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The map label for this gene is dmsA [H]

Identifier: 167622344

GI number: 167622344

Start: 472769

End: 475192

Strand: Reverse

Name: dmsA [H]

Synonym: Shal_0404

Alternate gene names: 167622344

Gene position: 475192-472769 (Counterclockwise)

Preceding gene: 167622345

Following gene: 167622343

Centisome position: 9.09

GC content: 46.95

Gene sequence:

>2424_bases
ATGTTTAATAAGCAAAAAAATACCTTAAGCACCGAGTCACAGGGTGTATCTCGTCGTGGCTTTCTTAAATTAGGTGCCTC
TCTTGGTGTAAGTGCTTTCATTTCGACTCAACCACTAAACGCTATCGCTGCCATGGTGATCGATAAGCATGTGGGTGAAG
TTGCCAAGTGGCATAACTGTTGGGCTCACTGTCACTCAAGCTGCCTACTTAAAATCATTACCCAAGATGGCCAGATAAAA
CGCATCGAAACCGATGATCAGGGCGATGATGTTTTTGGCCGTCATCAAGTCAGAGCTTGCTTACGAGGGCGTTCGCTGCA
TAAACGCACTTTCTCACCAGACAGACTCAAGTACCCAATGAAACGAGTCGGTAAGCGCGGTGAGGGTAAGTTCAAGCGCA
TCAGCTGGGATGAAGCCTTAACTGAAGTTCACAGCCAGATGAGTAAGATCATCACTGAACATGGTAACCAAGCTATTTTC
AGCCGTGTCGGTTATGGCAAACCCCACGGTCCGTATCACTATGTACCTAGATTTTTAAACCAGATTGGCGGCTTCTTATC
GCCATCGGGTAACTACAGTAGCCATCAAATTGATACTGCATCGCTATACACCTATGGTGATAAGTCTTATACCATCGGCA
GCGCGCCAACCGAAATCGCTCACTCAGATCTGGTGGTTTACTTCGGTAATAACCCAGCCAATACACGAATGAGTGGTGGC
AGTGATACCTATCATTATCAAGAGAGTAAAAGCCAAAGCTCTGCCCGTACGATTATTATCGACCCGCAATACACTGATAC
CGCCTGTGGTCGTGAAGATCTTTGGCTGGCGATCCGCCCCGGTACCGATGCAGCCTTAGTAGAAGCCGTAGCTTGGGTAT
TAATTAACGAAAAATATGTCGATGAAGCGTTTTTAAAGAGTCATTGCTATGGGTATGATGCCGAGCCAGGTGATGTTAGT
AAAGGGATCCCATCACTGGATCAATCTTTAAGTTACAAAGCCTACATCTTAGGTAAGGGCGCTGACGGTATCGAAAAAAC
GCCTGAATATACCGCTGCAATCTGCGGGATCCCTAAAGAGCAGATCTATCAGATGGCACGCTCACTCGGCCAAGCCAAGG
CACCCTTTATCGCTCAGGGCTGGGGGCCACAACGCCACGCAGCAGGTGAACAAACGGCTCGCGCAATCTATATGCTCCCA
ATCCTTTTAGGACAACTTGGATTGCCCGGTACCAATAATGGTGGCTCAGACTTCCTGTTCCATAAAACTGATATCATGCA
GATGCCTACTGGAGCTAACCCAGTTAAGGCTAAGGTCCCTTGTTTCAAATGGCTAGAAGCCGTTGAGCGGGGCCATGAGA
TGACAGAGTTTACTGATGGGATTACAGGTGCAGATAAGCTCACCAGTGACGTTAAGTGCGTCTTTATGTATCAGGGAAAC
TGGCTGCTAAACCAACACTCAGACTGCAATGCCACGGCGAAGATCCTTGCCGATGAAAGCAAATTAGAGTTCATCTTCGT
GATGGACAACCATATGACAGCAAGTGCCAAATATGCCGACATTCTGCTACCCGATATAACTTGGTTAGAGAACTCACGCA
TAGTAGCTTTCTCGACTCACCTCACCAAGACTGAGCATGTGCTCGATCCTATGTATGAGTGTCGCCACCCTTATGAAGTA
TTTGCCGATTTAGCCGATAAATTTGGCATTCGCCAGCAGTTTACCCAAGGTCGAAGCTGGGATGACTGGCAACGTCATCT
TTATGAACAAAGCCGTCTCAATCACCCGCAATTTCCACCATTTGAGGTGTTAGATAAACACAAAACGATTCGGATCCCAT
TCGATCCTAATGAAGAGAGATACACCCTAAAAGAGTTCCGAGAGGATCCTCTTACTAATCCATTAAAAACTGAATCTGGA
AAAATTCAGATTTATAGCCATAAGCTGGCAAAATTTGCGGCGACTTGGACCTTACCTGTTGGTGATAAGATTTCGCCACT
CCCCGAATACACGCCAACTTGGGAAAGCTATGCTGACAAAAAGCAGCTTGTAGAACATCCACTACAGCTTATTGGTTTTA
AATCTAAGGGACGTCCCCACTCTACCTTCCATAATGTACCTTGGTTAAGGGAAGTAATTGAAGACGCCTTGATGATGAAC
CCTATTGACGCTAAAGATCGACAGCTAAAGCAAGGCCAATTGGTGCATGTGTATAACAACCGAGGAACGATTCGTATCCC
AGTTAGGATCACCCCCAGAATTATGCCCGGCGTTGTCGCCATGGGTGAAGGTGCCTGGTACAGCCCAAATGAGCTTGGCG
TAGATGTTGGCGGTTGTATCAACACCCTAACCAACTTGCGACCGACTGCACTGGCAAAGGCTAACCCCCAAGGCACCAAC
CTAGTTGAAGTCTGCGGTATCTAG

Upstream 100 bases:

>100_bases
TACTGTGTTAACCGCTGAAATACTTGGGCGGATATTATTTTACGAACTCGGTTTACTCCAGCAGCTCTAGCTCTGCTTTT
AGGTTATAGGAACTTTCATT

Downstream 100 bases:

>100_bases
AGTAATAAATTGCAGTGTCACGAATATGTTGGCACTGCATTCATTGAACGAAGAAAGTAATTGTGGAAAACACACCATGA
GCAGTGAACAACTCATTAAT

Product: anaerobic dimethyl sulfoxide reductase subunit A

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 807; Mature: 807

Protein sequence:

>807_residues
MFNKQKNTLSTESQGVSRRGFLKLGASLGVSAFISTQPLNAIAAMVIDKHVGEVAKWHNCWAHCHSSCLLKIITQDGQIK
RIETDDQGDDVFGRHQVRACLRGRSLHKRTFSPDRLKYPMKRVGKRGEGKFKRISWDEALTEVHSQMSKIITEHGNQAIF
SRVGYGKPHGPYHYVPRFLNQIGGFLSPSGNYSSHQIDTASLYTYGDKSYTIGSAPTEIAHSDLVVYFGNNPANTRMSGG
SDTYHYQESKSQSSARTIIIDPQYTDTACGREDLWLAIRPGTDAALVEAVAWVLINEKYVDEAFLKSHCYGYDAEPGDVS
KGIPSLDQSLSYKAYILGKGADGIEKTPEYTAAICGIPKEQIYQMARSLGQAKAPFIAQGWGPQRHAAGEQTARAIYMLP
ILLGQLGLPGTNNGGSDFLFHKTDIMQMPTGANPVKAKVPCFKWLEAVERGHEMTEFTDGITGADKLTSDVKCVFMYQGN
WLLNQHSDCNATAKILADESKLEFIFVMDNHMTASAKYADILLPDITWLENSRIVAFSTHLTKTEHVLDPMYECRHPYEV
FADLADKFGIRQQFTQGRSWDDWQRHLYEQSRLNHPQFPPFEVLDKHKTIRIPFDPNEERYTLKEFREDPLTNPLKTESG
KIQIYSHKLAKFAATWTLPVGDKISPLPEYTPTWESYADKKQLVEHPLQLIGFKSKGRPHSTFHNVPWLREVIEDALMMN
PIDAKDRQLKQGQLVHVYNNRGTIRIPVRITPRIMPGVVAMGEGAWYSPNELGVDVGGCINTLTNLRPTALAKANPQGTN
LVEVCGI

Sequences:

>Translated_807_residues
MFNKQKNTLSTESQGVSRRGFLKLGASLGVSAFISTQPLNAIAAMVIDKHVGEVAKWHNCWAHCHSSCLLKIITQDGQIK
RIETDDQGDDVFGRHQVRACLRGRSLHKRTFSPDRLKYPMKRVGKRGEGKFKRISWDEALTEVHSQMSKIITEHGNQAIF
SRVGYGKPHGPYHYVPRFLNQIGGFLSPSGNYSSHQIDTASLYTYGDKSYTIGSAPTEIAHSDLVVYFGNNPANTRMSGG
SDTYHYQESKSQSSARTIIIDPQYTDTACGREDLWLAIRPGTDAALVEAVAWVLINEKYVDEAFLKSHCYGYDAEPGDVS
KGIPSLDQSLSYKAYILGKGADGIEKTPEYTAAICGIPKEQIYQMARSLGQAKAPFIAQGWGPQRHAAGEQTARAIYMLP
ILLGQLGLPGTNNGGSDFLFHKTDIMQMPTGANPVKAKVPCFKWLEAVERGHEMTEFTDGITGADKLTSDVKCVFMYQGN
WLLNQHSDCNATAKILADESKLEFIFVMDNHMTASAKYADILLPDITWLENSRIVAFSTHLTKTEHVLDPMYECRHPYEV
FADLADKFGIRQQFTQGRSWDDWQRHLYEQSRLNHPQFPPFEVLDKHKTIRIPFDPNEERYTLKEFREDPLTNPLKTESG
KIQIYSHKLAKFAATWTLPVGDKISPLPEYTPTWESYADKKQLVEHPLQLIGFKSKGRPHSTFHNVPWLREVIEDALMMN
PIDAKDRQLKQGQLVHVYNNRGTIRIPVRITPRIMPGVVAMGEGAWYSPNELGVDVGGCINTLTNLRPTALAKANPQGTN
LVEVCGI
>Mature_807_residues
MFNKQKNTLSTESQGVSRRGFLKLGASLGVSAFISTQPLNAIAAMVIDKHVGEVAKWHNCWAHCHSSCLLKIITQDGQIK
RIETDDQGDDVFGRHQVRACLRGRSLHKRTFSPDRLKYPMKRVGKRGEGKFKRISWDEALTEVHSQMSKIITEHGNQAIF
SRVGYGKPHGPYHYVPRFLNQIGGFLSPSGNYSSHQIDTASLYTYGDKSYTIGSAPTEIAHSDLVVYFGNNPANTRMSGG
SDTYHYQESKSQSSARTIIIDPQYTDTACGREDLWLAIRPGTDAALVEAVAWVLINEKYVDEAFLKSHCYGYDAEPGDVS
KGIPSLDQSLSYKAYILGKGADGIEKTPEYTAAICGIPKEQIYQMARSLGQAKAPFIAQGWGPQRHAAGEQTARAIYMLP
ILLGQLGLPGTNNGGSDFLFHKTDIMQMPTGANPVKAKVPCFKWLEAVERGHEMTEFTDGITGADKLTSDVKCVFMYQGN
WLLNQHSDCNATAKILADESKLEFIFVMDNHMTASAKYADILLPDITWLENSRIVAFSTHLTKTEHVLDPMYECRHPYEV
FADLADKFGIRQQFTQGRSWDDWQRHLYEQSRLNHPQFPPFEVLDKHKTIRIPFDPNEERYTLKEFREDPLTNPLKTESG
KIQIYSHKLAKFAATWTLPVGDKISPLPEYTPTWESYADKKQLVEHPLQLIGFKSKGRPHSTFHNVPWLREVIEDALMMN
PIDAKDRQLKQGQLVHVYNNRGTIRIPVRITPRIMPGVVAMGEGAWYSPNELGVDVGGCINTLTNLRPTALAKANPQGTN
LVEVCGI

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=810, Percent_Identity=48.0246913580247, Blast_Score=743, Evalue=0.0,
Organism=Escherichia coli, GI1787870, Length=810, Percent_Identity=46.1728395061728, Blast_Score=713, Evalue=0.0,
Organism=Escherichia coli, GI171474008, Length=808, Percent_Identity=44.4306930693069, Blast_Score=678, Evalue=0.0,
Organism=Escherichia coli, GI145693196, Length=770, Percent_Identity=29.0909090909091, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI87081994, Length=755, Percent_Identity=28.6092715231788, Blast_Score=225, Evalue=9e-60,
Organism=Escherichia coli, GI1787231, Length=756, Percent_Identity=25.9259259259259, Blast_Score=212, Evalue=9e-56,
Organism=Escherichia coli, GI3868721, Length=759, Percent_Identity=24.2424242424242, Blast_Score=129, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 90497; Mature: 90497

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNKQKNTLSTESQGVSRRGFLKLGASLGVSAFISTQPLNAIAAMVIDKHVGEVAKWHNC
CCCCCCCCCCCHHCCCCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
WAHCHSSCLLKIITQDGQIKRIETDDQGDDVFGRHQVRACLRGRSLHKRTFSPDRLKYPM
HHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCHHHHCCCCCHHHHCHH
KRVGKRGEGKFKRISWDEALTEVHSQMSKIITEHGNQAIFSRVGYGKPHGPYHYVPRFLN
HHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHH
QIGGFLSPSGNYSSHQIDTASLYTYGDKSYTIGSAPTEIAHSDLVVYFGNNPANTRMSGG
HHCCCCCCCCCCCCCEECCEEEEEECCCCEECCCCCCHHCCCCEEEEECCCCCCCCCCCC
SDTYHYQESKSQSSARTIIIDPQYTDTACGREDLWLAIRPGTDAALVEAVAWVLINEKYV
CCCEEECCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
DEAFLKSHCYGYDAEPGDVSKGIPSLDQSLSYKAYILGKGADGIEKTPEYTAAICGIPKE
HHHHHHHHCCCCCCCCCCHHCCCCCHHHCCCEEEEEEECCCCCCCCCCCHHHHHHCCCHH
QIYQMARSLGQAKAPFIAQGWGPQRHAAGEQTARAIYMLPILLGQLGLPGTNNGGSDFLF
HHHHHHHHHCCCCCCEEECCCCCCHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
HKTDIMQMPTGANPVKAKVPCFKWLEAVERGHEMTEFTDGITGADKLTSDVKCVFMYQGN
EECCCEECCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHCCCCCHHHHCCCCEEEEEEECC
WLLNQHSDCNATAKILADESKLEFIFVMDNHMTASAKYADILLPDITWLENSRIVAFSTH
EEECCCCCCCCHHHEEECCCCEEEEEEECCCEECCCCHHHEECCCEEEECCCEEEEEECC
LTKTEHVLDPMYECRHPYEVFADLADKFGIRQQFTQGRSWDDWQRHLYEQSRLNHPQFPP
CCHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCC
FEVLDKHKTIRIPFDPNEERYTLKEFREDPLTNPLKTESGKIQIYSHKLAKFAATWTLPV
HHHHCCCCEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHEEEECCC
GDKISPLPEYTPTWESYADKKQLVEHPLQLIGFKSKGRPHSTFHNVPWLREVIEDALMMN
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHHHHHHCC
PIDAKDRQLKQGQLVHVYNNRGTIRIPVRITPRIMPGVVAMGEGAWYSPNELGVDVGGCI
CCCCCHHHCCCCCEEEEECCCCEEEEEEEECCCCCCCEEEECCCCCCCCHHCCCCHHHHH
NTLTNLRPTALAKANPQGTNLVEVCGI
HHHHCCCCHHEECCCCCCCCEEEECCC
>Mature Secondary Structure
MFNKQKNTLSTESQGVSRRGFLKLGASLGVSAFISTQPLNAIAAMVIDKHVGEVAKWHNC
CCCCCCCCCCCHHCCCCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
WAHCHSSCLLKIITQDGQIKRIETDDQGDDVFGRHQVRACLRGRSLHKRTFSPDRLKYPM
HHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCHHHHCCCCCHHHHCHH
KRVGKRGEGKFKRISWDEALTEVHSQMSKIITEHGNQAIFSRVGYGKPHGPYHYVPRFLN
HHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHH
QIGGFLSPSGNYSSHQIDTASLYTYGDKSYTIGSAPTEIAHSDLVVYFGNNPANTRMSGG
HHCCCCCCCCCCCCCEECCEEEEEECCCCEECCCCCCHHCCCCEEEEECCCCCCCCCCCC
SDTYHYQESKSQSSARTIIIDPQYTDTACGREDLWLAIRPGTDAALVEAVAWVLINEKYV
CCCEEECCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
DEAFLKSHCYGYDAEPGDVSKGIPSLDQSLSYKAYILGKGADGIEKTPEYTAAICGIPKE
HHHHHHHHCCCCCCCCCCHHCCCCCHHHCCCEEEEEEECCCCCCCCCCCHHHHHHCCCHH
QIYQMARSLGQAKAPFIAQGWGPQRHAAGEQTARAIYMLPILLGQLGLPGTNNGGSDFLF
HHHHHHHHHCCCCCCEEECCCCCCHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
HKTDIMQMPTGANPVKAKVPCFKWLEAVERGHEMTEFTDGITGADKLTSDVKCVFMYQGN
EECCCEECCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHCCCCCHHHHCCCCEEEEEEECC
WLLNQHSDCNATAKILADESKLEFIFVMDNHMTASAKYADILLPDITWLENSRIVAFSTH
EEECCCCCCCCHHHEEECCCCEEEEEEECCCEECCCCHHHEECCCEEEECCCEEEEEECC
LTKTEHVLDPMYECRHPYEVFADLADKFGIRQQFTQGRSWDDWQRHLYEQSRLNHPQFPP
CCHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCC
FEVLDKHKTIRIPFDPNEERYTLKEFREDPLTNPLKTESGKIQIYSHKLAKFAATWTLPV
HHHHCCCCEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHEEEECCC
GDKISPLPEYTPTWESYADKKQLVEHPLQLIGFKSKGRPHSTFHNVPWLREVIEDALMMN
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHHHHHHCC
PIDAKDRQLKQGQLVHVYNNRGTIRIPVRITPRIMPGVVAMGEGAWYSPNELGVDVGGCI
CCCCCHHHCCCCCEEEEECCCCEEEEEEEECCCCCCCEEEECCCCCCCCHHCCCCHHHHH
NTLTNLRPTALAKANPQGTNLVEVCGI
HHHHCCCCHHEECCCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]