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The map label for this gene is aroE

Identifier: 167621976

GI number: 167621976

Start: 39744

End: 40583

Strand: Direct

Name: aroE

Synonym: Shal_0035

Alternate gene names: 167621976

Gene position: 39744-40583 (Clockwise)

Preceding gene: 167621975

Following gene: 167621977

Centisome position: 0.76

GC content: 45.71

Gene sequence:

>840_bases
ATGGCTAGAGTAGAGAACATGACTGAACGATATGCAGTATTTGGTAATCCGATAGGGCACAGTAAGTCTCCAAAAATTCA
TACAATGTTTGCCAAAGAGACTGGACAGTCATTAAGTTATGAGGCCATCTTAGCGCCCATCGATGCATTTGAGGCAAGCT
TTAAAGAGTTTGCTGCTAATGAGGGGTATGGCGCAAATGTTACTGTCCCATTTAAAGAGCAAGCGTTTAGCCTGTGCGAT
GAACTCAGCGAGCAAGCTCAGCTGGCTGGAGCGGTGAATACCTTATCAGTATTAGCCGATGGTAAAATTCGCGGCGATAA
TACCGATGGCCTAGGTTTAGTCGCCGACCTAAAGAGAAATTTAGGAGACTTGTGTGGGCTACAGGTTCTATTAATTGGTG
CGGGTGGTGCTGCGCGAGGTAGTGTGTTGCCATTATTACACTCTGGCATTGCTAAGTTGACGATTGTCAATCGCACTCAA
GCAAAGGCAGAGGCGTTAGTGGAGATCTTTACAAGCTATGGTGATGTAACATCTCTACCAATAACTCATGTAGGGCAAAG
CTATGACGTTATTATTAACTCAACCTCTTCAAGTTTATCTGGTGAAGTGCCAAACATTAGTCCTGATACCATTGCGCCGC
ATACCGTTTGCTACGATATGATGTATGGCAAACAGTCGACGGCTTTTAATCTGTGGGCGAAATCACTAGGAGCAGGCCAA
ACAATAGATGGCTTAGGCATGCTGGTGGGACAAGCCGCAGCAAGTTTTTCCATTTGGCGCAAGGTGACACCCAGTGTTGA
GCCTGTTCTGGCTCAGCTTAGATCAGAACTCATAGGCTAA

Upstream 100 bases:

>100_bases
AACCCTTTAAACAGACGGTAAAGGCACAACGCGGAGCTGAAAATAACTGGGGTAGAGTCGCTTGCCTGAGTCAAAATCCA
CGTTACACTACTATTTTTGG

Downstream 100 bases:

>100_bases
ACGAAAGTCAGAGCTTTAATCGAGATAAAGATGAACCAAAGTATTCTATTTCCGGATCTGCAAGATTGGGATCAACAAAG
CCAAACCATTATTTTCCCGG

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MARVENMTERYAVFGNPIGHSKSPKIHTMFAKETGQSLSYEAILAPIDAFEASFKEFAANEGYGANVTVPFKEQAFSLCD
ELSEQAQLAGAVNTLSVLADGKIRGDNTDGLGLVADLKRNLGDLCGLQVLLIGAGGAARGSVLPLLHSGIAKLTIVNRTQ
AKAEALVEIFTSYGDVTSLPITHVGQSYDVIINSTSSSLSGEVPNISPDTIAPHTVCYDMMYGKQSTAFNLWAKSLGAGQ
TIDGLGMLVGQAAASFSIWRKVTPSVEPVLAQLRSELIG

Sequences:

>Translated_279_residues
MARVENMTERYAVFGNPIGHSKSPKIHTMFAKETGQSLSYEAILAPIDAFEASFKEFAANEGYGANVTVPFKEQAFSLCD
ELSEQAQLAGAVNTLSVLADGKIRGDNTDGLGLVADLKRNLGDLCGLQVLLIGAGGAARGSVLPLLHSGIAKLTIVNRTQ
AKAEALVEIFTSYGDVTSLPITHVGQSYDVIINSTSSSLSGEVPNISPDTIAPHTVCYDMMYGKQSTAFNLWAKSLGAGQ
TIDGLGMLVGQAAASFSIWRKVTPSVEPVLAQLRSELIG
>Mature_278_residues
ARVENMTERYAVFGNPIGHSKSPKIHTMFAKETGQSLSYEAILAPIDAFEASFKEFAANEGYGANVTVPFKEQAFSLCDE
LSEQAQLAGAVNTLSVLADGKIRGDNTDGLGLVADLKRNLGDLCGLQVLLIGAGGAARGSVLPLLHSGIAKLTIVNRTQA
KAEALVEIFTSYGDVTSLPITHVGQSYDVIINSTSSSLSGEVPNISPDTIAPHTVCYDMMYGKQSTAFNLWAKSLGAGQT
IDGLGMLVGQAAASFSIWRKVTPSVEPVLAQLRSELIG

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1789675, Length=270, Percent_Identity=51.4814814814815, Blast_Score=267, Evalue=7e-73,
Organism=Escherichia coli, GI1787983, Length=278, Percent_Identity=30.5755395683453, Blast_Score=94, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320332, Length=174, Percent_Identity=37.3563218390805, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_SHEHH (B0TLD8)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001672270.1
- ProteinModelPortal:   B0TLD8
- SMR:   B0TLD8
- GeneID:   5904612
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_0035
- HOGENOM:   HBG553408
- OMA:   DQYVVFG
- ProtClustDB:   CLSK981509
- BioCyc:   SHAL458817:SHAL_0035-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 29453; Mature: 29322

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: ACT_SITE 72-72

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARVENMTERYAVFGNPIGHSKSPKIHTMFAKETGQSLSYEAILAPIDAFEASFKEFAAN
CCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
EGYGANVTVPFKEQAFSLCDELSEQAQLAGAVNTLSVLADGKIRGDNTDGLGLVADLKRN
CCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHH
LGDLCGLQVLLIGAGGAARGSVLPLLHSGIAKLTIVNRTQAKAEALVEIFTSYGDVTSLP
HHHHHCEEEEEEECCCCCCCCHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCC
ITHVGQSYDVIINSTSSSLSGEVPNISPDTIAPHTVCYDMMYGKQSTAFNLWAKSLGAGQ
HHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCC
TIDGLGMLVGQAAASFSIWRKVTPSVEPVLAQLRSELIG
CHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
ARVENMTERYAVFGNPIGHSKSPKIHTMFAKETGQSLSYEAILAPIDAFEASFKEFAAN
CCHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
EGYGANVTVPFKEQAFSLCDELSEQAQLAGAVNTLSVLADGKIRGDNTDGLGLVADLKRN
CCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHH
LGDLCGLQVLLIGAGGAARGSVLPLLHSGIAKLTIVNRTQAKAEALVEIFTSYGDVTSLP
HHHHHCEEEEEEECCCCCCCCHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCC
ITHVGQSYDVIINSTSSSLSGEVPNISPDTIAPHTVCYDMMYGKQSTAFNLWAKSLGAGQ
HHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCC
TIDGLGMLVGQAAASFSIWRKVTPSVEPVLAQLRSELIG
CHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA