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The map label for this gene is hcrC [H]

Identifier: 161525721

GI number: 161525721

Start: 2776483

End: 2778063

Strand: Reverse

Name: hcrC [H]

Synonym: Bmul_2552

Alternate gene names: 161525721

Gene position: 2778063-2776483 (Counterclockwise)

Preceding gene: 161525723

Following gene: 161525720

Centisome position: 80.56

GC content: 69.39

Gene sequence:

>1581_bases
ATGAGTGAGCCGATCCGCTTCTACCATCGTCACGCCGTCCGCGAAGTCAGCGGCGCGGACGTCACCCGCACCGTGCTGCA
GTACCTGCGCGAGGACGCGCACTGCACCGGCACCAAGGAAGGCTGCGCGGAAGGCGACTGCGGCGCGTGCACGGTCGTCG
TCGGCGAGCTGACCGACGCGGGCACGGTCGCGTTCAAGGCCGTCAACGCGTGCATCCAGTTCCTGCCGACGCTCGACGGC
AAGGCGCTGCTGACCGTCGAGGACCTGCGCCGCCCGGACGGCTCGCTGCATCCGGTTCAGCAGGCGATGGTCGACTGTCA
TGGGTCGCAGTGCGGGTTCTGCACGCCGGGCTTCGTGATGTCGATGTGGGCGCTCTACGAGAAGCACGGCCATGAACGCT
GCGGCGGTGCGTGCGAGAAGGCGAAGCACGTGCCGACGCGCACCGAGATCGCCGATGCGCTGACCGGCAACCTGTGCCGC
TGCACCGGCTATCGTCCGATCGTCGACGCGGCGGTGAGGATGTTCGATGCGACCGGCGTAGGTGCTACCGGCGAAGGCGC
AAACGGCGAAGGCTCCACCCCCGAACCGAACACCGCGCCCGTCGACCCGGCCGCGCTCGCGCGCACGCTTGCGTCGCTGC
GGCGCGACACGACGTTCGACTACACGGTCGGCGGCGCGCGCTTCGCGGCCCCGCGCACGCTCGACGCGCTGGCCGCGCTG
AAGGCGGAGCGTCCGGACGCTCGGATTCTCGCGGGCAGCACCGACATCGGGCTGTGGGTCACGAAGCAGATGCGCCGGCT
CGACGACCTGATCTACGTCGGCCAGATCGCCGAACTGCAGCGCATCGTGCACGGCGAGGACTGGATCGAGATCGGCGCGG
GCGTCACGGTCGAGAACGCCTATGCGGCGCTCGCCGAGACGTATCCCGAACTGACCGAGATGTGGAAGCGCTTCGCGTCG
CTGCCGATCCGCAACGCGGGCACGCTCGGCGGCAACGTTGCGAACGGCTCGCCGATCGGCGACTCGATGCCGGGCCTGAT
CGCACTGGGCGCGCGCGTCGTGCTGCGCGGCGGCGACACGGTGCGCGAACTGCCGCTCGAAGCGCTTTATACGGGCTACC
AGCAGAAGGACATGGCGCCGCACGAATTCGTCGTCGGCGTGAAGGTGCCGACACGCAGCGGCGCGCGCGCGAACCTGCAA
TTCCGCACCTACAAGCTGTCGAAACGGTTCGACTCCGACATTTCGGCCGTCTGCGCGGCGTTCGCGTTCATCGCGGACGG
CGACACGATCCGCGAGCCGCGCATCGCGTTCGGCGGGATGGCCGCGACGCCCAAGCGCGCGGCGCACACCGAAGCGGTGC
TCGACGGCGCGCAGTGGCACGAAGCGACCGCGCAGGCTGCGATGCAGGCGCTCGAACGCGATTATCAGCCGCTCACCGAC
ATGCGCGCGACGAGCACCTACCGGCTCGATACCGCGAAGAACCTGATGTACCGATTCTGGCTGGAGACGCGTCCGCACGA
TCCGCTGCCGCCGCAAGCCCTGAACGTGCGCGAAGTGCCCGCCGAAGCGGCGCGTGTCTGA

Upstream 100 bases:

>100_bases
TTGCGGAATTTGACGGTGATAGCGTGCAAACTGTCAGAGAAACGTCGGCCGAGCGCCCCGCGCAGGCCGCCTTTGCCCCC
ACTTGAAGAACGACAGAGAC

Downstream 100 bases:

