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The map label for this gene is folK [H]

Identifier: 161525797

GI number: 161525797

Start: 2863692

End: 2864231

Strand: Direct

Name: folK [H]

Synonym: Bmul_2628

Alternate gene names: 161525797

Gene position: 2863692-2864231 (Clockwise)

Preceding gene: 161525796

Following gene: 161525798

Centisome position: 83.04

GC content: 67.22

Gene sequence:

>540_bases
ATGACGGTTGCATATCTCGGGCTCGGCGCAAATCTCGGCGATGCGCGCCAGACCCTGAAGGACGCGGTGGTGTGTCTCGC
GCAGCAGCGCACCATCACGATTCTCGACAAGTCGAGCCTGTACCGCACCGCGCCGATCGATGCGGGCGGCGACGACTACT
ACAACTGCGTCGTCAAGGTCGACACGACGCTCGCCGCCCGCGAGCTGCTCGCGCTCTGCCAGAAGATCGAACATCACTTC
GGCCGCGAACGTCCGTACCGCAACGCGCCGCGCACGCTCGACATCGACATCCTGCTGTTCGGCGCCGATTCGATCGACGA
AGCCGACCTGATCGTCCCGCATCCGCGCCTGACCGAGCGCGCCTTCGCGCTCGTGCCGCTCGTCGAGATCGAGCCGCTGC
TCGACATTCCGGCGCGCGGCCGCGCCGACGCATTCCTCGCTGCGGTCGCGCACCAGCGCATCGAGAAGGTGCAGACCTGT
CAGTGCCTGATGAAGGCGCTCGCCGCCGGCGACGGCGCCGACAAGAACCGCTGCCGATGA

Upstream 100 bases:

>100_bases
ACCGCAAGTCGGGCGAAGGCGCCGCCGAGCAGGCGCCCGATACCGCGGGCAGCTCCGACGACTGACGCGCTCGCCGGCGA
ACGACGCAGGAAGTGATGCC

Downstream 100 bases:

>100_bases
ACCCGACACCGCTGACCGTCACCGCGCCCGATCTGCGCGCCCCGCATCGCTATCTCGTGATCGAAGGGCCGATCGGCGTC
GGCAAGACGACGCTCGCACG

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 179; Mature: 178

Protein sequence:

>179_residues
MTVAYLGLGANLGDARQTLKDAVVCLAQQRTITILDKSSLYRTAPIDAGGDDYYNCVVKVDTTLAARELLALCQKIEHHF
GRERPYRNAPRTLDIDILLFGADSIDEADLIVPHPRLTERAFALVPLVEIEPLLDIPARGRADAFLAAVAHQRIEKVQTC
QCLMKALAAGDGADKNRCR

Sequences:

>Translated_179_residues
MTVAYLGLGANLGDARQTLKDAVVCLAQQRTITILDKSSLYRTAPIDAGGDDYYNCVVKVDTTLAARELLALCQKIEHHF
GRERPYRNAPRTLDIDILLFGADSIDEADLIVPHPRLTERAFALVPLVEIEPLLDIPARGRADAFLAAVAHQRIEKVQTC
QCLMKALAAGDGADKNRCR
>Mature_178_residues
TVAYLGLGANLGDARQTLKDAVVCLAQQRTITILDKSSLYRTAPIDAGGDDYYNCVVKVDTTLAARELLALCQKIEHHFG
RERPYRNAPRTLDIDILLFGADSIDEADLIVPHPRLTERAFALVPLVEIEPLLDIPARGRADAFLAAVAHQRIEKVQTCQ
CLMKALAAGDGADKNRCR

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=139, Percent_Identity=43.1654676258993, Blast_Score=100, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6324073, Length=150, Percent_Identity=36, Blast_Score=95, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19655; Mature: 19524

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVAYLGLGANLGDARQTLKDAVVCLAQQRTITILDKSSLYRTAPIDAGGDDYYNCVVKV
CEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCEEECCCCCCCCCCEEEEEEE
DTTLAARELLALCQKIEHHFGRERPYRNAPRTLDIDILLFGADSIDEADLIVPHPRLTER
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEECCCCHHHH
AFALVPLVEIEPLLDIPARGRADAFLAAVAHQRIEKVQTCQCLMKALAAGDGADKNRCR
HHHHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TVAYLGLGANLGDARQTLKDAVVCLAQQRTITILDKSSLYRTAPIDAGGDDYYNCVVKV
EEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCEEECCCCCCCCCCEEEEEEE
DTTLAARELLALCQKIEHHFGRERPYRNAPRTLDIDILLFGADSIDEADLIVPHPRLTER
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEECCCCHHHH
AFALVPLVEIEPLLDIPARGRADAFLAAVAHQRIEKVQTCQCLMKALAAGDGADKNRCR
HHHHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 2123867 [H]