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The map label for this gene is mutL [H]

Identifier: 161525790

GI number: 161525790

Start: 2855843

End: 2857831

Strand: Direct

Name: mutL [H]

Synonym: Bmul_2621

Alternate gene names: 161525790

Gene position: 2855843-2857831 (Clockwise)

Preceding gene: 161525788

Following gene: 161525791

Centisome position: 82.81

GC content: 70.39

Gene sequence:

>1989_bases
ATGTCCGAATTCACCGAAACGGCCGCGACCGCCGCGCCCGCCCCTGCTCCGCGCCCGCTACGCGCGATCCAGCCCCTGCC
CGACCAGCTGATCAGCCAGATCGCCGCGGGCGAGGTCGTCGAACGTCCGGCGTCGGTCGTCAAGGAATTGCTCGAGAACG
CGATGGACGCCGGCGCGACGACGCTGCGCATCGTGCTCGAGGAAGGCGGCGTGAAGCGCATCTCGATCACCGACGACGGC
TGCGGGATTCCGCCCAACGAGCTGCCGCTCGCGCTGATGCGCCACGCGACGAGCAAGATCCGCTCGCTCGAGGAGCTCGA
AGCGGTCGCGACGCTCGGATTCCGCGGCGAGGCGCTCGCGTCGATCGCGTCGGTCGCCGAGATGTACATCACGAGCCGCA
CGGCGGACGCCGCGCACGCGACGCGCATCGACGCGCAGACGGGCGTGCTGTCGCCCGCGGCCGGCGCGGTCGGTACGACG
ATCGAGGTGCGCGAGCTGTACTTCAACACGCCCGCGCGCCGCAAGTTCCTCAAGAGCGAGCAGACCGAATTCGGCCACTG
CGTCGAAATGATCCGCCGCGCGGCGCTCGCGCGGCCGGATGTCGCGATCTCGGTGCTGCACAACGGCAAGGCCGTCGAGC
ACTGGAACGCGACCGAGCCTGCGCAGCGCGTCGCGAAGATCCTCGGCGACGGTTTTGCGACCGCGCACCTGCCGCTCGAC
GAGCGCGCGGGCCCGCTCGCCGTCTACGGCTGCGCCGGGCTGCCGACTGCAAGCCGCGGCCGCGCGGACCAGCAATACTT
CTTCGTGAACGGCCGCTTCGTGCGCGACAAGCTGCTCACGCACGCGGTGCGGGCCGCGTACGAGGACGTGCTGCACGGCG
ACCGCTATCCGTCGTACGTGCTGTTCCTCGACCTGCCGCCGGAAGCGGTCGACGTCAACGTGCATCCGTCGAAGATCGAG
GTACGGTTCCGCGATTCGCGCTCGATCCACCAGTTCGTATTCCATGCGGTGCAGCGCGCGCTTGCGCGCCATGCGGGCGC
GTCGCCGGAAACCACCGCGGGCGGTCACGCCGCGCATCTCGAACCGGCGCCGCGCGGCCCGGCATCGTTCCTCTCGACGC
CGCTCGGCCAAAGCCCGAATCAGCCCGCATCGACGGGCGGCAGCGGTTTCTCGTCGCCGTCTTCGTCGGCGCCGGGCAGC
ACATGGCTGCGCCAGGCACGCATGACGCAGGGCACGCTGCCCGTCGCGCAGCCGCTCGCGCTCTACGATGCGCTGTTCGG
CCGCAAGGACACGAGCGCGGCCACGCCGGACGCCACGACGGCGACGGCAGGCGACGCACCCGACGACTCGGCTGCGCCGC
TGGCGGGGTTCGCGGCGCTGCCGTCTGCCGCGTCCATGCACGACGAGCAGCCGCTCGGTTTTGCGCTCGGCCAGATCCAC
GGCATCTACGTGCTGGCGCAGAACGCGCACGGGCTCGTGATCGTCGACATGCATGCGGCGCACGAACGCATCCTGTACGA
GCAGTTCAAGAACGCGCTGGCGGACCGCACGGTGGCCGTGCAGTCGCTGCTGCTGCCGGTATCGATGACGGCGACGCCGG
TCGAGATCGGCACCGTCGAGGAAGAGCGCGACACGCTCGAAGCGCTCGGCTTCGATCTCGCCGTGCTGTCGCCGACGTCG
CTCGCGATCCGCGCGGTGCCTGCGCTGCTGAAGGACGCCGACCTGCAGGCGCTCGCGCGCGCGGTGCTCGCCGATCTGCA
CGCGTTCGGCGGCTCGCGCGTGCTGACCGAACGCCAGCACGAACTGCTCGGCACGCTCGCGTGCCATCACGCGGTGCGCG
CGAACCGGCGTCTGACGCTCGACGAAATGAACGCGCTGCTGCGTCAGATGGAAGCGACCGAACGCGCGGACCAGTGCAAT
CACGGCCGGCCGACCTGGTATCAGCTCACGCTGAGCGATCTCGACCGCCTGTTCATGCGCGGCCAATGA

Upstream 100 bases:

>100_bases
CGCGACGCAGCCATGATACCCAAACTGCCTTCGCGCTCCGTGAAAAAACGTAACGGCCGGCAGCGCCGGCACGCATCCGC
GGCCTCGCTATAATTCGGCC

Downstream 100 bases:

>100_bases
GCGTGTCCGCGCAGTCCGTCCCGACGACGATCGCCTGTCTGCTCGGCCCCACCGCATCGGGCAAGACGGCCGCTGCGCTG
GCGCTCGCCGCGCGCCGGCC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 662; Mature: 661

Protein sequence:

>662_residues
MSEFTETAATAAPAPAPRPLRAIQPLPDQLISQIAAGEVVERPASVVKELLENAMDAGATTLRIVLEEGGVKRISITDDG
CGIPPNELPLALMRHATSKIRSLEELEAVATLGFRGEALASIASVAEMYITSRTADAAHATRIDAQTGVLSPAAGAVGTT
IEVRELYFNTPARRKFLKSEQTEFGHCVEMIRRAALARPDVAISVLHNGKAVEHWNATEPAQRVAKILGDGFATAHLPLD
ERAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYVLFLDLPPEAVDVNVHPSKIE
VRFRDSRSIHQFVFHAVQRALARHAGASPETTAGGHAAHLEPAPRGPASFLSTPLGQSPNQPASTGGSGFSSPSSSAPGS
TWLRQARMTQGTLPVAQPLALYDALFGRKDTSAATPDATTATAGDAPDDSAAPLAGFAALPSAASMHDEQPLGFALGQIH
GIYVLAQNAHGLVIVDMHAAHERILYEQFKNALADRTVAVQSLLLPVSMTATPVEIGTVEEERDTLEALGFDLAVLSPTS
LAIRAVPALLKDADLQALARAVLADLHAFGGSRVLTERQHELLGTLACHHAVRANRRLTLDEMNALLRQMEATERADQCN
HGRPTWYQLTLSDLDRLFMRGQ

Sequences:

>Translated_662_residues
MSEFTETAATAAPAPAPRPLRAIQPLPDQLISQIAAGEVVERPASVVKELLENAMDAGATTLRIVLEEGGVKRISITDDG
CGIPPNELPLALMRHATSKIRSLEELEAVATLGFRGEALASIASVAEMYITSRTADAAHATRIDAQTGVLSPAAGAVGTT
IEVRELYFNTPARRKFLKSEQTEFGHCVEMIRRAALARPDVAISVLHNGKAVEHWNATEPAQRVAKILGDGFATAHLPLD
ERAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYVLFLDLPPEAVDVNVHPSKIE
VRFRDSRSIHQFVFHAVQRALARHAGASPETTAGGHAAHLEPAPRGPASFLSTPLGQSPNQPASTGGSGFSSPSSSAPGS
TWLRQARMTQGTLPVAQPLALYDALFGRKDTSAATPDATTATAGDAPDDSAAPLAGFAALPSAASMHDEQPLGFALGQIH
GIYVLAQNAHGLVIVDMHAAHERILYEQFKNALADRTVAVQSLLLPVSMTATPVEIGTVEEERDTLEALGFDLAVLSPTS
LAIRAVPALLKDADLQALARAVLADLHAFGGSRVLTERQHELLGTLACHHAVRANRRLTLDEMNALLRQMEATERADQCN
HGRPTWYQLTLSDLDRLFMRGQ
>Mature_661_residues
SEFTETAATAAPAPAPRPLRAIQPLPDQLISQIAAGEVVERPASVVKELLENAMDAGATTLRIVLEEGGVKRISITDDGC
GIPPNELPLALMRHATSKIRSLEELEAVATLGFRGEALASIASVAEMYITSRTADAAHATRIDAQTGVLSPAAGAVGTTI
EVRELYFNTPARRKFLKSEQTEFGHCVEMIRRAALARPDVAISVLHNGKAVEHWNATEPAQRVAKILGDGFATAHLPLDE
RAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYVLFLDLPPEAVDVNVHPSKIEV
RFRDSRSIHQFVFHAVQRALARHAGASPETTAGGHAAHLEPAPRGPASFLSTPLGQSPNQPASTGGSGFSSPSSSAPGST
WLRQARMTQGTLPVAQPLALYDALFGRKDTSAATPDATTATAGDAPDDSAAPLAGFAALPSAASMHDEQPLGFALGQIHG
IYVLAQNAHGLVIVDMHAAHERILYEQFKNALADRTVAVQSLLLPVSMTATPVEIGTVEEERDTLEALGFDLAVLSPTSL
AIRAVPALLKDADLQALARAVLADLHAFGGSRVLTERQHELLGTLACHHAVRANRRLTLDEMNALLRQMEATERADQCNH
GRPTWYQLTLSDLDRLFMRGQ

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=330, Percent_Identity=34.8484848484849, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI4505911, Length=351, Percent_Identity=29.0598290598291, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI189458898, Length=351, Percent_Identity=29.0598290598291, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI189458896, Length=341, Percent_Identity=30.791788856305, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI4505913, Length=347, Percent_Identity=26.8011527377522, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI310128478, Length=347, Percent_Identity=26.8011527377522, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI263191589, Length=235, Percent_Identity=31.4893617021277, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI310128480, Length=300, Percent_Identity=25, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI91992162, Length=269, Percent_Identity=26.3940520446097, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI91992160, Length=269, Percent_Identity=26.3940520446097, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1790612, Length=580, Percent_Identity=38.6206896551724, Blast_Score=333, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=34.6875, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17562796, Length=364, Percent_Identity=26.0989010989011, Blast_Score=136, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6323819, Length=313, Percent_Identity=34.185303514377, Blast_Score=183, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6324247, Length=361, Percent_Identity=25.7617728531856, Blast_Score=124, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6325093, Length=703, Percent_Identity=20.3413940256046, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6323063, Length=386, Percent_Identity=24.3523316062176, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136968, Length=313, Percent_Identity=34.8242811501597, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI17136970, Length=384, Percent_Identity=27.34375, Blast_Score=107, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 70829; Mature: 70698

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFTETAATAAPAPAPRPLRAIQPLPDQLISQIAAGEVVERPASVVKELLENAMDAGAT
CCCHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
TLRIVLEEGGVKRISITDDGCGIPPNELPLALMRHATSKIRSLEELEAVATLGFRGEALA
EEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
SIASVAEMYITSRTADAAHATRIDAQTGVLSPAAGAVGTTIEVRELYFNTPARRKFLKSE
HHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCCCEEEEHHHHHCCHHHHHHHHHH
QTEFGHCVEMIRRAALARPDVAISVLHNGKAVEHWNATEPAQRVAKILGDGFATAHLPLD
CCHHHHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCCHHHHHHHHHCCCCEEEECCCC
ERAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYV
CCCCCEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEE
LFLDLPPEAVDVNVHPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPETTAGGHAAHL
EEEECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEC
EPAPRGPASFLSTPLGQSPNQPASTGGSGFSSPSSSAPGSTWLRQARMTQGTLPVAQPLA
CCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHH
LYDALFGRKDTSAATPDATTATAGDAPDDSAAPLAGFAALPSAASMHDEQPLGFALGQIH
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHCCCCCCCHHHHHHHC
GIYVLAQNAHGLVIVDMHAAHERILYEQFKNALADRTVAVQSLLLPVSMTATPVEIGTVE
EEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCH
EERDTLEALGFDLAVLSPTSLAIRAVPALLKDADLQALARAVLADLHAFGGSRVLTERQH
HHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
ELLGTLACHHAVRANRRLTLDEMNALLRQMEATERADQCNHGRPTWYQLTLSDLDRLFMR
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHC
GQ
CC
>Mature Secondary Structure 
SEFTETAATAAPAPAPRPLRAIQPLPDQLISQIAAGEVVERPASVVKELLENAMDAGAT
CCHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
TLRIVLEEGGVKRISITDDGCGIPPNELPLALMRHATSKIRSLEELEAVATLGFRGEALA
EEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
SIASVAEMYITSRTADAAHATRIDAQTGVLSPAAGAVGTTIEVRELYFNTPARRKFLKSE
HHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCCCEEEEHHHHHCCHHHHHHHHHH
QTEFGHCVEMIRRAALARPDVAISVLHNGKAVEHWNATEPAQRVAKILGDGFATAHLPLD
CCHHHHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCCHHHHHHHHHCCCCEEEECCCC
ERAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYV
CCCCCEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEE
LFLDLPPEAVDVNVHPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPETTAGGHAAHL
EEEECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEC
EPAPRGPASFLSTPLGQSPNQPASTGGSGFSSPSSSAPGSTWLRQARMTQGTLPVAQPLA
CCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHH
LYDALFGRKDTSAATPDATTATAGDAPDDSAAPLAGFAALPSAASMHDEQPLGFALGQIH
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHCCCCCCCHHHHHHHC
GIYVLAQNAHGLVIVDMHAAHERILYEQFKNALADRTVAVQSLLLPVSMTATPVEIGTVE
EEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCH
EERDTLEALGFDLAVLSPTSLAIRAVPALLKDADLQALARAVLADLHAFGGSRVLTERQH
HHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
ELLGTLACHHAVRANRRLTLDEMNALLRQMEATERADQCNHGRPTWYQLTLSDLDRLFMR
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHC
GQ
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]