>100_bases
CGACGGAGAACACCGAACATGAACCAGCAAGCAGAACCGTTCCTCAGCACCCTCGATCCGCAAGCCGACGCCGCGCAGGT
GCACGTGTCGCGTGCGCACG

Product: xanthine dehydrogenase, small subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MSEPIRFYHRHAVREVSGADVTRTVLQYLREDAHCTGTKEGCAEGDCGACTVVVGELTDAGTVAFKAVNACIQFLPTLDG
KALLTVEDLRRPDGSLHPVQQAMVDCHGSQCGFCTPGFVMSMWALYEKHGHERCGGACEKAKHVPTRTEIADALTGNLCR
CTGYRPIVDAAVRMFDATGVGATGEGANGEGSTPEPNTAPVDPAALARTLASLRRDTTFDYTVGGARFAAPRTLDALAAL
KAERPDARILAGSTDIGLWVTKQMRRLDDLIYVGQIAELQRIVHGEDWIEIGAGVTVENAYAALAETYPELTEMWKRFAS
LPIRNAGTLGGNVANGSPIGDSMPGLIALGARVVLRGGDTVRELPLEALYTGYQQKDMAPHEFVVGVKVPTRSGARANLQ
FRTYKLSKRFDSDISAVCAAFAFIADGDTIREPRIAFGGMAATPKRAAHTEAVLDGAQWHEATAQAAMQALERDYQPLTD
MRATSTYRLDTAKNLMYRFWLETRPHDPLPPQALNVREVPAEAARV

Sequences:

>Translated_526_residues
MSEPIRFYHRHAVREVSGADVTRTVLQYLREDAHCTGTKEGCAEGDCGACTVVVGELTDAGTVAFKAVNACIQFLPTLDG
KALLTVEDLRRPDGSLHPVQQAMVDCHGSQCGFCTPGFVMSMWALYEKHGHERCGGACEKAKHVPTRTEIADALTGNLCR
CTGYRPIVDAAVRMFDATGVGATGEGANGEGSTPEPNTAPVDPAALARTLASLRRDTTFDYTVGGARFAAPRTLDALAAL
KAERPDARILAGSTDIGLWVTKQMRRLDDLIYVGQIAELQRIVHGEDWIEIGAGVTVENAYAALAETYPELTEMWKRFAS
LPIRNAGTLGGNVANGSPIGDSMPGLIALGARVVLRGGDTVRELPLEALYTGYQQKDMAPHEFVVGVKVPTRSGARANLQ
FRTYKLSKRFDSDISAVCAAFAFIADGDTIREPRIAFGGMAATPKRAAHTEAVLDGAQWHEATAQAAMQALERDYQPLTD
MRATSTYRLDTAKNLMYRFWLETRPHDPLPPQALNVREVPAEAARV
>Mature_525_residues
SEPIRFYHRHAVREVSGADVTRTVLQYLREDAHCTGTKEGCAEGDCGACTVVVGELTDAGTVAFKAVNACIQFLPTLDGK
ALLTVEDLRRPDGSLHPVQQAMVDCHGSQCGFCTPGFVMSMWALYEKHGHERCGGACEKAKHVPTRTEIADALTGNLCRC
TGYRPIVDAAVRMFDATGVGATGEGANGEGSTPEPNTAPVDPAALARTLASLRRDTTFDYTVGGARFAAPRTLDALAALK
AERPDARILAGSTDIGLWVTKQMRRLDDLIYVGQIAELQRIVHGEDWIEIGAGVTVENAYAALAETYPELTEMWKRFASL
PIRNAGTLGGNVANGSPIGDSMPGLIALGARVVLRGGDTVRELPLEALYTGYQQKDMAPHEFVVGVKVPTRSGARANLQF
RTYKLSKRFDSDISAVCAAFAFIADGDTIREPRIAFGGMAATPKRAAHTEAVLDGAQWHEATAQAAMQALERDYQPLTDM
RATSTYRLDTAKNLMYRFWLETRPHDPLPPQALNVREVPAEAARV

Specific function: Catalyzes reductive dehydroxylation of 4-hydroxybenzoyl- CoA. Reaction is not reversible [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=524, Percent_Identity=29.5801526717557, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI71773480, Length=476, Percent_Identity=27.9411764705882, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI1789231, Length=292, Percent_Identity=27.3972602739726, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1786480, Length=153, Percent_Identity=35.9477124183007, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1789232, Length=147, Percent_Identity=38.0952380952381, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17540638, Length=551, Percent_Identity=30.4900181488203, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI32566215, Length=480, Percent_Identity=26.875, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17539860, Length=475, Percent_Identity=27.3684210526316, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI17737937, Length=504, Percent_Identity=32.7380952380952, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24647201, Length=503, Percent_Identity=26.8389662027833, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24647197, Length=527, Percent_Identity=27.3244781783681, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24647199, Length=504, Percent_Identity=28.1746031746032, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI24647195, Length=343, Percent_Identity=30.3206997084548, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24647193, Length=505, Percent_Identity=27.3267326732673, Blast_Score=143, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR017606
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.20 [H]

Molecular weight: Translated: 56850; Mature: 56719

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00059 ADH_ZINC ; PS00197 2FE2S_FER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPIRFYHRHAVREVSGADVTRTVLQYLREDAHCTGTKEGCAEGDCGACTVVVGELTDA
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCC
GTVAFKAVNACIQFLPTLDGKALLTVEDLRRPDGSLHPVQQAMVDCHGSQCGFCTPGFVM
HHHHHHHHHHHHHHHCCCCCCEEEEHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHH
SMWALYEKHGHERCGGACEKAKHVPTRTEIADALTGNLCRCTGYRPIVDAAVRMFDATGV
HHHHHHHHHCHHHCCHHHHHHHCCCCHHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCC
GATGEGANGEGSTPEPNTAPVDPAALARTLASLRRDTTFDYTVGGARFAAPRTLDALAAL
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCHHCCCHHHHHHHHH
KAERPDARILAGSTDIGLWVTKQMRRLDDLIYVGQIAELQRIVHGEDWIEIGAGVTVENA
HCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEHHH
YAALAETYPELTEMWKRFASLPIRNAGTLGGNVANGSPIGDSMPGLIALGARVVLRGGDT
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCH
VRELPLEALYTGYQQKDMAPHEFVVGVKVPTRSGARANLQFRTYKLSKRFDSDISAVCAA
HHHCCHHHHHCCCHHCCCCCCCEEEEEECCCCCCCCEEEEEEEEEHHHHHCCHHHHHHHH
FAFIADGDTIREPRIAFGGMAATPKRAAHTEAVLDGAQWHEATAQAAMQALERDYQPLTD
HHHHCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHH
MRATSTYRLDTAKNLMYRFWLETRPHDPLPPQALNVREVPAEAARV
HHCCCEEECHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCHHHHCC
>Mature Secondary Structure 
SEPIRFYHRHAVREVSGADVTRTVLQYLREDAHCTGTKEGCAEGDCGACTVVVGELTDA
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCC
GTVAFKAVNACIQFLPTLDGKALLTVEDLRRPDGSLHPVQQAMVDCHGSQCGFCTPGFVM
HHHHHHHHHHHHHHHCCCCCCEEEEHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHH
SMWALYEKHGHERCGGACEKAKHVPTRTEIADALTGNLCRCTGYRPIVDAAVRMFDATGV
HHHHHHHHHCHHHCCHHHHHHHCCCCHHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCC
GATGEGANGEGSTPEPNTAPVDPAALARTLASLRRDTTFDYTVGGARFAAPRTLDALAAL
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCHHCCCHHHHHHHHH
KAERPDARILAGSTDIGLWVTKQMRRLDDLIYVGQIAELQRIVHGEDWIEIGAGVTVENA
HCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEHHH
YAALAETYPELTEMWKRFASLPIRNAGTLGGNVANGSPIGDSMPGLIALGARVVLRGGDT
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCH
VRELPLEALYTGYQQKDMAPHEFVVGVKVPTRSGARANLQFRTYKLSKRFDSDISAVCAA
HHHCCHHHHHCCCHHCCCCCCCEEEEEECCCCCCCCEEEEEEEEEHHHHHCCHHHHHHHH
FAFIADGDTIREPRIAFGGMAATPKRAAHTEAVLDGAQWHEATAQAAMQALERDYQPLTD
HHHHCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHH
MRATSTYRLDTAKNLMYRFWLETRPHDPLPPQALNVREVPAEAARV
HHCCCEEECHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9490068 [H]