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The map label for this gene is modD [H]

Identifier: 162146280

GI number: 162146280

Start: 450607

End: 451428

Strand: Direct

Name: modD [H]

Synonym: GDI_0455

Alternate gene names: 162146280

Gene position: 450607-451428 (Clockwise)

Preceding gene: 162146279

Following gene: 162146281

Centisome position: 11.42

GC content: 71.78

Gene sequence:

>822_bases
TTGCTGGCCGAGGACGTGCCCTTTGGCGACCTGACGACACGGGCGCTGGGCATCGGCGGGCAGCCCGGCCTCATGAATTT
CTCCGCCCGGGACGAACAGGTCGTCTGCGGAAGCGAGGAAGCCGCCGCCATACTGACCCGGCTGGGTGCGACGGTGGACG
TGCTGCGCTCCAGCGGCGGCCGGGTCACGCCGGGCACGCCCCTGCTGCGGGCCACGGGCCCGGCGGGGGCGCTCCATATG
GGGTGGAAGACCGCCCAGACGCTGATGGAATGGGCGGCCGGCATCGCCACCGCCACGAACGCCATCGTCCTGGCCGCCGC
ATCCGGCGGGGCGGCGGCTGGAACGGTCGCGGTCGCCTGTACGCGAAAGGCGCCGCCGTTGACGCGGGCGCTGGCGATGC
GGGCGGTGGTGGCCGGCGGCGGGGTGATGCATCGCGTCGGCCTGTCCGACACCATCCTGGTATTTCCCGAACACCTGGCC
TTCATGGACCCGCATGACGGCCTGGCTCAGGCGGTCCAGACGCTGCGCCGCACCGCGCCGGAACGGCGGATCGTCATCGA
GGTCACCAGCCCGGACCAGGCCATCGCGGCCGCACGGGCCGGGGCGGACATCCTGCAGATGGAGAAATTTCCCGTCCGGG
ACGTCGCGCGACTGGCCGAACGGCTGAAGGCACTTTCCCTCTGCCCACGTCTGGCCGCGGCCGGGGGCATCAATGCCCGC
AACGTCGCGGACTACGTCGCGGCGGGCGCGGACCTTGTCGTGACCTCGGCACCGTATACCGCGCCGCCCTGTGACGTGCA
GGTCGAACTGAAGGCGCGATAG

Upstream 100 bases:

>100_bases
ACGGGCGATATCGAATGGCAGTATCCGCGTGGTGGATACGGTGTCCTTTTCAAGTTCGGTTAACGGGCTGCCGCCTCTGC
CGGCGACGCTGATCGATGCG

Downstream 100 bases:

>100_bases
CAGGCCCGGCGCACGGTCCCCGAGCGACCGGAAGCGCCGGGCGATTCCCATGCGCATCCAGCTCCCTATCTTGCGTATCG
AGAAGCCTCCGATCCGGGGC

Product: pyrophosphorylase modD

Products: CO2; Nicotinate D-ribonucleotide; Diphosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MLAEDVPFGDLTTRALGIGGQPGLMNFSARDEQVVCGSEEAAAILTRLGATVDVLRSSGGRVTPGTPLLRATGPAGALHM
GWKTAQTLMEWAAGIATATNAIVLAAASGGAAAGTVAVACTRKAPPLTRALAMRAVVAGGGVMHRVGLSDTILVFPEHLA
FMDPHDGLAQAVQTLRRTAPERRIVIEVTSPDQAIAAARAGADILQMEKFPVRDVARLAERLKALSLCPRLAAAGGINAR
NVADYVAAGADLVVTSAPYTAPPCDVQVELKAR

Sequences:

>Translated_273_residues
MLAEDVPFGDLTTRALGIGGQPGLMNFSARDEQVVCGSEEAAAILTRLGATVDVLRSSGGRVTPGTPLLRATGPAGALHM
GWKTAQTLMEWAAGIATATNAIVLAAASGGAAAGTVAVACTRKAPPLTRALAMRAVVAGGGVMHRVGLSDTILVFPEHLA
FMDPHDGLAQAVQTLRRTAPERRIVIEVTSPDQAIAAARAGADILQMEKFPVRDVARLAERLKALSLCPRLAAAGGINAR
NVADYVAAGADLVVTSAPYTAPPCDVQVELKAR
>Mature_273_residues
MLAEDVPFGDLTTRALGIGGQPGLMNFSARDEQVVCGSEEAAAILTRLGATVDVLRSSGGRVTPGTPLLRATGPAGALHM
GWKTAQTLMEWAAGIATATNAIVLAAASGGAAAGTVAVACTRKAPPLTRALAMRAVVAGGGVMHRVGLSDTILVFPEHLA
FMDPHDGLAQAVQTLRRTAPERRIVIEVTSPDQAIAAARAGADILQMEKFPVRDVARLAERLKALSLCPRLAAAGGINAR
NVADYVAAGADLVVTSAPYTAPPCDVQVELKAR

Specific function: NAD biosynthesis; aspartate to NaMN; third (last) step. [C]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=277, Percent_Identity=29.2418772563177, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1786299, Length=234, Percent_Identity=24.7863247863248, Blast_Score=63, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321162, Length=272, Percent_Identity=26.8382352941176, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006242
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: 2.4.2.19 [C]

Molecular weight: Translated: 28058; Mature: 28058

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAEDVPFGDLTTRALGIGGQPGLMNFSARDEQVVCGSEEAAAILTRLGATVDVLRSSGG
CCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHCCHHHHHHCCCC
RVTPGTPLLRATGPAGALHMGWKTAQTLMEWAAGIATATNAIVLAAASGGAAAGTVAVAC
EECCCCCEEEECCCCCEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEE
TRKAPPLTRALAMRAVVAGGGVMHRVGLSDTILVFPEHLAFMDPHDGLAQAVQTLRRTAP
CCCCCHHHHHHHHHHHHHCCCEEEECCCCCEEEEEHHHHEECCCCHHHHHHHHHHHHCCC
ERRIVIEVTSPDQAIAAARAGADILQMEKFPVRDVARLAERLKALSLCPRLAAAGGINAR
CCEEEEEECCCCHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
NVADYVAAGADLVVTSAPYTAPPCDVQVELKAR
HHHHHHHCCCCEEEECCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MLAEDVPFGDLTTRALGIGGQPGLMNFSARDEQVVCGSEEAAAILTRLGATVDVLRSSGG
CCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHCCHHHHHHCCCC
RVTPGTPLLRATGPAGALHMGWKTAQTLMEWAAGIATATNAIVLAAASGGAAAGTVAVAC
EECCCCCEEEECCCCCEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEE
TRKAPPLTRALAMRAVVAGGGVMHRVGLSDTILVFPEHLAFMDPHDGLAQAVQTLRRTAP
CCCCCHHHHHHHHHHHHHCCCEEEECCCCCEEEEEHHHHEECCCCHHHHHHHHHHHHCCC
ERRIVIEVTSPDQAIAAARAGADILQMEKFPVRDVARLAERLKALSLCPRLAAAGGINAR
CCEEEEEECCCCHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
NVADYVAAGADLVVTSAPYTAPPCDVQVELKAR
HHHHHHHCCCCEEEECCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H+; 5-Phospho-alpha-D-ribose 1-diphosphate; Quinolinate [C]

Specific reaction: (2) H+ + 5-Phospho-alpha-D-ribose 1-diphosphate + Quinolinate --> CO2 + Nicotinate D-ribonucleotide + Diphosphate [C]

General reaction: Pentosyl group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA