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The map label for this gene is hemF

Identifier: 167621975

GI number: 167621975

Start: 38739

End: 39653

Strand: Direct

Name: hemF

Synonym: Shal_0034

Alternate gene names: 167621975

Gene position: 38739-39653 (Clockwise)

Preceding gene: 167621974

Following gene: 167621976

Centisome position: 0.74

GC content: 46.78

Gene sequence:

>915_bases
ATGAATGCACCAGATTCAACACTAGTAAAAGCTTTCTTACTAGATCTTCAACATCGAATTTGTAATGGACTCGAGGCCCT
AGATGGTTCGGCAAAATTTGCTGAAGACGCTTGGAAGCGTGAAGAGGGGGGCGGTGGTCAAAGCCGTGTGTTGACTGGTG
GTACTGTCTTTGAACAAGCTGGCGTTAACTTTTCCCATGTAATGGGGGCGTCTATGCCCGCATCGGCAACGGCGCATCGC
CCTGAACTTGCTGGTCGCAGTTTTGAAGCTATGGGGGTGTCCTTAGTTATTCACCCAAATAATCCTCATATTCCAACGAC
GCATGCCAATGTACGTTTCTTCATTGCTCATAAAGATGGGGCCGATCCGGTATGGTGGTTTGGTGGGGGTTTTGACTTAA
CACCTTACTACCCTTATCTAGAAGATGTGGTTGAGTGGCACCAAAGCGCTAAGTCATTGTGTGAGCCTTTTGGCGACGAG
ATTTATCCTGAATATAAGCAGTGGTGTGATGAATACTTCTTCCTTCCACACCGCAATGAAACCCGTGGTGTGGGGGGATT
GTTCTTTGATGACCTTAACAAGCAAGGTTTTGATACTAGCTTTGCCTTTATGCAGGCCGTCGGTAATGGTTTCTTAACTG
CTTACGCACCTATTGTTGAGCGCCGTAAAGATACTGTATATGGTGAACATGAACGTCAATTCCAACTCTATCGTCGTGGT
CGTTATGTTGAATTCAATTTAGTCTATGATCGTGGCACCCTGTTTGGTCTGCAAACTGGAGGACGCACCGAGTCGATTCT
AATGTCTATGCCGCCGTTAGTGCGTTGGGAGTATGCTTACACGCCTGAAGCGGGTAGTGCAGAAGCGGCGCTTTATAGTG
ACTATCTCAAACCAAGAGATTGGTTAACCCTTTAA

Upstream 100 bases:

>100_bases
GATAGGTGACTTAGGGATTCAGGCGTCGCCATCAACAATTATCGATGCCAAGAGTGGACAAGTTATAAGAAAAGGCTAAT
CAGCTTCAACGAGGAATGAT

Downstream 100 bases:

>100_bases
ACAGACGGTAAAGGCACAACGCGGAGCTGAAAATAACTGGGGTAGAGTCGCTTGCCTGAGTCAAAATCCACGTTACACTA
CTATTTTTGGATGGCTAGAG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MNAPDSTLVKAFLLDLQHRICNGLEALDGSAKFAEDAWKREEGGGGQSRVLTGGTVFEQAGVNFSHVMGASMPASATAHR
PELAGRSFEAMGVSLVIHPNNPHIPTTHANVRFFIAHKDGADPVWWFGGGFDLTPYYPYLEDVVEWHQSAKSLCEPFGDE
IYPEYKQWCDEYFFLPHRNETRGVGGLFFDDLNKQGFDTSFAFMQAVGNGFLTAYAPIVERRKDTVYGEHERQFQLYRRG
RYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWEYAYTPEAGSAEAALYSDYLKPRDWLTL

Sequences:

>Translated_304_residues
MNAPDSTLVKAFLLDLQHRICNGLEALDGSAKFAEDAWKREEGGGGQSRVLTGGTVFEQAGVNFSHVMGASMPASATAHR
PELAGRSFEAMGVSLVIHPNNPHIPTTHANVRFFIAHKDGADPVWWFGGGFDLTPYYPYLEDVVEWHQSAKSLCEPFGDE
IYPEYKQWCDEYFFLPHRNETRGVGGLFFDDLNKQGFDTSFAFMQAVGNGFLTAYAPIVERRKDTVYGEHERQFQLYRRG
RYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWEYAYTPEAGSAEAALYSDYLKPRDWLTL
>Mature_304_residues
MNAPDSTLVKAFLLDLQHRICNGLEALDGSAKFAEDAWKREEGGGGQSRVLTGGTVFEQAGVNFSHVMGASMPASATAHR
PELAGRSFEAMGVSLVIHPNNPHIPTTHANVRFFIAHKDGADPVWWFGGGFDLTPYYPYLEDVVEWHQSAKSLCEPFGDE
IYPEYKQWCDEYFFLPHRNETRGVGGLFFDDLNKQGFDTSFAFMQAVGNGFLTAYAPIVERRKDTVYGEHERQFQLYRRG
RYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWEYAYTPEAGSAEAALYSDYLKPRDWLTL

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family

Homologues:

Organism=Homo sapiens, GI41393599, Length=304, Percent_Identity=45.3947368421053, Blast_Score=281, Evalue=4e-76,
Organism=Escherichia coli, GI1788777, Length=299, Percent_Identity=73.5785953177257, Blast_Score=463, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6320249, Length=320, Percent_Identity=45.625, Blast_Score=271, Evalue=8e-74,
Organism=Drosophila melanogaster, GI17864388, Length=302, Percent_Identity=46.6887417218543, Blast_Score=286, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM6_SHEHH (B0TLD7)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001672269.1
- ProteinModelPortal:   B0TLD7
- SMR:   B0TLD7
- GeneID:   5904611
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_0034
- HOGENOM:   HBG631180
- OMA:   HMNTRFV
- ProtClustDB:   PRK05330
- BioCyc:   SHAL458817:SHAL_0034-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00333
- InterPro:   IPR001260
- InterPro:   IPR018375
- Gene3D:   G3DSA:3.40.1500.10
- PANTHER:   PTHR10755
- PIRSF:   PIRSF000166
- PRINTS:   PR00073

Pfam domain/function: PF01218 Coprogen_oxidas; SSF102886 Coprogen_oxidas

EC number: =1.3.3.3

Molecular weight: Translated: 34297; Mature: 34297

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: ACT_SITE 108-108 BINDING 94-94

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPDSTLVKAFLLDLQHRICNGLEALDGSAKFAEDAWKREEGGGGQSRVLTGGTVFEQA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEECCHHHHHC
GVNFSHVMGASMPASATAHRPELAGRSFEAMGVSLVIHPNNPHIPTTHANVRFFIAHKDG
CCCHHHHHCCCCCCCCCCCCCHHCCCCEECCCEEEEEECCCCCCCCCCCCEEEEEEECCC
ADPVWWFGGGFDLTPYYPYLEDVVEWHQSAKSLCEPFGDEIYPEYKQWCDEYFFLPHRNE
CCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHEECCCCCC
TRGVGGLFFDDLNKQGFDTSFAFMQAVGNGFLTAYAPIVERRKDTVYGEHERQFQLYRRG
CCCCCCHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
RYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWEYAYTPEAGSAEAALYSDYLKPRD
CEEEEEEEEECCEEEEECCCCCCHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCC
WLTL
CCCC
>Mature Secondary Structure
MNAPDSTLVKAFLLDLQHRICNGLEALDGSAKFAEDAWKREEGGGGQSRVLTGGTVFEQA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEECCHHHHHC
GVNFSHVMGASMPASATAHRPELAGRSFEAMGVSLVIHPNNPHIPTTHANVRFFIAHKDG
CCCHHHHHCCCCCCCCCCCCCHHCCCCEECCCEEEEEECCCCCCCCCCCCEEEEEEECCC
ADPVWWFGGGFDLTPYYPYLEDVVEWHQSAKSLCEPFGDEIYPEYKQWCDEYFFLPHRNE
CCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHEECCCCCC
TRGVGGLFFDDLNKQGFDTSFAFMQAVGNGFLTAYAPIVERRKDTVYGEHERQFQLYRRG
CCCCCCHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
RYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWEYAYTPEAGSAEAALYSDYLKPRD
CEEEEEEEEECCEEEEECCCCCCHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCC
WLTL
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA