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The map label for this gene is lrp [H]

Identifier: 162148450

GI number: 162148450

Start: 2761576

End: 2762034

Strand: Reverse

Name: lrp [H]

Synonym: GDI_2669

Alternate gene names: 162148450

Gene position: 2762034-2761576 (Counterclockwise)

Preceding gene: 162148452

Following gene: 162148448

Centisome position: 70.03

GC content: 62.75

Gene sequence:

>459_bases
TTGGACGACGCGGATCGCAGGATTCTCGGCTATTTGCAGAAGGACGGGCGCATCACGAACGTCGAGCTCGCCCGCCTGAT
CCATCTCAGCCCGGCGGCGACCCTGGAGAGGGTGCGCAAGCTGGAACAGGCCGGGATCATACAGGGATATATGGCGCGCC
TCGACCCCGAGGCGCTGCAACTGGGTCTGCTGGTCTTCATCCAGGTCACGCTGGACCGCACCGACCCGGGCCTGTTCGAT
GAATTCGCAAAGGCGATCAAGTCGATCCCGCAGGTCCGTGAATGCTATATGGTCGCCGGCGGGTTCGATTACCTGATCAA
GGCCCGCGTCCGGGACATGGGCGCGTATCGCAATTTCCTTGGAAAGACGCTGACGCGCCTGCCGGGCGTCCGGCAGACCC
ATACCTACACGGTCATGGAGGAGGTGAAGGCCGAGGCCGGGCTTCCGTTGTCGATATGA

Upstream 100 bases:

>100_bases
GCTGTTGTGACCGAACGAGGTATCGAATATAAGAAATATTACCGAATTTTGGACGGTGAACCTCTGATCGGACATATTAT
ATTCGGGGAAGGGGTGGCGC

Downstream 100 bases:

>100_bases
TGCTGGTGGCGAATGGCCGATCGGTCGCCTGACGCCCTACAGGATCGGCAGTCAGGTGTCGCGCGAGAATATCCCGATCA
CCGCCTGGATGTGCCGGCGC

Product: leucine-responsive regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 152; Mature: 152

Protein sequence:

>152_residues
MDDADRRILGYLQKDGRITNVELARLIHLSPAATLERVRKLEQAGIIQGYMARLDPEALQLGLLVFIQVTLDRTDPGLFD
EFAKAIKSIPQVRECYMVAGGFDYLIKARVRDMGAYRNFLGKTLTRLPGVRQTHTYTVMEEVKAEAGLPLSI

Sequences:

>Translated_152_residues
MDDADRRILGYLQKDGRITNVELARLIHLSPAATLERVRKLEQAGIIQGYMARLDPEALQLGLLVFIQVTLDRTDPGLFD
EFAKAIKSIPQVRECYMVAGGFDYLIKARVRDMGAYRNFLGKTLTRLPGVRQTHTYTVMEEVKAEAGLPLSI
>Mature_152_residues
MDDADRRILGYLQKDGRITNVELARLIHLSPAATLERVRKLEQAGIIQGYMARLDPEALQLGLLVFIQVTLDRTDPGLFD
EFAKAIKSIPQVRECYMVAGGFDYLIKARVRDMGAYRNFLGKTLTRLPGVRQTHTYTVMEEVKAEAGLPLSI

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=148, Percent_Identity=54.7297297297297, Blast_Score=172, Evalue=1e-44,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=30, Blast_Score=93, Evalue=7e-21,
Organism=Escherichia coli, GI1790182, Length=143, Percent_Identity=32.1678321678322, Blast_Score=61, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17108; Mature: 17108

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDADRRILGYLQKDGRITNVELARLIHLSPAATLERVRKLEQAGIIQGYMARLDPEALQ
CCCHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LGLLVFIQVTLDRTDPGLFDEFAKAIKSIPQVRECYMVAGGFDYLIKARVRDMGAYRNFL
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
GKTLTRLPGVRQTHTYTVMEEVKAEAGLPLSI
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDDADRRILGYLQKDGRITNVELARLIHLSPAATLERVRKLEQAGIIQGYMARLDPEALQ
CCCHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LGLLVFIQVTLDRTDPGLFDEFAKAIKSIPQVRECYMVAGGFDYLIKARVRDMGAYRNFL
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
GKTLTRLPGVRQTHTYTVMEEVKAEAGLPLSI
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]