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The map label for this gene is serA [H]

Identifier: 162146043

GI number: 162146043

Start: 228330

End: 229289

Strand: Direct

Name: serA [H]

Synonym: GDI_0211

Alternate gene names: 162146043

Gene position: 228330-229289 (Clockwise)

Preceding gene: 162146042

Following gene: 162146047

Centisome position: 5.79

GC content: 72.71

Gene sequence:

>960_bases
GTGGCCACCTGTTTCATCACCCAGCCGATCCACCCCGACGCGGTAGCGCATCTGAACGGCGCGGGCATCGCCACGTGCTA
TGCCAGCCGCGCGACGATGGAGGTGGCAGCGGCCGAAATCGGCGATGCCGAGGCCGTCATCACCCGCGATCTCGGATTCG
ATGAAGCCGCCATCCGTGCCGCGCCCAACCTGCGTCTGATCGCCTGTCACGGCTCGGGCACCAACAGGATCGCGGTTGCC
GCAGCGGCGGCACGGGGGATCTGGGTGACCAACGCGCCGAATACGAACAGCCGCTCGGTCGCGGAACTGACCATGGGGCT
GATCCTGGCCGCCGCGCGGCGCATTCCCGTCGCCGACCGCGCCGTTCGCGACGGGCAGTGGGACTTCCGCTATGCGGCCG
GCGGGATCGAACTCGCCGGCAAGACCCTTGGCCTGATCGGTTTCGGCGCGATCGCGCGGCATGTGGCGGTGATGGCGGGG
GCGGGTTTCGGCATGCGGGTGATGGCCTGGTCCCCCAACGTACCGGACGCGATCTTCGCGCAGGCCGGCGTCATGCGCGC
GGACGGGGTGGAGGCGCTGCTGCGCAGCGCGGACGTCGTCTCCCTGCATCGGCCGGCGGACGCTGCGGGGGCCGCCCCGA
TCGACGCCGCTGCCCTGGCCCTGCTGAAGCCGGGTGCGCTGCTGGTCAATACCAGCCGTGGCACCGCGATCGACGGTGCC
GCCCTGGTCGCGGCCCTGCGGGCCGGAACGCTGGCCGGGGCGGCGCTGGACGTTCTGGCGCAAGAACCCCCGCCCGCGCA
TGACCCGGTGCTATCGGCACCCGGCCTGGTCCTGACGCCCCATCTGGGCGGTGCGACGGACGAGGCCTTGCGCCGCACCG
CGATGCTCTGCGCCCGGCAGGTCGTCGATGCGCTGGCGGGGCGGGCGCCGGCGCACCGCGTGCAAGCGTCCGGCGCCTGA

Upstream 100 bases:

>100_bases
GCGGCCCTGTCCCGCCCCTTCGGCACCGAACTGACGATCGCGGACGGGTCGATCCGGCTTCCCCTTGTGCCCGCGGCCGC
CGGAATGGACGCCTGACGTC

Downstream 100 bases:

>100_bases
TCGGCGCCGATGCCGCCAGGGACTATTTGGCGAAAAGCTGCCCGATATCGGCAAATGCCTTGATTTCGATCGCGTTGCCG
CTGGGGTCCAGGAAGAACAT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MATCFITQPIHPDAVAHLNGAGIATCYASRATMEVAAAEIGDAEAVITRDLGFDEAAIRAAPNLRLIACHGSGTNRIAVA
AAAARGIWVTNAPNTNSRSVAELTMGLILAAARRIPVADRAVRDGQWDFRYAAGGIELAGKTLGLIGFGAIARHVAVMAG
AGFGMRVMAWSPNVPDAIFAQAGVMRADGVEALLRSADVVSLHRPADAAGAAPIDAAALALLKPGALLVNTSRGTAIDGA
ALVAALRAGTLAGAALDVLAQEPPPAHDPVLSAPGLVLTPHLGGATDEALRRTAMLCARQVVDALAGRAPAHRVQASGA

Sequences:

>Translated_319_residues
MATCFITQPIHPDAVAHLNGAGIATCYASRATMEVAAAEIGDAEAVITRDLGFDEAAIRAAPNLRLIACHGSGTNRIAVA
AAAARGIWVTNAPNTNSRSVAELTMGLILAAARRIPVADRAVRDGQWDFRYAAGGIELAGKTLGLIGFGAIARHVAVMAG
AGFGMRVMAWSPNVPDAIFAQAGVMRADGVEALLRSADVVSLHRPADAAGAAPIDAAALALLKPGALLVNTSRGTAIDGA
ALVAALRAGTLAGAALDVLAQEPPPAHDPVLSAPGLVLTPHLGGATDEALRRTAMLCARQVVDALAGRAPAHRVQASGA
>Mature_318_residues
ATCFITQPIHPDAVAHLNGAGIATCYASRATMEVAAAEIGDAEAVITRDLGFDEAAIRAAPNLRLIACHGSGTNRIAVAA
AAARGIWVTNAPNTNSRSVAELTMGLILAAARRIPVADRAVRDGQWDFRYAAGGIELAGKTLGLIGFGAIARHVAVMAGA
GFGMRVMAWSPNVPDAIFAQAGVMRADGVEALLRSADVVSLHRPADAAGAAPIDAAALALLKPGALLVNTSRGTAIDGAA
LVAALRAGTLAGAALDVLAQEPPPAHDPVLSAPGLVLTPHLGGATDEALRRTAMLCARQVVDALAGRAPAHRVQASGA

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=311, Percent_Identity=34.4051446945338, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI145580578, Length=315, Percent_Identity=32.3809523809524, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI4557499, Length=315, Percent_Identity=32.3809523809524, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI61743967, Length=315, Percent_Identity=30.7936507936508, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI4557497, Length=315, Percent_Identity=30.7936507936508, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI145580575, Length=315, Percent_Identity=32.3809523809524, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI6912396, Length=250, Percent_Identity=28, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI1789279, Length=305, Percent_Identity=35.4098360655738, Blast_Score=158, Evalue=4e-40,
Organism=Escherichia coli, GI87082289, Length=290, Percent_Identity=30.6896551724138, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1787645, Length=200, Percent_Identity=33.5, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788660, Length=233, Percent_Identity=25.3218884120172, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=308, Percent_Identity=34.0909090909091, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI25147481, Length=316, Percent_Identity=26.8987341772152, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322116, Length=266, Percent_Identity=36.4661654135338, Blast_Score=152, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6320925, Length=278, Percent_Identity=35.2517985611511, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6324055, Length=257, Percent_Identity=29.5719844357977, Blast_Score=105, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6324964, Length=307, Percent_Identity=26.3843648208469, Blast_Score=90, Evalue=4e-19,
Organism=Drosophila melanogaster, GI19921140, Length=312, Percent_Identity=34.6153846153846, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24646446, Length=315, Percent_Identity=33.968253968254, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646448, Length=315, Percent_Identity=33.968253968254, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646452, Length=315, Percent_Identity=33.968253968254, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646450, Length=315, Percent_Identity=33.968253968254, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI62472511, Length=315, Percent_Identity=33.968253968254, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI28574286, Length=260, Percent_Identity=31.1538461538462, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24585516, Length=259, Percent_Identity=27.027027027027, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24585514, Length=265, Percent_Identity=27.5471698113208, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI28574282, Length=265, Percent_Identity=27.5471698113208, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI45552429, Length=265, Percent_Identity=27.5471698113208, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI28574284, Length=265, Percent_Identity=27.5471698113208, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI28571528, Length=250, Percent_Identity=31.2, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI45551003, Length=265, Percent_Identity=27.5471698113208, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 32229; Mature: 32098

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATCFITQPIHPDAVAHLNGAGIATCYASRATMEVAAAEIGDAEAVITRDLGFDEAAIRA
CEEEEEECCCCCCHHHEECCCCCEEHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHC
APNLRLIACHGSGTNRIAVAAAAARGIWVTNAPNTNSRSVAELTMGLILAAARRIPVADR
CCCEEEEEEECCCCCEEEEEEEHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHH
AVRDGQWDFRYAAGGIELAGKTLGLIGFGAIARHVAVMAGAGFGMRVMAWSPNVPDAIFA
HHCCCCCCEEEECCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHH
QAGVMRADGVEALLRSADVVSLHRPADAAGAAPIDAAALALLKPGALLVNTSRGTAIDGA
HCCCCCCCCHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCHHH
ALVAALRAGTLAGAALDVLAQEPPPAHDPVLSAPGLVLTPHLGGATDEALRRTAMLCARQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHH
VVDALAGRAPAHRVQASGA
HHHHHHCCCCCHHHCCCCC
>Mature Secondary Structure 
ATCFITQPIHPDAVAHLNGAGIATCYASRATMEVAAAEIGDAEAVITRDLGFDEAAIRA
EEEEEECCCCCCHHHEECCCCCEEHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHC
APNLRLIACHGSGTNRIAVAAAAARGIWVTNAPNTNSRSVAELTMGLILAAARRIPVADR
CCCEEEEEEECCCCCEEEEEEEHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHH
AVRDGQWDFRYAAGGIELAGKTLGLIGFGAIARHVAVMAGAGFGMRVMAWSPNVPDAIFA
HHCCCCCCEEEECCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHH
QAGVMRADGVEALLRSADVVSLHRPADAAGAAPIDAAALALLKPGALLVNTSRGTAIDGA
HCCCCCCCCHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCHHH
ALVAALRAGTLAGAALDVLAQEPPPAHDPVLSAPGLVLTPHLGGATDEALRRTAMLCARQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHH
VVDALAGRAPAHRVQASGA
HHHHHHCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]