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The map label for this gene is purL [H]

Identifier: 167039180

GI number: 167039180

Start: 535479

End: 537680

Strand: Direct

Name: purL [H]

Synonym: Teth514_0521

Alternate gene names: 167039180

Gene position: 535479-537680 (Clockwise)

Preceding gene: 167039179

Following gene: 167039181

Centisome position: 21.79

GC content: 37.38

Gene sequence:

>2202_bases
ATGGATAAAATATGGAGAGAATTAGGACTTACTGATGAGGAGTATGAGAAGATTATTTCGATATTAGGAAGAGAGCCTAA
TATAACTGAAATAGGTATGTATAGTGTTATGTGGTCTGAACATTGTGCCTATAAAAATTCTAAACCTCTTTTAAAATATC
TACCTACAAAAGGTGAAAGAGTAATACAAGGACCGGGAGAAAATGCAGGAGTATTGGATATTGGAGATAATTTGGCAGTT
GTGATGAAGATAGAAAGCCATAACCACCCTTCTGCGATTGAACCCTATCAAGGAGCAGCCACAGGTGTCGGGGGAATAAT
AAGAGATATATTCACAATGGGGGCAAGGCCAATTGCTCTTTTAGATTCTTTGAGATTTGGAATTCCTGATGATAAAAGGA
CTAAATATCTCATCGAAAACGTAGTAGCCGGTATAGCGGATTATGGAAATTGCATAGGAATTCCTACAGTAGGTGGGGAT
ACCTATTTTGAAGAAAGTTACAAAGGAAATCCTTTAGTAAATGCGATGTGTGTAGGAATAGTAGAAAAAGACAAGATAAA
AAAAGGGATAGCAAAAGGTATAGGTAACCCTGTTATGATAGTAGGTGCTACTACGGGGAGAGACGGTATTGGAGGTGCAA
GTTTTGCTTCTCAGGAATTAAGCGAGGAATCAGAAGAAAAAAGACCTTCTGTTCAGGTTGGCGACCCTTTTATGGAAAAA
CTGCTTTTGGAAGCATGTTTAGAACTTTTTGAAACAGATGCCGTAGTTGCTATACAAGATATGGGAGCGGCAGGTCTTAC
CTCTTCTTCTTGCGAGATGGCTTCCCGCGGTGGAGTTGGGATGGAAATTGACCTTGATAAAGTGCCTTTGAGAGAAAAGG
GAATGACACCTTATGAAATAATGCTTTCTGAATCTCAAGAGAGGATGTTGGTTGTTGTAGAGAAAGGTAAGGAAGAAGAT
GTACAAAAGGTATTTAAAAAATGGGGACTGAATGCCGCCACAATAGGGAAAATCACTGATGATGGAATGATAAGAGTGAT
TAAAGAGGGAAAAATAGTTGCGGAAGTTCCAGCTAAGTCTTTAGCAGAGGATGCTCCACAATATATTAGAGAAGAAGAAG
TGCCTAAATGGCAAGAAGATGTCAATAAGTTGAATATAAATGAAGTAAAACCTCCGGAGGATATGAATAAAGCTCTAAAA
GATGTAATTTCTTCTTTAAACGTTGCAAGTAAAGAATGGATATACAGTCAATATGATTATATGGTGAGGACAGACACAGC
AATAACTCCAGGAATGGATGCAGCTGTTGTGAGGATAAAAGGTACAAAAAAAGCTATTGCATTGACAACGGATTGCAATG
GTAGATATTGTTATTTAGATCCCTATATAGGTTCTCAAATTGCTGTAGCAGAGGCAGCTCGAAATCTTTGCATGGTTGGT
GCTAAGCCTATAGGGGTTACGGATTGTTTGAATTTTGGCAATCCGGAAAAGAAAGAAATATATTGGCAGTTAAAAAATTC
TATATTTGGAATAGCTAAAGCCTGTGAAACACTTCAAATCCCTGTGGTAAGCGGAAATGTCAGTCTTTACAATGAAAATG
AGGAAGGAGCCATTTATCCTACTCCTGTAATAGGAATGGCAGGCCTTATAGAGGATGTATCAAAAATTTGTACAATGGAC
TTTAAAAAAGAAAGAGATGTAATTATAATTTTAGGTGAGAATAAAGGAGAGATTGGAGGAAGTGAGTATCTTAAAGTTTG
CTTTGGAATGGTAAAAGGGCAACCACCTCAAATAGACTTGGAAGAGGAAAAAAGATTGCAAGAATTGGTGTTAAAACTTA
TAGAGGAAGGTTTAATTAATTCTTCTCATGACATATCAGAGGGCGGTTTTGCGGCTGCTTTGGTTGAAAGTGCAATTTCA
GGCAAAAAAGGTGCAAAAATTTCGCTACAAACTTCTCTTAGAGAGGATGTAGAGTTGTTCTCTGAATCTCCACCAAGAGC
ATTAATTACTGTAAGTCCTGAAAAAGTAGAGGAAGTATTAAAAATAGCTTATGAATACCAAGTTCCAGCTCAAAAGGTAG
GAGTTGTAGAAGGCAAAAAGATTGCAATTGAGGTAAATGGTAAAAAAATAATAGACCTTCCTTTAGAAGTCTTAGAGGAA
AGCTGGAGAGGGAGAATAAAATGGGAAATGGAGAGAAATTAA

Upstream 100 bases:

>100_bases
CTCATCCAGAGAGAGCTTATGCCCCCTTGCTGGGTAATACTGACGGGCTTTATATCTTAGGGTCAATAATGGATAATTTT
GTAAAAGGCGGGGTTTAAGG

Downstream 100 bases:

>100_bases
AAGAGGAATGTGGTGTTTTTGGTGCCTTTAGTTTGTCCACTTCAGTTACTTCTTATATCTATTATGGCTTACAAGCCTTG
CAGCACAGAGGGCAGGAAAG

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 733; Mature: 733

Protein sequence:

>733_residues
MDKIWRELGLTDEEYEKIISILGREPNITEIGMYSVMWSEHCAYKNSKPLLKYLPTKGERVIQGPGENAGVLDIGDNLAV
VMKIESHNHPSAIEPYQGAATGVGGIIRDIFTMGARPIALLDSLRFGIPDDKRTKYLIENVVAGIADYGNCIGIPTVGGD
TYFEESYKGNPLVNAMCVGIVEKDKIKKGIAKGIGNPVMIVGATTGRDGIGGASFASQELSEESEEKRPSVQVGDPFMEK
LLLEACLELFETDAVVAIQDMGAAGLTSSSCEMASRGGVGMEIDLDKVPLREKGMTPYEIMLSESQERMLVVVEKGKEED
VQKVFKKWGLNAATIGKITDDGMIRVIKEGKIVAEVPAKSLAEDAPQYIREEEVPKWQEDVNKLNINEVKPPEDMNKALK
DVISSLNVASKEWIYSQYDYMVRTDTAITPGMDAAVVRIKGTKKAIALTTDCNGRYCYLDPYIGSQIAVAEAARNLCMVG
AKPIGVTDCLNFGNPEKKEIYWQLKNSIFGIAKACETLQIPVVSGNVSLYNENEEGAIYPTPVIGMAGLIEDVSKICTMD
FKKERDVIIILGENKGEIGGSEYLKVCFGMVKGQPPQIDLEEEKRLQELVLKLIEEGLINSSHDISEGGFAAALVESAIS
GKKGAKISLQTSLREDVELFSESPPRALITVSPEKVEEVLKIAYEYQVPAQKVGVVEGKKIAIEVNGKKIIDLPLEVLEE
SWRGRIKWEMERN

Sequences:

>Translated_733_residues
MDKIWRELGLTDEEYEKIISILGREPNITEIGMYSVMWSEHCAYKNSKPLLKYLPTKGERVIQGPGENAGVLDIGDNLAV
VMKIESHNHPSAIEPYQGAATGVGGIIRDIFTMGARPIALLDSLRFGIPDDKRTKYLIENVVAGIADYGNCIGIPTVGGD
TYFEESYKGNPLVNAMCVGIVEKDKIKKGIAKGIGNPVMIVGATTGRDGIGGASFASQELSEESEEKRPSVQVGDPFMEK
LLLEACLELFETDAVVAIQDMGAAGLTSSSCEMASRGGVGMEIDLDKVPLREKGMTPYEIMLSESQERMLVVVEKGKEED
VQKVFKKWGLNAATIGKITDDGMIRVIKEGKIVAEVPAKSLAEDAPQYIREEEVPKWQEDVNKLNINEVKPPEDMNKALK
DVISSLNVASKEWIYSQYDYMVRTDTAITPGMDAAVVRIKGTKKAIALTTDCNGRYCYLDPYIGSQIAVAEAARNLCMVG
AKPIGVTDCLNFGNPEKKEIYWQLKNSIFGIAKACETLQIPVVSGNVSLYNENEEGAIYPTPVIGMAGLIEDVSKICTMD
FKKERDVIIILGENKGEIGGSEYLKVCFGMVKGQPPQIDLEEEKRLQELVLKLIEEGLINSSHDISEGGFAAALVESAIS
GKKGAKISLQTSLREDVELFSESPPRALITVSPEKVEEVLKIAYEYQVPAQKVGVVEGKKIAIEVNGKKIIDLPLEVLEE
SWRGRIKWEMERN
>Mature_733_residues
MDKIWRELGLTDEEYEKIISILGREPNITEIGMYSVMWSEHCAYKNSKPLLKYLPTKGERVIQGPGENAGVLDIGDNLAV
VMKIESHNHPSAIEPYQGAATGVGGIIRDIFTMGARPIALLDSLRFGIPDDKRTKYLIENVVAGIADYGNCIGIPTVGGD
TYFEESYKGNPLVNAMCVGIVEKDKIKKGIAKGIGNPVMIVGATTGRDGIGGASFASQELSEESEEKRPSVQVGDPFMEK
LLLEACLELFETDAVVAIQDMGAAGLTSSSCEMASRGGVGMEIDLDKVPLREKGMTPYEIMLSESQERMLVVVEKGKEED
VQKVFKKWGLNAATIGKITDDGMIRVIKEGKIVAEVPAKSLAEDAPQYIREEEVPKWQEDVNKLNINEVKPPEDMNKALK
DVISSLNVASKEWIYSQYDYMVRTDTAITPGMDAAVVRIKGTKKAIALTTDCNGRYCYLDPYIGSQIAVAEAARNLCMVG
AKPIGVTDCLNFGNPEKKEIYWQLKNSIFGIAKACETLQIPVVSGNVSLYNENEEGAIYPTPVIGMAGLIEDVSKICTMD
FKKERDVIIILGENKGEIGGSEYLKVCFGMVKGQPPQIDLEEEKRLQELVLKLIEEGLINSSHDISEGGFAAALVESAIS
GKKGAKISLQTSLREDVELFSESPPRALITVSPEKVEEVLKIAYEYQVPAQKVGVVEGKKIAIEVNGKKIIDLPLEVLEE
SWRGRIKWEMERN

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=729, Percent_Identity=25.5144032921811, Blast_Score=124, Evalue=4e-28,
Organism=Escherichia coli, GI48994899, Length=832, Percent_Identity=25.3605769230769, Blast_Score=152, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17553022, Length=745, Percent_Identity=23.6241610738255, Blast_Score=112, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6321498, Length=854, Percent_Identity=22.5995316159251, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24582111, Length=751, Percent_Identity=25.5659121171771, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24582109, Length=751, Percent_Identity=25.5659121171771, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17137292, Length=751, Percent_Identity=25.5659121171771, Blast_Score=130, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 80363; Mature: 80363

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKIWRELGLTDEEYEKIISILGREPNITEIGMYSVMWSEHCAYKNSKPLLKYLPTKGER
CCHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCE
VIQGPGENAGVLDIGDNLAVVMKIESHNHPSAIEPYQGAATGVGGIIRDIFTMGARPIAL
EEECCCCCCCEEEECCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHH
LDSLRFGIPDDKRTKYLIENVVAGIADYGNCIGIPTVGGDTYFEESYKGNPLVNAMCVGI
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHCCCCCCCCHHHHHHHH
VEKDKIKKGIAKGIGNPVMIVGATTGRDGIGGASFASQELSEESEEKRPSVQVGDPFMEK
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCHHHHH
LLLEACLELFETDAVVAIQDMGAAGLTSSSCEMASRGGVGMEIDLDKVPLREKGMTPYEI
HHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHCCCCCEEEECCCCCHHHCCCCCCEE
MLSESQERMLVVVEKGKEEDVQKVFKKWGLNAATIGKITDDGMIRVIKEGKIVAEVPAKS
EECCCCCEEEEEEECCCHHHHHHHHHHHCCCEEEECCCCCCCEEEEEECCCEEEECCHHH
LAEDAPQYIREEEVPKWQEDVNKLNINEVKPPEDMNKALKDVISSLNVASKEWIYSQYDY
HHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCE
MVRTDTAITPGMDAAVVRIKGTKKAIALTTDCNGRYCYLDPYIGSQIAVAEAARNLCMVG
EEEECCCCCCCCCEEEEEEECCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHEEEC
AKPIGVTDCLNFGNPEKKEIYWQLKNSIFGIAKACETLQIPVVSGNVSLYNENEEGAIYP
CCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEECCEEEEECCCCCCCCC
TPVIGMAGLIEDVSKICTMDFKKERDVIIILGENKGEIGGSEYLKVCFGMVKGQPPQIDL
CCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCC
EEEKRLQELVLKLIEEGLINSSHDISEGGFAAALVESAISGKKGAKISLQTSLREDVELF
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHH
SESPPRALITVSPEKVEEVLKIAYEYQVPAQKVGVVEGKKIAIEVNGKKIIDLPLEVLEE
HCCCCCEEEEECHHHHHHHHHHHHHCCCCHHHCCEECCCEEEEEECCCEEEECCHHHHHH
SWRGRIKWEMERN
HCCCCEEEEECCC
>Mature Secondary Structure
MDKIWRELGLTDEEYEKIISILGREPNITEIGMYSVMWSEHCAYKNSKPLLKYLPTKGER
CCHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCE
VIQGPGENAGVLDIGDNLAVVMKIESHNHPSAIEPYQGAATGVGGIIRDIFTMGARPIAL
EEECCCCCCCEEEECCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHH
LDSLRFGIPDDKRTKYLIENVVAGIADYGNCIGIPTVGGDTYFEESYKGNPLVNAMCVGI
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHCCCCCCCCHHHHHHHH
VEKDKIKKGIAKGIGNPVMIVGATTGRDGIGGASFASQELSEESEEKRPSVQVGDPFMEK
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCHHHHH
LLLEACLELFETDAVVAIQDMGAAGLTSSSCEMASRGGVGMEIDLDKVPLREKGMTPYEI
HHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHCCCCCEEEECCCCCHHHCCCCCCEE
MLSESQERMLVVVEKGKEEDVQKVFKKWGLNAATIGKITDDGMIRVIKEGKIVAEVPAKS
EECCCCCEEEEEEECCCHHHHHHHHHHHCCCEEEECCCCCCCEEEEEECCCEEEECCHHH
LAEDAPQYIREEEVPKWQEDVNKLNINEVKPPEDMNKALKDVISSLNVASKEWIYSQYDY
HHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCE
MVRTDTAITPGMDAAVVRIKGTKKAIALTTDCNGRYCYLDPYIGSQIAVAEAARNLCMVG
EEEECCCCCCCCCEEEEEEECCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHEEEC
AKPIGVTDCLNFGNPEKKEIYWQLKNSIFGIAKACETLQIPVVSGNVSLYNENEEGAIYP
CCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEECCEEEEECCCCCCCCC
TPVIGMAGLIEDVSKICTMDFKKERDVIIILGENKGEIGGSEYLKVCFGMVKGQPPQIDL
CCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCC
EEEKRLQELVLKLIEEGLINSSHDISEGGFAAALVESAISGKKGAKISLQTSLREDVELF
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHH
SESPPRALITVSPEKVEEVLKIAYEYQVPAQKVGVVEGKKIAIEVNGKKIIDLPLEVLEE
HCCCCCEEEEECHHHHHHHHHHHHHCCCCHHHCCEECCCEEEEEECCCEEEECCHHHHHH
SWRGRIKWEMERN
HCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA