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The map label for this gene is ntpA [H]

Identifier: 161869575

GI number: 161869575

Start: 613182

End: 613640

Strand: Reverse

Name: ntpA [H]

Synonym: NMCC_0590

Alternate gene names: 161869575

Gene position: 613640-613182 (Counterclockwise)

Preceding gene: 161869598

Following gene: 161869574

Centisome position: 28.5

GC content: 57.08

Gene sequence:

>459_bases
ATGCCGATGGCAAAACCGCTCAAATACCCCGTTTCCGCACTGGTCGTCCTTTATAGCGGGGACGGCGGCATCCTGCTCAT
CGAACGCACGCATCCGGAAGGATTTTGGCAGTCGGTAACCGGCAGCCTCGAACCGGGCGAAACCGTCGCCCAAACGGCAA
GGCGCGAAGTTTGGGAAGAAACCGGCATCCTGCTGGCGGACGGGCAGCTTCAAGACTGGCACGACAGCACGGTTTACGAA
ATCTACCACCACTGGCGGCACCGCTATCCAAAAGGCGTGTTTGAAAACCGCGAACACCTCTTCTCTGCCGAAATCCCGCG
TGATACGCCCATCGCCCTGCAACCCGAAGAACACGTCTCCTACGGTTGGTTCGATATGGAAGAAGCAGCGGAAAAAGTAT
TTTCCCCGTCCAACAGGCGCGCGATTTTGGAACTGGGCAGGTTTTTGGGCAAACGGTAA

Upstream 100 bases:

>100_bases
CGTCCCATCCGTGCAGAAAAAAGGATACGGAAAAGGATAAACGCCATAACGTGCGGCGTTTGCTATAATCCGCCCCTTCA
TTACCGCAGCCCGCCGAAAG

Downstream 100 bases:

>100_bases
CACGCGCCCGTACACCCTTTCAGAGGCATCGGGCGCATTTTCAGCCGGACGTTTGTGCTATACTTTCAAACTTCACACTT
TCCCAAACAAAGGAAACCAA

Product: dATP pyrophosphohydrolase

Products: dAMP; pyrophosphate [C]

Alternate protein names: dATP pyrophosphohydrolase [H]

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MPMAKPLKYPVSALVVLYSGDGGILLIERTHPEGFWQSVTGSLEPGETVAQTARREVWEETGILLADGQLQDWHDSTVYE
IYHHWRHRYPKGVFENREHLFSAEIPRDTPIALQPEEHVSYGWFDMEEAAEKVFSPSNRRAILELGRFLGKR

Sequences:

>Translated_152_residues
MPMAKPLKYPVSALVVLYSGDGGILLIERTHPEGFWQSVTGSLEPGETVAQTARREVWEETGILLADGQLQDWHDSTVYE
IYHHWRHRYPKGVFENREHLFSAEIPRDTPIALQPEEHVSYGWFDMEEAAEKVFSPSNRRAILELGRFLGKR
>Mature_151_residues
PMAKPLKYPVSALVVLYSGDGGILLIERTHPEGFWQSVTGSLEPGETVAQTARREVWEETGILLADGQLQDWHDSTVYEI
YHHWRHRYPKGVFENREHLFSAEIPRDTPIALQPEEHVSYGWFDMEEAAEKVFSPSNRRAILELGRFLGKR

Specific function: Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788172, Length=141, Percent_Identity=43.9716312056738, Blast_Score=102, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003564
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 17504; Mature: 17373

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMAKPLKYPVSALVVLYSGDGGILLIERTHPEGFWQSVTGSLEPGETVAQTARREVWEE
CCCCCCCCCCCEEEEEEEECCCCEEEEEECCCCHHHHHHCCCCCCCHHHHHHHHHHHHHH
TGILLADGQLQDWHDSTVYEIYHHWRHRYPKGVFENREHLFSAEIPRDTPIALQPEEHVS
CCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHEECCCCCCCCEEECCHHHCC
YGWFDMEEAAEKVFSPSNRRAILELGRFLGKR
CCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
PMAKPLKYPVSALVVLYSGDGGILLIERTHPEGFWQSVTGSLEPGETVAQTARREVWEE
CCCCCCCCCCEEEEEEEECCCCEEEEEECCCCHHHHHHCCCCCCCHHHHHHHHHHHHHH
TGILLADGQLQDWHDSTVYEIYHHWRHRYPKGVFENREHLFSAEIPRDTPIALQPEEHVS
CCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHEECCCCCCCCEEECCHHHCC
YGWFDMEEAAEKVFSPSNRRAILELGRFLGKR
CCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxy-ATP; H2O [C]

Specific reaction: deoxy-ATP + H2O = dAMP + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]