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The map label for this gene is ugd [H]

Identifier: 162148328

GI number: 162148328

Start: 2641637

End: 2642986

Strand: Direct

Name: ugd [H]

Synonym: GDI_2545

Alternate gene names: 162148328

Gene position: 2641637-2642986 (Clockwise)

Preceding gene: 162148327

Following gene: 162148330

Centisome position: 66.98

GC content: 65.63

Gene sequence:

>1350_bases
ATGCAGACCGCAATGATTGGCGGCGGGTACGTCGGACTGGTGTCCGGCGCCTGCTTCGCCGAATTCGGCACCAACGTGGC
CATCGTCGAAACCGACCCGGACCGCCTGGCGGCGCTGCGCGAGGGCCGTATCCCGATTTACGAACCGGGCCTGGACAAGC
TGGTGGCCGACAACGTGGCCGCCGGACGCCTGACCTTCGGCGACAATATCGAACAGGCGGTCCAGGGAGCGGAGGCGATC
TTCATCGCGGTGGGCACCCCCACCCGGCGCGGCGACGGGCATGCCGACCTGCGCTATGTCTATGCCGCGACGGAACAGAT
CGCGAAATGCATGAAGGATTATGCCGTCGTCGTCACCAAGTCGACGGTGCCGGTCGGGACGGGACGCCAGGTTTCCGACC
TGATCCGCCGGGTACGGCCGGACCTGGATTTCGACGTCGCCTCCAATCCCGAATTCCTGCGCGAGGGCAACGCCATCGGC
GATTTCATGCGCCCCGATCGCGTGATCATCGGCACCGACACGACCAAGGAAGGGGGTGCGCACCGTGCGATGGAGATCAT
GCGCCGGCTCTACCGCCCGCTGTACCTGATCGAGGCCCCGATCCTGTTCACCAGCCTGGAAACCGCGGAACTGGCCAAAT
ATGCCGCCAATTCCTTCCTGGCCATGAAAGTCACCTTCATCAACGAGATCGCGGATTTGTGCGAAAAGGTCGGGGCCGAT
GTCCACGACATTGCCCGCGGCATCGGACTGGACAACCGGATCGGCCGCAAGTTCCTCCACCCGGGCCCCGGCTTCGGCGG
CTCGTGCTTCCCCAAGGACACGCTGGCGCTGGTCCACATCGCCCAGAACGCGGGCTCGCCCATGCGGCTGATCGAAACGA
CGGTGGACATCAACGATACGCGCAAGACCCGCATGGCCCACCGCATCGTCGCGGCCTGCGGCGGGTCCGTGGCCGGCCTG
ACGATCGGGGTGCTGGGGCTGACCTTCAAGCCCGAGACAGACGACATGCGCGCGGCATCGTCCATTCCCATCCTGCATCA
CCTGGCCGGCGCGGGTGCGACGCTGCGCGCGTTCGACCCGGCGGGAATGGAGGCCGCCCAACCGCTGTTGCCCGAGGAAG
TCGTCTATTGCCATGACGCGCTGGACGCCGCGACGGGGGTCGATGCCCTGGTGGTGCTGACCGAATGGAACGAATTCCGC
GCCCTGTCGCCCGCCCGGCTGCGCGAACTGATGAAAGGCGACGTCATCGTCGACCTGCGCAATGTCTGGGAACCCAAGGC
CATGCGCGACCATGGTTTCCAATACGAATCAATCGGCCGCCCCCTGATCGAAGGCCCCGTGCGGAAATAA

Upstream 100 bases:

>100_bases
TGGCAGATCGGGCGCGCGATGCAACGCCGGGTCGCGCAATGGCGTTCGGCATGACCGGCGGCGCCCCCCATGGACCCATC
ATGAAGCAGAGGAGTGGATC

Downstream 100 bases:

>100_bases
CGGGCCACGACGGCGCCCCGATGCCCCTGCGAAATCGGGGCACCGGGGGGCCGAGGCACGACATCGTTCATTTCTTCTGC
CTACATCACGAGTTTCTAAA

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MQTAMIGGGYVGLVSGACFAEFGTNVAIVETDPDRLAALREGRIPIYEPGLDKLVADNVAAGRLTFGDNIEQAVQGAEAI
FIAVGTPTRRGDGHADLRYVYAATEQIAKCMKDYAVVVTKSTVPVGTGRQVSDLIRRVRPDLDFDVASNPEFLREGNAIG
DFMRPDRVIIGTDTTKEGGAHRAMEIMRRLYRPLYLIEAPILFTSLETAELAKYAANSFLAMKVTFINEIADLCEKVGAD
VHDIARGIGLDNRIGRKFLHPGPGFGGSCFPKDTLALVHIAQNAGSPMRLIETTVDINDTRKTRMAHRIVAACGGSVAGL
TIGVLGLTFKPETDDMRAASSIPILHHLAGAGATLRAFDPAGMEAAQPLLPEEVVYCHDALDAATGVDALVVLTEWNEFR
ALSPARLRELMKGDVIVDLRNVWEPKAMRDHGFQYESIGRPLIEGPVRK

Sequences:

>Translated_449_residues
MQTAMIGGGYVGLVSGACFAEFGTNVAIVETDPDRLAALREGRIPIYEPGLDKLVADNVAAGRLTFGDNIEQAVQGAEAI
FIAVGTPTRRGDGHADLRYVYAATEQIAKCMKDYAVVVTKSTVPVGTGRQVSDLIRRVRPDLDFDVASNPEFLREGNAIG
DFMRPDRVIIGTDTTKEGGAHRAMEIMRRLYRPLYLIEAPILFTSLETAELAKYAANSFLAMKVTFINEIADLCEKVGAD
VHDIARGIGLDNRIGRKFLHPGPGFGGSCFPKDTLALVHIAQNAGSPMRLIETTVDINDTRKTRMAHRIVAACGGSVAGL
TIGVLGLTFKPETDDMRAASSIPILHHLAGAGATLRAFDPAGMEAAQPLLPEEVVYCHDALDAATGVDALVVLTEWNEFR
ALSPARLRELMKGDVIVDLRNVWEPKAMRDHGFQYESIGRPLIEGPVRK
>Mature_449_residues
MQTAMIGGGYVGLVSGACFAEFGTNVAIVETDPDRLAALREGRIPIYEPGLDKLVADNVAAGRLTFGDNIEQAVQGAEAI
FIAVGTPTRRGDGHADLRYVYAATEQIAKCMKDYAVVVTKSTVPVGTGRQVSDLIRRVRPDLDFDVASNPEFLREGNAIG
DFMRPDRVIIGTDTTKEGGAHRAMEIMRRLYRPLYLIEAPILFTSLETAELAKYAANSFLAMKVTFINEIADLCEKVGAD
VHDIARGIGLDNRIGRKFLHPGPGFGGSCFPKDTLALVHIAQNAGSPMRLIETTVDINDTRKTRMAHRIVAACGGSVAGL
TIGVLGLTFKPETDDMRAASSIPILHHLAGAGATLRAFDPAGMEAAQPLLPEEVVYCHDALDAATGVDALVVLTEWNEFR
ALSPARLRELMKGDVIVDLRNVWEPKAMRDHGFQYESIGRPLIEGPVRK

Specific function: Unknown

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=469, Percent_Identity=37.3134328358209, Blast_Score=281, Evalue=1e-75,
Organism=Homo sapiens, GI296040438, Length=370, Percent_Identity=38.1081081081081, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI296040443, Length=318, Percent_Identity=39.3081761006289, Blast_Score=206, Evalue=5e-53,
Organism=Escherichia coli, GI1788340, Length=370, Percent_Identity=30.8108108108108, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI48994968, Length=443, Percent_Identity=30.9255079006772, Blast_Score=155, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17560350, Length=459, Percent_Identity=36.3834422657952, Blast_Score=264, Evalue=8e-71,
Organism=Drosophila melanogaster, GI17136908, Length=466, Percent_Identity=37.5536480686695, Blast_Score=286, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 48566; Mature: 48566

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTAMIGGGYVGLVSGACFAEFGTNVAIVETDPDRLAALREGRIPIYEPGLDKLVADNVA
CCCEEECCCHHHHHCCHHHHHHCCCEEEEECCHHHHHHHHCCCCCEECCCHHHHHHCCCC
AGRLTFGDNIEQAVQGAEAIFIAVGTPTRRGDGHADLRYVYAATEQIAKCMKDYAVVVTK
CCEEECCCCHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHEEEEEE
STVPVGTGRQVSDLIRRVRPDLDFDVASNPEFLREGNAIGDFMRPDRVIIGTDTTKEGGA
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCHHHCCCCCEEEEECCCCCCCCH
HRAMEIMRRLYRPLYLIEAPILFTSLETAELAKYAANSFLAMKVTFINEIADLCEKVGAD
HHHHHHHHHHHCCHHHHCCCHHHCCCCHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHCCC
VHDIARGIGLDNRIGRKFLHPGPGFGGSCFPKDTLALVHIAQNAGSPMRLIETTVDINDT
HHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCHHHEEEEEECCCCCCEEEEEEEECCCCH
RKTRMAHRIVAACGGSVAGLTIGVLGLTFKPETDDMRAASSIPILHHLAGAGATLRAFDP
HHHHHHHHHHHHHCCCHHHHEEEEEEEEECCCCCHHHHHCCCCHHHHHHCCCCEEEECCC
AGMEAAQPLLPEEVVYCHDALDAATGVDALVVLTEWNEFRALSPARLRELMKGDVIVDLR
CCCHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHCCCCHHHHHHHHCCCEEEEHH
NVWEPKAMRDHGFQYESIGRPLIEGPVRK
HCCCCCHHHHCCCCHHHCCCCHHCCCCCC
>Mature Secondary Structure
MQTAMIGGGYVGLVSGACFAEFGTNVAIVETDPDRLAALREGRIPIYEPGLDKLVADNVA
CCCEEECCCHHHHHCCHHHHHHCCCEEEEECCHHHHHHHHCCCCCEECCCHHHHHHCCCC
AGRLTFGDNIEQAVQGAEAIFIAVGTPTRRGDGHADLRYVYAATEQIAKCMKDYAVVVTK
CCEEECCCCHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHEEEEEE
STVPVGTGRQVSDLIRRVRPDLDFDVASNPEFLREGNAIGDFMRPDRVIIGTDTTKEGGA
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCHHHCCCCCEEEEECCCCCCCCH
HRAMEIMRRLYRPLYLIEAPILFTSLETAELAKYAANSFLAMKVTFINEIADLCEKVGAD
HHHHHHHHHHHCCHHHHCCCHHHCCCCHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHCCC
VHDIARGIGLDNRIGRKFLHPGPGFGGSCFPKDTLALVHIAQNAGSPMRLIETTVDINDT
HHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCHHHEEEEEECCCCCCEEEEEEEECCCCH
RKTRMAHRIVAACGGSVAGLTIGVLGLTFKPETDDMRAASSIPILHHLAGAGATLRAFDP
HHHHHHHHHHHHHCCCHHHHEEEEEEEEECCCCCHHHHHCCCCHHHHHHCCCCEEEECCC
AGMEAAQPLLPEEVVYCHDALDAATGVDALVVLTEWNEFRALSPARLRELMKGDVIVDLR
CCCHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHCCCCHHHHHHHHCCCEEEEHH
NVWEPKAMRDHGFQYESIGRPLIEGPVRK
HCCCCCHHHHCCCCHHHCCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]