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The map label for this gene is hemC [H]

Identifier: 161524048

GI number: 161524048

Start: 952006

End: 953214

Strand: Direct

Name: hemC [H]

Synonym: Bmul_0869

Alternate gene names: 161524048

Gene position: 952006-953214 (Clockwise)

Preceding gene: 161524046

Following gene: 161524049

Centisome position: 27.61

GC content: 69.98

Gene sequence:

>1209_bases
ATGGGTTTCCTTGGGAAAGCTCGAGTCAAAAGGAACTGCGGAAACTGCGAGAACTGTGGTCAAGCAACCAGCTACGTACG
GCACATCCGCGCATCCGCGCCGCAGGCCGCGCGAGGGCGCGGCGGCCGCGGGCGCCCGGCCCGGGCGGGCCGAAGCGTGC
GTGCTACCATTGTTCGGTCTTCAATCCCGTCCTTCGATGTTCCTGCAATGAATTCCGAGATTCTCGCGGCCGGGCCGCGA
CCGGCACAGCCGCCGGCGACGCTGACGATCGCTTCGCGCGAAAGCCGCCTGGCGATGTGGCAAGCCGAACATGTGCGTGA
TGCGCTGCGCAAATTATATCCAGCTTGTGACGTGAAAATCCTCGGGATGACGACGCGCGGCGATCAGATTCTCGATCGCA
CGCTGTCGAAGGTCGGCGGCAAGGGACTCTTCGTCAAGGAGCTCGAGAGCGCGCTCGCCGACGGCCGCGCCGATCTCGCC
GTGCACTCGCTGAAGGACGTGCCGATGATGCTGCCGGACGGCTTCGCGCTCGCCGCGATCATGCAGCGCGAGGATCCGCG
CGACGCGTTCGTGTCGAACGACTACGCGTCGCTCGACGCGCTGCCGGCCGGCGCGGTCGTCGGCACGTCGAGCCTGCGCC
GCGAAGCGATGCTGCGCGCGCGTTATCCGCAGCTGCAGGTGCTGCCGCTGCGCGGCAATCTCGATACGCGGCTCTCGAAG
CTCGATCGCGGCGATTACGCGGCGATCATTCTCGCCGCCGCGGGCCTGAAGCGGCTCGGTCTGGAGGCGCGGATCCGCGC
GCTGCTCGACGTCGAGGACAGCCCGCCCGCAGCCGGTCAGGGTGCGCTCGGCATCGAGATCGCCGCACACCGCACGGACG
TCGCCGCATGGCTCGAACCGCTGCACGACGCGCAGACGGCGCTCGCCGTCGAGGCCGAGCGGATGGTGTCGCGCGCGCTC
GGCGGCAGCTGCGAGGTGCCGCTCGCCGCGCACGCCGTGTGGCGGGCCGGCGAGCTCTATCTGACGGGCCGCGTGTCGAC
GATCGACGGCACGCGCGTGCTGACGGCCGAGGAGTGCGCGTCCGTCGTGACGGTCGCCGATGCGCTCGCGCTCGGCCGCG
CGGTTTCCGACGAGCTCGAGGCGCAGGGCGCGCTCGAGATCGTCCGCGCACTGCTCGCCGGCTCGCAGGCCGGCAAGGGC
GAGGCCTGA

Upstream 100 bases:

>100_bases
ACGGCCGTTCGCGGCGGTGGCGACGGCGCTCGTCGGGGCGTCGGAGGAGGGCAGGGCAGCATTGCGGCGCGTCGCGCGCA
CCGATCCGGAAGACTTCACG

Downstream 100 bases:

>100_bases
TGGCGGGCGGCGCGCGCGCATTCACCGCCGTTCTCACGCGCCCCGACGGCCAGTCGGCCGGGCTCGCCGCGCAACTGGCC
GACGCCGGTTGCGACGTGCT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MGFLGKARVKRNCGNCENCGQATSYVRHIRASAPQAARGRGGRGRPARAGRSVRATIVRSSIPSFDVPAMNSEILAAGPR
PAQPPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGLFVKELESALADGRADLA
VHSLKDVPMMLPDGFALAAIMQREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRARYPQLQVLPLRGNLDTRLSK
LDRGDYAAIILAAAGLKRLGLEARIRALLDVEDSPPAAGQGALGIEIAAHRTDVAAWLEPLHDAQTALAVEAERMVSRAL
GGSCEVPLAAHAVWRAGELYLTGRVSTIDGTRVLTAEECASVVTVADALALGRAVSDELEAQGALEIVRALLAGSQAGKG
EA

Sequences:

>Translated_402_residues
MGFLGKARVKRNCGNCENCGQATSYVRHIRASAPQAARGRGGRGRPARAGRSVRATIVRSSIPSFDVPAMNSEILAAGPR
PAQPPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGLFVKELESALADGRADLA
VHSLKDVPMMLPDGFALAAIMQREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRARYPQLQVLPLRGNLDTRLSK
LDRGDYAAIILAAAGLKRLGLEARIRALLDVEDSPPAAGQGALGIEIAAHRTDVAAWLEPLHDAQTALAVEAERMVSRAL
GGSCEVPLAAHAVWRAGELYLTGRVSTIDGTRVLTAEECASVVTVADALALGRAVSDELEAQGALEIVRALLAGSQAGKG
EA
>Mature_401_residues
GFLGKARVKRNCGNCENCGQATSYVRHIRASAPQAARGRGGRGRPARAGRSVRATIVRSSIPSFDVPAMNSEILAAGPRP
AQPPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGLFVKELESALADGRADLAV
HSLKDVPMMLPDGFALAAIMQREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRARYPQLQVLPLRGNLDTRLSKL
DRGDYAAIILAAAGLKRLGLEARIRALLDVEDSPPAAGQGALGIEIAAHRTDVAAWLEPLHDAQTALAVEAERMVSRALG
GSCEVPLAAHAVWRAGELYLTGRVSTIDGTRVLTAEECASVVTVADALALGRAVSDELEAQGALEIVRALLAGSQAGKGE
A

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=266, Percent_Identity=46.9924812030075, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI66933009, Length=266, Percent_Identity=46.9924812030075, Blast_Score=235, Evalue=7e-62,
Organism=Escherichia coli, GI48994974, Length=308, Percent_Identity=52.2727272727273, Blast_Score=288, Evalue=3e-79,
Organism=Saccharomyces cerevisiae, GI6319996, Length=316, Percent_Identity=40.1898734177215, Blast_Score=214, Evalue=2e-56,
Organism=Drosophila melanogaster, GI20130425, Length=280, Percent_Identity=44.2857142857143, Blast_Score=210, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 42513; Mature: 42382

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFLGKARVKRNCGNCENCGQATSYVRHIRASAPQAARGRGGRGRPARAGRSVRATIVRS
CCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCEEHHHHC
SIPSFDVPAMNSEILAAGPRPAQPPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKI
CCCCCCCCCCCCCEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEE
LGMTTRGDQILDRTLSKVGGKGLFVKELESALADGRADLAVHSLKDVPMMLPDGFALAAI
EEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCEECCCCHHHHHH
MQREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRARYPQLQVLPLRGNLDTRLSK
HHCCCCCHHHHCCCCHHHCCCCCCHHHCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHH
LDRGDYAAIILAAAGLKRLGLEARIRALLDVEDSPPAAGQGALGIEIAAHRTDVAAWLEP
CCCCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHHH
LHDAQTALAVEAERMVSRALGGSCEVPLAAHAVWRAGELYLTGRVSTIDGTRVLTAEECA
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEEEEEEECCCCEEEEHHHHH
SVVTVADALALGRAVSDELEAQGALEIVRALLAGSQAGKGEA
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
GFLGKARVKRNCGNCENCGQATSYVRHIRASAPQAARGRGGRGRPARAGRSVRATIVRS
CCCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCEEHHHHC
SIPSFDVPAMNSEILAAGPRPAQPPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKI
CCCCCCCCCCCCCEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEE
LGMTTRGDQILDRTLSKVGGKGLFVKELESALADGRADLAVHSLKDVPMMLPDGFALAAI
EEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCEECCCCHHHHHH
MQREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRARYPQLQVLPLRGNLDTRLSK
HHCCCCCHHHHCCCCHHHCCCCCCHHHCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHH
LDRGDYAAIILAAAGLKRLGLEARIRALLDVEDSPPAAGQGALGIEIAAHRTDVAAWLEP
CCCCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHHH
LHDAQTALAVEAERMVSRALGGSCEVPLAAHAVWRAGELYLTGRVSTIDGTRVLTAEECA
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEEEEEEECCCCEEEEHHHHH
SVVTVADALALGRAVSDELEAQGALEIVRALLAGSQAGKGEA
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA