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The map label for this gene is hisA

Identifier: 167623749

GI number: 167623749

Start: 2175550

End: 2176287

Strand: Reverse

Name: hisA

Synonym: Shal_1819

Alternate gene names: 167623749

Gene position: 2176287-2175550 (Counterclockwise)

Preceding gene: 167623750

Following gene: 167623748

Centisome position: 41.64

GC content: 46.34

Gene sequence:

>738_bases
ATGATTATTCCTGCAATCGATCTTATCGACGGTCAAGTCGTTCGCCTCTACCAAGGTGATTACGAACAACAAACAACCTT
TAATTTGAGTCCGTTAGATCAACTAAAATCTTATCAGGCCCAAGGGGCCAACTTGCTGCATATCGTCGACTTAACCGGAG
CAAAAGATCCTACTAAGCGTCAAACAGCCTTAATCTCTGAACTGGTTAATCACCTAGATACCCCCATTCAAGTCGGTGGT
GGAATTCGCACCGAAGCCCAATTAAATGAGCTATTAGAAATTGGTGTCAGCCGTGTTGTTATCGGCTCATTGGCCGTAAA
GGAGCCTGAGCTTGTAAAAAGCTGGTTCGAAAAGTATGGCAATGAAGCAATTTGCTTGGCACTCGATGTCAATATCAATG
AGCAAGGCGAAAAAATTGTCGCCGTATCGGGCTGGCAAACTGGGGGCGGTAAGAGCCTTGAGTCACTGGTTGAAGAGTTC
AAAACGGTTGACCTAAAACATGCGTTAGTCACTGATATTAGTCGTGATGGTACTCTGCAAGGCGCTAATACCGAACTTTA
CCGTGAAATTGCCGCTAGCTATCCAGAGATCCAGTGGCAAGCCTCCGGTGGCATCGCCACCTTGGCCGATGTCAATGCAG
TAAAAGATAGCGGCGCCGATGGCATCATCATCGGAAAAGCCTTACTCATTAAACAGTTTTCAGTAAAGGAGGCGATTGCA
TGTTGGCCAAACGCATAG

Upstream 100 bases:

>100_bases
AGATATTGGCAAACTTCCTCACTATGGACAGAAATACCTTTGGCCAATCAAGCACTCAACAAGCGAGTAAACTTGCTAAA
AAGCAATTAGAGGCACTGTA

Downstream 100 bases:

>100_bases
TCCCTTGCCTCGATGTCAAAGAGGGTAAAGTGGTTAAAGGGGTTCAATTTAGAAACCATGAAATTGTAGGTGATATTGTG
CCGCTCGCTAAGCGCTACGC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MIIPAIDLIDGQVVRLYQGDYEQQTTFNLSPLDQLKSYQAQGANLLHIVDLTGAKDPTKRQTALISELVNHLDTPIQVGG
GIRTEAQLNELLEIGVSRVVIGSLAVKEPELVKSWFEKYGNEAICLALDVNINEQGEKIVAVSGWQTGGGKSLESLVEEF
KTVDLKHALVTDISRDGTLQGANTELYREIAASYPEIQWQASGGIATLADVNAVKDSGADGIIIGKALLIKQFSVKEAIA
CWPNA

Sequences:

>Translated_245_residues
MIIPAIDLIDGQVVRLYQGDYEQQTTFNLSPLDQLKSYQAQGANLLHIVDLTGAKDPTKRQTALISELVNHLDTPIQVGG
GIRTEAQLNELLEIGVSRVVIGSLAVKEPELVKSWFEKYGNEAICLALDVNINEQGEKIVAVSGWQTGGGKSLESLVEEF
KTVDLKHALVTDISRDGTLQGANTELYREIAASYPEIQWQASGGIATLADVNAVKDSGADGIIIGKALLIKQFSVKEAIA
CWPNA
>Mature_245_residues
MIIPAIDLIDGQVVRLYQGDYEQQTTFNLSPLDQLKSYQAQGANLLHIVDLTGAKDPTKRQTALISELVNHLDTPIQVGG
GIRTEAQLNELLEIGVSRVVIGSLAVKEPELVKSWFEKYGNEAICLALDVNINEQGEKIVAVSGWQTGGGKSLESLVEEF
KTVDLKHALVTDISRDGTLQGANTELYREIAASYPEIQWQASGGIATLADVNAVKDSGADGIIIGKALLIKQFSVKEAIA
CWPNA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=245, Percent_Identity=59.1836734693878, Blast_Score=300, Evalue=4e-83,
Organism=Escherichia coli, GI1788336, Length=234, Percent_Identity=25.6410256410256, Blast_Score=68, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_SHEHH (B0TQY9)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001674043.1
- ProteinModelPortal:   B0TQY9
- GeneID:   5904616
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_1819
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- ProtClustDB:   PRK00748
- BioCyc:   SHAL458817:SHAL_1819-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 26469; Mature: 26469

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: NA

Important sites: ACT_SITE 7-7 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIPAIDLIDGQVVRLYQGDYEQQTTFNLSPLDQLKSYQAQGANLLHIVDLTGAKDPTKR
CCCCCEECCCCCEEEEECCCCCCCCEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHH
QTALISELVNHLDTPIQVGGGIRTEAQLNELLEIGVSRVVIGSLAVKEPELVKSWFEKYG
HHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
NEAICLALDVNINEQGEKIVAVSGWQTGGGKSLESLVEEFKTVDLKHALVTDISRDGTLQ
CCEEEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GANTELYREIAASYPEIQWQASGGIATLADVNAVKDSGADGIIIGKALLIKQFSVKEAIA
CCCHHHHHHHHHCCCCEEEECCCCEEEEHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHH
CWPNA
CCCCC
>Mature Secondary Structure
MIIPAIDLIDGQVVRLYQGDYEQQTTFNLSPLDQLKSYQAQGANLLHIVDLTGAKDPTKR
CCCCCEECCCCCEEEEECCCCCCCCEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHH
QTALISELVNHLDTPIQVGGGIRTEAQLNELLEIGVSRVVIGSLAVKEPELVKSWFEKYG
HHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
NEAICLALDVNINEQGEKIVAVSGWQTGGGKSLESLVEEFKTVDLKHALVTDISRDGTLQ
CCEEEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GANTELYREIAASYPEIQWQASGGIATLADVNAVKDSGADGIIIGKALLIKQFSVKEAIA
CCCHHHHHHHHHCCCCEEEECCCCEEEEHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHH
CWPNA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA