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The map label for this gene is uvrC [H]

Identifier: 162147602

GI number: 162147602

Start: 1850908

End: 1852821

Strand: Direct

Name: uvrC [H]

Synonym: GDI_1818

Alternate gene names: 162147602

Gene position: 1850908-1852821 (Clockwise)

Preceding gene: 162147599

Following gene: 162147603

Centisome position: 46.93

GC content: 67.92

Gene sequence:

>1914_bases
GTGGATGAACGGACGTGCCGCCTGATGGATGCCGATGTCGTGCCGGCCTCGTCGGTGAAGGGGGTCGAGGCGATCCTGCT
GGCCCTGCAGACCATGCCGCTTTCCCCGGGCGTCTATCGGATGCTGGGAGAGAAGGGCGAGGTCCTGTACGTGGGCAAGG
CCCGGATCCTGAAGCGGCGGGTGACGTCGTACACGCATCTGAGCAAGCTGCCCGAGCGCCTGCGCCGCATGGTGTCCGAG
ACGGTCACGATGGAGATCGTGACCACGCACACCGAGGCCGAGGCCCTGCTGCTGGAAGCCAACTACATCAAGCGCATGAA
GCCGCGCTTCAATATCCTGCTGCGCGACGACAAGAGCTATCCCTGGATCATGCTGACGGATGGCGCGGAATTCCCCCAGG
TGACCAAGCATCGGGGCAAGCCGGTCAAGGGGGCGTCGTACTGGGGACCGTTCGCCTCGGCCTGGGCGGTCAACCAGACG
CTGAACCTGATCCAGCGGGTCTTCCTGCTGCGCACCTGTTCGGATTCGGTGTTCGCGTCCCGGACGCGGCCCTGCCTGCT
GTTCCAGATCAAGCGCTGTTCCGCCCCCTGCGTCGCGCGCATCGGTCAGGCGGAATACGCCCATCTGGTCGAGCAGGCGC
GGGCCTTCCTGTCCGGCCAGCGCGGCGGCATCCGCGAGGAACTGGTGCGCGAGATGGAGGCGGCGGCGGCCTCGCTGGAA
TTCGAGCGGGCGGCGACCATTCGCGACCGTATCCGTGGCTTCGCCGCGATGCAGGATTCCTCGGTCATCAACCCGGCGTC
GCTGGATGACGCGGATATCGTGGCGATCGCGCAGGCGGCGGGGCATTCCTGCATCCAGGTCTTCTTCATCCGTGGCGGGC
GCAATAACGGCAACCGCGCCTTCTTCCCCGCCCATGCGCGCGACGAGGCGGCGCCGGACATCGTGGGCGCGTTCCTGGCG
CAGTTCTATGACGACAAGCCGCCGCCGGCGCAGATCCTGCTGAACTGCGAGATCGCGGAACACGACCTGATGGCCGATGC
CCTGGGGATCAAGCGCGGCCGCAAGGTCGAAATCCTGGTGCCGAAGCGGGGCGAGAAGCGGGCTGTGGTCGAACACGCCG
AAACGAACGCCCGCGAGGCGCTGGAGCGCAAGCTGGCCGAAAGCACGGCCCAGGCGCGCCTGCTGGAGGGCATGGCCGAC
CTGTTCGGACTGGATGCCCCCCCGCGGCGGATCGAGATCTACGACAACAGCCATATCATGGGGACCAATGCCTATGGCGT
CATGGTGGTGGCGGGACCCGAGGGCTTCGACAAGCGCAGCTACCGCAAGTTCTCGATCCGTGGCCCGATCACGCCGGGCG
ACGATTTCGCGATGATGCGCGAGGTCCTGGAACGGCGCTTCAGCCGTGCCCTGCGCGAGCGCGACGACTCTGCCGGCGCG
TCCAGTCCGGCCGACTGGCCGGATATCGTGCTGATCGACGGCGGCGCCGGCCAGTATTCGGCAGTACGGGCCGTGCTGGA
CGAACTGGGGGTGACGGACGTGACCCTGGTCGCCATCGCCAAGGGGCCGGACCGCGATGCGGGGCGAGAGTGGTTCCATA
TGGCGGATCGGCCGCCCTTCCAGTTACCGCCGCGCGATCCGGTGCTGTACTACCTGCAGCGGTTGCGGGACGAGGCCCAC
CGCTTCGCCATCACCACCCACCGGGCGGGCCGGTCCAAGGCCCTGGTGAAATCGGAACTGGACGAGATCCCGGGCGTGGG
CGCGGCGCGCAAGCGGGCGCTGCTGAACCAGTTCGGGTCCGCCCGCGGCGTGCGGCAGGCGGGGCTGGCGGAACTGGAGG
CCACGCAAGGGATCAATCGCGAAACCGCGCGCGTTGTCTACGGGCACTTCCATCCGGGCTGGACCGGCGCCTGA

Upstream 100 bases:

>100_bases
TTGTTGTGCTGTTTTTTTGTGCAATTCAAGCCGGGGGCAGGAAAACCGCCGCCCCCACGATTCTGTCAGCGTCTGCTCCA
CAGACTTATCCACATGATCG

Downstream 100 bases:

>100_bases
CGGACGGGCAAGAAGGGTGTACGGTCTGCCAGGCGTGAGCAAATTCGTCATCAGACCGTCGTGAAGAGCCGTTCCTGTCC
CCCTCGTGTTGTTGTACTGT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 637; Mature: 637

Protein sequence:

>637_residues
MDERTCRLMDADVVPASSVKGVEAILLALQTMPLSPGVYRMLGEKGEVLYVGKARILKRRVTSYTHLSKLPERLRRMVSE
TVTMEIVTTHTEAEALLLEANYIKRMKPRFNILLRDDKSYPWIMLTDGAEFPQVTKHRGKPVKGASYWGPFASAWAVNQT
LNLIQRVFLLRTCSDSVFASRTRPCLLFQIKRCSAPCVARIGQAEYAHLVEQARAFLSGQRGGIREELVREMEAAAASLE
FERAATIRDRIRGFAAMQDSSVINPASLDDADIVAIAQAAGHSCIQVFFIRGGRNNGNRAFFPAHARDEAAPDIVGAFLA
QFYDDKPPPAQILLNCEIAEHDLMADALGIKRGRKVEILVPKRGEKRAVVEHAETNAREALERKLAESTAQARLLEGMAD
LFGLDAPPRRIEIYDNSHIMGTNAYGVMVVAGPEGFDKRSYRKFSIRGPITPGDDFAMMREVLERRFSRALRERDDSAGA
SSPADWPDIVLIDGGAGQYSAVRAVLDELGVTDVTLVAIAKGPDRDAGREWFHMADRPPFQLPPRDPVLYYLQRLRDEAH
RFAITTHRAGRSKALVKSELDEIPGVGAARKRALLNQFGSARGVRQAGLAELEATQGINRETARVVYGHFHPGWTGA

Sequences:

>Translated_637_residues
MDERTCRLMDADVVPASSVKGVEAILLALQTMPLSPGVYRMLGEKGEVLYVGKARILKRRVTSYTHLSKLPERLRRMVSE
TVTMEIVTTHTEAEALLLEANYIKRMKPRFNILLRDDKSYPWIMLTDGAEFPQVTKHRGKPVKGASYWGPFASAWAVNQT
LNLIQRVFLLRTCSDSVFASRTRPCLLFQIKRCSAPCVARIGQAEYAHLVEQARAFLSGQRGGIREELVREMEAAAASLE
FERAATIRDRIRGFAAMQDSSVINPASLDDADIVAIAQAAGHSCIQVFFIRGGRNNGNRAFFPAHARDEAAPDIVGAFLA
QFYDDKPPPAQILLNCEIAEHDLMADALGIKRGRKVEILVPKRGEKRAVVEHAETNAREALERKLAESTAQARLLEGMAD
LFGLDAPPRRIEIYDNSHIMGTNAYGVMVVAGPEGFDKRSYRKFSIRGPITPGDDFAMMREVLERRFSRALRERDDSAGA
SSPADWPDIVLIDGGAGQYSAVRAVLDELGVTDVTLVAIAKGPDRDAGREWFHMADRPPFQLPPRDPVLYYLQRLRDEAH
RFAITTHRAGRSKALVKSELDEIPGVGAARKRALLNQFGSARGVRQAGLAELEATQGINRETARVVYGHFHPGWTGA
>Mature_637_residues
MDERTCRLMDADVVPASSVKGVEAILLALQTMPLSPGVYRMLGEKGEVLYVGKARILKRRVTSYTHLSKLPERLRRMVSE
TVTMEIVTTHTEAEALLLEANYIKRMKPRFNILLRDDKSYPWIMLTDGAEFPQVTKHRGKPVKGASYWGPFASAWAVNQT
LNLIQRVFLLRTCSDSVFASRTRPCLLFQIKRCSAPCVARIGQAEYAHLVEQARAFLSGQRGGIREELVREMEAAAASLE
FERAATIRDRIRGFAAMQDSSVINPASLDDADIVAIAQAAGHSCIQVFFIRGGRNNGNRAFFPAHARDEAAPDIVGAFLA
QFYDDKPPPAQILLNCEIAEHDLMADALGIKRGRKVEILVPKRGEKRAVVEHAETNAREALERKLAESTAQARLLEGMAD
LFGLDAPPRRIEIYDNSHIMGTNAYGVMVVAGPEGFDKRSYRKFSIRGPITPGDDFAMMREVLERRFSRALRERDDSAGA
SSPADWPDIVLIDGGAGQYSAVRAVLDELGVTDVTLVAIAKGPDRDAGREWFHMADRPPFQLPPRDPVLYYLQRLRDEAH
RFAITTHRAGRSKALVKSELDEIPGVGAARKRALLNQFGSARGVRQAGLAELEATQGINRETARVVYGHFHPGWTGA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=609, Percent_Identity=38.9162561576355, Blast_Score=427, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 70640; Mature: 70640

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDERTCRLMDADVVPASSVKGVEAILLALQTMPLSPGVYRMLGEKGEVLYVGKARILKRR
CCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEECHHHHHHHH
VTSYTHLSKLPERLRRMVSETVTMEIVTTHTEAEALLLEANYIKRMKPRFNILLRDDKSY
HHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCHHHEEEEHHHHHHCCCCEEEEEECCCCC
PWIMLTDGAEFPQVTKHRGKPVKGASYWGPFASAWAVNQTLNLIQRVFLLRTCSDSVFAS
CEEEEECCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHC
RTRPCLLFQIKRCSAPCVARIGQAEYAHLVEQARAFLSGQRGGIREELVREMEAAAASLE
CCCCEEEEEEHHCCCHHHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
FERAATIRDRIRGFAAMQDSSVINPASLDDADIVAIAQAAGHSCIQVFFIRGGRNNGNRA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCEE
FFPAHARDEAAPDIVGAFLAQFYDDKPPPAQILLNCEIAEHDLMADALGIKRGRKVEILV
EECCCCCCCCCHHHHHHHHHHHHCCCCCCHHEEEEEEHHHHHHHHHHHHCCCCCEEEEEE
PKRGEKRAVVEHAETNAREALERKLAESTAQARLLEGMADLFGLDAPPRRIEIYDNSHIM
CCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEE
GTNAYGVMVVAGPEGFDKRSYRKFSIRGPITPGDDFAMMREVLERRFSRALRERDDSAGA
ECCCCEEEEEECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
SSPADWPDIVLIDGGAGQYSAVRAVLDELGVTDVTLVAIAKGPDRDAGREWFHMADRPPF
CCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHCCCCCCC
QLPPRDPVLYYLQRLRDEAHRFAITTHRAGRSKALVKSELDEIPGVGAARKRALLNQFGS
CCCCCCHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
ARGVRQAGLAELEATQGINRETARVVYGHFHPGWTGA
CCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure
MDERTCRLMDADVVPASSVKGVEAILLALQTMPLSPGVYRMLGEKGEVLYVGKARILKRR
CCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEECHHHHHHHH
VTSYTHLSKLPERLRRMVSETVTMEIVTTHTEAEALLLEANYIKRMKPRFNILLRDDKSY
HHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCHHHEEEEHHHHHHCCCCEEEEEECCCCC
PWIMLTDGAEFPQVTKHRGKPVKGASYWGPFASAWAVNQTLNLIQRVFLLRTCSDSVFAS
CEEEEECCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHC
RTRPCLLFQIKRCSAPCVARIGQAEYAHLVEQARAFLSGQRGGIREELVREMEAAAASLE
CCCCEEEEEEHHCCCHHHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
FERAATIRDRIRGFAAMQDSSVINPASLDDADIVAIAQAAGHSCIQVFFIRGGRNNGNRA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCEE
FFPAHARDEAAPDIVGAFLAQFYDDKPPPAQILLNCEIAEHDLMADALGIKRGRKVEILV
EECCCCCCCCCHHHHHHHHHHHHCCCCCCHHEEEEEEHHHHHHHHHHHHCCCCCEEEEEE
PKRGEKRAVVEHAETNAREALERKLAESTAQARLLEGMADLFGLDAPPRRIEIYDNSHIM
CCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEE
GTNAYGVMVVAGPEGFDKRSYRKFSIRGPITPGDDFAMMREVLERRFSRALRERDDSAGA
ECCCCEEEEEECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
SSPADWPDIVLIDGGAGQYSAVRAVLDELGVTDVTLVAIAKGPDRDAGREWFHMADRPPF
CCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHCCCCCCC
QLPPRDPVLYYLQRLRDEAHRFAITTHRAGRSKALVKSELDEIPGVGAARKRALLNQFGS
CCCCCCHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
ARGVRQAGLAELEATQGINRETARVVYGHFHPGWTGA
CCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA