEALKLHVAGQLASYKVPSTIHIIDDDLPRNPAGKLQHNQLKA
AYSANQ

Specific function: Could Catalyze The Transfer Of CoA To Crotonobetaine Or Carnitine. [C]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=559, Percent_Identity=26.4758497316637, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI42544132, Length=559, Percent_Identity=23.0769230769231, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI187761345, Length=397, Percent_Identity=27.9596977329975, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI187761343, Length=397, Percent_Identity=27.9596977329975, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI122937307, Length=233, Percent_Identity=31.3304721030043, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI38505220, Length=495, Percent_Identity=23.8383838383838, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI227499619, Length=545, Percent_Identity=21.8348623853211, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI27477105, Length=486, Percent_Identity=23.4567901234568, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI58082049, Length=503, Percent_Identity=23.4592445328032, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI115511026, Length=497, Percent_Identity=23.3400402414487, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI157311624, Length=285, Percent_Identity=27.3684210526316, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI157311622, Length=285, Percent_Identity=27.3684210526316, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI40807491, Length=136, Percent_Identity=34.5588235294118, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI221142682, Length=526, Percent_Identity=27.1863117870722, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1788107, Length=567, Percent_Identity=26.63139329806, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI145693145, Length=514, Percent_Identity=25.2918287937743, Blast_Score=132, Evalue=8e-32,
Organism=Escherichia coli, GI1786810, Length=523, Percent_Identity=25.2390057361377, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1788595, Length=515, Percent_Identity=23.3009708737864, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17557194, Length=505, Percent_Identity=26.7326732673267, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI71994690, Length=547, Percent_Identity=24.3144424131627, Blast_Score=143, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71994694, Length=547, Percent_Identity=24.3144424131627, Blast_Score=143, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71994703, Length=547, Percent_Identity=24.3144424131627, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17538037, Length=527, Percent_Identity=25.6166982922201, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17531443, Length=508, Percent_Identity=24.6062992125984, Blast_Score=136, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17558820, Length=487, Percent_Identity=26.0780287474333, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17559526, Length=513, Percent_Identity=26.3157894736842, Blast_Score=128, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI32563687, Length=527, Percent_Identity=25.8064516129032, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17560140, Length=377, Percent_Identity=28.6472148541114, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17560308, Length=528, Percent_Identity=24.4318181818182, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71996755, Length=513, Percent_Identity=24.5614035087719, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17510401, Length=495, Percent_Identity=25.4545454545455, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI25141359, Length=526, Percent_Identity=22.8136882129278, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71985884, Length=208, Percent_Identity=27.4038461538462, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=501, Percent_Identity=26.5469061876248, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6323182, Length=564, Percent_Identity=25.177304964539, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6319264, Length=550, Percent_Identity=22.9090909090909, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24581924, Length=542, Percent_Identity=28.0442804428044, Blast_Score=176, Evalue=4e-44,
Organism=Drosophila melanogaster, GI21355181, Length=506, Percent_Identity=26.0869565217391, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI18859661, Length=528, Percent_Identity=24.0530303030303, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI21356441, Length=494, Percent_Identity=24.2914979757085, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24648253, Length=490, Percent_Identity=22.8571428571429, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24648255, Length=490, Percent_Identity=22.8571428571429, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI161076582, Length=523, Percent_Identity=22.3709369024857, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653035, Length=512, Percent_Identity=22.4609375, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI281365686, Length=431, Percent_Identity=23.6658932714617, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI21356947, Length=431, Percent_Identity=25.9860788863109, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24648260, Length=431, Percent_Identity=24.8259860788863, Blast_Score=102, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19922652, Length=495, Percent_Identity=23.030303030303, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21358303, Length=247, Percent_Identity=26.7206477732794, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI20130357, Length=521, Percent_Identity=22.6487523992322, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24656500, Length=499, Percent_Identity=21.8436873747495, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24648257, Length=448, Percent_Identity=25, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.2.1.3

Molecular weight: Translated: 61678; Mature: 61678

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIMDHAQEVKAQLTAVGAPFELVQLDQGEISVPVYLNAPKDLSEVIEASRRDDESTFLV
CCHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCHHHHHHHHHHCCCCCCEEEE
YQDDVYSYRRFYSEVDALAIWFHEQGVVQGTRVAIALRNRPEWAVSFAAIAKLGAVPVPL
EECCHHHHHHHHHHHHHEEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCH
NSLGQPKELWSAIDEVMPKILVCDKARWNKLDTQVSNNIFKVLVVDDNDKITAEVSHYED
HCCCCHHHHHHHHHHHHHHHEEECCCCCCHHHHHHCCCEEEEEEEECCCCEEEEECHHHH
AIVEANTKTSLPRLNILPEDTALILFTSGASSNAKAVISTQRAVCQALYNIDYISAISAM
HHEECCCCCCCCCEEECCCCCEEEEEECCCCCCCEEEHHHHHHHHHHHHCCHHHHHHHHH
TSPKIVARIMANAKPPMLLTAVPLFHVSGLHAQLLTALRSGRGMVMMHRWDPTEAVKMIK
CCHHHHHHHHHCCCCCEEEEECHHHHHCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHH
QHNITQFNGAPSMVMQLLREPGFLSTSILDNMAGLGFGGSGLPEVLVELVLKEMPNHMVG
HCCCCEECCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHC
SGFGMTESNGVGSSSSGELFRVSPKSSGMLSPLVKIKVCDPIGDELSEGEIGEICIQSVT
CCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHH
VMREYLNNHAGTQEAIRNGWLHTGDIGYLDHNGFLFIVDRLKNVIIRNGENIASVEVESS
HHHHHHHCCCCHHHHHHCCCEECCCEEEEECCCEEEEHHHHHHHHEECCCCEEEEEEHHH
LMLHNAVKEAAVFGVADEMVGESVVAVISLKNGHSTDEEALKLHVAGQLASYKVPSTIHI
HHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHEEEEEECCHHCCCCCCEEEE
IDDDLPRNPAGKLQHNQLKAAYSANQ
ECCCCCCCCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MDIMDHAQEVKAQLTAVGAPFELVQLDQGEISVPVYLNAPKDLSEVIEASRRDDESTFLV
CCHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCHHHHHHHHHHCCCCCCEEEE
YQDDVYSYRRFYSEVDALAIWFHEQGVVQGTRVAIALRNRPEWAVSFAAIAKLGAVPVPL
EECCHHHHHHHHHHHHHEEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCH
NSLGQPKELWSAIDEVMPKILVCDKARWNKLDTQVSNNIFKVLVVDDNDKITAEVSHYED
HCCCCHHHHHHHHHHHHHHHEEECCCCCCHHHHHHCCCEEEEEEEECCCCEEEEECHHHH
AIVEANTKTSLPRLNILPEDTALILFTSGASSNAKAVISTQRAVCQALYNIDYISAISAM
HHEECCCCCCCCCEEECCCCCEEEEEECCCCCCCEEEHHHHHHHHHHHHCCHHHHHHHHH
TSPKIVARIMANAKPPMLLTAVPLFHVSGLHAQLLTALRSGRGMVMMHRWDPTEAVKMIK
CCHHHHHHHHHCCCCCEEEEECHHHHHCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHH
QHNITQFNGAPSMVMQLLREPGFLSTSILDNMAGLGFGGSGLPEVLVELVLKEMPNHMVG
HCCCCEECCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHC
SGFGMTESNGVGSSSSGELFRVSPKSSGMLSPLVKIKVCDPIGDELSEGEIGEICIQSVT
CCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHH
VMREYLNNHAGTQEAIRNGWLHTGDIGYLDHNGFLFIVDRLKNVIIRNGENIASVEVESS
HHHHHHHCCCCHHHHHHCCCEECCCEEEEECCCEEEEHHHHHHHHEECCCCEEEEEEHHH
LMLHNAVKEAAVFGVADEMVGESVVAVISLKNGHSTDEEALKLHVAGQLASYKVPSTIHI
HHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHEEEEEECCHHCCCCCCEEEE
IDDDLPRNPAGKLQHNQLKAAYSANQ
ECCCCCCCCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; long-chain carboxylic acid; CoA

Specific reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]