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The map label for this gene is srrA [H]

Identifier: 167040839

GI number: 167040839

Start: 2218519

End: 2219193

Strand: Direct

Name: srrA [H]

Synonym: Teth514_2216

Alternate gene names: 167040839

Gene position: 2218519-2219193 (Clockwise)

Preceding gene: 167040836

Following gene: 167040840

Centisome position: 90.28

GC content: 31.7

Gene sequence:

>675_bases
ATGCAAAAAGTTTTAGTAATTGAAGACGAAGAAGGAATGAGAGATATTTTAAAAACTTATTTAGAAAATAATGGATATGA
AGTATTGGTAGCTGAAAATGGCAAAATAGGGCTTGAATATTTTAATAATAATAAAGATATAAGCATAATCCTTTTAGATA
TAATGCTTCCAGATATAAGTGGTTGGAGCCTTTTAAAAACAATTAGAGAAAAGTCAAAAGTGCCTGTAATGATGATAACA
GCAAGAGGAGAAGAGTATGATAAACTTTTAGGGTTTGAATTAGGAGCAGATGATTACGTTGTAAAACCTTTTAGCCCTAA
AGAAGTAATCGCTCGCGTTAAAGCAATTTTGTCAAGAACTTATGGAGCTTCAGAAGAAGAGGGGAAAACAGAATATGAAG
GAATTTCTATAAATGTAAGTTCTAGAGAAGTCACGGTTGATGGAGAAAAAATTGACCTTACGCCAAAAGAATTTGACCTT
TTAAAACTCTTAATAGATAATAAAGGAAAAGTTGTATCCCGCGAAAAGTGCCTTAATGAAGTATGGGGATATGATTTTTA
TGGAGATTTAAGAACAGTTGATACCCATATAAAACAGTTAAGAGAAAAATTAGGAGAAAAGCGCAAACTCATAAAAACAG
TGTGGGGAATAGGTTACAAATTGGATGGTGAATAA

Upstream 100 bases:

>100_bases
GAAGTAATTTTATATAATTTGTGAGGAAAGTGTGAAGTTTAATTTTAAATATTGTAAACTGATTAAAAAATAATTAAACT
AAAGATGGGAGGTGTTTTTT

Downstream 100 bases:

>100_bases
ATTTGAAAGGAATAAGAAAAAAGCTTTTTATCTCTTACCTTATCATAGGCCTTATAATTTTATCTATGTTTTGGCTTACT
CAAGTAGTTTTTATTAATAA

Product: two component transcriptional regulator

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MQKVLVIEDEEGMRDILKTYLENNGYEVLVAENGKIGLEYFNNNKDISIILLDIMLPDISGWSLLKTIREKSKVPVMMIT
ARGEEYDKLLGFELGADDYVVKPFSPKEVIARVKAILSRTYGASEEEGKTEYEGISINVSSREVTVDGEKIDLTPKEFDL
LKLLIDNKGKVVSREKCLNEVWGYDFYGDLRTVDTHIKQLREKLGEKRKLIKTVWGIGYKLDGE

Sequences:

>Translated_224_residues
MQKVLVIEDEEGMRDILKTYLENNGYEVLVAENGKIGLEYFNNNKDISIILLDIMLPDISGWSLLKTIREKSKVPVMMIT
ARGEEYDKLLGFELGADDYVVKPFSPKEVIARVKAILSRTYGASEEEGKTEYEGISINVSSREVTVDGEKIDLTPKEFDL
LKLLIDNKGKVVSREKCLNEVWGYDFYGDLRTVDTHIKQLREKLGEKRKLIKTVWGIGYKLDGE
>Mature_224_residues
MQKVLVIEDEEGMRDILKTYLENNGYEVLVAENGKIGLEYFNNNKDISIILLDIMLPDISGWSLLKTIREKSKVPVMMIT
ARGEEYDKLLGFELGADDYVVKPFSPKEVIARVKAILSRTYGASEEEGKTEYEGISINVSSREVTVDGEKIDLTPKEFDL
LKLLIDNKGKVVSREKCLNEVWGYDFYGDLRTVDTHIKQLREKLGEKRKLIKTVWGIGYKLDGE

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=40.4444444444444, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=39.8230088495575, Blast_Score=164, Evalue=4e-42,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=34.070796460177, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=37.6681614349776, Blast_Score=150, Evalue=8e-38,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=36.8421052631579, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=37.5565610859729, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1790860, Length=232, Percent_Identity=40.0862068965517, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=36.2445414847162, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=35.1111111111111, Blast_Score=143, Evalue=8e-36,
Organism=Escherichia coli, GI1790863, Length=236, Percent_Identity=35.1694915254237, Blast_Score=137, Evalue=4e-34,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=36.8181818181818, Blast_Score=128, Evalue=2e-31,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=35, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=33.9366515837104, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=28.755364806867, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=33.6448598130841, Blast_Score=71, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25560; Mature: 25560

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKVLVIEDEEGMRDILKTYLENNGYEVLVAENGKIGLEYFNNNKDISIILLDIMLPDIS
CCCEEEEECCCCHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCEEEEEEEEECCCCC
GWSLLKTIREKSKVPVMMITARGEEYDKLLGFELGADDYVVKPFSPKEVIARVKAILSRT
CHHHHHHHHHHCCCCEEEEEECCCHHHHHHCEEECCCCEEECCCCHHHHHHHHHHHHHHH
YGASEEEGKTEYEGISINVSSREVTVDGEKIDLTPKEFDLLKLLIDNKGKVVSREKCLNE
CCCCCCCCCCEECCEEEEECCCEEEECCCEEECCCCHHHHHHHHHCCCCCEEHHHHHHHH
VWGYDFYGDLRTVDTHIKQLREKLGEKRKLIKTVWGIGYKLDGE
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
>Mature Secondary Structure
MQKVLVIEDEEGMRDILKTYLENNGYEVLVAENGKIGLEYFNNNKDISIILLDIMLPDIS
CCCEEEEECCCCHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCEEEEEEEEECCCCC
GWSLLKTIREKSKVPVMMITARGEEYDKLLGFELGADDYVVKPFSPKEVIARVKAILSRT
CHHHHHHHHHHCCCCEEEEEECCCHHHHHHCEEECCCCEEECCCCHHHHHHHHHHHHHHH
YGASEEEGKTEYEGISINVSSREVTVDGEKIDLTPKEFDLLKLLIDNKGKVVSREKCLNE
CCCCCCCCCCEECCEEEEECCCEEEECCCEEECCCCHHHHHHHHHCCCCCEEHHHHHHHH
VWGYDFYGDLRTVDTHIKQLREKLGEKRKLIKTVWGIGYKLDGE
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA