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The map label for this gene is birA [H]

Identifier: 167039708

GI number: 167039708

Start: 1095900

End: 1096880

Strand: Reverse

Name: birA [H]

Synonym: Teth514_1058

Alternate gene names: 167039708

Gene position: 1096880-1095900 (Counterclockwise)

Preceding gene: 167039734

Following gene: 167039692

Centisome position: 44.64

GC content: 33.84

Gene sequence:

>981_bases
ATGTTAAGGTCAAAGCTTCTTAAACTTTTAAAAGAAAACAAAGGGGAATATATCTCTGGGCAAAAACTTTCTGATCAACT
CAACGTCTCAAGAACTGCTATATGGAAACATATAAATGAATTAAAAAATGAAGGATACCAAATAGAAGCCCATCACAAGC
TGGGGTATATGTTAGTTTCTGAGCCTGATTTGTTAATTTATGAAGAAGTATCCCCTTATCTTACTACAAATTTTATAGGA
AAAAATTATATACATAAGTTAGTCATTGATTCTACAAACAACTTCGCAAAAGAAATGGCATCAAAGGTTCCTGATGGTAC
AGTAATTATTGCCGAAGAGCAGATAGCAGGAAGAGGCCGATTAGGAAGAAGTTGGATATCTCAAAAAGGCTGTGGCATCT
GGATGTCTATCATTTTAAAACCAAATATACAGCCACAGGAGGCACTTAATCTCACACAAGTAGCGGCAATTTCTGTAGTC
AAAGCTATTGAAGAAGTATTTCATGTAGAAAGCAAAATAAAGTGGCCAAATGATATAATACTAAACAATAAAAAAGTGTG
TGGAATATTGACAGAGATGAGTTCAGAAATTGACAAAATAAACTATGTGATAATAGGAATTGGAGTCAATGTAAATTGTG
ACAATTTCCCTGAAGAATTAAAAGGGAAAGCCACTTCCTTGTACTTAGAAACCAACTCTAAAGTTGATAGGAAAAAACTT
ACCGCCAGCATTTTAAATAACCTGGAATTTTATTATAATGCATATTTACAAAAAGGCTTTGAATACATAGGGCCTATATG
CATTGAAAAGTCCATAACAATAGGAAGGCAGATAAAAGTCATTGCCAATGAAGGTGAAATTGAAGGAAAAGCTGTCACTA
TTGACAATAATGGAAGTTTGGTAGTAGAGACAAAAGAGGGCAAAAGACTTAGTATTATGTCAGGAGATGTGTCTGTAAGG
GGGTTACTGGATTATGTTTAA

Upstream 100 bases:

>100_bases
TATTATTTAATGTAAAATAAGTAAATAGACAAAACCTTTTCTTCTTGGAAGATGTAAATTATAATATGTTTATAGCCATA
TAAACTTTTGAGGTGAAAAA

Downstream 100 bases:

>100_bases
ACAAAATCTTGACGCTCCAGTTTGTTGACAAAGTTAAAAAATGTTCAAAGGAGATATTTTGCATCGTCGCTCCGGTGTTC
CAAAGCGACAAAACTAAAGC

Product: biotin--acetyl-CoA-carboxylase ligase

Products: NA

Alternate protein names: Biotin operon repressor; Biotin--[acetyl-CoA-carboxylase] synthetase; Biotin--protein ligase [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MLRSKLLKLLKENKGEYISGQKLSDQLNVSRTAIWKHINELKNEGYQIEAHHKLGYMLVSEPDLLIYEEVSPYLTTNFIG
KNYIHKLVIDSTNNFAKEMASKVPDGTVIIAEEQIAGRGRLGRSWISQKGCGIWMSIILKPNIQPQEALNLTQVAAISVV
KAIEEVFHVESKIKWPNDIILNNKKVCGILTEMSSEIDKINYVIIGIGVNVNCDNFPEELKGKATSLYLETNSKVDRKKL
TASILNNLEFYYNAYLQKGFEYIGPICIEKSITIGRQIKVIANEGEIEGKAVTIDNNGSLVVETKEGKRLSIMSGDVSVR
GLLDYV

Sequences:

>Translated_326_residues
MLRSKLLKLLKENKGEYISGQKLSDQLNVSRTAIWKHINELKNEGYQIEAHHKLGYMLVSEPDLLIYEEVSPYLTTNFIG
KNYIHKLVIDSTNNFAKEMASKVPDGTVIIAEEQIAGRGRLGRSWISQKGCGIWMSIILKPNIQPQEALNLTQVAAISVV
KAIEEVFHVESKIKWPNDIILNNKKVCGILTEMSSEIDKINYVIIGIGVNVNCDNFPEELKGKATSLYLETNSKVDRKKL
TASILNNLEFYYNAYLQKGFEYIGPICIEKSITIGRQIKVIANEGEIEGKAVTIDNNGSLVVETKEGKRLSIMSGDVSVR
GLLDYV
>Mature_326_residues
MLRSKLLKLLKENKGEYISGQKLSDQLNVSRTAIWKHINELKNEGYQIEAHHKLGYMLVSEPDLLIYEEVSPYLTTNFIG
KNYIHKLVIDSTNNFAKEMASKVPDGTVIIAEEQIAGRGRLGRSWISQKGCGIWMSIILKPNIQPQEALNLTQVAAISVV
KAIEEVFHVESKIKWPNDIILNNKKVCGILTEMSSEIDKINYVIIGIGVNVNCDNFPEELKGKATSLYLETNSKVDRKKL
TASILNNLEFYYNAYLQKGFEYIGPICIEKSITIGRQIKVIANEGEIEGKAVTIDNNGSLVVETKEGKRLSIMSGDVSVR
GLLDYV

Specific function: BirA acts both as a biotin-operon repressor and as the enzyme that synthesizes the corepressor, acetyl-CoA:carbon-dioxide ligase. This protein also activates biotin to form biotinyl-5'- adenylate and transfers the biotin moiety to biotin-accepting protein

COG id: COG0340

COG function: function code H; Biotin-(acetyl-CoA carboxylase) ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biotin--protein ligase family [H]

Homologues:

Organism=Homo sapiens, GI46255045, Length=253, Percent_Identity=25.6916996047431, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790408, Length=316, Percent_Identity=29.746835443038, Blast_Score=135, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: =6.3.4.15 [H]

Molecular weight: Translated: 36551; Mature: 36551

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRSKLLKLLKENKGEYISGQKLSDQLNVSRTAIWKHINELKNEGYQIEAHHKLGYMLVS
CCHHHHHHHHHHCCCCEECCCCCCHHHCHHHHHHHHHHHHHHCCCEEEEEECCEEEEEEC
EPDLLIYEEVSPYLTTNFIGKNYIHKLVIDSTNNFAKEMASKVPDGTVIIAEEQIAGRGR
CCCEEEEECCCCCHHHHHCCHHHEEEEEEECCCHHHHHHHHHCCCCEEEEEECCCCCCCC
LGRSWISQKGCGIWMSIILKPNIQPQEALNLTQVAAISVVKAIEEVFHVESKIKWPNDII
CCHHHHHCCCCCEEEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
LNNKKVCGILTEMSSEIDKINYVIIGIGVNVNCDNFPEELKGKATSLYLETNSKVDRKKL
ECCCHHHHHHHHHHHHHCCEEEEEEEEEEECCCCCCCHHHCCCEEEEEEECCCCHHHHHH
TASILNNLEFYYNAYLQKGFEYIGPICIEKSITIGRQIKVIANEGEIEGKAVTIDNNGSL
HHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEEECCCCCCCEEEEEECCCEE
VVETKEGKRLSIMSGDVSVRGLLDYV
EEEECCCCEEEEEECCEEEHHHCCCC
>Mature Secondary Structure
MLRSKLLKLLKENKGEYISGQKLSDQLNVSRTAIWKHINELKNEGYQIEAHHKLGYMLVS
CCHHHHHHHHHHCCCCEECCCCCCHHHCHHHHHHHHHHHHHHCCCEEEEEECCEEEEEEC
EPDLLIYEEVSPYLTTNFIGKNYIHKLVIDSTNNFAKEMASKVPDGTVIIAEEQIAGRGR
CCCEEEEECCCCCHHHHHCCHHHEEEEEEECCCHHHHHHHHHCCCCEEEEEECCCCCCCC
LGRSWISQKGCGIWMSIILKPNIQPQEALNLTQVAAISVVKAIEEVFHVESKIKWPNDII
CCHHHHHCCCCCEEEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
LNNKKVCGILTEMSSEIDKINYVIIGIGVNVNCDNFPEELKGKATSLYLETNSKVDRKKL
ECCCHHHHHHHHHHHHHCCEEEEEEEEEEECCCCCCCHHHCCCEEEEEEECCCCHHHHHH
TASILNNLEFYYNAYLQKGFEYIGPICIEKSITIGRQIKVIANEGEIEGKAVTIDNNGSL
HHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEEECCCCCCCEEEEEECCCEE
VVETKEGKRLSIMSGDVSVRGLLDYV
EEEECCCCEEEEEECCEEEHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7730294 [H]