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The map label for this gene is hisB [H]

Identifier: 167623751

GI number: 167623751

Start: 2177000

End: 2178079

Strand: Reverse

Name: hisB [H]

Synonym: Shal_1821

Alternate gene names: 167623751

Gene position: 2178079-2177000 (Counterclockwise)

Preceding gene: 167623752

Following gene: 167623750

Centisome position: 41.67

GC content: 46.94

Gene sequence:

>1080_bases
ATGAAGCAGAAAATTTTATTTATTGACCGTGATGGCACCCTCATCGAAGAACCAGTGACAGATAAGCAAGTCGATAGCTT
AGCCAAGCTTGTTTTTGAGCCTAATGTGATCCCTGCTCTACTGAAACTACAAAACGCCGGTTATCGATTAGTCATGGTGA
GTAATCAAGACGGTCTTGGCACGCCGTCGTTCCCAAGAGATGATTTCGACGCACCGCAAAATATGATGATGCAGATCTTA
AACAGCCAAGGCGTGCTGTTTGATGATGTCCTTATCTGCCCTCACTTTAATGATGAGAACTGCAGTTGCCGTAAGCCTAA
GCTTGGGCTAGTTAAAGATTACCTGACTTCTGGCAAGATTGATTTTACTCAGTCTGCTGTCATAGGAGACCGTGAAACCG
ACTTAGGTCTTGCCGACTCGATGGGGATATTAGGTTTGCAATATCACCCTCAAAACCTTAACTGGAATGCCATTGCCGAC
AAGCTTCTGAATAAGAACCGCAGTGCGACCGTTACTCGTACCACTAAAGAAACCGATATTCGCGTCACCGTCGATTTAGA
TTCAAATGACAAAGGCGAGATCAACACTGGTATCGGCTTTTTCGACCATATGCTTGAGCAGATCTCAACTCACGGCAACT
TTAAAATGGATGTAAAGGTTGATGGCGACTTGGAGATCGATGACCACCACAGCGTAGAAGATACCGCACTGGCTATCGGT
GATGCGCTGCGCCAAGCCCTCGGTGACAAACGCGGTATCGCCCGTTTTGGCAATGCGTTTGAGCAGGCTATTCCTATGGA
TGAGGCTAGTGCAACCTGTCTTTTGGACTTATCTGGTCGCCCGTTTATCAAGTTCGCTGGTGAGTTTGAGCGTGAACTCG
TTGGCCAAATGGCAACCGAGATGGTACCGCACTTCTTCCGCTCGTTTGCCGATGGTCTGCGCTGTACATTACACATCAGC
ACTCAAGGCGATAACGACCACCACAAAGTTGAAAGTTTATATAAGGTGTTAGGTCGGACTCTAAGGCAAGCTGTTGCAGT
TGAAGGAGATAGCCTTCCCTCAAGTAAAGGTGTGTTATGA

Upstream 100 bases:

>100_bases
TTAAAAGAATAACAATAGCTTGGCTGAGTATTAAATGAGTTTCGACTTGTTTAACCTTGTTTTAACTCAGTTAAGCCAGA
ATCTGAAAGGTATAACCGCT

Downstream 100 bases:

>100_bases
GCCAAACAGATATAGCAGCCATAGTCGGTAATACCGTCATTATCGATACTGGCTGCGCCAATTTAAGTTCTGTCCGCTAC
GCCTTTGAACGCTTGATGAC

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD [H]

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MKQKILFIDRDGTLIEEPVTDKQVDSLAKLVFEPNVIPALLKLQNAGYRLVMVSNQDGLGTPSFPRDDFDAPQNMMMQIL
NSQGVLFDDVLICPHFNDENCSCRKPKLGLVKDYLTSGKIDFTQSAVIGDRETDLGLADSMGILGLQYHPQNLNWNAIAD
KLLNKNRSATVTRTTKETDIRVTVDLDSNDKGEINTGIGFFDHMLEQISTHGNFKMDVKVDGDLEIDDHHSVEDTALAIG
DALRQALGDKRGIARFGNAFEQAIPMDEASATCLLDLSGRPFIKFAGEFERELVGQMATEMVPHFFRSFADGLRCTLHIS
TQGDNDHHKVESLYKVLGRTLRQAVAVEGDSLPSSKGVL

Sequences:

>Translated_359_residues
MKQKILFIDRDGTLIEEPVTDKQVDSLAKLVFEPNVIPALLKLQNAGYRLVMVSNQDGLGTPSFPRDDFDAPQNMMMQIL
NSQGVLFDDVLICPHFNDENCSCRKPKLGLVKDYLTSGKIDFTQSAVIGDRETDLGLADSMGILGLQYHPQNLNWNAIAD
KLLNKNRSATVTRTTKETDIRVTVDLDSNDKGEINTGIGFFDHMLEQISTHGNFKMDVKVDGDLEIDDHHSVEDTALAIG
DALRQALGDKRGIARFGNAFEQAIPMDEASATCLLDLSGRPFIKFAGEFERELVGQMATEMVPHFFRSFADGLRCTLHIS
TQGDNDHHKVESLYKVLGRTLRQAVAVEGDSLPSSKGVL
>Mature_359_residues
MKQKILFIDRDGTLIEEPVTDKQVDSLAKLVFEPNVIPALLKLQNAGYRLVMVSNQDGLGTPSFPRDDFDAPQNMMMQIL
NSQGVLFDDVLICPHFNDENCSCRKPKLGLVKDYLTSGKIDFTQSAVIGDRETDLGLADSMGILGLQYHPQNLNWNAIAD
KLLNKNRSATVTRTTKETDIRVTVDLDSNDKGEINTGIGFFDHMLEQISTHGNFKMDVKVDGDLEIDDHHSVEDTALAIG
DALRQALGDKRGIARFGNAFEQAIPMDEASATCLLDLSGRPFIKFAGEFERELVGQMATEMVPHFFRSFADGLRCTLHIS
TQGDNDHHKVESLYKVLGRTLRQAVAVEGDSLPSSKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=359, Percent_Identity=60.7242339832869, Blast_Score=455, Evalue=1e-129,
Organism=Escherichia coli, GI1786399, Length=143, Percent_Identity=31.4685314685315, Blast_Score=65, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6324776, Length=219, Percent_Identity=37.8995433789954, Blast_Score=158, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR013954
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD; PF08645 PNK3P [H]

EC number: =3.1.3.15; =4.2.1.19 [H]

Molecular weight: Translated: 39728; Mature: 39728

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2 ; PS00307 LECTIN_LEGUME_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQKILFIDRDGTLIEEPVTDKQVDSLAKLVFEPNVIPALLKLQNAGYRLVMVSNQDGLG
CCCEEEEEECCCCEECCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEECCCCCC
TPSFPRDDFDAPQNMMMQILNSQGVLFDDVLICPHFNDENCSCRKPKLGLVKDYLTSGKI
CCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCC
DFTQSAVIGDRETDLGLADSMGILGLQYHPQNLNWNAIADKLLNKNRSATVTRTTKETDI
CCCHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCCCEE
RVTVDLDSNDKGEINTGIGFFDHMLEQISTHGNFKMDVKVDGDLEIDDHHSVEDTALAIG
EEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCCHHHHHHHH
DALRQALGDKRGIARFGNAFEQAIPMDEASATCLLDLSGRPFIKFAGEFERELVGQMATE
HHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEECCHHHHHHHHHHHHH
MVPHFFRSFADGLRCTLHISTQGDNDHHKVESLYKVLGRTLRQAVAVEGDSLPSSKGVL
HHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MKQKILFIDRDGTLIEEPVTDKQVDSLAKLVFEPNVIPALLKLQNAGYRLVMVSNQDGLG
CCCEEEEEECCCCEECCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEECCCCCC
TPSFPRDDFDAPQNMMMQILNSQGVLFDDVLICPHFNDENCSCRKPKLGLVKDYLTSGKI
CCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCC
DFTQSAVIGDRETDLGLADSMGILGLQYHPQNLNWNAIADKLLNKNRSATVTRTTKETDI
CCCHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCCCEE
RVTVDLDSNDKGEINTGIGFFDHMLEQISTHGNFKMDVKVDGDLEIDDHHSVEDTALAIG
EEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCCHHHHHHHH
DALRQALGDKRGIARFGNAFEQAIPMDEASATCLLDLSGRPFIKFAGEFERELVGQMATE
HHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEECCHHHHHHHHHHHHH
MVPHFFRSFADGLRCTLHISTQGDNDHHKVESLYKVLGRTLRQAVAVEGDSLPSSKGVL
HHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]