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The map label for this gene is hisD [H]

Identifier: 161523508

GI number: 161523508

Start: 359427

End: 360743

Strand: Direct

Name: hisD [H]

Synonym: Bmul_0328

Alternate gene names: 161523508

Gene position: 359427-360743 (Clockwise)

Preceding gene: 161523507

Following gene: 161523509

Centisome position: 10.42

GC content: 69.4

Gene sequence:

>1317_bases
ATGTCCATCACCATCCGCAAACTCGATTCGACGAGCGAAGGCTTCGACGCCGCGCTGCGTGCGGTGCTCGCGTTCGAAGC
GAGCGAAGACGAGGCGATCGAGCGCTCGGTCGCGCAGATCCTCGCCGACGTGAAGTCGCGCGGCGACGCCGCGGTGCTCG
AGTACACGAATCGCTTCGACCGGCTGAACGCGGACAGCGTCGCCGCGCTCGAGCTGCCGCAGGACGCGCTGCAGGCCGCG
CTGGACGGCCTCGAGCCGAAGGCGCGCGCCGCGCTGGAAGCGGCTGCCGCACGCGTGCGCGGGTACCACGAGAAGCAGAA
GATCGAATGCGGCACGCATAGCTGGCAGTACACGGAAAGCGACGGCACGGTGCTCGGCCAGAAGATCACGCCGCTCGATC
GCGTCGGCCTCTACGTGCCGGGCGGCAAGGCCGCGTATCCGTCGTCGGTGCTGATGAATGCGATTCCCGCGCGCGTCGCG
GGCGTCGGCGAGATCGTGATGGTGGTCCCGACCCCGGATGGCGTGAAGAACGACCTCGTGCTCGCCGCCGCGCTGCTCGG
CGGCGTCGACCGCGTGTTCACGATCGGCGGTGCGCAGGCCGTCGGCGCGCTTGCGTACGGCACCGCGACCGTGCCGGCCG
TCGACAAGATCTGCGGGCCCGGCAATGCGTACGTCGCGTCGGCGAAGCGCCGCGTGTTCGGCACGGTCGGCATCGACATG
ATCGCCGGCCCGTCGGAGATCCTCGTGCTGTGCGACGGCACGACCGATCCGAGCTGGGTCGCGATGGACCTGTTCTCGCA
GGCCGAGCACGACGAACTCGCGCAGTCGATCCTGCTGTGCCCGGACGCGTCGTTCATCGAGCGCGTCGAGAAGGCGATCG
CCGAGCTGCTGCCGTCGATGCCGCGCCAGGACGTGATCCGCGCGTCGCTCGAAGGGCGCGGCGCGCTGATCAAGGTGCGC
GACATGACTGAAGCGTGCCGGATCGCCAACGACATCGCGCCCGAGCACCTCGAGATTTCCGCGCTCGAGCCGCAGCAATG
GAGCCAGCAGATCCGCCACGCGGGCGCGATCTTCCTCGGCCGCTACACGAGCGAGAGCCTCGGCGACTACTGCGCGGGGC
CGAACCACGTGCTGCCGACGTCGCGCACGGCGCGCTTCTCGTCGCCGCTCGGCGTGTACGACTTCATCAAGCGCTCGAGC
CTGATCGAGGTCAGCGCGGAAGGCGCGCATACGCTCGGCGAAATCGCGGCCGAACTCGCGTACGGCGAGGGCCTGCAGGC
GCACGCGAAGAGCGCCGAGTTTCGGATGAAGGGGTGA

Upstream 100 bases:

>100_bases
TGCGCTGAAGTTGAAGCGCGCGGCGCTCAAGCCGTTCCTCGACGCGTTCGAACGCGCGTCGCAGAATGGCGTATGAGCGC
ATCACCGTAACGGAACTCCC

Downstream 100 bases:

>100_bases
CCGGCCGCCGGAACCGCGTTCCGGCGCCGCGCAGGAGACGAGCGCAGGGCGGCAGCCGCCGCCTTGCCGACCATTTGACG
CCGGCGCGATGCACGCCGGC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MSITIRKLDSTSEGFDAALRAVLAFEASEDEAIERSVAQILADVKSRGDAAVLEYTNRFDRLNADSVAALELPQDALQAA
LDGLEPKARAALEAAAARVRGYHEKQKIECGTHSWQYTESDGTVLGQKITPLDRVGLYVPGGKAAYPSSVLMNAIPARVA
GVGEIVMVVPTPDGVKNDLVLAAALLGGVDRVFTIGGAQAVGALAYGTATVPAVDKICGPGNAYVASAKRRVFGTVGIDM
IAGPSEILVLCDGTTDPSWVAMDLFSQAEHDELAQSILLCPDASFIERVEKAIAELLPSMPRQDVIRASLEGRGALIKVR
DMTEACRIANDIAPEHLEISALEPQQWSQQIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSS
LIEVSAEGAHTLGEIAAELAYGEGLQAHAKSAEFRMKG

Sequences:

>Translated_438_residues
MSITIRKLDSTSEGFDAALRAVLAFEASEDEAIERSVAQILADVKSRGDAAVLEYTNRFDRLNADSVAALELPQDALQAA
LDGLEPKARAALEAAAARVRGYHEKQKIECGTHSWQYTESDGTVLGQKITPLDRVGLYVPGGKAAYPSSVLMNAIPARVA
GVGEIVMVVPTPDGVKNDLVLAAALLGGVDRVFTIGGAQAVGALAYGTATVPAVDKICGPGNAYVASAKRRVFGTVGIDM
IAGPSEILVLCDGTTDPSWVAMDLFSQAEHDELAQSILLCPDASFIERVEKAIAELLPSMPRQDVIRASLEGRGALIKVR
DMTEACRIANDIAPEHLEISALEPQQWSQQIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSS
LIEVSAEGAHTLGEIAAELAYGEGLQAHAKSAEFRMKG
>Mature_437_residues
SITIRKLDSTSEGFDAALRAVLAFEASEDEAIERSVAQILADVKSRGDAAVLEYTNRFDRLNADSVAALELPQDALQAAL
DGLEPKARAALEAAAARVRGYHEKQKIECGTHSWQYTESDGTVLGQKITPLDRVGLYVPGGKAAYPSSVLMNAIPARVAG
VGEIVMVVPTPDGVKNDLVLAAALLGGVDRVFTIGGAQAVGALAYGTATVPAVDKICGPGNAYVASAKRRVFGTVGIDMI
AGPSEILVLCDGTTDPSWVAMDLFSQAEHDELAQSILLCPDASFIERVEKAIAELLPSMPRQDVIRASLEGRGALIKVRD
MTEACRIANDIAPEHLEISALEPQQWSQQIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSSL
IEVSAEGAHTLGEIAAELAYGEGLQAHAKSAEFRMKG

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=415, Percent_Identity=40.9638554216867, Blast_Score=282, Evalue=4e-77,
Organism=Saccharomyces cerevisiae, GI6319819, Length=409, Percent_Identity=35.4523227383863, Blast_Score=233, Evalue=4e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46515; Mature: 46384

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITIRKLDSTSEGFDAALRAVLAFEASEDEAIERSVAQILADVKSRGDAAVLEYTNRFD
CCEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
RLNADSVAALELPQDALQAALDGLEPKARAALEAAAARVRGYHEKQKIECGTHSWQYTES
CCCCCCEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCEEECC
DGTVLGQKITPLDRVGLYVPGGKAAYPSSVLMNAIPARVAGVGEIVMVVPTPDGVKNDLV
CCCEECCCCCCHHHCCEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHH
LAAALLGGVDRVFTIGGAQAVGALAYGTATVPAVDKICGPGNAYVASAKRRVFGTVGIDM
HHHHHHCCCHHEEEECCHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHEECCHHE
IAGPSEILVLCDGTTDPSWVAMDLFSQAEHDELAQSILLCPDASFIERVEKAIAELLPSM
ECCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
PRQDVIRASLEGRGALIKVRDMTEACRIANDIAPEHLEISALEPQQWSQQIRHAGAIFLG
CHHHHHHHHCCCCCCEEEEHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCEEEE
RYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSSLIEVSAEGAHTLGEIAAELA
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCCHHHHHHHHHHH
YGEGLQAHAKSAEFRMKG
HCCCCHHHCCCCCEEECC
>Mature Secondary Structure 
SITIRKLDSTSEGFDAALRAVLAFEASEDEAIERSVAQILADVKSRGDAAVLEYTNRFD
CEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
RLNADSVAALELPQDALQAALDGLEPKARAALEAAAARVRGYHEKQKIECGTHSWQYTES
CCCCCCEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCEEECC
DGTVLGQKITPLDRVGLYVPGGKAAYPSSVLMNAIPARVAGVGEIVMVVPTPDGVKNDLV
CCCEECCCCCCHHHCCEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHH
LAAALLGGVDRVFTIGGAQAVGALAYGTATVPAVDKICGPGNAYVASAKRRVFGTVGIDM
HHHHHHCCCHHEEEECCHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHEECCHHE
IAGPSEILVLCDGTTDPSWVAMDLFSQAEHDELAQSILLCPDASFIERVEKAIAELLPSM
ECCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
PRQDVIRASLEGRGALIKVRDMTEACRIANDIAPEHLEISALEPQQWSQQIRHAGAIFLG
CHHHHHHHHCCCCCCEEEEHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCEEEE
RYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSSLIEVSAEGAHTLGEIAAELA
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCCHHHHHHHHHHH
YGEGLQAHAKSAEFRMKG
HCCCCHHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA