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The map label for this gene is hisI [H]

Identifier: 161869560

GI number: 161869560

Start: 600457

End: 600807

Strand: Reverse

Name: hisI [H]

Synonym: NMCC_0575

Alternate gene names: 161869560

Gene position: 600807-600457 (Counterclockwise)

Preceding gene: 161869561

Following gene: 161869559

Centisome position: 27.9

GC content: 57.26

Gene sequence:

>351_bases
TTGGTTTGCGCCATCGCCCAAGATGCCGAAACCAAACGTGTTTTAATGGTGGCGTGGATGAACGCCGAAGCCCTGCAAAA
AACCGTCGAAACCGGCTTTGCCCACTATTACAGCCGTTCGCGCCAAAAACAATGGATGAAGGGCGAAGAGTCGGGACACA
CGCAAAAAGTCCGCGAACTGCGCCTCGACTGCGACGGTGACGCCATTGTGATGCTCATCGCCCAAAACGGCGGCATCGCC
TGCCACACCGGGCGCGAAAGCTGCTTTTACAAAGTCTGGCGCGGCGGCGCGTGGGAAACCGCCGATGCCGTCCTGAAAGA
CGAAAAAGAGATTTACGGCAGCACGCACTGA

Upstream 100 bases:

>100_bases
AGCCGGCATCGAAGTGCGCCTCTGACCGCCCCGACTATGCCGTCTGAAAGGAAATATGGATAAAAACCTGCTTGAAGCCG
TCAAATTTGACGAAAAAGGT

Downstream 100 bases:

>100_bases
CCGCCTCCAACATTGAATTATCAGGCATTTTTTTGTACAATTTCGCCGTCTCAAACACTGTCCGGGCCGTCTGAAAAGCG
GCCTGAACTTTTTACAAAGA

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 116; Mature: 116

Protein sequence:

>116_residues
MVCAIAQDAETKRVLMVAWMNAEALQKTVETGFAHYYSRSRQKQWMKGEESGHTQKVRELRLDCDGDAIVMLIAQNGGIA
CHTGRESCFYKVWRGGAWETADAVLKDEKEIYGSTH

Sequences:

>Translated_116_residues
MVCAIAQDAETKRVLMVAWMNAEALQKTVETGFAHYYSRSRQKQWMKGEESGHTQKVRELRLDCDGDAIVMLIAQNGGIA
CHTGRESCFYKVWRGGAWETADAVLKDEKEIYGSTH
>Mature_116_residues
MVCAIAQDAETKRVLMVAWMNAEALQKTVETGFAHYYSRSRQKQWMKGEESGHTQKVRELRLDCDGDAIVMLIAQNGGIA
CHTGRESCFYKVWRGGAWETADAVLKDEKEIYGSTH

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=89, Percent_Identity=42.6966292134831, Blast_Score=82, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319819, Length=80, Percent_Identity=36.25, Blast_Score=67, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 13100; Mature: 13100

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVCAIAQDAETKRVLMVAWMNAEALQKTVETGFAHYYSRSRQKQWMKGEESGHTQKVREL
CEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
RLDCDGDAIVMLIAQNGGIACHTGRESCFYKVWRGGAWETADAVLKDEKEIYGSTH
HCCCCCCEEEEEEECCCCEEEECCCCHHHHHHHCCCCCCHHHHHHHCCHHHCCCCC
>Mature Secondary Structure
MVCAIAQDAETKRVLMVAWMNAEALQKTVETGFAHYYSRSRQKQWMKGEESGHTQKVREL
CEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
RLDCDGDAIVMLIAQNGGIACHTGRESCFYKVWRGGAWETADAVLKDEKEIYGSTH
HCCCCCCEEEEEEECCCCEEEECCCCHHHHHHHCCCCCCHHHHHHHCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA