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The map label for this gene is mcpA [H]

Identifier: 162146281

GI number: 162146281

Start: 451802

End: 453397

Strand: Direct

Name: mcpA [H]

Synonym: GDI_0456

Alternate gene names: 162146281

Gene position: 451802-453397 (Clockwise)

Preceding gene: 162146280

Following gene: 162146282

Centisome position: 11.45

GC content: 64.29

Gene sequence:

>1596_bases
GTGACGAAAGAATCACAGATTGTCGAACGCCTTAGCTTCATGAATCTGGACTCCACCGCGCAACAGAATATCAAAAATGC
CAAGCCAATTCTGATGAAGGCCCTTCCAGGGGCGCTGGATACATTTTACGATCAGGCGCGCACGTTCCCCCATACCGCCC
AATTCTTCCATAACGCGAATCTGATCGCCTCGGCGAAGAATCGTCAACTTGGCCATTGGGATTACATATCCAGCGGTGAA
TTCAATCAGGATTACGTCAAGGCCGTCACCACGATCGGGCAGACGCATGCGCGGATCGGGCTGGAGCCGCGCTGGTATAT
CGGGGGCTATGCCCTGGTTCTCGAATCCCTGATCGCGGCGATCGTCGAGGCGCGCTGGCCGAGGGGAATCCTGGGGGCCG
GGCGGTCATCGGCCAGACAGGTGACGGCGGAACTGAGCGCCGTCGTCAAGGCCACCATGCTCGATATGGATTTCGCGATT
TCCGTCTATCTCGATGCGCTGGAGACGGCGCGCCAGGCGTCGGAGGCGCGTGCCAGGGCGACCAACGACGCCGTCATGAA
AGCGGTCGGCGAGGCCCTGGGCAGGATCGCGCAAGGCGACCTGACCCATCGCATCGGCGACGACATGCCCGAGGAATACA
GGCAGTTGCGCGACGACTTCAACCTCGCCATCGCGCAATTGTCCGAAACGCTGTCCCAGGTCCAGGGCACGGCCGAGACG
ATCAGCCGGGGCGCGGATGAAATCGCGAATGCCGCCGACGACCTGTCGCAGCGGACCGAAAGACAGGCGGCCAGCATCCA
GCAGACGGCGGCGGCCCTCGACCAGATCACCGCGTCGGTGACCCGGACGGCCGGCGGCACAAAGCGGGCCAGCGGGGCGG
TCAACGCGGCCAAGGCGGACACCCGGCATTCGGGCACGGTGGTGGACCAGGCCATCCTCGCGATGAGCGAAATCGAGAAA
TCGTCGAACCAGATCGCCCGGATCAACGGAATCATCTACGACATCGCATTCCAGACCAATCTGCTGGCCCTGAACGCGGG
GGTCGAGGCCGCCCGTGCCGGCGACCAGGGCCGTGGCTTCGCGGTCGTCGCGCAGGAGGTACGCGCCCTGGCGCAACGGT
CGTCCGAGGCCGCCAGGGAAATCAAGGCCCTGATCCTGGCCTCGGCACAGCATGTGAATCACGGCGTCGGCCTGGTGGAC
GAGACCGGCAAGGCGCTGAAGGCCATCATGGCCAAGGTCACCGAAATCGACGACCTGGTGGGCGAAATCGCCTCCTCGAC
CCAGGAGCAGGCGGCCGGACTCAGCCAGGTGAACATCGCCGTGAACCAGGTGGACCAGGTCGTGCAGCAGAATGCGGCGA
TGGTCGAGGAAACCACCGCCGCCACGCGGTCCCTCAAGGGTGAAACCGAGGAACTGGCTGCCCTGGTCGGACGCTTCGCG
GTCGATGACGGGCAGGATCAAAGCCGGACCATGGCCCGACCCGATGCGCCTGCAAGCCGACAGGCGGTGTCCCAGCTTCA
GGCCCTGGCCGACAGGATTTCCGCCAGCTTTGCCCGCAGGCCGCGATACAGCGACGGCCCCCGGGAAGAAGTCTGA

Upstream 100 bases:

>100_bases
TCATGCATGCGGCCCAGGTGGTTTGTGTATGAATAATGAATACGGAACTGATACGGAATAATGTAACTATAACAAATACA
AGCCGGTGGGAGTTGATGAA

Downstream 100 bases:

>100_bases
GGGTATCCGGGACAGGCCGGGCGGCGTTTCCAGGACCGGGTCGCAGTGCGATGCTTGATGAGGCGCGCGTCCGTGACTAC
GTGATTTCCCATGCCGGTTC

Product: chemoreceptor mcpA

Products: NA

Alternate protein names: Methyl-accepting chemotaxis protein [H]

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MTKESQIVERLSFMNLDSTAQQNIKNAKPILMKALPGALDTFYDQARTFPHTAQFFHNANLIASAKNRQLGHWDYISSGE
FNQDYVKAVTTIGQTHARIGLEPRWYIGGYALVLESLIAAIVEARWPRGILGAGRSSARQVTAELSAVVKATMLDMDFAI
SVYLDALETARQASEARARATNDAVMKAVGEALGRIAQGDLTHRIGDDMPEEYRQLRDDFNLAIAQLSETLSQVQGTAET
ISRGADEIANAADDLSQRTERQAASIQQTAAALDQITASVTRTAGGTKRASGAVNAAKADTRHSGTVVDQAILAMSEIEK
SSNQIARINGIIYDIAFQTNLLALNAGVEAARAGDQGRGFAVVAQEVRALAQRSSEAAREIKALILASAQHVNHGVGLVD
ETGKALKAIMAKVTEIDDLVGEIASSTQEQAAGLSQVNIAVNQVDQVVQQNAAMVEETTAATRSLKGETEELAALVGRFA
VDDGQDQSRTMARPDAPASRQAVSQLQALADRISASFARRPRYSDGPREEV

Sequences:

>Translated_531_residues
MTKESQIVERLSFMNLDSTAQQNIKNAKPILMKALPGALDTFYDQARTFPHTAQFFHNANLIASAKNRQLGHWDYISSGE
FNQDYVKAVTTIGQTHARIGLEPRWYIGGYALVLESLIAAIVEARWPRGILGAGRSSARQVTAELSAVVKATMLDMDFAI
SVYLDALETARQASEARARATNDAVMKAVGEALGRIAQGDLTHRIGDDMPEEYRQLRDDFNLAIAQLSETLSQVQGTAET
ISRGADEIANAADDLSQRTERQAASIQQTAAALDQITASVTRTAGGTKRASGAVNAAKADTRHSGTVVDQAILAMSEIEK
SSNQIARINGIIYDIAFQTNLLALNAGVEAARAGDQGRGFAVVAQEVRALAQRSSEAAREIKALILASAQHVNHGVGLVD
ETGKALKAIMAKVTEIDDLVGEIASSTQEQAAGLSQVNIAVNQVDQVVQQNAAMVEETTAATRSLKGETEELAALVGRFA
VDDGQDQSRTMARPDAPASRQAVSQLQALADRISASFARRPRYSDGPREEV
>Mature_530_residues
TKESQIVERLSFMNLDSTAQQNIKNAKPILMKALPGALDTFYDQARTFPHTAQFFHNANLIASAKNRQLGHWDYISSGEF
NQDYVKAVTTIGQTHARIGLEPRWYIGGYALVLESLIAAIVEARWPRGILGAGRSSARQVTAELSAVVKATMLDMDFAIS
VYLDALETARQASEARARATNDAVMKAVGEALGRIAQGDLTHRIGDDMPEEYRQLRDDFNLAIAQLSETLSQVQGTAETI
SRGADEIANAADDLSQRTERQAASIQQTAAALDQITASVTRTAGGTKRASGAVNAAKADTRHSGTVVDQAILAMSEIEKS
SNQIARINGIIYDIAFQTNLLALNAGVEAARAGDQGRGFAVVAQEVRALAQRSSEAAREIKALILASAQHVNHGVGLVDE
TGKALKAIMAKVTEIDDLVGEIASSTQEQAAGLSQVNIAVNQVDQVVQQNAAMVEETTAATRSLKGETEELAALVGRFAV
DDGQDQSRTMARPDAPASRQAVSQLQALADRISASFARRPRYSDGPREEV

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein. Note=Localized at the flagellum-bearing pole of the swarmer cell [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI2367378, Length=316, Percent_Identity=43.9873417721519, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1788195, Length=312, Percent_Identity=42.9487179487179, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1788194, Length=295, Percent_Identity=42.3728813559322, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1787690, Length=288, Percent_Identity=42.7083333333333, Blast_Score=192, Evalue=6e-50,
Organism=Escherichia coli, GI1789453, Length=249, Percent_Identity=39.3574297188755, Blast_Score=157, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 56956; Mature: 56825

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2 ; PS50192 T_SNARE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKESQIVERLSFMNLDSTAQQNIKNAKPILMKALPGALDTFYDQARTFPHTAQFFHNAN
CCCHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHCCCHHHHHHHCCC
LIASAKNRQLGHWDYISSGEFNQDYVKAVTTIGQTHARIGLEPRWYIGGYALVLESLIAA
CEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
IVEARWPRGILGAGRSSARQVTAELSAVVKATMLDMDFAISVYLDALETARQASEARARA
HHHHCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNDAVMKAVGEALGRIAQGDLTHRIGDDMPEEYRQLRDDFNLAIAQLSETLSQVQGTAET
HHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
ISRGADEIANAADDLSQRTERQAASIQQTAAALDQITASVTRTAGGTKRASGAVNAAKAD
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCC
TRHSGTVVDQAILAMSEIEKSSNQIARINGIIYDIAFQTNLLALNAGVEAARAGDQGRGF
CCCCCHHHHHHHHHHHHHHHHHCCEEHHHHEEEEEEHHCCEEEEECCCHHHHCCCCCCCH
AVVAQEVRALAQRSSEAAREIKALILASAQHVNHGVGLVDETGKALKAIMAKVTEIDDLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
GEIASSTQEQAAGLSQVNIAVNQVDQVVQQNAAMVEETTAATRSLKGETEELAALVGRFA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VDDGQDQSRTMARPDAPASRQAVSQLQALADRISASFARRPRYSDGPREEV
CCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TKESQIVERLSFMNLDSTAQQNIKNAKPILMKALPGALDTFYDQARTFPHTAQFFHNAN
CCHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHCCCHHHHHHHCCC
LIASAKNRQLGHWDYISSGEFNQDYVKAVTTIGQTHARIGLEPRWYIGGYALVLESLIAA
CEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
IVEARWPRGILGAGRSSARQVTAELSAVVKATMLDMDFAISVYLDALETARQASEARARA
HHHHCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNDAVMKAVGEALGRIAQGDLTHRIGDDMPEEYRQLRDDFNLAIAQLSETLSQVQGTAET
HHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
ISRGADEIANAADDLSQRTERQAASIQQTAAALDQITASVTRTAGGTKRASGAVNAAKAD
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCC
TRHSGTVVDQAILAMSEIEKSSNQIARINGIIYDIAFQTNLLALNAGVEAARAGDQGRGF
CCCCCHHHHHHHHHHHHHHHHHCCEEHHHHEEEEEEHHCCEEEEECCCHHHHCCCCCCCH
AVVAQEVRALAQRSSEAAREIKALILASAQHVNHGVGLVDETGKALKAIMAKVTEIDDLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
GEIASSTQEQAAGLSQVNIAVNQVDQVVQQNAAMVEETTAATRSLKGETEELAALVGRFA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VDDGQDQSRTMARPDAPASRQAVSQLQALADRISASFARRPRYSDGPREEV
CCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1577276; 11259647 [H]