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The map label for this gene is trpE [H]

Identifier: 167623589

GI number: 167623589

Start: 1988317

End: 1989909

Strand: Reverse

Name: trpE [H]

Synonym: Shal_1658

Alternate gene names: 167623589

Gene position: 1989909-1988317 (Counterclockwise)

Preceding gene: 167623595

Following gene: 167623588

Centisome position: 38.07

GC content: 49.22

Gene sequence:

>1593_bases
ATGGAACACACTATCGCTAAGGTTATCACCCAAAAAGAAGCGCTGGCGTATCATGACGATCCACTTAGTCTATACCAGGA
TGTGACTCAAGATGCCCCTCACACCATGCTGCTAGAGTCGGCTGAAATAGACAGCAAAGATCACCTAAAGAGTATCGTAT
TAACTCACGCAGCAATGATGATCCGTTGCAGTGGCTACCAGCTTGAGTTTAGCGCGTTAACAGACAATGGTAAGACACTA
CTCGCGCCAATCAAGTCCTTTTTCGAGCAAACTTTTCTGGCCACGGAAATTAACCATATTAATGGATCAAGCCTAAGCCT
AACGCTACAAAAAGAGTCTAATCAACTCGATGAAGACGCTCGCCTAAAGTCAACCTCTCCTCTCGATGGCCTGCGAGCGC
TAGTTAAGCACATTCGCTGCGATGAAAGCCCCGAGTTTGAAGATCTGTTTCTAGGTGGCGTACTCTCCTATGACTTAATC
GATACCGTCGAGCCACTGCCAAGCGTGCCAGAAGGCGATAACACCTGCCCTGACTATCTATTTTATCTCGCCGAAACCTT
AATTCTTGTGGATCATCAGCTACAAAGCGCCGAAATTGTGACTCACCAATTTGTGCTGCCAGGCTACAACAGCTTAAACA
AGCACTCAGACAAGAGTGCGGCACAGCTTGCAACCCGCATGAGCAAGCTGCAACAAAAGTGTCATTCACTCGCGCCCATT
GCCGAGCTACTAGGTGTCGATGCCGAGACTCAGGTTAATATTTCAGACAATGACTTCAAAGACACGGTCAACAGCCTAAA
AGAGCACATCGTCGCTGGCGATATTTTCCAAGTGGTTCCATCGCGCAGTTTCAGCCTACCTTGCCCCAATACATTAGGTG
CCTATCGCGCACTAAGGCTGACAAACCCAAGCCCTTACATGTTCTACTTTCGCGGCGATGACTTTACCTTGTTTGGCGCC
TCACCAGAAAGTGCCCTTAAGTATGAGGCGAAGAGCAATCAGGTTGAGATCTACCCGATTGCCGGAACACGTAAACGTGG
CAAAACCGCCAGCGGTGATATTGATTTTGATCTCGATAGCCGTAACGAGCTTGAACTGCGCCTAGATAAAAAAGAGCTGT
CTGAGCACATCATGTTGGTGGACTTGGCTCGCAACGATATCGCTCGCATCAGCCAAAGTGGTACTCGCAAAGTACCTGAG
CTACTAAAGGTGGATAGATACTCCCATGTAATGCACCTCGTTAGCCGCGTCACAGGCCAGCTTCGATCCGATTTAGATGC
ACTGCATGCCTATCAAGCTTGCATGAATATGGGCACCTTAACTGGCGCGCCAAAAGTGAGTGCCGCTCAGCTGATTCGCG
GCGCTGAAAAAACACGTCGTGGCAGCTACGGCGGTGCGGTCGGTTACCTCAATGGTCTTGGTGATATGGATACCTGTATT
GTAATCCGCTCAGCCTTTGTTAAAAACGACATCGCCTACATTCAAGCCGGAGCCGGCGTGGTATTTGATTCAGACCCTCA
GGCGGAAGCCGATGAAACCCGCCAAAAGGCACAAGCGGTTATTTCAGCCATTAAGATGGGAGGTGGGCTATGA

Upstream 100 bases:

>100_bases
TAATAAAATAAGCAAGAAGATAGAAAACTCGCAGCGGCAGGCTAGAAAAGTGAGATAAAACAATGAACAATGCATTACCC
TACAAGGCAGGAGCATAAGC

Downstream 100 bases:

>100_bases
AAATCTATCTGTTAGATAACTTTGACTCCTTCACTTACAACCTAGTCGATCAGTTTAGAAGTCTAGGCTACGAAGTGGTG
ATTTATCGTAATGATGTCGA

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 530; Mature: 530

Protein sequence:

>530_residues
MEHTIAKVITQKEALAYHDDPLSLYQDVTQDAPHTMLLESAEIDSKDHLKSIVLTHAAMMIRCSGYQLEFSALTDNGKTL
LAPIKSFFEQTFLATEINHINGSSLSLTLQKESNQLDEDARLKSTSPLDGLRALVKHIRCDESPEFEDLFLGGVLSYDLI
DTVEPLPSVPEGDNTCPDYLFYLAETLILVDHQLQSAEIVTHQFVLPGYNSLNKHSDKSAAQLATRMSKLQQKCHSLAPI
AELLGVDAETQVNISDNDFKDTVNSLKEHIVAGDIFQVVPSRSFSLPCPNTLGAYRALRLTNPSPYMFYFRGDDFTLFGA
SPESALKYEAKSNQVEIYPIAGTRKRGKTASGDIDFDLDSRNELELRLDKKELSEHIMLVDLARNDIARISQSGTRKVPE
LLKVDRYSHVMHLVSRVTGQLRSDLDALHAYQACMNMGTLTGAPKVSAAQLIRGAEKTRRGSYGGAVGYLNGLGDMDTCI
VIRSAFVKNDIAYIQAGAGVVFDSDPQAEADETRQKAQAVISAIKMGGGL

Sequences:

>Translated_530_residues
MEHTIAKVITQKEALAYHDDPLSLYQDVTQDAPHTMLLESAEIDSKDHLKSIVLTHAAMMIRCSGYQLEFSALTDNGKTL
LAPIKSFFEQTFLATEINHINGSSLSLTLQKESNQLDEDARLKSTSPLDGLRALVKHIRCDESPEFEDLFLGGVLSYDLI
DTVEPLPSVPEGDNTCPDYLFYLAETLILVDHQLQSAEIVTHQFVLPGYNSLNKHSDKSAAQLATRMSKLQQKCHSLAPI
AELLGVDAETQVNISDNDFKDTVNSLKEHIVAGDIFQVVPSRSFSLPCPNTLGAYRALRLTNPSPYMFYFRGDDFTLFGA
SPESALKYEAKSNQVEIYPIAGTRKRGKTASGDIDFDLDSRNELELRLDKKELSEHIMLVDLARNDIARISQSGTRKVPE
LLKVDRYSHVMHLVSRVTGQLRSDLDALHAYQACMNMGTLTGAPKVSAAQLIRGAEKTRRGSYGGAVGYLNGLGDMDTCI
VIRSAFVKNDIAYIQAGAGVVFDSDPQAEADETRQKAQAVISAIKMGGGL
>Mature_530_residues
MEHTIAKVITQKEALAYHDDPLSLYQDVTQDAPHTMLLESAEIDSKDHLKSIVLTHAAMMIRCSGYQLEFSALTDNGKTL
LAPIKSFFEQTFLATEINHINGSSLSLTLQKESNQLDEDARLKSTSPLDGLRALVKHIRCDESPEFEDLFLGGVLSYDLI
DTVEPLPSVPEGDNTCPDYLFYLAETLILVDHQLQSAEIVTHQFVLPGYNSLNKHSDKSAAQLATRMSKLQQKCHSLAPI
AELLGVDAETQVNISDNDFKDTVNSLKEHIVAGDIFQVVPSRSFSLPCPNTLGAYRALRLTNPSPYMFYFRGDDFTLFGA
SPESALKYEAKSNQVEIYPIAGTRKRGKTASGDIDFDLDSRNELELRLDKKELSEHIMLVDLARNDIARISQSGTRKVPE
LLKVDRYSHVMHLVSRVTGQLRSDLDALHAYQACMNMGTLTGAPKVSAAQLIRGAEKTRRGSYGGAVGYLNGLGDMDTCI
VIRSAFVKNDIAYIQAGAGVVFDSDPQAEADETRQKAQAVISAIKMGGGL

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1787518, Length=510, Percent_Identity=53.5294117647059, Blast_Score=504, Evalue=1e-144,
Organism=Escherichia coli, GI1788114, Length=425, Percent_Identity=30.1176470588235, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI87082077, Length=267, Percent_Identity=27.3408239700375, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1786809, Length=228, Percent_Identity=28.9473684210526, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320935, Length=407, Percent_Identity=37.8378378378378, Blast_Score=226, Evalue=5e-60,
Organism=Saccharomyces cerevisiae, GI6324361, Length=231, Percent_Identity=25.5411255411255, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005257
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 58333; Mature: 58333

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHTIAKVITQKEALAYHDDPLSLYQDVTQDAPHTMLLESAEIDSKDHLKSIVLTHAAMM
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHH
IRCSGYQLEFSALTDNGKTLLAPIKSFFEQTFLATEINHINGSSLSLTLQKESNQLDEDA
HEECCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHH
RLKSTSPLDGLRALVKHIRCDESPEFEDLFLGGVLSYDLIDTVEPLPSVPEGDNTCPDYL
HCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
FYLAETLILVDHQLQSAEIVTHQFVLPGYNSLNKHSDKSAAQLATRMSKLQQKCHSLAPI
HHHHHHHHHHHCCCCHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AELLGVDAETQVNISDNDFKDTVNSLKEHIVAGDIFQVVPSRSFSLPCPNTLGAYRALRL
HHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHEEEEE
TNPSPYMFYFRGDDFTLFGASPESALKYEAKSNQVEIYPIAGTRKRGKTASGDIDFDLDS
CCCCCEEEEEECCCEEEECCCCHHHHEEECCCCEEEEEECCCCCCCCCCCCCCEEECCCC
RNELELRLDKKELSEHIMLVDLARNDIARISQSGTRKVPELLKVDRYSHVMHLVSRVTGQ
CCCEEEEECHHHHHCCEEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LRSDLDALHAYQACMNMGTLTGAPKVSAAQLIRGAEKTRRGSYGGAVGYLNGLGDMDTCI
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHH
VIRSAFVKNDIAYIQAGAGVVFDSDPQAEADETRQKAQAVISAIKMGGGL
HHHHHHHHCCHHEEEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEHTIAKVITQKEALAYHDDPLSLYQDVTQDAPHTMLLESAEIDSKDHLKSIVLTHAAMM
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHH
IRCSGYQLEFSALTDNGKTLLAPIKSFFEQTFLATEINHINGSSLSLTLQKESNQLDEDA
HEECCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHH
RLKSTSPLDGLRALVKHIRCDESPEFEDLFLGGVLSYDLIDTVEPLPSVPEGDNTCPDYL
HCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
FYLAETLILVDHQLQSAEIVTHQFVLPGYNSLNKHSDKSAAQLATRMSKLQQKCHSLAPI
HHHHHHHHHHHCCCCHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AELLGVDAETQVNISDNDFKDTVNSLKEHIVAGDIFQVVPSRSFSLPCPNTLGAYRALRL
HHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHEEEEE
TNPSPYMFYFRGDDFTLFGASPESALKYEAKSNQVEIYPIAGTRKRGKTASGDIDFDLDS
CCCCCEEEEEECCCEEEECCCCHHHHEEECCCCEEEEEECCCCCCCCCCCCCCEEECCCC
RNELELRLDKKELSEHIMLVDLARNDIARISQSGTRKVPELLKVDRYSHVMHLVSRVTGQ
CCCEEEEECHHHHHCCEEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LRSDLDALHAYQACMNMGTLTGAPKVSAAQLIRGAEKTRRGSYGGAVGYLNGLGDMDTCI
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHH
VIRSAFVKNDIAYIQAGAGVVFDSDPQAEADETRQKAQAVISAIKMGGGL
HHHHHHHHCCHHEEEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]