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The map label for this gene is thrS [H]

Identifier: 161524952

GI number: 161524952

Start: 1966751

End: 1968658

Strand: Reverse

Name: thrS [H]

Synonym: Bmul_1779

Alternate gene names: 161524952

Gene position: 1968658-1966751 (Counterclockwise)

Preceding gene: 161524953

Following gene: 161524951

Centisome position: 57.09

GC content: 61.79

Gene sequence:

>1908_bases
ATGGTTTCGATACGCTTGCCTGACGGGTCAGTTCGACAATACGAGCATCCGGTGACGGTCGCCGAAGTGGCGGCGTCGAT
CGGTCCCGGCCTTGCGAAGGCTGCGCTCGGCGGCAAGCTGGACGGCGAACTCGTGGATACGTCCGCCGTCATCGATCACG
ACGCATCGCTCGCGATCGTCACCGACAAGGATCCGGACGGTCTCGACATCATCCGTCACTCGACCGCGCACTTGCTGGCC
TATGCGGTGAAGGAGCTCTATCCGGACGCGCAGGTCACGATCGGGCCGGTCATCGACAACGGCTTCTACTACGATTTCGC
GTACCACCGCCCGTTCACGCCCGAAGATCTGGAAAAGATCGAGAAGCGGATGCAGGAGCTCGCGAAGAAGGACGAGCCCG
TCACGCGCCGTGTCGTGTCGCGCGACGAGGCGGCCGGCTACTTCCGCAGCATCGGCGAAAAGTACAAGGCCGAGATCATC
GAGTCGATTCCGGAGAGCGACGAAATCAAGCTTTACTCGCACGGCGGCTTTACCGACCTGTGTCGCGGCCCGCACGTGCC
GTCGACCGGCAAGCTGAAGGTCTTCAAGCTGATGAAGGTGGCCGGCGCGTACTGGCGCGGCGACTCGAAGAACGAGCAGC
TGCAGCGCATTTACGGTACCGCGTGGACCAAGAAGGAAGATCAGGACCAGTACCTGCACATGCTCGAGGAAGCCGAGAAG
CGCGATCACCGCAAGCTCGGCAAGCAGCTCGACCTGTTCCATATGCAGGAAGAGTCGCCCGGCATGGTGTTCTGGCACCC
GAAGGGCTGGGCATTGTGGCAGCAGGTCGAGCAGTACATGCGCCGCCGCGTGAACGAAGCCGGCTATCTCGAGATCAAGA
CGCCGATGATCATGGACCGCTCGCTCTGGGAAGCGTCCGGTCACTGGCAGAACTATCGCGAGAACATGTTCACGACCGAG
TCGGAGAAGCGCGACTACGCGATCAAGCCGATGAACTGCCCCGGTCACGTGCAGGTGTTCAAGCACGGCCTGCGCTCGTA
TCGCGACCTGCCGCTGCGCTACGCGGAATTCGGCTCGTGCCACCGCAACGAGGCATCGGGCGCGCTGCACGGGCTGATGC
GCGTACGCGGCTTCGTGCAGGACGACGCGCACATCTTCTGTACCGAAGAGCAGATCATTGCCGAGTCGATCGCGTTCAAC
AAGCTCGCGATGAGCGTCTATCGCGATTTCGGGTTCGATCACATCGACATCAAGCTGTCGCTGCGTCCCGAGCAGCGCAT
GGGTTCCGATGAAACCTGGGACCGTGCGGAGCAAGGCCTGCGCGAAGCGCTGACCGCCTGCGGCCTGCAATGGGAAGAGC
TGCCAGGCGAGGGTGCGTTCTACGGTCCGAAGATCGAGTACCACATCAAGGATGCGCTCGGCCGTTCGTGGCAGTGCGGC
ACGCTGCAGCTCGACATGATGCTGCCGGAGCGTCTCGGCGCCGAGTACGTCGCGGAAGACAACAGCCGCCGCCGCCCGGT
CATGCTGCACCGTGCGATCGTCGGTTCGATGGAGCGCTTCCTCGGCATTCTGATCGAGCACCATGCGGGTGCAATGCCGG
TCTGGCTCGCGCCGGTGCAGGCCGTTGTGCTCAATATCGCCGAAAGTCAGGTCGAATATGCGCAGTCTCTGGCCCAAACG
TTGCAAAAACAAGGGCTTAGAGTGACGGCCGATTTGCGCAACGAGAAGATTAGCTATAAAATACGCGAGCACACGCTGGA
AAAGGTGCCTTATCTGCTCGTCGTGGGCGACAAGGAGCGTGATGCACAAACGGTAGCCGTGCGTGCCCGTGGCGGCGTCG
ATCTTGGCGTTATGCCGGTCGAAGCCTTCGTTGAGCGTCTGCAGGAAGACCTGCGCTCGTTCAAGTAA

Upstream 100 bases:

>100_bases
CGAAAGCGGGGCCGCATTTTTTTTGTCGCGAAATTTTCGCGTGCGACGTGCGTCGTGCGCCTTTGGTCTGCCGCCCACGG
TCGGCATCACGGAGAGTGCT

Downstream 100 bases:

>100_bases
CCACCCTGGCAGCGCGGCTCGTTTTTTTAATTTTTAGAGGAAACGTAACATCGCTACTGATAAGTCGTCGCATCGCATCA
ACGGTGAAATCACTGCGCCG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MVSIRLPDGSVRQYEHPVTVAEVAASIGPGLAKAALGGKLDGELVDTSAVIDHDASLAIVTDKDPDGLDIIRHSTAHLLA
YAVKELYPDAQVTIGPVIDNGFYYDFAYHRPFTPEDLEKIEKRMQELAKKDEPVTRRVVSRDEAAGYFRSIGEKYKAEII
ESIPESDEIKLYSHGGFTDLCRGPHVPSTGKLKVFKLMKVAGAYWRGDSKNEQLQRIYGTAWTKKEDQDQYLHMLEEAEK
RDHRKLGKQLDLFHMQEESPGMVFWHPKGWALWQQVEQYMRRRVNEAGYLEIKTPMIMDRSLWEASGHWQNYRENMFTTE
SEKRDYAIKPMNCPGHVQVFKHGLRSYRDLPLRYAEFGSCHRNEASGALHGLMRVRGFVQDDAHIFCTEEQIIAESIAFN
KLAMSVYRDFGFDHIDIKLSLRPEQRMGSDETWDRAEQGLREALTACGLQWEELPGEGAFYGPKIEYHIKDALGRSWQCG
TLQLDMMLPERLGAEYVAEDNSRRRPVMLHRAIVGSMERFLGILIEHHAGAMPVWLAPVQAVVLNIAESQVEYAQSLAQT
LQKQGLRVTADLRNEKISYKIREHTLEKVPYLLVVGDKERDAQTVAVRARGGVDLGVMPVEAFVERLQEDLRSFK

Sequences:

>Translated_635_residues
MVSIRLPDGSVRQYEHPVTVAEVAASIGPGLAKAALGGKLDGELVDTSAVIDHDASLAIVTDKDPDGLDIIRHSTAHLLA
YAVKELYPDAQVTIGPVIDNGFYYDFAYHRPFTPEDLEKIEKRMQELAKKDEPVTRRVVSRDEAAGYFRSIGEKYKAEII
ESIPESDEIKLYSHGGFTDLCRGPHVPSTGKLKVFKLMKVAGAYWRGDSKNEQLQRIYGTAWTKKEDQDQYLHMLEEAEK
RDHRKLGKQLDLFHMQEESPGMVFWHPKGWALWQQVEQYMRRRVNEAGYLEIKTPMIMDRSLWEASGHWQNYRENMFTTE
SEKRDYAIKPMNCPGHVQVFKHGLRSYRDLPLRYAEFGSCHRNEASGALHGLMRVRGFVQDDAHIFCTEEQIIAESIAFN
KLAMSVYRDFGFDHIDIKLSLRPEQRMGSDETWDRAEQGLREALTACGLQWEELPGEGAFYGPKIEYHIKDALGRSWQCG
TLQLDMMLPERLGAEYVAEDNSRRRPVMLHRAIVGSMERFLGILIEHHAGAMPVWLAPVQAVVLNIAESQVEYAQSLAQT
LQKQGLRVTADLRNEKISYKIREHTLEKVPYLLVVGDKERDAQTVAVRARGGVDLGVMPVEAFVERLQEDLRSFK
>Mature_635_residues
MVSIRLPDGSVRQYEHPVTVAEVAASIGPGLAKAALGGKLDGELVDTSAVIDHDASLAIVTDKDPDGLDIIRHSTAHLLA
YAVKELYPDAQVTIGPVIDNGFYYDFAYHRPFTPEDLEKIEKRMQELAKKDEPVTRRVVSRDEAAGYFRSIGEKYKAEII
ESIPESDEIKLYSHGGFTDLCRGPHVPSTGKLKVFKLMKVAGAYWRGDSKNEQLQRIYGTAWTKKEDQDQYLHMLEEAEK
RDHRKLGKQLDLFHMQEESPGMVFWHPKGWALWQQVEQYMRRRVNEAGYLEIKTPMIMDRSLWEASGHWQNYRENMFTTE
SEKRDYAIKPMNCPGHVQVFKHGLRSYRDLPLRYAEFGSCHRNEASGALHGLMRVRGFVQDDAHIFCTEEQIIAESIAFN
KLAMSVYRDFGFDHIDIKLSLRPEQRMGSDETWDRAEQGLREALTACGLQWEELPGEGAFYGPKIEYHIKDALGRSWQCG
TLQLDMMLPERLGAEYVAEDNSRRRPVMLHRAIVGSMERFLGILIEHHAGAMPVWLAPVQAVVLNIAESQVEYAQSLAQT
LQKQGLRVTADLRNEKISYKIREHTLEKVPYLLVVGDKERDAQTVAVRARGGVDLGVMPVEAFVERLQEDLRSFK

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38570111, Length=632, Percent_Identity=39.873417721519, Blast_Score=479, Evalue=1e-135,
Organism=Homo sapiens, GI38202255, Length=638, Percent_Identity=39.0282131661442, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI20070344, Length=651, Percent_Identity=37.6344086021505, Blast_Score=413, Evalue=1e-115,
Organism=Escherichia coli, GI1788013, Length=634, Percent_Identity=59.7791798107255, Blast_Score=796, Evalue=0.0,
Organism=Escherichia coli, GI1786392, Length=158, Percent_Identity=26.5822784810127, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71984184, Length=631, Percent_Identity=38.1933438985737, Blast_Score=472, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI71984192, Length=631, Percent_Identity=38.1933438985737, Blast_Score=471, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6322112, Length=654, Percent_Identity=38.5321100917431, Blast_Score=463, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6322654, Length=396, Percent_Identity=39.6464646464646, Blast_Score=306, Evalue=6e-84,
Organism=Drosophila melanogaster, GI24583842, Length=631, Percent_Identity=39.7781299524564, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI28574141, Length=631, Percent_Identity=39.7781299524564, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24583839, Length=631, Percent_Identity=39.7781299524564, Blast_Score=485, Evalue=1e-137,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 72419; Mature: 72419

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSIRLPDGSVRQYEHPVTVAEVAASIGPGLAKAALGGKLDGELVDTSAVIDHDASLAIV
CEEEECCCCCCHHHCCCCHHHHHHHHHCCCHHHHHHCCCCCCCEECCHHEEECCCCEEEE
TDKDPDGLDIIRHSTAHLLAYAVKELYPDAQVTIGPVIDNGFYYDFAYHRPFTPEDLEKI
ECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEECCCCCHHHHHHH
EKRMQELAKKDEPVTRRVVSRDEAAGYFRSIGEKYKAEIIESIPESDEIKLYSHGGFTDL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHH
CRGPHVPSTGKLKVFKLMKVAGAYWRGDSKNEQLQRIYGTAWTKKEDQDQYLHMLEEAEK
HCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
RDHRKLGKQLDLFHMQEESPGMVFWHPKGWALWQQVEQYMRRRVNEAGYLEIKTPMIMDR
HHHHHHCCCCCCEEECCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECCCHHHCH
SLWEASGHWQNYRENMFTTESEKRDYAIKPMNCPGHVQVFKHGLRSYRDLPLRYAEFGSC
HHHHCCCCHHHHHHHCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCC
HRNEASGALHGLMRVRGFVQDDAHIFCTEEQIIAESIAFNKLAMSVYRDFGFDHIDIKLS
CCCCHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
LRPEQRMGSDETWDRAEQGLREALTACGLQWEELPGEGAFYGPKIEYHIKDALGRSWQCG
ECCHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCCCEECCEEEEEEHHHCCCCCCCC
TLQLDMMLPERLGAEYVAEDNSRRRPVMLHRAIVGSMERFLGILIEHHAGAMPVWLAPVQ
CEEEEECCHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
AVVLNIAESQVEYAQSLAQTLQKQGLRVTADLRNEKISYKIREHTLEKVPYLLVVGDKER
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEHHHHHHHHHCCEEEEECCCCC
DAQTVAVRARGGVDLGVMPVEAFVERLQEDLRSFK
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVSIRLPDGSVRQYEHPVTVAEVAASIGPGLAKAALGGKLDGELVDTSAVIDHDASLAIV
CEEEECCCCCCHHHCCCCHHHHHHHHHCCCHHHHHHCCCCCCCEECCHHEEECCCCEEEE
TDKDPDGLDIIRHSTAHLLAYAVKELYPDAQVTIGPVIDNGFYYDFAYHRPFTPEDLEKI
ECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEECCCCCHHHHHHH
EKRMQELAKKDEPVTRRVVSRDEAAGYFRSIGEKYKAEIIESIPESDEIKLYSHGGFTDL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHH
CRGPHVPSTGKLKVFKLMKVAGAYWRGDSKNEQLQRIYGTAWTKKEDQDQYLHMLEEAEK
HCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
RDHRKLGKQLDLFHMQEESPGMVFWHPKGWALWQQVEQYMRRRVNEAGYLEIKTPMIMDR
HHHHHHCCCCCCEEECCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECCCHHHCH
SLWEASGHWQNYRENMFTTESEKRDYAIKPMNCPGHVQVFKHGLRSYRDLPLRYAEFGSC
HHHHCCCCHHHHHHHCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCC
HRNEASGALHGLMRVRGFVQDDAHIFCTEEQIIAESIAFNKLAMSVYRDFGFDHIDIKLS
CCCCHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
LRPEQRMGSDETWDRAEQGLREALTACGLQWEELPGEGAFYGPKIEYHIKDALGRSWQCG
ECCHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCCCEECCEEEEEEHHHCCCCCCCC
TLQLDMMLPERLGAEYVAEDNSRRRPVMLHRAIVGSMERFLGILIEHHAGAMPVWLAPVQ
CEEEEECCHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
AVVLNIAESQVEYAQSLAQTLQKQGLRVTADLRNEKISYKIREHTLEKVPYLLVVGDKER
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEHHHHHHHHHCCEEEEECCCCC
DAQTVAVRARGGVDLGVMPVEAFVERLQEDLRSFK
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA