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The map label for this gene is mscS [H]

Identifier: 161525788

GI number: 161525788

Start: 2853979

End: 2854791

Strand: Direct

Name: mscS [H]

Synonym: Bmul_2619

Alternate gene names: 161525788

Gene position: 2853979-2854791 (Clockwise)

Preceding gene: 161525786

Following gene: 161525790

Centisome position: 82.76

GC content: 65.44

Gene sequence:

>813_bases
ATGCTGAACCTGGAAACCGCCCAACAATTCCTGATGACCCGCGGCCTCGACTTCGGCCTGAACCTGCTCGCCGCGATCGC
GCTCTGGTTCATCGGCCGCTGGGCGATTCACGTCGGCACACGCCTGCTCGGCAAGGTCGTGCGCCGCTCCGGCAAGGTCG
ATCCGACGCTTGCCGACTATCTGAGCTCCGTCGTCAGCGTGCTGCTGACGATCCTGCTGATCCTCGCCATCCTGCAGCTC
TTCGGTGTGCAGACCACGTCGTTCGCCGCGCTGCTCGCCGGCCTCGGTCTCGCGATCGGTACGGCATGGGGCGGGCTGCT
GTCGCATTTCGCCGCAGGCGTGTTCATGCAGGTGCTGCGCCCGTTCAAGGTCGGCGACGTCATCAGCGCGGGCGGCGTCA
CCGGTACGGTGAAGGAGCTCGGCCTGTTCGGCACGACGATCATCACGGCCGACAACATCGTGACGATCGTCGGCAACAAC
AAGATCTTCTCCGACAACATCGCCAACTACAGCGCAACGCCGTACCGCCGCGTCGATCTGACGGCGAAGATTGCGAACGG
CGTCGATGCGGTCGACGCGATCAACCGGCTCAAGGCCGCGGTCCAGAAGATTCCGAACGTGCTGACCGATCCGGCGCCCG
ACGTCGGCGTGCTGCAGTTCACGCCCGAAGGGCCGCTGCTGTTCGTGCGCCCATCCACGCAGCCCGCGAACTACTGGCAG
GTCTACTGCGACACGCACCGCGTGATTCTCGAAACGTTCCGCGACGCGCAGTACCCGACGCCCGAAACGCCGGTCGCGCA
TCGCAGCGCATGA

Upstream 100 bases:

>100_bases
CGTTTTAACACTCTTTCATTTTCGATCGTTATTTCTTCGGTTATAACCGTCCGATTCAAAATCGGCCCCCGGCCGCCCTT
CAACCCGCCACGGAGCCCCC

Downstream 100 bases:

>100_bases
TGGCGTCGCGACGCAAACGCAAACGCGACACGGCAGCCTCCACCGAAACGACGAACGAACAAAGCGGGCGGACCGCGCCG
AAAGCGGCCGCCACAAAACA

Product: MscS mechanosensitive ion channel

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MLNLETAQQFLMTRGLDFGLNLLAAIALWFIGRWAIHVGTRLLGKVVRRSGKVDPTLADYLSSVVSVLLTILLILAILQL
FGVQTTSFAALLAGLGLAIGTAWGGLLSHFAAGVFMQVLRPFKVGDVISAGGVTGTVKELGLFGTTIITADNIVTIVGNN
KIFSDNIANYSATPYRRVDLTAKIANGVDAVDAINRLKAAVQKIPNVLTDPAPDVGVLQFTPEGPLLFVRPSTQPANYWQ
VYCDTHRVILETFRDAQYPTPETPVAHRSA

Sequences:

>Translated_270_residues
MLNLETAQQFLMTRGLDFGLNLLAAIALWFIGRWAIHVGTRLLGKVVRRSGKVDPTLADYLSSVVSVLLTILLILAILQL
FGVQTTSFAALLAGLGLAIGTAWGGLLSHFAAGVFMQVLRPFKVGDVISAGGVTGTVKELGLFGTTIITADNIVTIVGNN
KIFSDNIANYSATPYRRVDLTAKIANGVDAVDAINRLKAAVQKIPNVLTDPAPDVGVLQFTPEGPLLFVRPSTQPANYWQ
VYCDTHRVILETFRDAQYPTPETPVAHRSA
>Mature_270_residues
MLNLETAQQFLMTRGLDFGLNLLAAIALWFIGRWAIHVGTRLLGKVVRRSGKVDPTLADYLSSVVSVLLTILLILAILQL
FGVQTTSFAALLAGLGLAIGTAWGGLLSHFAAGVFMQVLRPFKVGDVISAGGVTGTVKELGLFGTTIITADNIVTIVGNN
KIFSDNIANYSATPYRRVDLTAKIANGVDAVDAINRLKAAVQKIPNVLTDPAPDVGVLQFTPEGPLLFVRPSTQPANYWQ
VYCDTHRVILETFRDAQYPTPETPVAHRSA

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=259, Percent_Identity=32.4324324324324, Blast_Score=123, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 29028; Mature: 29028

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNLETAQQFLMTRGLDFGLNLLAAIALWFIGRWAIHVGTRLLGKVVRRSGKVDPTLADY
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
LSSVVSVLLTILLILAILQLFGVQTTSFAALLAGLGLAIGTAWGGLLSHFAAGVFMQVLR
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PFKVGDVISAGGVTGTVKELGLFGTTIITADNIVTIVGNNKIFSDNIANYSATPYRRVDL
CCCCCCHHHCCCCCHHHHHHHHHHHHEEECCCEEEEEECCEEECCCCCCCCCCCCEEEEH
TAKIANGVDAVDAINRLKAAVQKIPNVLTDPAPDVGVLQFTPEGPLLFVRPSTQPANYWQ
HHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEECCCCCCCCEE
VYCDTHRVILETFRDAQYPTPETPVAHRSA
EEEHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLNLETAQQFLMTRGLDFGLNLLAAIALWFIGRWAIHVGTRLLGKVVRRSGKVDPTLADY
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
LSSVVSVLLTILLILAILQLFGVQTTSFAALLAGLGLAIGTAWGGLLSHFAAGVFMQVLR
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PFKVGDVISAGGVTGTVKELGLFGTTIITADNIVTIVGNNKIFSDNIANYSATPYRRVDL
CCCCCCHHHCCCCCHHHHHHHHHHHHEEECCCEEEEEECCEEECCCCCCCCCCCCEEEEH
TAKIANGVDAVDAINRLKAAVQKIPNVLTDPAPDVGVLQFTPEGPLLFVRPSTQPANYWQ
HHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEECCCCCCCCEE
VYCDTHRVILETFRDAQYPTPETPVAHRSA
EEEHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]