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The map label for this gene is yclK [H]

Identifier: 167040840

GI number: 167040840

Start: 2219196

End: 2220536

Strand: Direct

Name: yclK [H]

Synonym: Teth514_2217

Alternate gene names: 167040840

Gene position: 2219196-2220536 (Clockwise)

Preceding gene: 167040839

Following gene: 167040847

Centisome position: 90.31

GC content: 31.25

Gene sequence:

>1341_bases
TTGAAAGGAATAAGAAAAAAGCTTTTTATCTCTTACCTTATCATAGGCCTTATAATTTTATCTATGTTTTGGCTTACTCA
AGTAGTTTTTATTAATAAGATATACTCTTATTACAAAATAAATCAACTTAAAAATTACAGTGAAAAAATTGTAGAAGCAA
TAAATAACAACGATGAAATGCTTATAAGTGAACTTATTGACAAATCTAATGCCCAAGTCGTCGCAATGACACAAAACAAC
ATAATAATTGCAGGAAATAACAGAGGATACGGTCGAGGTTTGGGAATCCCTGAAGTACTTCTTCACCCTATAAACACTGT
AAAAGTTGTAAAATATGAGCATCCTTTTTTGCATATAGAATATCTTTCTATTGTAAGGCCTTTTTTATATAACGGAAAAC
CCGCTACTTTAATAATGAGCATCCCTATCGCCGCTATAAACGACTCTGTCAATCTTTTTAAACAAGTTTTTTGGCGGATT
TTTGTCGTCACAATAGCAGCAATTTTATTTGTGTCAATTTACATGTCAAAAAAGTTTACTCGACCTATACAAATTTTGAA
AAATGCTGCTCACCAAATCGCTTCTGGAAATTTAGATGTCAAAATAAATTACAAAGAAGACGATGAATTAGGAGACCTTG
CAAAATCTATGAACACAATGGTAAAACAGTTATCTATCACAGACAAGTTCAGAAAAGATTTGATTGCAAATATAAGCCAT
GATTTAAAAACACCTCTTGGCCTTATACGTGGATATTCTGAAATGCTTTTAGACTACTATGGAGACGATAAAGAAAAAAG
AGAAAAATATTTAAATACAGTGATTAAAGAAACAGAGAGAATGTCTAAATTAGTAGACGACGTGTTACAGCTTTCTAAGC
TCCAATCAGGAATGGTAGAAATAAAAGAGGAACCTATAGATTTAGAAAAACTTATATTTGAAACTTTAGACATATTTGAA
ATTCAAATTTTAGAAAAAAATATAGAAGTAAAGCTTAATAATCTTAAACTTAAGGTAATAGCGGATAGGGAAATGATAAA
ACGGGCAATTATAAATATAATAAGCAATGCTATAGCAAGTATAGAAAATGGTGGCATTCTTGCAATAGAGGCAATTCCAC
AAGATAAAGAAGTTTTAATAAAAATATCAGATACAGGATGCGGCATACCTCAAAAAGATTTAGAGCACATCTTTGACAGG
TATTACAAAGGAAACAAATCGGGAACAGGCCTTGGCCTTGCAATAGTAAAAGAAATATTGACATTGCACGGCAGCAAATA
TGGAATAGAAAGCAAAGAAGGAGTAGGTACCACTTTTTATTTCACATTAAAAGCGGGTTAA

Upstream 100 bases:

>100_bases
TTGATACCCATATAAAACAGTTAAGAGAAAAATTAGGAGAAAAGCGCAAACTCATAAAAACAGTGTGGGGAATAGGTTAC
AAATTGGATGGTGAATAAAT

Downstream 100 bases:

>100_bases
TCCCGCTTTTAATCTTAAAAAAATAGCAAATCAATGTGTCTCATCACATTCCTGTAAATATCGCTAATTGAATTCCCAGT
CTTTTCAGCAATGGCTTTAA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MKGIRKKLFISYLIIGLIILSMFWLTQVVFINKIYSYYKINQLKNYSEKIVEAINNNDEMLISELIDKSNAQVVAMTQNN
IIIAGNNRGYGRGLGIPEVLLHPINTVKVVKYEHPFLHIEYLSIVRPFLYNGKPATLIMSIPIAAINDSVNLFKQVFWRI
FVVTIAAILFVSIYMSKKFTRPIQILKNAAHQIASGNLDVKINYKEDDELGDLAKSMNTMVKQLSITDKFRKDLIANISH
DLKTPLGLIRGYSEMLLDYYGDDKEKREKYLNTVIKETERMSKLVDDVLQLSKLQSGMVEIKEEPIDLEKLIFETLDIFE
IQILEKNIEVKLNNLKLKVIADREMIKRAIINIISNAIASIENGGILAIEAIPQDKEVLIKISDTGCGIPQKDLEHIFDR
YYKGNKSGTGLGLAIVKEILTLHGSKYGIESKEGVGTTFYFTLKAG

Sequences:

>Translated_446_residues
MKGIRKKLFISYLIIGLIILSMFWLTQVVFINKIYSYYKINQLKNYSEKIVEAINNNDEMLISELIDKSNAQVVAMTQNN
IIIAGNNRGYGRGLGIPEVLLHPINTVKVVKYEHPFLHIEYLSIVRPFLYNGKPATLIMSIPIAAINDSVNLFKQVFWRI
FVVTIAAILFVSIYMSKKFTRPIQILKNAAHQIASGNLDVKINYKEDDELGDLAKSMNTMVKQLSITDKFRKDLIANISH
DLKTPLGLIRGYSEMLLDYYGDDKEKREKYLNTVIKETERMSKLVDDVLQLSKLQSGMVEIKEEPIDLEKLIFETLDIFE
IQILEKNIEVKLNNLKLKVIADREMIKRAIINIISNAIASIENGGILAIEAIPQDKEVLIKISDTGCGIPQKDLEHIFDR
YYKGNKSGTGLGLAIVKEILTLHGSKYGIESKEGVGTTFYFTLKAG
>Mature_446_residues
MKGIRKKLFISYLIIGLIILSMFWLTQVVFINKIYSYYKINQLKNYSEKIVEAINNNDEMLISELIDKSNAQVVAMTQNN
IIIAGNNRGYGRGLGIPEVLLHPINTVKVVKYEHPFLHIEYLSIVRPFLYNGKPATLIMSIPIAAINDSVNLFKQVFWRI
FVVTIAAILFVSIYMSKKFTRPIQILKNAAHQIASGNLDVKINYKEDDELGDLAKSMNTMVKQLSITDKFRKDLIANISH
DLKTPLGLIRGYSEMLLDYYGDDKEKREKYLNTVIKETERMSKLVDDVLQLSKLQSGMVEIKEEPIDLEKLIFETLDIFE
IQILEKNIEVKLNNLKLKVIADREMIKRAIINIISNAIASIENGGILAIEAIPQDKEVLIKISDTGCGIPQKDLEHIFDR
YYKGNKSGTGLGLAIVKEILTLHGSKYGIESKEGVGTTFYFTLKAG

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=466, Percent_Identity=24.2489270386266, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1786600, Length=285, Percent_Identity=28.0701754385965, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1786783, Length=329, Percent_Identity=27.6595744680851, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1788549, Length=214, Percent_Identity=30.3738317757009, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1789149, Length=345, Percent_Identity=24.0579710144928, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI48994928, Length=222, Percent_Identity=28.8288288288288, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1790861, Length=221, Percent_Identity=29.4117647058824, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786912, Length=227, Percent_Identity=26.8722466960352, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790436, Length=212, Percent_Identity=27.8301886792453, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788713, Length=224, Percent_Identity=26.3392857142857, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790346, Length=257, Percent_Identity=29.1828793774319, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI87081816, Length=222, Percent_Identity=24.7747747747748, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789808, Length=297, Percent_Identity=27.2727272727273, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1787894, Length=300, Percent_Identity=24.6666666666667, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87082128, Length=292, Percent_Identity=21.5753424657534, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1788279, Length=225, Percent_Identity=29.7777777777778, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI145693157, Length=261, Percent_Identity=24.1379310344828, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790551, Length=291, Percent_Identity=21.3058419243986, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789403, Length=222, Percent_Identity=24.7747747747748, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50614; Mature: 50614

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIRKKLFISYLIIGLIILSMFWLTQVVFINKIYSYYKINQLKNYSEKIVEAINNNDEM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LISELIDKSNAQVVAMTQNNIIIAGNNRGYGRGLGIPEVLLHPINTVKVVKYEHPFLHIE
HHHHHHCCCCCEEEEEECCCEEEEECCCCCCCCCCCHHHHHCCCCCEEEEEECCCEEEEH
YLSIVRPFLYNGKPATLIMSIPIAAINDSVNLFKQVFWRIFVVTIAAILFVSIYMSKKFT
HHHHHHHHHHCCCCCEEEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RPIQILKNAAHQIASGNLDVKINYKEDDELGDLAKSMNTMVKQLSITDKFRKDLIANISH
HHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLKTPLGLIRGYSEMLLDYYGDDKEKREKYLNTVIKETERMSKLVDDVLQLSKLQSGMVE
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKEEPIDLEKLIFETLDIFEIQILEKNIEVKLNNLKLKVIADREMIKRAIINIISNAIAS
HCCCCCCHHHHHHHHHHHHHEEEEECCCEEEEEEEEEEEEECHHHHHHHHHHHHHHHHHH
IENGGILAIEAIPQDKEVLIKISDTGCGIPQKDLEHIFDRYYKGNKSGTGLGLAIVKEIL
CCCCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
TLHGSKYGIESKEGVGTTFYFTLKAG
HHCCCCCCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MKGIRKKLFISYLIIGLIILSMFWLTQVVFINKIYSYYKINQLKNYSEKIVEAINNNDEM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LISELIDKSNAQVVAMTQNNIIIAGNNRGYGRGLGIPEVLLHPINTVKVVKYEHPFLHIE
HHHHHHCCCCCEEEEEECCCEEEEECCCCCCCCCCCHHHHHCCCCCEEEEEECCCEEEEH
YLSIVRPFLYNGKPATLIMSIPIAAINDSVNLFKQVFWRIFVVTIAAILFVSIYMSKKFT
HHHHHHHHHHCCCCCEEEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RPIQILKNAAHQIASGNLDVKINYKEDDELGDLAKSMNTMVKQLSITDKFRKDLIANISH
HHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLKTPLGLIRGYSEMLLDYYGDDKEKREKYLNTVIKETERMSKLVDDVLQLSKLQSGMVE
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKEEPIDLEKLIFETLDIFEIQILEKNIEVKLNNLKLKVIADREMIKRAIINIISNAIAS
HCCCCCCHHHHHHHHHHHHHEEEEECCCEEEEEEEEEEEEECHHHHHHHHHHHHHHHHHH
IENGGILAIEAIPQDKEVLIKISDTGCGIPQKDLEHIFDRYYKGNKSGTGLGLAIVKEIL
CCCCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
TLHGSKYGIESKEGVGTTFYFTLKAG
HHCCCCCCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]