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The map label for this gene is mutT [H]

Identifier: 167622404

GI number: 167622404

Start: 552397

End: 552786

Strand: Reverse

Name: mutT [H]

Synonym: Shal_0464

Alternate gene names: 167622404

Gene position: 552786-552397 (Counterclockwise)

Preceding gene: 167622405

Following gene: 167622401

Centisome position: 10.58

GC content: 44.1

Gene sequence:

>390_bases
ATGAGCCAGCAAATTCATGTTGCCGTTGGTGTTATTCAAGACTCAGATAATCGAATCCTCATAGCGAAACGCCCAGAACA
CCTTCACCAAGGAGGAAAGTGGGAATTCCCAGGTGGTAAAGTTGAAGATTCAGAAACGACCTCTCAGGCGCTAATCAGAG
AGCTTAAAGAGGAAGTAAACCTAGATGTCGTAGAAACTTTTCCTCTAATGGAAATCCACCATGACTATGGTGATAAACAA
GTCTTCTTAGATATCCATTGGGTGACCAATTTTAGCGGCGAAGCAAAAGGCCTTGAGGGCCAACAAGTCAGCTGGGTTGA
GAAAGCACAACTCCGGCAGTACGAGTTCCCAGAAGCCAATAAAGCTATTTTAGAAAAAATCCTCGGCTAA

Upstream 100 bases:

>100_bases
CAGTCAAATCTGAGTTCGATCCTGAGATGCTAGATCAATTAGGTTATGATGAAGCCGATTTTTTCCTTGATGAAAATCCT
TTTAAGGATGACAAAAACCA

Downstream 100 bases:

>100_bases
CAAACAGCCTTGAGCCATAAACAGCCCTGAGCCACAAAAGTGGCTCTGCTTTACCCTATGGTCAGCAATAGCCATAATCA
TCCCTCTACAGGTTCTAGCG

Product: mutator MutT protein

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 129; Mature: 128

Protein sequence:

>129_residues
MSQQIHVAVGVIQDSDNRILIAKRPEHLHQGGKWEFPGGKVEDSETTSQALIRELKEEVNLDVVETFPLMEIHHDYGDKQ
VFLDIHWVTNFSGEAKGLEGQQVSWVEKAQLRQYEFPEANKAILEKILG

Sequences:

>Translated_129_residues
MSQQIHVAVGVIQDSDNRILIAKRPEHLHQGGKWEFPGGKVEDSETTSQALIRELKEEVNLDVVETFPLMEIHHDYGDKQ
VFLDIHWVTNFSGEAKGLEGQQVSWVEKAQLRQYEFPEANKAILEKILG
>Mature_128_residues
SQQIHVAVGVIQDSDNRILIAKRPEHLHQGGKWEFPGGKVEDSETTSQALIRELKEEVNLDVVETFPLMEIHHDYGDKQV
FLDIHWVTNFSGEAKGLEGQQVSWVEKAQLRQYEFPEANKAILEKILG

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1786288, Length=126, Percent_Identity=36.5079365079365, Blast_Score=87, Evalue=5e-19,
Organism=Escherichia coli, GI1788056, Length=121, Percent_Identity=32.2314049586777, Blast_Score=71, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003561
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-

Molecular weight: Translated: 14720; Mature: 14589

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQQIHVAVGVIQDSDNRILIAKRPEHLHQGGKWEFPGGKVEDSETTSQALIRELKEEVN
CCCEEEEEEEEEECCCCEEEEEECCHHHHCCCCEECCCCCCCCCCHHHHHHHHHHHHHCC
LDVVETFPLMEIHHDYGDKQVFLDIHWVTNFSGEAKGLEGQQVSWVEKAQLRQYEFPEAN
CEEEHHCCHHHHHCCCCCEEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
KAILEKILG
HHHHHHHCC
>Mature Secondary Structure 
SQQIHVAVGVIQDSDNRILIAKRPEHLHQGGKWEFPGGKVEDSETTSQALIRELKEEVN
CCEEEEEEEEEECCCCEEEEEECCHHHHCCCCEECCCCCCCCCCHHHHHHHHHHHHHCC
LDVVETFPLMEIHHDYGDKQVFLDIHWVTNFSGEAKGLEGQQVSWVEKAQLRQYEFPEAN
CEEEHHCCHHHHHCCCCCEEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
KAILEKILG
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8244038 [H]