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The map label for this gene is aroA

Identifier: 167623969

GI number: 167623969

Start: 2466009

End: 2467289

Strand: Direct

Name: aroA

Synonym: Shal_2043

Alternate gene names: 167623969

Gene position: 2466009-2467289 (Clockwise)

Preceding gene: 167623967

Following gene: 167623970

Centisome position: 47.18

GC content: 45.43

Gene sequence:

>1281_bases
ATGAATCAATTACGTTTAGAGCCGATTAAAAAAGTATCAGGTACCATTAATATTCCTGGTTCAAAGAGTATCTCAAATCG
TGCTTTATTATTGGCGACACTCGCTAGTGGAACCACGACACTCACCAATTTACTCGACTCCGATGATATTCGTTATATGT
TGGCCTCGCTTAAGCAGTTAGGCGTCAGCTATCGTTTATCAAATAACAACACAGTTTGTGAATTAGATGGCTTAGCCGGT
CCATTAAATGCGGGTGAGCCACAAACGCTATTTTTAGGTAATGCTGGCACTGCTATGCGGCCTTTGTGCGCTGCGCTGAC
ATTAGGCCAAGGTCAGTTTACCTTAACAGGTGAGCCGCGAATGGAAGAGCGTCCTATTGGCGATCTCGTCGACGCGCTGC
GCCAACTTGGTGCCGAGGTAAGCTATCTTAAAAATGAAGGCTTTCCGCCGCTAAATATCACTTCTACCGGTTTAAATGGT
GGCAATGTCGAGATTGCGGGCGATCTATCCAGCCAGTTTTTAACGGCACTACTGATGGTTGCGCCACTGGCCAAAGGCGA
TGTCAATATCAAGATTAAAGGCGAGCTTGTCTCAAAACCTTATATCGATATTACGCTTGCTTTGATGGCGCAGTTTGGCG
TCGAAGTGCAAAACAATGACTACGCCTCATTCGTCATTAAAGCGGGTCAGCGTTATGTGTCACCTGGAAAAGTACTCGTA
GAAGGTGATGCGTCATCGGCATCATATTTTCTTGCTGCCGGAGCGATTCAAGGTGGAGAAGTAAAAGTTACTGGTGTAGG
CAAGCTCAGTATTCAAGGTGATGTTAAGTTTGCCGATGTGCTCGAGCAAATGGGTGCAGATATAGAATGGGGCGATGATT
ACATTATCGCTCGTCAAGCAAAGCTAAAAGCGGTTGATCTTGATATGAATCATATCCCAGATGCGGCGATGACGATTGCA
ACTGCTGCGCTGTTTGCGACAGGTACAACCCGTATTCGCAATATTTATAACTGGCGTATTAAAGAGACCGATCGCCTTGC
AGCGATGGCAACAGAACTGCGAAAGGTAGGGGCGATTGTGGATGAAGGTCATGACTACATTAGTGTGACGCCACCCGCTA
AGTTAAATACTGCGGCAATTGATACCTACAATGATCACCGTATGGCGATGTGCTTTTCTATGATGGCATTTGCTGATTGC
GGGATCACCATTAATGAACCTGAGTGTACGTCTAAAACATTCCCTGATTATTTCAATCAATTCAACGCGCTTGCTAACTA
A

Upstream 100 bases:

>100_bases
CTAAATCCTATCCGATTAGGAGCAAAAGCCGTCTTGCATGAACATCTACTGTTAACCCGCGGGCGAGTTTGACTCCTGCA
GCAATAATAAGAAGTACGGA

Downstream 100 bases:

>100_bases
GCGTGCACCACGATAAACAGTGATAGCTTTCAGGTTAATCGTGGTTAACCTGAAGGTTTGCTGAACCAAGTTCCCGAATA
TTTGAAGTTTTTGCCGCTTT

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MNQLRLEPIKKVSGTINIPGSKSISNRALLLATLASGTTTLTNLLDSDDIRYMLASLKQLGVSYRLSNNNTVCELDGLAG
PLNAGEPQTLFLGNAGTAMRPLCAALTLGQGQFTLTGEPRMEERPIGDLVDALRQLGAEVSYLKNEGFPPLNITSTGLNG
GNVEIAGDLSSQFLTALLMVAPLAKGDVNIKIKGELVSKPYIDITLALMAQFGVEVQNNDYASFVIKAGQRYVSPGKVLV
EGDASSASYFLAAGAIQGGEVKVTGVGKLSIQGDVKFADVLEQMGADIEWGDDYIIARQAKLKAVDLDMNHIPDAAMTIA
TAALFATGTTRIRNIYNWRIKETDRLAAMATELRKVGAIVDEGHDYISVTPPAKLNTAAIDTYNDHRMAMCFSMMAFADC
GITINEPECTSKTFPDYFNQFNALAN

Sequences:

>Translated_426_residues
MNQLRLEPIKKVSGTINIPGSKSISNRALLLATLASGTTTLTNLLDSDDIRYMLASLKQLGVSYRLSNNNTVCELDGLAG
PLNAGEPQTLFLGNAGTAMRPLCAALTLGQGQFTLTGEPRMEERPIGDLVDALRQLGAEVSYLKNEGFPPLNITSTGLNG
GNVEIAGDLSSQFLTALLMVAPLAKGDVNIKIKGELVSKPYIDITLALMAQFGVEVQNNDYASFVIKAGQRYVSPGKVLV
EGDASSASYFLAAGAIQGGEVKVTGVGKLSIQGDVKFADVLEQMGADIEWGDDYIIARQAKLKAVDLDMNHIPDAAMTIA
TAALFATGTTRIRNIYNWRIKETDRLAAMATELRKVGAIVDEGHDYISVTPPAKLNTAAIDTYNDHRMAMCFSMMAFADC
GITINEPECTSKTFPDYFNQFNALAN
>Mature_426_residues
MNQLRLEPIKKVSGTINIPGSKSISNRALLLATLASGTTTLTNLLDSDDIRYMLASLKQLGVSYRLSNNNTVCELDGLAG
PLNAGEPQTLFLGNAGTAMRPLCAALTLGQGQFTLTGEPRMEERPIGDLVDALRQLGAEVSYLKNEGFPPLNITSTGLNG
GNVEIAGDLSSQFLTALLMVAPLAKGDVNIKIKGELVSKPYIDITLALMAQFGVEVQNNDYASFVIKAGQRYVSPGKVLV
EGDASSASYFLAAGAIQGGEVKVTGVGKLSIQGDVKFADVLEQMGADIEWGDDYIIARQAKLKAVDLDMNHIPDAAMTIA
TAALFATGTTRIRNIYNWRIKETDRLAAMATELRKVGAIVDEGHDYISVTPPAKLNTAAIDTYNDHRMAMCFSMMAFADC
GITINEPECTSKTFPDYFNQFNALAN

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family

Homologues:

Organism=Escherichia coli, GI1787137, Length=421, Percent_Identity=68.4085510688836, Blast_Score=580, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6320332, Length=450, Percent_Identity=36.6666666666667, Blast_Score=241, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROA_SHEHH (B0TT43)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001674263.1
- ProteinModelPortal:   B0TT43
- SMR:   B0TT43
- GeneID:   5905201
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_2043
- HOGENOM:   HBG646626
- OMA:   GADIEWG
- ProtClustDB:   PRK02427
- BioCyc:   SHAL458817:SHAL_2043-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00210
- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792
- Gene3D:   G3DSA:3.65.10.10
- PIRSF:   PIRSF000505
- TIGRFAMs:   TIGR01356

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.19

Molecular weight: Translated: 45661; Mature: 45661

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00104 EPSP_SYNTHASE_1; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQLRLEPIKKVSGTINIPGSKSISNRALLLATLASGTTTLTNLLDSDDIRYMLASLKQL
CCCCCCCHHHHCCCEEECCCCCCCCCCEEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHC
GVSYRLSNNNTVCELDGLAGPLNAGEPQTLFLGNAGTAMRPLCAALTLGQGQFTLTGEPR
CEEEEECCCCEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHEECCCEEEECCCCC
MEERPIGDLVDALRQLGAEVSYLKNEGFPPLNITSTGLNGGNVEIAGDLSSQFLTALLMV
CCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCEEEECCCCCCCEEEECCCHHHHHHHHHHH
APLAKGDVNIKIKGELVSKPYIDITLALMAQFGVEVQNNDYASFVIKAGQRYVSPGKVLV
HCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCEEECCCCEEHEEECCCCCCCCCCEEE
EGDASSASYFLAAGAIQGGEVKVTGVGKLSIQGDVKFADVLEQMGADIEWGDDYIIARQA
ECCCCCCEEEEEECCCCCCEEEEEEEEEEEEECCCHHHHHHHHHCCCCCCCCCEEEEECC
KLKAVDLDMNHIPDAAMTIATAALFATGTTRIRNIYNWRIKETDRLAAMATELRKVGAIV
EEEEEECCHHHCCHHHHHHHHHHHHHCCHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHH
DEGHDYISVTPPAKLNTAAIDTYNDHRMAMCFSMMAFADCGITINEPECTSKTFPDYFNQ
CCCCCEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHHHH
FNALAN
HHHHCC
>Mature Secondary Structure
MNQLRLEPIKKVSGTINIPGSKSISNRALLLATLASGTTTLTNLLDSDDIRYMLASLKQL
CCCCCCCHHHHCCCEEECCCCCCCCCCEEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHC
GVSYRLSNNNTVCELDGLAGPLNAGEPQTLFLGNAGTAMRPLCAALTLGQGQFTLTGEPR
CEEEEECCCCEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHEECCCEEEECCCCC
MEERPIGDLVDALRQLGAEVSYLKNEGFPPLNITSTGLNGGNVEIAGDLSSQFLTALLMV
CCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCEEEECCCCCCCEEEECCCHHHHHHHHHHH
APLAKGDVNIKIKGELVSKPYIDITLALMAQFGVEVQNNDYASFVIKAGQRYVSPGKVLV
HCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCEEECCCCEEHEEECCCCCCCCCCEEE
EGDASSASYFLAAGAIQGGEVKVTGVGKLSIQGDVKFADVLEQMGADIEWGDDYIIARQA
ECCCCCCEEEEEECCCCCCEEEEEEEEEEEEECCCHHHHHHHHHCCCCCCCCCEEEEECC
KLKAVDLDMNHIPDAAMTIATAALFATGTTRIRNIYNWRIKETDRLAAMATELRKVGAIV
EEEEEECCHHHCCHHHHHHHHHHHHHCCHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHH
DEGHDYISVTPPAKLNTAAIDTYNDHRMAMCFSMMAFADCGITINEPECTSKTFPDYFNQ
CCCCCEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHHHH
FNALAN
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA