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The map label for this gene is hisD [H]

Identifier: 167623753

GI number: 167623753

Start: 2179318

End: 2180676

Strand: Reverse

Name: hisD [H]

Synonym: Shal_1823

Alternate gene names: 167623753

Gene position: 2180676-2179318 (Counterclockwise)

Preceding gene: 167623754

Following gene: 167623752

Centisome position: 41.72

GC content: 48.86

Gene sequence:

>1359_bases
ATGCAGATCCTCAATTGGCAAACTCTCGACTCTCAAGTTCAAACTAAAGCACTTGAGCGCTCACCACTCATAGGTGATAA
CGGTCTCGAGCAGAGTGTGGCAGATATCATTAATGCCGTCGTCACGGGTGGTGATAAGGCGTTATTTGAATTTAATCAGA
AATTTGATGGTGTCAGTATCGATAACTTAAGGTTGTCGAATACCGATATCGAGCAGAGCTGTGCCAAGGTTTCTTCCGAG
GTAAAACAAGCTATTGCTCAAGCAAAGGCCAACATTGAGACCTTCCACAACGCACAAGTTCAGCCAAGTATTGATCTAGA
AACTCAAGCCGGGATCCGCTGCGAGCTACGCTCTGAGCCTATCGAACGTGTTGGCCTATATATTCCTGGAGGCACTGCGC
CGCTTATTTCAACCGTGCTCATGTTAGCCCTCCCCGCTAACATTGCCGGTTGTAACAAGCGCGTACTCGTGAGCCCACCG
CCGATTAATGATGCCATCATTTATGCGGCAAAAGAGTGTGGTATTGAAGAGATCTATCAAGTGGGTGGCGCCCAAGCTAT
TGCCGCATTAGCATTTGGTACCGAGTCAGTTCCGCAAGTAGATAAGATTTTTGGCCCAGGTAATCGCTTTGTGACCGAAG
CCAAGCGCGCCGTCAGTCAAGACAACCGCTGTACAGTGAGCATTGATATGCCTGCCGGCCCATCGGAAGTGCTCATCATT
GCCGATGCCGAGGCTAACCCTGAATTTGTTGCAGCCGATCTTTTATCACAAGCCGAGCACGGCGCGGACTCACAAGTCAT
GTTAGTCACCGATTCAAACTTACTTGCAGAAAAAGTAAATCAAGCTTTGCAGCAGCAACTGGCGCAGCTGCCACGTGCAG
ATATTGCCAGAAAGGCCCTTACTAGCAGCCGCACCATTATAGTGAACGATATGGCCATGGCTGCAGCGGTTTCTAATCAA
TATGGACCTGAACACTTAATCATACAAACTGAGCAGCCACGACAAGTATTAGCCAATATTCGGGCTGCGGGTTCAGTATT
TTTGGGCCCCTATACACCAGAGTCTGTGGGCGATTATGCCAGCGGCACGAATCATGTATTACCCACGTATGGTTACAGCA
AAACCGTGTCGAGCTTATCACTTGCAGATTTCAGCCGCCGATTTACCGTACAAGAGCTCACCGCTCAAGGGCTAGAAACT
ATTGCTGATAGCGTGATGATACTGGCGGCAGCTGAACAACTTGATGCACACAAGAATGCCATTGCAGTTCGAATTGCCAG
CCTTGACGCTAATGTAGATAACGAAGAGTTCGCCAGCAAGGGCGCAGATAAAGCGAACTCGATTAAGGAGGCGCTATGA

Upstream 100 bases:

>100_bases
AGCACCGAAGACTTGTTCTGGGACACTATGGAGCAATTAACGCAACTGGGCGCCAGCTCAATTCTTGTTATGCCTATTGA
AAAAATGATGGGGTAGAGTC

Downstream 100 bases:

>100_bases
TAACTTCAGGGATAACTTCATACACTAGTTCAGAGTCAAGTTTAGAGACAACGTCAAGCAAGCTGAATTTGGCGCAGCGT
CTCGCGAGACCGGAACTATT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MQILNWQTLDSQVQTKALERSPLIGDNGLEQSVADIINAVVTGGDKALFEFNQKFDGVSIDNLRLSNTDIEQSCAKVSSE
VKQAIAQAKANIETFHNAQVQPSIDLETQAGIRCELRSEPIERVGLYIPGGTAPLISTVLMLALPANIAGCNKRVLVSPP
PINDAIIYAAKECGIEEIYQVGGAQAIAALAFGTESVPQVDKIFGPGNRFVTEAKRAVSQDNRCTVSIDMPAGPSEVLII
ADAEANPEFVAADLLSQAEHGADSQVMLVTDSNLLAEKVNQALQQQLAQLPRADIARKALTSSRTIIVNDMAMAAAVSNQ
YGPEHLIIQTEQPRQVLANIRAAGSVFLGPYTPESVGDYASGTNHVLPTYGYSKTVSSLSLADFSRRFTVQELTAQGLET
IADSVMILAAAEQLDAHKNAIAVRIASLDANVDNEEFASKGADKANSIKEAL

Sequences:

>Translated_452_residues
MQILNWQTLDSQVQTKALERSPLIGDNGLEQSVADIINAVVTGGDKALFEFNQKFDGVSIDNLRLSNTDIEQSCAKVSSE
VKQAIAQAKANIETFHNAQVQPSIDLETQAGIRCELRSEPIERVGLYIPGGTAPLISTVLMLALPANIAGCNKRVLVSPP
PINDAIIYAAKECGIEEIYQVGGAQAIAALAFGTESVPQVDKIFGPGNRFVTEAKRAVSQDNRCTVSIDMPAGPSEVLII
ADAEANPEFVAADLLSQAEHGADSQVMLVTDSNLLAEKVNQALQQQLAQLPRADIARKALTSSRTIIVNDMAMAAAVSNQ
YGPEHLIIQTEQPRQVLANIRAAGSVFLGPYTPESVGDYASGTNHVLPTYGYSKTVSSLSLADFSRRFTVQELTAQGLET
IADSVMILAAAEQLDAHKNAIAVRIASLDANVDNEEFASKGADKANSIKEAL
>Mature_452_residues
MQILNWQTLDSQVQTKALERSPLIGDNGLEQSVADIINAVVTGGDKALFEFNQKFDGVSIDNLRLSNTDIEQSCAKVSSE
VKQAIAQAKANIETFHNAQVQPSIDLETQAGIRCELRSEPIERVGLYIPGGTAPLISTVLMLALPANIAGCNKRVLVSPP
PINDAIIYAAKECGIEEIYQVGGAQAIAALAFGTESVPQVDKIFGPGNRFVTEAKRAVSQDNRCTVSIDMPAGPSEVLII
ADAEANPEFVAADLLSQAEHGADSQVMLVTDSNLLAEKVNQALQQQLAQLPRADIARKALTSSRTIIVNDMAMAAAVSNQ
YGPEHLIIQTEQPRQVLANIRAAGSVFLGPYTPESVGDYASGTNHVLPTYGYSKTVSSLSLADFSRRFTVQELTAQGLET
IADSVMILAAAEQLDAHKNAIAVRIASLDANVDNEEFASKGADKANSIKEAL

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=426, Percent_Identity=57.0422535211268, Blast_Score=507, Evalue=1e-145,
Organism=Saccharomyces cerevisiae, GI6319819, Length=422, Percent_Identity=46.9194312796209, Blast_Score=375, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 48196; Mature: 48196

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQILNWQTLDSQVQTKALERSPLIGDNGLEQSVADIINAVVTGGDKALFEFNQKFDGVSI
CCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEE
DNLRLSNTDIEQSCAKVSSEVKQAIAQAKANIETFHNAQVQPSIDLETQAGIRCELRSEP
CCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCC
IERVGLYIPGGTAPLISTVLMLALPANIAGCNKRVLVSPPPINDAIIYAAKECGIEEIYQ
HHHCEEECCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEEEHHHCCHHHHHH
VGGAQAIAALAFGTESVPQVDKIFGPGNRFVTEAKRAVSQDNRCTVSIDMPAGPSEVLII
CCCHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEE
ADAEANPEFVAADLLSQAEHGADSQVMLVTDSNLLAEKVNQALQQQLAQLPRADIARKAL
EECCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
TSSRTIIVNDMAMAAAVSNQYGPEHLIIQTEQPRQVLANIRAAGSVFLGPYTPESVGDYA
CCCCEEEEEHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCEEECCCCCHHHCCCC
SGTNHVLPTYGYSKTVSSLSLADFSRRFTVQELTAQGLETIADSVMILAAAEQLDAHKNA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
IAVRIASLDANVDNEEFASKGADKANSIKEAL
EEEEEEECCCCCCHHHHHHCCCCHHHHHHHCC
>Mature Secondary Structure
MQILNWQTLDSQVQTKALERSPLIGDNGLEQSVADIINAVVTGGDKALFEFNQKFDGVSI
CCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEE
DNLRLSNTDIEQSCAKVSSEVKQAIAQAKANIETFHNAQVQPSIDLETQAGIRCELRSEP
CCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCC
IERVGLYIPGGTAPLISTVLMLALPANIAGCNKRVLVSPPPINDAIIYAAKECGIEEIYQ
HHHCEEECCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEEEHHHCCHHHHHH
VGGAQAIAALAFGTESVPQVDKIFGPGNRFVTEAKRAVSQDNRCTVSIDMPAGPSEVLII
CCCHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEE
ADAEANPEFVAADLLSQAEHGADSQVMLVTDSNLLAEKVNQALQQQLAQLPRADIARKAL
EECCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
TSSRTIIVNDMAMAAAVSNQYGPEHLIIQTEQPRQVLANIRAAGSVFLGPYTPESVGDYA
CCCCEEEEEHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCEEECCCCCHHHCCCC
SGTNHVLPTYGYSKTVSSLSLADFSRRFTVQELTAQGLETIADSVMILAAAEQLDAHKNA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
IAVRIASLDANVDNEEFASKGADKANSIKEAL
EEEEEEECCCCCCHHHHHHCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]