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The map label for this gene is hemD [H]

Identifier: 161524049

GI number: 161524049

Start: 953214

End: 955184

Strand: Direct

Name: hemD [H]

Synonym: Bmul_0870

Alternate gene names: 161524049

Gene position: 953214-955184 (Clockwise)

Preceding gene: 161524048

Following gene: 161524050

Centisome position: 27.64

GC content: 70.37

Gene sequence:

>1971_bases
ATGGCGGGCGGCGCGCGCGCATTCACCGCCGTTCTCACGCGCCCCGACGGCCAGTCGGCCGGGCTCGCCGCGCAACTGGC
CGACGCCGGTTGCGACGTGCTCGAATTTCCGCTGATCGACATCGCGCCGGTCGACGATCCGGCGCCGCTCGCGGCCGCGT
TCGCCGCGCTGGCCGACTATGCGCTCGTGATCTTCGTGTCGCCGAACGCGATCGATCGTGCGCTCGCGCAGTACGGCGCG
ATCTGGCCGAACGCGCTGCCGGTCGGCGTGGTCGGCCCCGGCAGCGTCGCCGCGCTCGAGCGTCACGGCATCGCGCCGCC
CGCGTATCGCGTGATCGCGCCGCAGCCGGGCAGCGACGGCAGCGCACCGCACTACGATTCCGAAGGACTGTTCGCGAGCA
TCGAGGCCGCGTTCGGCGGCGCCGCCGCGCTCGCCGGCAAGCGCGTGCTGATCGTGCGCGGCGACGGCGGCCGCGAATGG
CTTGCCGATCGACTGCGCGAAGCGGGCGCCGACGTGACGCTCGTCGCCGCGTACCGGCGCGTCGTGCCCGAACCGCGCAT
CGGCACGTGGGAGCGCGTGCATGCGCTTCTCGGCGGCGAGCCGCACGCGTGGCTCGTCACGAGTTCGGAGGGCGTGCGCA
ATCTGCACGAACTTGCGCGCGCGCATCTGAACGACACCGAGATCGAAGCGCTGAAGCACGCGCCGCTCGTGACGCCGCAT
CCGCGGATCGAGCAGACCGCGCGCGCATTGGGTTTTGATAGGATTACGCTGACCGGCGCGGGCGATGAGCGCATCGTCCG
CGCGTTTCGAACGATGGCCGACGAGGCCGTCCAACCGGCGACAGCCGCACCGGTGACTAAACGCATGACAGATACCAACG
ATTCCAAAAGCGTCGCTTCCCAGCCGGCCGCCGCTTCCGCGCCGCCGTCGCAACCTTCGTACACCGCATCCGAACCGCCC
GCGCGCCGCGGCGGCAGTGCGGTGCTGTGGTTCGTCGTCGTCGTGCTCGGCTGCGCGGCGGGCGTCGGCGGCTACGCGCT
GAACCGCAAGATCGACCGGCTCGACGACGCGCTCGTCGCGCGCCAGAAGACGCTCGACGCGCAGGTCGCCGAGACGCGCA
CGAAGACCGAGCAGGCGCTCGCGAGCACGCATCAGGTCGACACGCAGCTCGCGCAGCTCGACGGCAAGCTCGCCGATGCG
CAAAGCGCGCAGCAGGCGCTGCAGCAGCAGTACCAGGATCTGTCGCGCAACCGCGATGCGTGGATGCTCGAGGAAGTCGA
TCAGATGCTGTCGAGCGCGAGCCAGCAGCTGCAGCTGACGGGCAATACGCAGCTCGCGCTGATCGCGCTGCAGAATGCCG
ATGCGCGGCTCGCGACGTCGCAGAGCGCGCAGGCCGTGACGGTGCGCAAGGCGCTCGCGCAGGACATCGAGAAGCTGAAG
GCTGCACCGTCGGCCGATCTGACCGGGCTCGCGATCAAGCTCGACGACGCGATCGCGCGGATCGACGCGCTGCCGCTGTC
CGGCGAGGCGATCGTGCCGCACGCGGCGCCGAAGGCCGCACCTGCCGACACGGCATCGGCCGCCGCCGCGGGCGAACCGC
GCTGGAAGACGTGGTGGCACGACTTCTCGTCGGGTCTGACGCAGCAGCTGAAGGGGCTCGTGCAGGTGCGCCGGATCGAC
AACGCGGACGCGATGCTCGCGTCGCCCGACCAGGGTTACTTCGTGCGCGAGAACGTGAAGCTGCGGCTGCTCGCCGCGCG
GCTGTCGCTGCTCGCGCGCAACGAGAGCGCGATGAAGGCCGACCTGCACGCCGCGCAGGCGTCGGTCGGCAAGTATTTCG
ATCAGGCATCGAAGGACACGCAGACGGTCGAGGATCTGCTCAAGCAGGTCGACGGCGCGTCGCTGACGGTCGCGGTGCCG
AACCTGAACACGAGCCTGAACGCCGTTCAGCAGTTCAAGAGCCGGGGGTAA

Upstream 100 bases:

>100_bases
CGCTCGGCCGCGCGGTTTCCGACGAGCTCGAGGCGCAGGGCGCGCTCGAGATCGTCCGCGCACTGCTCGCCGGCTCGCAG
GCCGGCAAGGGCGAGGCCTG

Downstream 100 bases:

>100_bases
CGATGACGCTTCGAGGAATCGTCTGGCTCGCGGTCCTGTTCGCGATCGCCGTCGCGCTCGCCACCGTCGGGCGTTTCGAC
GCGGGGCAGGTGCTGATCGT

Product: bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 656; Mature: 655

Protein sequence:

>656_residues
MAGGARAFTAVLTRPDGQSAGLAAQLADAGCDVLEFPLIDIAPVDDPAPLAAAFAALADYALVIFVSPNAIDRALAQYGA
IWPNALPVGVVGPGSVAALERHGIAPPAYRVIAPQPGSDGSAPHYDSEGLFASIEAAFGGAAALAGKRVLIVRGDGGREW
LADRLREAGADVTLVAAYRRVVPEPRIGTWERVHALLGGEPHAWLVTSSEGVRNLHELARAHLNDTEIEALKHAPLVTPH
PRIEQTARALGFDRITLTGAGDERIVRAFRTMADEAVQPATAAPVTKRMTDTNDSKSVASQPAAASAPPSQPSYTASEPP
ARRGGSAVLWFVVVVLGCAAGVGGYALNRKIDRLDDALVARQKTLDAQVAETRTKTEQALASTHQVDTQLAQLDGKLADA
QSAQQALQQQYQDLSRNRDAWMLEEVDQMLSSASQQLQLTGNTQLALIALQNADARLATSQSAQAVTVRKALAQDIEKLK
AAPSADLTGLAIKLDDAIARIDALPLSGEAIVPHAAPKAAPADTASAAAAGEPRWKTWWHDFSSGLTQQLKGLVQVRRID
NADAMLASPDQGYFVRENVKLRLLAARLSLLARNESAMKADLHAAQASVGKYFDQASKDTQTVEDLLKQVDGASLTVAVP
NLNTSLNAVQQFKSRG

Sequences:

>Translated_656_residues
MAGGARAFTAVLTRPDGQSAGLAAQLADAGCDVLEFPLIDIAPVDDPAPLAAAFAALADYALVIFVSPNAIDRALAQYGA
IWPNALPVGVVGPGSVAALERHGIAPPAYRVIAPQPGSDGSAPHYDSEGLFASIEAAFGGAAALAGKRVLIVRGDGGREW
LADRLREAGADVTLVAAYRRVVPEPRIGTWERVHALLGGEPHAWLVTSSEGVRNLHELARAHLNDTEIEALKHAPLVTPH
PRIEQTARALGFDRITLTGAGDERIVRAFRTMADEAVQPATAAPVTKRMTDTNDSKSVASQPAAASAPPSQPSYTASEPP
ARRGGSAVLWFVVVVLGCAAGVGGYALNRKIDRLDDALVARQKTLDAQVAETRTKTEQALASTHQVDTQLAQLDGKLADA
QSAQQALQQQYQDLSRNRDAWMLEEVDQMLSSASQQLQLTGNTQLALIALQNADARLATSQSAQAVTVRKALAQDIEKLK
AAPSADLTGLAIKLDDAIARIDALPLSGEAIVPHAAPKAAPADTASAAAAGEPRWKTWWHDFSSGLTQQLKGLVQVRRID
NADAMLASPDQGYFVRENVKLRLLAARLSLLARNESAMKADLHAAQASVGKYFDQASKDTQTVEDLLKQVDGASLTVAVP
NLNTSLNAVQQFKSRG
>Mature_655_residues
AGGARAFTAVLTRPDGQSAGLAAQLADAGCDVLEFPLIDIAPVDDPAPLAAAFAALADYALVIFVSPNAIDRALAQYGAI
WPNALPVGVVGPGSVAALERHGIAPPAYRVIAPQPGSDGSAPHYDSEGLFASIEAAFGGAAALAGKRVLIVRGDGGREWL
ADRLREAGADVTLVAAYRRVVPEPRIGTWERVHALLGGEPHAWLVTSSEGVRNLHELARAHLNDTEIEALKHAPLVTPHP
RIEQTARALGFDRITLTGAGDERIVRAFRTMADEAVQPATAAPVTKRMTDTNDSKSVASQPAAASAPPSQPSYTASEPPA
RRGGSAVLWFVVVVLGCAAGVGGYALNRKIDRLDDALVARQKTLDAQVAETRTKTEQALASTHQVDTQLAQLDGKLADAQ
SAQQALQQQYQDLSRNRDAWMLEEVDQMLSSASQQLQLTGNTQLALIALQNADARLATSQSAQAVTVRKALAQDIEKLKA
APSADLTGLAIKLDDAIARIDALPLSGEAIVPHAAPKAAPADTASAAAAGEPRWKTWWHDFSSGLTQQLKGLVQVRRIDN
ADAMLASPDQGYFVRENVKLRLLAARLSLLARNESAMKADLHAAQASVGKYFDQASKDTQTVEDLLKQVDGASLTVAVPN
LNTSLNAVQQFKSRG

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790235, Length=365, Percent_Identity=24.6575342465753, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI1790236, Length=275, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 69258; Mature: 69127

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGGARAFTAVLTRPDGQSAGLAAQLADAGCDVLEFPLIDIAPVDDPAPLAAAFAALADY
CCCCHHHHEEEEECCCCCCCCHHHHHHHCCCCEEECCCEEEECCCCCHHHHHHHHHHHCC
ALVIFVSPNAIDRALAQYGAIWPNALPVGVVGPGSVAALERHGIAPPAYRVIAPQPGSDG
EEEEEECCCHHHHHHHHHCCCCCCCCEECEECCCCHHHHHHCCCCCCCEEEECCCCCCCC
SAPHYDSEGLFASIEAAFGGAAALAGKRVLIVRGDGGREWLADRLREAGADVTLVAAYRR
CCCCCCCCCCEEEHHHHHCCHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCEEEHHHHHH
VVPEPRIGTWERVHALLGGEPHAWLVTSSEGVRNLHELARAHLNDTEIEALKHAPLVTPH
HCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCC
PRIEQTARALGFDRITLTGAGDERIVRAFRTMADEAVQPATAAPVTKRMTDTNDSKSVAS
CCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCHHHHC
QPAAASAPPSQPSYTASEPPARRGGSAVLWFVVVVLGCAAGVGGYALNRKIDRLDDALVA
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
RQKTLDAQVAETRTKTEQALASTHQVDTQLAQLDGKLADAQSAQQALQQQYQDLSRNRDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
WMLEEVDQMLSSASQQLQLTGNTQLALIALQNADARLATSQSAQAVTVRKALAQDIEKLK
HHHHHHHHHHHHHHHEEEEECCCEEEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHH
AAPSADLTGLAIKLDDAIARIDALPLSGEAIVPHAAPKAAPADTASAAAAGEPRWKTWWH
CCCCCCCCEEEEEEHHHHHHHHCCCCCCCEECCCCCCCCCCCCCHHHHCCCCCCHHHHHH
DFSSGLTQQLKGLVQVRRIDNADAMLASPDQGYFVRENVKLRLLAARLSLLARNESAMKA
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEEEECCCEEEHHHHHHHHHHCCCHHHHH
DLHAAQASVGKYFDQASKDTQTVEDLLKQVDGASLTVAVPNLNTSLNAVQQFKSRG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AGGARAFTAVLTRPDGQSAGLAAQLADAGCDVLEFPLIDIAPVDDPAPLAAAFAALADY
CCCHHHHEEEEECCCCCCCCHHHHHHHCCCCEEECCCEEEECCCCCHHHHHHHHHHHCC
ALVIFVSPNAIDRALAQYGAIWPNALPVGVVGPGSVAALERHGIAPPAYRVIAPQPGSDG
EEEEEECCCHHHHHHHHHCCCCCCCCEECEECCCCHHHHHHCCCCCCCEEEECCCCCCCC
SAPHYDSEGLFASIEAAFGGAAALAGKRVLIVRGDGGREWLADRLREAGADVTLVAAYRR
CCCCCCCCCCEEEHHHHHCCHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCEEEHHHHHH
VVPEPRIGTWERVHALLGGEPHAWLVTSSEGVRNLHELARAHLNDTEIEALKHAPLVTPH
HCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCC
PRIEQTARALGFDRITLTGAGDERIVRAFRTMADEAVQPATAAPVTKRMTDTNDSKSVAS
CCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCHHHHC
QPAAASAPPSQPSYTASEPPARRGGSAVLWFVVVVLGCAAGVGGYALNRKIDRLDDALVA
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
RQKTLDAQVAETRTKTEQALASTHQVDTQLAQLDGKLADAQSAQQALQQQYQDLSRNRDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
WMLEEVDQMLSSASQQLQLTGNTQLALIALQNADARLATSQSAQAVTVRKALAQDIEKLK
HHHHHHHHHHHHHHHEEEEECCCEEEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHH
AAPSADLTGLAIKLDDAIARIDALPLSGEAIVPHAAPKAAPADTASAAAAGEPRWKTWWH
CCCCCCCCEEEEEEHHHHHHHHCCCCCCCEECCCCCCCCCCCCCHHHHCCCCCCHHHHHH
DFSSGLTQQLKGLVQVRRIDNADAMLASPDQGYFVRENVKLRLLAARLSLLARNESAMKA
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEEEECCCEEEHHHHHHHHHHCCCHHHHH
DLHAAQASVGKYFDQASKDTQTVEDLLKQVDGASLTVAVPNLNTSLNAVQQFKSRG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8159168; 10984043 [H]