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The map label for this gene is fixC [H]

Identifier: 162146278

GI number: 162146278

Start: 448976

End: 450256

Strand: Direct

Name: fixC [H]

Synonym: GDI_0453

Alternate gene names: 162146278

Gene position: 448976-450256 (Clockwise)

Preceding gene: 162146277

Following gene: 162146279

Centisome position: 11.38

GC content: 63.23

Gene sequence:

>1281_bases
ATGACACAGCACCAATTCGACGCCATCGTCGTGGGGGCCGGCCCGTCGGGGAACGCGGCGGCCTATACGATGGCGCAGCG
CGGCCTGCGCGTCCTGCAGATCGAGCGCGGGGAATATGCGGGATCGAAGAACGTCCAGGGGGCGATCCTGTATTCCGACG
CGCTGGAACGCATCATTCCCGATTTCCGGGAAGACGCGCCGCTGGAACGTCACGTGATCGAACAGCGGATCTGGATGATG
GACGATGCCGGGCATACCGGCATGCATCATCGCAGCGACGATTATAACGAGGAAAGCCCCAACCGTTATACGATCATCCG
CGCCCAGTTCGACAAATGGTTCAACCGCCGCGTGCGGGATGCCGGGGTGACGGTGCTGTATGAAACCACCGTGACCCGGC
TGATCACCGATGCGCGCAAGCGCGTCGTCGGCGTGCAGACCGATCGCGACGGCAACGGCATCTTCGCCGATGTGGTCGTC
CTGGCCGAAGGCGTGAACGGCCTGGTCGGCCTGCGGTCCGGGCTGCGTGACGAATTGCGGCCCGAGAACGTGGCCCTGGC
GGTCAAGGAAATGCATTTCCTGCCGCAGGAGGTGATCGACGCGCGTTTCAACCTCAAGGGCGAGGAAGGCGTGGTGATCG
AGGCCATGGGCACCGTGACCGACGGCATGGTGGGCACGGCGTTCCTGTATACCAACCGCGAATCCATCTCGGTCGGGATC
GGCTGCCTGGTCAGCGAATTCGCCAGGAGCGGCGCCGCGACGCCGCATGGCCTGCTGGACCGCTTCAAGGCGCACCCCAG
CATCCGTCCCCTGCTGGAAGGATCGGAAATCAAGGAATACGCCGCCCACCTGATCCCCGAGGGCGGATATCGCGCCGTCC
CCGAACTGGTGGGTGACGGGTGGATCGTCGCGGGCGATGCCGGGCATTTCGTGAATGCCGTGCACCGGGAAGGATCGAAT
CTCGCGATGACGACCGGTCGCATGGCCGGCGAGGTCGTTGCCAATATCCTGACGAGCGGCCTTTCGTGCTCCGCGACGAA
CCTGGGGGCCTACAAGACGCTCCTGAAGGAATCCTTCGTGATGAAGGACCTGAAGAAATACCGGAACGTGCCGAAAATGC
TGGAAGAAGGCGGGTACAACATCATGAATCTGTATCCGCGCCTGGTGAACCGCGCGGCACAGACGTGGTTCCGCGTGGAC
GGCGTGGACAAGAAGGCCAAGGAATCTGAAATTCTGAAGAATGCATGGCGCGCGCACAGGTGTCGCGGGCCTGCTGGGTG
A

Upstream 100 bases:

>100_bases
GTCGGGATCGTGGCCGATGCGATCACCCTTCTGCCGGCGCTGACCGAGGCTTTCGGACGGCGCCTGTCGGTCAACCGGAT
GGCGAGCTGAGGACAGCATA

Downstream 100 bases:

>100_bases
CGCAATTCAAACTGGCGAGGGCATGGCGATGAGCGATCGGGTCGAAGACCGTCTGTTCCAGAACAGGTATGTCGTGGATG
TCGGGCGGCCGCATATTACC

Product: protein fixC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MTQHQFDAIVVGAGPSGNAAAYTMAQRGLRVLQIERGEYAGSKNVQGAILYSDALERIIPDFREDAPLERHVIEQRIWMM
DDAGHTGMHHRSDDYNEESPNRYTIIRAQFDKWFNRRVRDAGVTVLYETTVTRLITDARKRVVGVQTDRDGNGIFADVVV
LAEGVNGLVGLRSGLRDELRPENVALAVKEMHFLPQEVIDARFNLKGEEGVVIEAMGTVTDGMVGTAFLYTNRESISVGI
GCLVSEFARSGAATPHGLLDRFKAHPSIRPLLEGSEIKEYAAHLIPEGGYRAVPELVGDGWIVAGDAGHFVNAVHREGSN
LAMTTGRMAGEVVANILTSGLSCSATNLGAYKTLLKESFVMKDLKKYRNVPKMLEEGGYNIMNLYPRLVNRAAQTWFRVD
GVDKKAKESEILKNAWRAHRCRGPAG

Sequences:

>Translated_426_residues
MTQHQFDAIVVGAGPSGNAAAYTMAQRGLRVLQIERGEYAGSKNVQGAILYSDALERIIPDFREDAPLERHVIEQRIWMM
DDAGHTGMHHRSDDYNEESPNRYTIIRAQFDKWFNRRVRDAGVTVLYETTVTRLITDARKRVVGVQTDRDGNGIFADVVV
LAEGVNGLVGLRSGLRDELRPENVALAVKEMHFLPQEVIDARFNLKGEEGVVIEAMGTVTDGMVGTAFLYTNRESISVGI
GCLVSEFARSGAATPHGLLDRFKAHPSIRPLLEGSEIKEYAAHLIPEGGYRAVPELVGDGWIVAGDAGHFVNAVHREGSN
LAMTTGRMAGEVVANILTSGLSCSATNLGAYKTLLKESFVMKDLKKYRNVPKMLEEGGYNIMNLYPRLVNRAAQTWFRVD
GVDKKAKESEILKNAWRAHRCRGPAG
>Mature_425_residues
TQHQFDAIVVGAGPSGNAAAYTMAQRGLRVLQIERGEYAGSKNVQGAILYSDALERIIPDFREDAPLERHVIEQRIWMMD
DAGHTGMHHRSDDYNEESPNRYTIIRAQFDKWFNRRVRDAGVTVLYETTVTRLITDARKRVVGVQTDRDGNGIFADVVVL
AEGVNGLVGLRSGLRDELRPENVALAVKEMHFLPQEVIDARFNLKGEEGVVIEAMGTVTDGMVGTAFLYTNRESISVGIG
CLVSEFARSGAATPHGLLDRFKAHPSIRPLLEGSEIKEYAAHLIPEGGYRAVPELVGDGWIVAGDAGHFVNAVHREGSNL
AMTTGRMAGEVVANILTSGLSCSATNLGAYKTLLKESFVMKDLKKYRNVPKMLEEGGYNIMNLYPRLVNRAAQTWFRVDG
VDKKAKESEILKNAWRAHRCRGPAG

Specific function: Could be required for the formation of a functional nitrogenase Fe protein. Probably accepts electrons from fixA/fixB and reduces a quinone [H]

COG id: COG0644

COG function: function code C; Dehydrogenases (flavoproteins)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF-QO/fixC family [H]

Homologues:

Organism=Homo sapiens, GI119703746, Length=404, Percent_Identity=27.7227722772277, Blast_Score=119, Evalue=5e-27,
Organism=Escherichia coli, GI1787991, Length=431, Percent_Identity=36.4269141531323, Blast_Score=256, Evalue=1e-69,
Organism=Escherichia coli, GI1786227, Length=419, Percent_Identity=35.799522673031, Blast_Score=255, Evalue=5e-69,
Organism=Escherichia coli, GI87082155, Length=367, Percent_Identity=34.3324250681199, Blast_Score=192, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI25144720, Length=392, Percent_Identity=25.2551020408163, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324932, Length=413, Percent_Identity=25.4237288135593, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24652256, Length=414, Percent_Identity=24.8792270531401, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.5.5.-

Molecular weight: Translated: 46982; Mature: 46851

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQHQFDAIVVGAGPSGNAAAYTMAQRGLRVLQIERGEYAGSKNVQGAILYSDALERIIP
CCCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEHHHHHHHHCC
DFREDAPLERHVIEQRIWMMDDAGHTGMHHRSDDYNEESPNRYTIIRAQFDKWFNRRVRD
HHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHH
AGVTVLYETTVTRLITDARKRVVGVQTDRDGNGIFADVVVLAEGVNGLVGLRSGLRDELR
CCCEEEEHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCC
PENVALAVKEMHFLPQEVIDARFNLKGEEGVVIEAMGTVTDGMVGTAFLYTNRESISVGI
CCHHHHHHHHHHHCHHHHHHHHCCCCCCCCEEEEECCCHHCCCCEEEEEEECCCHHHHHH
GCLVSEFARSGAATPHGLLDRFKAHPSIRPLLEGSEIKEYAAHLIPEGGYRAVPELVGDG
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCC
WIVAGDAGHFVNAVHREGSNLAMTTGRMAGEVVANILTSGLSCSATNLGAYKTLLKESFV
EEEECCCCHHHHHHHHCCCCEEEECHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
MKDLKKYRNVPKMLEEGGYNIMNLYPRLVNRAAQTWFRVDGVDKKAKESEILKNAWRAHR
HHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHC
CRGPAG
CCCCCC
>Mature Secondary Structure 
TQHQFDAIVVGAGPSGNAAAYTMAQRGLRVLQIERGEYAGSKNVQGAILYSDALERIIP
CCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEHHHHHHHHCC
DFREDAPLERHVIEQRIWMMDDAGHTGMHHRSDDYNEESPNRYTIIRAQFDKWFNRRVRD
HHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHH
AGVTVLYETTVTRLITDARKRVVGVQTDRDGNGIFADVVVLAEGVNGLVGLRSGLRDELR
CCCEEEEHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCC
PENVALAVKEMHFLPQEVIDARFNLKGEEGVVIEAMGTVTDGMVGTAFLYTNRESISVGI
CCHHHHHHHHHHHCHHHHHHHHCCCCCCCCEEEEECCCHHCCCCEEEEEEECCCHHHHHH
GCLVSEFARSGAATPHGLLDRFKAHPSIRPLLEGSEIKEYAAHLIPEGGYRAVPELVGDG
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCC
WIVAGDAGHFVNAVHREGSNLAMTTGRMAGEVVANILTSGLSCSATNLGAYKTLLKESFV
EEEECCCCHHHHHHHHCCCCEEEECHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
MKDLKKYRNVPKMLEEGGYNIMNLYPRLVNRAAQTWFRVDGVDKKAKESEILKNAWRAHR
HHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHC
CRGPAG
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1850088 [H]