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The map label for this gene is hisC [H]

Identifier: 167623752

GI number: 167623752

Start: 2178188

End: 2179321

Strand: Reverse

Name: hisC [H]

Synonym: Shal_1822

Alternate gene names: 167623752

Gene position: 2179321-2178188 (Counterclockwise)

Preceding gene: 167623753

Following gene: 167623751

Centisome position: 41.69

GC content: 46.38

Gene sequence:

>1134_bases
ATGATAACTTCAGGGATAACTTCATACACTAGTTCAGAGTCAAGTTTAGAGACAACGTCAAGCAAGCTGAATTTGGCGCA
GCGTCTCGCGAGACCGGAACTATTAGCGTTACAGGTTTATCAATCAGCAAGACGTATTGGCGGCCAGGGGGATATCTGGA
TCAATGCCAATGAATCCCCCTTTAACAATAGTGAACTAGTCGGCCTCAACCGTTACCCTGAGTGCCAGCCACCTGCATTA
TTACGTGCGTATAGCCAATATAGTGGTGTAAATGAGAACAGCATTATCACAAGCCGCGGCGCCGACGAAGCGATTGAGCT
GCTAATTCGTGCCTTCTGTGTACCAGGGCAAGATAGCATCGCAACCTTCGGCCCAACATATGGCATGTATGCCATCAGTG
CCCAAACCTTCAATGTTGGGGTAAAAGCGCTGTCACTAACAGATGATTTTCAGCTCCCCACTGATTACCTAACTCAAGTC
AGTGGCGCTAAGCTGGTATTTATCTGTAACCCAAACAATCCCACAGGCAGTGTGATCCCAAGAAGTAAAATCATCGAAGT
TATCGAGCGCTGCCAAAACGCTATCGTGGTTGTCGATGAGGCTTACATTGAGTTTAGCCCAGAGTACAGTGTGGCCGATT
TAGTTGCCAGCTATGCAAATCTTGTGGTGCTTCGCACCTTATCAAAAGCGTTTTCCTTAGCTGGTGCGCGCTGTGGTTTT
ATGTTGGCAAATCCTGACATTATCGACATTTGCATGCGAGTCATTGCTCCTTATCCAGTGCCACTTCCTGTGAGCGAACT
CGCTATCAAAGCCCTGAACACCAGTGGCCTTGAAACCATGAGGCAACAGGTTAATGTAATGAAGCAACAGGGATTAAGGT
TGGCAGAAACATTATGCGATTATGGCGCCAACGTTATCAAAGCACATGGTAACTATCTGCTCGCAGAGTTTGATGACAAA
GCGCAGGTGCAACAAATGCTCACAACCGCTGGCGTAATCGCTAGAAGCTATAACGATCCTCGTCTGAATAAGGCGATTCG
CTTTAGCTTTACTGATCAGGCGCAAACAGACTATCTCATCAATCTGTTTCAACAGCCGTTTCAACAATCGGTTTCAACAA
CAGAATATAAGTAA

Upstream 100 bases:

>100_bases
ATGCCATTGCAGTTCGAATTGCCAGCCTTGACGCTAATGTAGATAACGAAGAGTTCGCCAGCAAGGGCGCAGATAAAGCG
AACTCGATTAAGGAGGCGCT

Downstream 100 bases:

>100_bases
GCTGACGTTTAAAAGAATAACAATAGCTTGGCTGAGTATTAAATGAGTTTCGACTTGTTTAACCTTGTTTTAACTCAGTT
AAGCCAGAATCTGAAAGGTA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MITSGITSYTSSESSLETTSSKLNLAQRLARPELLALQVYQSARRIGGQGDIWINANESPFNNSELVGLNRYPECQPPAL
LRAYSQYSGVNENSIITSRGADEAIELLIRAFCVPGQDSIATFGPTYGMYAISAQTFNVGVKALSLTDDFQLPTDYLTQV
SGAKLVFICNPNNPTGSVIPRSKIIEVIERCQNAIVVVDEAYIEFSPEYSVADLVASYANLVVLRTLSKAFSLAGARCGF
MLANPDIIDICMRVIAPYPVPLPVSELAIKALNTSGLETMRQQVNVMKQQGLRLAETLCDYGANVIKAHGNYLLAEFDDK
AQVQQMLTTAGVIARSYNDPRLNKAIRFSFTDQAQTDYLINLFQQPFQQSVSTTEYK

Sequences:

>Translated_377_residues
MITSGITSYTSSESSLETTSSKLNLAQRLARPELLALQVYQSARRIGGQGDIWINANESPFNNSELVGLNRYPECQPPAL
LRAYSQYSGVNENSIITSRGADEAIELLIRAFCVPGQDSIATFGPTYGMYAISAQTFNVGVKALSLTDDFQLPTDYLTQV
SGAKLVFICNPNNPTGSVIPRSKIIEVIERCQNAIVVVDEAYIEFSPEYSVADLVASYANLVVLRTLSKAFSLAGARCGF
MLANPDIIDICMRVIAPYPVPLPVSELAIKALNTSGLETMRQQVNVMKQQGLRLAETLCDYGANVIKAHGNYLLAEFDDK
AQVQQMLTTAGVIARSYNDPRLNKAIRFSFTDQAQTDYLINLFQQPFQQSVSTTEYK
>Mature_377_residues
MITSGITSYTSSESSLETTSSKLNLAQRLARPELLALQVYQSARRIGGQGDIWINANESPFNNSELVGLNRYPECQPPAL
LRAYSQYSGVNENSIITSRGADEAIELLIRAFCVPGQDSIATFGPTYGMYAISAQTFNVGVKALSLTDDFQLPTDYLTQV
SGAKLVFICNPNNPTGSVIPRSKIIEVIERCQNAIVVVDEAYIEFSPEYSVADLVASYANLVVLRTLSKAFSLAGARCGF
MLANPDIIDICMRVIAPYPVPLPVSELAIKALNTSGLETMRQQVNVMKQQGLRLAETLCDYGANVIKAHGNYLLAEFDDK
AQVQQMLTTAGVIARSYNDPRLNKAIRFSFTDQAQTDYLINLFQQPFQQSVSTTEYK

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=345, Percent_Identity=43.4782608695652, Blast_Score=281, Evalue=4e-77,
Organism=Saccharomyces cerevisiae, GI6322075, Length=374, Percent_Identity=31.0160427807487, Blast_Score=159, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41395; Mature: 41395

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITSGITSYTSSESSLETTSSKLNLAQRLARPELLALQVYQSARRIGGQGDIWINANESP
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCC
FNNSELVGLNRYPECQPPALLRAYSQYSGVNENSIITSRGADEAIELLIRAFCVPGQDSI
CCCCCEEECCCCCCCCCHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCC
ATFGPTYGMYAISAQTFNVGVKALSLTDDFQLPTDYLTQVSGAKLVFICNPNNPTGSVIP
EECCCCCCEEEEEEEEEECCEEEEEECCCCCCCHHHHHHCCCCEEEEEECCCCCCCCCCC
RSKIIEVIERCQNAIVVVDEAYIEFSPEYSVADLVASYANLVVLRTLSKAFSLAGARCGF
HHHHHHHHHHHCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
MLANPDIIDICMRVIAPYPVPLPVSELAIKALNTSGLETMRQQVNVMKQQGLRLAETLCD
EECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHH
YGANVIKAHGNYLLAEFDDKAQVQQMLTTAGVIARSYNDPRLNKAIRFSFTDQAQTDYLI
CCCCEEEECCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHH
NLFQQPFQQSVSTTEYK
HHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MITSGITSYTSSESSLETTSSKLNLAQRLARPELLALQVYQSARRIGGQGDIWINANESP
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCC
FNNSELVGLNRYPECQPPALLRAYSQYSGVNENSIITSRGADEAIELLIRAFCVPGQDSI
CCCCCEEECCCCCCCCCHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCC
ATFGPTYGMYAISAQTFNVGVKALSLTDDFQLPTDYLTQVSGAKLVFICNPNNPTGSVIP
EECCCCCCEEEEEEEEEECCEEEEEECCCCCCCHHHHHHCCCCEEEEEECCCCCCCCCCC
RSKIIEVIERCQNAIVVVDEAYIEFSPEYSVADLVASYANLVVLRTLSKAFSLAGARCGF
HHHHHHHHHHHCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
MLANPDIIDICMRVIAPYPVPLPVSELAIKALNTSGLETMRQQVNVMKQQGLRLAETLCD
EECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHH
YGANVIKAHGNYLLAEFDDKAQVQQMLTTAGVIARSYNDPRLNKAIRFSFTDQAQTDYLI
CCCCEEEECCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHH
NLFQQPFQQSVSTTEYK
HHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]