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The map label for this gene is serC

Identifier: 167623967

GI number: 167623967

Start: 2463191

End: 2464282

Strand: Direct

Name: serC

Synonym: Shal_2041

Alternate gene names: 167623967

Gene position: 2463191-2464282 (Clockwise)

Preceding gene: 167623965

Following gene: 167623969

Centisome position: 47.13

GC content: 44.41

Gene sequence:

>1092_bases
GTGAGCGCGATTTTCAACTTCTGTGCAGGCCCTGCCATGTTACCCCCCGCTGTAATGCAAAAGGCTCAGAAAGAACTATT
AAACTGGAATGGCCAAGGTGTTTCCGTAATGGAAGTGAGTCATCGAAGTAAAGAATTTATCGCGTTAACCGAGCAAGCTG
AAGCTGACTTACGTCAATTAATGGATATCCCATTCAACTATCACGTGCTATTTATGCATGGCGGCGGGCGAGGGCAGTTT
TCTGCTGTTGTGAATAATTTTTTAGGTAACGATGGCAAAGCACTCTATTTAGTCGATGGTAGCTGGTCAAAGGCTGCAGT
CGAAGAGGCGGAAAAATTAGCGGGTAAAGACAAGATTGATACAATCGATATTGTCAGTACAGTACAGGGAAAGAGAGAAG
TTTCGATTCCGGATCTCACCCAAATTGATAAAGACTATCGCTATCTACACTACTGTCCAAATGAGACTGTAGATGGTATC
GAAATTTTTGAAAGCATTAACAGCCCTTGGCCCGTTATCGCCGATATGTCATCTAATATTTTGTCGCGTAAGATTGATGT
TAGCCAGTTTGGTTTAATTTATGCGGGCGCGCAAAAGAACATTGGCCCATCGGGATTAAGCATCGTAATCGTTCGTGATG
ATATGCTGGTTCTGCCGAGCCTACCTCAGTCATCAATAATGGATTACCGCTTAGCGGTAGAAAACGATTCTATGTACAAC
ACGCCGCCTACCTTTGCCTGGTATTTAGCTGCTGAAGTCTTTAGCTGGCTGAAAAGCGTCGGTGGTGTCTGTGAGATGGA
AAAGCTCAACCTTGAGAAGGCTAAGCGACTTTATCAGTGTATCGATGAGTTAGATTTTTATGTTAGTGGTGTGGCAAAGC
AAAATCGTAGCCGAATGAATGTGACGTTCCAACTGACGAATTCTGAGTTGAACAGCCAGTTTTTAGAAGAGGCTCAAGTG
GCTGGTTTAGTCGCGCTTAAAGGCCACCGTAGTGTCGGTGGAATGCGTGCCAGTATATACAACGCAATGCCACTAGAAGG
TGTGGACACTTTAGTTGAGTTTATGCAGGCGTTTGCTGCAAAGCATAGCTAA

Upstream 100 bases:

>100_bases
TTTGATTTTTTCATGTTAGCTGCCAATGAGTTGGGATATACTGCTGTAAAGAATGCTAATACCCTAATGTTTCTACTGAT
AATAATAGAAGGACAATACT

Downstream 100 bases:

>100_bases
CCGCATCGAACCTCAATATTGAGACGAAAAAGCCGATAATATTTCTATTATCGGCTTTTTAATTTTTAAGTCGTGTACGG
AATATTAGAGTGACAGATTT

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MSAIFNFCAGPAMLPPAVMQKAQKELLNWNGQGVSVMEVSHRSKEFIALTEQAEADLRQLMDIPFNYHVLFMHGGGRGQF
SAVVNNFLGNDGKALYLVDGSWSKAAVEEAEKLAGKDKIDTIDIVSTVQGKREVSIPDLTQIDKDYRYLHYCPNETVDGI
EIFESINSPWPVIADMSSNILSRKIDVSQFGLIYAGAQKNIGPSGLSIVIVRDDMLVLPSLPQSSIMDYRLAVENDSMYN
TPPTFAWYLAAEVFSWLKSVGGVCEMEKLNLEKAKRLYQCIDELDFYVSGVAKQNRSRMNVTFQLTNSELNSQFLEEAQV
AGLVALKGHRSVGGMRASIYNAMPLEGVDTLVEFMQAFAAKHS

Sequences:

>Translated_363_residues
MSAIFNFCAGPAMLPPAVMQKAQKELLNWNGQGVSVMEVSHRSKEFIALTEQAEADLRQLMDIPFNYHVLFMHGGGRGQF
SAVVNNFLGNDGKALYLVDGSWSKAAVEEAEKLAGKDKIDTIDIVSTVQGKREVSIPDLTQIDKDYRYLHYCPNETVDGI
EIFESINSPWPVIADMSSNILSRKIDVSQFGLIYAGAQKNIGPSGLSIVIVRDDMLVLPSLPQSSIMDYRLAVENDSMYN
TPPTFAWYLAAEVFSWLKSVGGVCEMEKLNLEKAKRLYQCIDELDFYVSGVAKQNRSRMNVTFQLTNSELNSQFLEEAQV
AGLVALKGHRSVGGMRASIYNAMPLEGVDTLVEFMQAFAAKHS
>Mature_362_residues
SAIFNFCAGPAMLPPAVMQKAQKELLNWNGQGVSVMEVSHRSKEFIALTEQAEADLRQLMDIPFNYHVLFMHGGGRGQFS
AVVNNFLGNDGKALYLVDGSWSKAAVEEAEKLAGKDKIDTIDIVSTVQGKREVSIPDLTQIDKDYRYLHYCPNETVDGIE
IFESINSPWPVIADMSSNILSRKIDVSQFGLIYAGAQKNIGPSGLSIVIVRDDMLVLPSLPQSSIMDYRLAVENDSMYNT
PPTFAWYLAAEVFSWLKSVGGVCEMEKLNLEKAKRLYQCIDELDFYVSGVAKQNRSRMNVTFQLTNSELNSQFLEEAQVA
GLVALKGHRSVGGMRASIYNAMPLEGVDTLVEFMQAFAAKHS

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=368, Percent_Identity=43.75, Blast_Score=301, Evalue=7e-82,
Organism=Homo sapiens, GI10863955, Length=363, Percent_Identity=39.3939393939394, Blast_Score=247, Evalue=1e-65,
Organism=Escherichia coli, GI1787136, Length=364, Percent_Identity=56.8681318681319, Blast_Score=410, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17506897, Length=370, Percent_Identity=42.972972972973, Blast_Score=282, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6324758, Length=390, Percent_Identity=41.2820512820513, Blast_Score=260, Evalue=2e-70,
Organism=Drosophila melanogaster, GI21356589, Length=364, Percent_Identity=43.4065934065934, Blast_Score=303, Evalue=1e-82,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_SHEHH (B0TT41)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001674261.1
- ProteinModelPortal:   B0TT41
- SMR:   B0TT41
- GeneID:   5905050
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_2041
- HOGENOM:   HBG289982
- OMA:   TFAWYLA
- ProtClustDB:   PRK05355
- BioCyc:   SHAL458817:SHAL_2041-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01364

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 40246; Mature: 40115

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 42-42 BINDING 102-102 BINDING 156-156 BINDING 175-175 BINDING 198-198

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIFNFCAGPAMLPPAVMQKAQKELLNWNGQGVSVMEVSHRSKEFIALTEQAEADLRQL
CCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEHHHHHHHHHHH
MDIPFNYHVLFMHGGGRGQFSAVVNNFLGNDGKALYLVDGSWSKAAVEEAEKLAGKDKID
HHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCC
TIDIVSTVQGKREVSIPDLTQIDKDYRYLHYCPNETVDGIEIFESINSPWPVIADMSSNI
HHHHHHHCCCCCCCCCCCHHHHCCCCCEEEECCCCCCCHHHHHHHCCCCCCEEECCHHHH
LSRKIDVSQFGLIYAGAQKNIGPSGLSIVIVRDDMLVLPSLPQSSIMDYRLAVENDSMYN
HHHCCCHHHCCEEEECCCCCCCCCCEEEEEEECCEEEECCCCHHHHCEEEEEECCCCCCC
TPPTFAWYLAAEVFSWLKSVGGVCEMEKLNLEKAKRLYQCIDELDFYVSGVAKQNRSRMN
CCCHHHHHHHHHHHHHHHHHCCCEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VTFQLTNSELNSQFLEEAQVAGLVALKGHRSVGGMRASIYNAMPLEGVDTLVEFMQAFAA
EEEEECCCHHHHHHHHHHHHHCEEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHH
KHS
CCC
>Mature Secondary Structure 
SAIFNFCAGPAMLPPAVMQKAQKELLNWNGQGVSVMEVSHRSKEFIALTEQAEADLRQL
CCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEHHHHHHHHHHH
MDIPFNYHVLFMHGGGRGQFSAVVNNFLGNDGKALYLVDGSWSKAAVEEAEKLAGKDKID
HHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCC
TIDIVSTVQGKREVSIPDLTQIDKDYRYLHYCPNETVDGIEIFESINSPWPVIADMSSNI
HHHHHHHCCCCCCCCCCCHHHHCCCCCEEEECCCCCCCHHHHHHHCCCCCCEEECCHHHH
LSRKIDVSQFGLIYAGAQKNIGPSGLSIVIVRDDMLVLPSLPQSSIMDYRLAVENDSMYN
HHHCCCHHHCCEEEECCCCCCCCCCEEEEEEECCEEEECCCCHHHHCEEEEEECCCCCCC
TPPTFAWYLAAEVFSWLKSVGGVCEMEKLNLEKAKRLYQCIDELDFYVSGVAKQNRSRMN
CCCHHHHHHHHHHHHHHHHHCCCEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VTFQLTNSELNSQFLEEAQVAGLVALKGHRSVGGMRASIYNAMPLEGVDTLVEFMQAFAA
EEEEECCCHHHHHHHHHHHHHCEEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHH
KHS
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA