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The map label for this gene is lysA [H]

Identifier: 167039692

GI number: 167039692

Start: 1074682

End: 1076019

Strand: Reverse

Name: lysA [H]

Synonym: Teth514_1042

Alternate gene names: 167039692

Gene position: 1076019-1074682 (Counterclockwise)

Preceding gene: 167039708

Following gene: 167039684

Centisome position: 43.79

GC content: 34.3

Gene sequence:

>1338_bases
ATGTTGCATGGGACAATGAAGATAAATTCAAAGGGTCATTTGGAAATAGGTGGTTGCGATACTGTAACTCTTGCAAAAAA
GTTTGGTACACCGCTTTATGTAATAGACGAAGAGTTATTGCGGCAAAATTGTAGAGCATTTTATAATGGCTTTAAAAAAG
ATTATCCAGGAAATGAAGTGATTTATGCCAGCAAAGCTTTCATGACAATGGCAATATGCAAAATAATTGAAGAAGAAAAC
TTGGGTCTTGATGTCGTTTCTGGTGGAGAACTATATACTGCGTTAAAAGCAGGATTCCCTGCTGAAAAAATATACTTTCA
CGGCAACAATAAATCAAAAGAAGAACTTATAATGGCATTAGAAAATAATATTGGGAGAATCATTGTAGATAATTGGTATG
AACTAAATATGTTAAATGACTTGGCAAAAAAGATGAATAAAGTTCCTAATATTTATATAAGAGTATCTCCTGGTGTAGAA
GCTCATACTCACCAATATGTAAAAACAGGACAAATGGATTCAAAATTTGGCTTCCCTCTTTTTAATGGAGACGCAATGAG
AGCCATAGAATATGCTTTAACTTTGGAAAATGTAAATCTAGTAGGTCTACATTCTCATATCGGTTCTCAGATTTTTGATG
CAGAATCTTATAAAGCTGAAATAGAAATTATGATGAATTTCTTAAAATTAGTAAAAGAATTTTTAGGTTGGGAAGTAGGG
GAACTAGATTTAGGTGGAGGTTTTGGAATAGCATATGTAGAAGAGGACGATCCCCAGCCAATCGAACAAATAGCTCAAGA
AATAATGCAAGCAGTAAAAGAATACTCCGTTGCTTTAAATATAAAAATGCCAAACATAATTGTAGAGCCAGGTCGTTCTA
TAATAGGAAATGCCGGAACTACTCTTTACACAGTAGGAGCAATTAAAGACATACCAGGTGTCAGAAAATACGTAGCGGTA
GATGGAGGAATGTCTGATAATATACGTACCGCTTTATATGGAGCAAAATATGATGCTATTGTAGCTAATAAAGCTAAGAA
TATAAAATCAGAAAAAGTTTCAATAGCAGGAAAGCTTTGCGAATCAGGTGATATGCTAATTTGGGACATTACTCTACCTA
AAATTGAAGAAGGAGATATACTAGCTGTAACCTGTACAGGTGCTTACAATTATTCGATGGCCAGCAATTATAACAGGTTA
CCTCGTCCTGCTGCAGTACTCGTATCTAATGGTCAGGCTGATATAATTGTTGCGCGAGAAACTTATGAAGACTTAATCCG
AAATGATATAATCCCAGAAAGGCTAACCAATGAAAAAAGAAAAATAGCTAATTATTAA

Upstream 100 bases:

>100_bases
GTCTATGTGCAAACTAGACAGCTGAGGTAATACTTAGCTGTATTTTATTTTGTTATTTAGTTTCATAATTTAAATTATTA
AAGTAAATGAGGTTGATAGA

Downstream 100 bases:

>100_bases
AAAAAGAGAGGTATAACCTCTCTTTTTTTATTATTCACTTTCTTTCGCTGTTTCAGTAGCCTCTTCTTCTGCCTCTTCTT
CACTTTCTCTAGGTGCCAAT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MLHGTMKINSKGHLEIGGCDTVTLAKKFGTPLYVIDEELLRQNCRAFYNGFKKDYPGNEVIYASKAFMTMAICKIIEEEN
LGLDVVSGGELYTALKAGFPAEKIYFHGNNKSKEELIMALENNIGRIIVDNWYELNMLNDLAKKMNKVPNIYIRVSPGVE
AHTHQYVKTGQMDSKFGFPLFNGDAMRAIEYALTLENVNLVGLHSHIGSQIFDAESYKAEIEIMMNFLKLVKEFLGWEVG
ELDLGGGFGIAYVEEDDPQPIEQIAQEIMQAVKEYSVALNIKMPNIIVEPGRSIIGNAGTTLYTVGAIKDIPGVRKYVAV
DGGMSDNIRTALYGAKYDAIVANKAKNIKSEKVSIAGKLCESGDMLIWDITLPKIEEGDILAVTCTGAYNYSMASNYNRL
PRPAAVLVSNGQADIIVARETYEDLIRNDIIPERLTNEKRKIANY

Sequences:

>Translated_445_residues
MLHGTMKINSKGHLEIGGCDTVTLAKKFGTPLYVIDEELLRQNCRAFYNGFKKDYPGNEVIYASKAFMTMAICKIIEEEN
LGLDVVSGGELYTALKAGFPAEKIYFHGNNKSKEELIMALENNIGRIIVDNWYELNMLNDLAKKMNKVPNIYIRVSPGVE
AHTHQYVKTGQMDSKFGFPLFNGDAMRAIEYALTLENVNLVGLHSHIGSQIFDAESYKAEIEIMMNFLKLVKEFLGWEVG
ELDLGGGFGIAYVEEDDPQPIEQIAQEIMQAVKEYSVALNIKMPNIIVEPGRSIIGNAGTTLYTVGAIKDIPGVRKYVAV
DGGMSDNIRTALYGAKYDAIVANKAKNIKSEKVSIAGKLCESGDMLIWDITLPKIEEGDILAVTCTGAYNYSMASNYNRL
PRPAAVLVSNGQADIIVARETYEDLIRNDIIPERLTNEKRKIANY
>Mature_445_residues
MLHGTMKINSKGHLEIGGCDTVTLAKKFGTPLYVIDEELLRQNCRAFYNGFKKDYPGNEVIYASKAFMTMAICKIIEEEN
LGLDVVSGGELYTALKAGFPAEKIYFHGNNKSKEELIMALENNIGRIIVDNWYELNMLNDLAKKMNKVPNIYIRVSPGVE
AHTHQYVKTGQMDSKFGFPLFNGDAMRAIEYALTLENVNLVGLHSHIGSQIFDAESYKAEIEIMMNFLKLVKEFLGWEVG
ELDLGGGFGIAYVEEDDPQPIEQIAQEIMQAVKEYSVALNIKMPNIIVEPGRSIIGNAGTTLYTVGAIKDIPGVRKYVAV
DGGMSDNIRTALYGAKYDAIVANKAKNIKSEKVSIAGKLCESGDMLIWDITLPKIEEGDILAVTCTGAYNYSMASNYNRL
PRPAAVLVSNGQADIIVARETYEDLIRNDIIPERLTNEKRKIANY

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=403, Percent_Identity=25.3101736972705, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI1789203, Length=421, Percent_Identity=28.2660332541568, Blast_Score=145, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17562780, Length=378, Percent_Identity=24.6031746031746, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24586472, Length=363, Percent_Identity=25.068870523416, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24586474, Length=358, Percent_Identity=27.3743016759777, Blast_Score=79, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 49413; Mature: 49413

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHGTMKINSKGHLEIGGCDTVTLAKKFGTPLYVIDEELLRQNCRAFYNGFKKDYPGNEV
CCEEEEEECCCCCEEECCCCEEEHHHHHCCCEEEECHHHHHHHHHHHHCCCCCCCCCCEE
IYASKAFMTMAICKIIEEENLGLDVVSGGELYTALKAGFPAEKIYFHGNNKSKEELIMAL
EEEHHHHHHHHHHHHHHCCCCCEEEECCCCEEHHHHCCCCCCEEEEECCCCCHHHHHHHH
ENNIGRIIVDNWYELNMLNDLAKKMNKVPNIYIRVSPGVEAHTHQYVKTGQMDSKFGFPL
HCCCCEEEECCEEEEHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCEE
FNGDAMRAIEYALTLENVNLVGLHSHIGSQIFDAESYKAEIEIMMNFLKLVKEFLGWEVG
ECCCHHHHEEEEEEECCCEEEEEHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCEEC
ELDLGGGFGIAYVEEDDPQPIEQIAQEIMQAVKEYSVALNIKMPNIIVEPGRSIIGNAGT
EEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCEEEEEEECCCEEECCCCHHHCCCCC
TLYTVGAIKDIPGVRKYVAVDGGMSDNIRTALYGAKYDAIVANKAKNIKSEKVSIAGKLC
EEEEECCHHCCCCCEEEEEECCCCCCCCEEEEECCCCCEEEECCHHCCCHHHHHHHHHHC
ESGDMLIWDITLPKIEEGDILAVTCTGAYNYSMASNYNRLPRPAAVLVSNGQADIIVARE
CCCCEEEEEEECCCCCCCCEEEEEECCCCCCHHHCCCCCCCCCEEEEEECCCEEEEEEHH
TYEDLIRNDIIPERLTNEKRKIANY
HHHHHHHHCCCCHHHCCHHHHHCCC
>Mature Secondary Structure
MLHGTMKINSKGHLEIGGCDTVTLAKKFGTPLYVIDEELLRQNCRAFYNGFKKDYPGNEV
CCEEEEEECCCCCEEECCCCEEEHHHHHCCCEEEECHHHHHHHHHHHHCCCCCCCCCCEE
IYASKAFMTMAICKIIEEENLGLDVVSGGELYTALKAGFPAEKIYFHGNNKSKEELIMAL
EEEHHHHHHHHHHHHHHCCCCCEEEECCCCEEHHHHCCCCCCEEEEECCCCCHHHHHHHH
ENNIGRIIVDNWYELNMLNDLAKKMNKVPNIYIRVSPGVEAHTHQYVKTGQMDSKFGFPL
HCCCCEEEECCEEEEHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCEE
FNGDAMRAIEYALTLENVNLVGLHSHIGSQIFDAESYKAEIEIMMNFLKLVKEFLGWEVG
ECCCHHHHEEEEEEECCCEEEEEHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCEEC
ELDLGGGFGIAYVEEDDPQPIEQIAQEIMQAVKEYSVALNIKMPNIIVEPGRSIIGNAGT
EEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCEEEEEEECCCEEECCCCHHHCCCCC
TLYTVGAIKDIPGVRKYVAVDGGMSDNIRTALYGAKYDAIVANKAKNIKSEKVSIAGKLC
EEEEECCHHCCCCCEEEEEECCCCCCCCEEEEECCCCCEEEECCHHCCCHHHHHHHHHHC
ESGDMLIWDITLPKIEEGDILAVTCTGAYNYSMASNYNRLPRPAAVLVSNGQADIIVARE
CCCCEEEEEEECCCCCCCCEEEEEECCCCCCHHHCCCCCCCCCEEEEEECCCEEEEEEHH
TYEDLIRNDIIPERLTNEKRKIANY
HHHHHHHHCCCCHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2513554; 7934829; 1368705; 8969508; 9384377 [H]