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The map label for this gene is hisE [H]

Identifier: 162145906

GI number: 162145906

Start: 74335

End: 74862

Strand: Reverse

Name: hisE [H]

Synonym: GDI_0068

Alternate gene names: 162145906

Gene position: 74862-74335 (Counterclockwise)

Preceding gene: 162145907

Following gene: 162145905

Centisome position: 1.9

GC content: 67.8

Gene sequence:

>528_bases
ATGCCAAAGATCCTGAAGACGACCCGCAAGAGCGCCGAGACCAAGGCCGTGGACGACAAGGCCGCCGGCAAGAAAACCGT
CAGCAAGAAGACCGTTGCCAAGAAGGTCGGTGCCAAGAAGACGGTTGCCAAGAAAGCCGTCGGCAAGAAAGTCGCGACGA
CCGCCCCCCTGCCCCCCGCCGTCCCTCCGGCAGCGACGGCCGAGGTGCTGGACCGCCTGTTCGACGTCGTGACCTCCCGC
AAGGGCACCAACCCGTCGATCAGCCATTCGGCGCGGCTGCTGGCGCGGGGCCGGCGCAAGATCGCCCAGAAATTCGGCGA
GGAAGCGGTCGAGTGCCTGATCGAGGCGGTCGCCGGCAACACCGGCGAGCTGGTGGGCGAAAGCGCGGACGTGCTGTACC
ACCTGATCGTCATGTGGGTGGATGCCGGCGTTCACCCGGCGGAGGTGTGGGCCGAACTGCACCGCCGCGAGGGCACCAGC
GGCATCGCCGAAAAGGCCGCCCGCCCCCACGACCCGCTGGCGGAATAA

Upstream 100 bases:

>100_bases
AGGCGCTGGCCGATGCCGGCCTGCCGGTGCGCCACACGCCCGCACACCCCGTACCCTGAACCGCGCCCCCAGCCGCGCCG
GACACCCAGCAGAGGGCATG

Downstream 100 bases:

>100_bases
CACACTACCGAGGAGAGATGTCCATGGCCGTTTCCGGACTGGGTCCGTACGATCCGCAGAACGTCTTCGCCAAGATCCTG
CGTGGGGAAATCCCGTGCCG

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH [H]

Number of amino acids: Translated: 175; Mature: 174

Protein sequence:

>175_residues
MPKILKTTRKSAETKAVDDKAAGKKTVSKKTVAKKVGAKKTVAKKAVGKKVATTAPLPPAVPPAATAEVLDRLFDVVTSR
KGTNPSISHSARLLARGRRKIAQKFGEEAVECLIEAVAGNTGELVGESADVLYHLIVMWVDAGVHPAEVWAELHRREGTS
GIAEKAARPHDPLAE

Sequences:

>Translated_175_residues
MPKILKTTRKSAETKAVDDKAAGKKTVSKKTVAKKVGAKKTVAKKAVGKKVATTAPLPPAVPPAATAEVLDRLFDVVTSR
KGTNPSISHSARLLARGRRKIAQKFGEEAVECLIEAVAGNTGELVGESADVLYHLIVMWVDAGVHPAEVWAELHRREGTS
GIAEKAARPHDPLAE
>Mature_174_residues
PKILKTTRKSAETKAVDDKAAGKKTVSKKTVAKKVGAKKTVAKKAVGKKVATTAPLPPAVPPAATAEVLDRLFDVVTSRK
GTNPSISHSARLLARGRRKIAQKFGEEAVECLIEAVAGNTGELVGESADVLYHLIVMWVDAGVHPAEVWAELHRREGTSG
IAEKAARPHDPLAE

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=88, Percent_Identity=37.5, Blast_Score=66, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008179
- InterPro:   IPR021130 [H]

Pfam domain/function: PF01503 PRA-PH [H]

EC number: =3.6.1.31 [H]

Molecular weight: Translated: 18571; Mature: 18439

Theoretical pI: Translated: 10.60; Mature: 10.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKILKTTRKSAETKAVDDKAAGKKTVSKKTVAKKVGAKKTVAKKAVGKKVATTAPLPPA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCC
VPPAATAEVLDRLFDVVTSRKGTNPSISHSARLLARGRRKIAQKFGEEAVECLIEAVAGN
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TGELVGESADVLYHLIVMWVDAGVHPAEVWAELHRREGTSGIAEKAARPHDPLAE
CHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PKILKTTRKSAETKAVDDKAAGKKTVSKKTVAKKVGAKKTVAKKAVGKKVATTAPLPPA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCC
VPPAATAEVLDRLFDVVTSRKGTNPSISHSARLLARGRRKIAQKFGEEAVECLIEAVAGN
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TGELVGESADVLYHLIVMWVDAGVHPAEVWAELHRREGTSGIAEKAARPHDPLAE
CHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA