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The map label for this gene is hisC

Identifier: 161523509

GI number: 161523509

Start: 360832

End: 361926

Strand: Direct

Name: hisC

Synonym: Bmul_0329

Alternate gene names: 161523509

Gene position: 360832-361926 (Clockwise)

Preceding gene: 161523508

Following gene: 161523510

Centisome position: 10.46

GC content: 68.31

Gene sequence:

>1095_bases
ATGCACGCCGGCTTGCCTACCATGACGACGCCACAAGACATCATCCGCCGCGACGTGCTCGCCATGACGAGCTATCCGGT
GCCGGACGCGAGCGGGTTCGTGAAGCTCGACGCGATGGAGAACCCGTACCCGCTGCCCGAGCCGCTCGCCGCGGCGCTCG
GCGAACGGCTCGCGCGGGTCGCGCTGAACCGCTATCCGGCGCCGCGCCCGGCCGCGCTGCTCGACAAGCTGCGCCACGCG
ATGGGCGTGCCGGGCACGTGCGACGTGCTGCTCGGCAACGGTTCCGACGAAATCATCAGCATGATCTCGGTCGCGTGCGC
GAAACCGGGCGCGAAGGTGCTCGCGCCCGTGCCGGGCTTCGTGATGTACGAACTGTCCGCGCGATTCGCGCAGCTCGATT
TCGTCGGCGTGCCGTTGAAGGCCGACCTGACGCTCGACGTCGACGCGATGCTCGCGGCGATCGCCGAGCATCGGCCGGCC
ATCGTGTATCTCGCGTATCCGAACAACCCGACCGGCACGCTGTACGACGATGCCGACATCGAGCGCATCCTGCGCGCCGC
GACGCACAGCCTGATCGTGATCGACGAGGCGTACCAGCCGTTCGCGCAGCACAGCTGGCTGCCGCGCGCGGGCGAGTTCG
ACAACGTCGTCGTGATGCGCACGGTGTCGAAGCTCGGTCTCGCGGGGATCCGGCTCGGCTACCTGGTCGGCCGGCCTGCA
TGGCTGAACGAATTCGACAAGGTGCGCCCGCCGTACAACATCAACGTGCTGACGCAGGCGACCGCCGATTTCCTGCTCGA
CCATCTCGACGTGCTCGATGCACAGGCGGCCGAATTGCGCGCCGAACGCGCGCGGCTCGCGCAGGCGGTGGCCGCGCTGC
CGGGCGCGACGGTGTTCCCGAGCGCCGGCAATTTCCTGCTGGTGCGCGTGCCCGACGCGGCTGCCGTGTTCGACGCGCTG
CTCACCGAGCGGGTGCTCGTCAAAAACGTGAGTAAAATGCATCCGTTGCTGGCCGAATGCGTGCGGCTGACCGTCGGTTC
TCCCGACGAAAACGCGCGCCTGCTGGCTGCCCTGAAACTCGCGCTGCCCGATTGA

Upstream 100 bases:

>100_bases
ATGAAGGGGTGACCGGCCGCCGGAACCGCGTTCCGGCGCCGCGCAGGAGACGAGCGCAGGGCGGCAGCCGCCGCCTTGCC
GACCATTTGACGCCGGCGCG

Downstream 100 bases:

>100_bases
CGCCACGGCGCGGCGGCGCGCGACGATCAATCCCCATTTACATCAGACTCATTCAAGGAATTGCCATGCGTGTGGCGGAA
GTCGTTCGCAATACCAGCGA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MHAGLPTMTTPQDIIRRDVLAMTSYPVPDASGFVKLDAMENPYPLPEPLAAALGERLARVALNRYPAPRPAALLDKLRHA
MGVPGTCDVLLGNGSDEIISMISVACAKPGAKVLAPVPGFVMYELSARFAQLDFVGVPLKADLTLDVDAMLAAIAEHRPA
IVYLAYPNNPTGTLYDDADIERILRAATHSLIVIDEAYQPFAQHSWLPRAGEFDNVVVMRTVSKLGLAGIRLGYLVGRPA
WLNEFDKVRPPYNINVLTQATADFLLDHLDVLDAQAAELRAERARLAQAVAALPGATVFPSAGNFLLVRVPDAAAVFDAL
LTERVLVKNVSKMHPLLAECVRLTVGSPDENARLLAALKLALPD

Sequences:

>Translated_364_residues
MHAGLPTMTTPQDIIRRDVLAMTSYPVPDASGFVKLDAMENPYPLPEPLAAALGERLARVALNRYPAPRPAALLDKLRHA
MGVPGTCDVLLGNGSDEIISMISVACAKPGAKVLAPVPGFVMYELSARFAQLDFVGVPLKADLTLDVDAMLAAIAEHRPA
IVYLAYPNNPTGTLYDDADIERILRAATHSLIVIDEAYQPFAQHSWLPRAGEFDNVVVMRTVSKLGLAGIRLGYLVGRPA
WLNEFDKVRPPYNINVLTQATADFLLDHLDVLDAQAAELRAERARLAQAVAALPGATVFPSAGNFLLVRVPDAAAVFDAL
LTERVLVKNVSKMHPLLAECVRLTVGSPDENARLLAALKLALPD
>Mature_364_residues
MHAGLPTMTTPQDIIRRDVLAMTSYPVPDASGFVKLDAMENPYPLPEPLAAALGERLARVALNRYPAPRPAALLDKLRHA
MGVPGTCDVLLGNGSDEIISMISVACAKPGAKVLAPVPGFVMYELSARFAQLDFVGVPLKADLTLDVDAMLAAIAEHRPA
IVYLAYPNNPTGTLYDDADIERILRAATHSLIVIDEAYQPFAQHSWLPRAGEFDNVVVMRTVSKLGLAGIRLGYLVGRPA
WLNEFDKVRPPYNINVLTQATADFLLDHLDVLDAQAAELRAERARLAQAVAALPGATVFPSAGNFLLVRVPDAAAVFDAL
LTERVLVKNVSKMHPLLAECVRLTVGSPDENARLLAALKLALPD

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=369, Percent_Identity=30.0813008130081, Blast_Score=132, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6322075, Length=365, Percent_Identity=29.5890410958904, Blast_Score=123, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_BURM1 (Q845V2)

Other databases:

- EMBL:   AB091436
- EMBL:   CP000868
- EMBL:   AP009385
- RefSeq:   YP_001578521.1
- RefSeq:   YP_001947346.1
- ProteinModelPortal:   Q845V2
- SMR:   Q845V2
- GeneID:   5765442
- GeneID:   6359503
- GenomeReviews:   AP009385_GR
- GenomeReviews:   CP000868_GR
- KEGG:   bmj:BMULJ_02925
- KEGG:   bmu:Bmul_0329
- HOGENOM:   HBG646350
- OMA:   DEAYYAY
- ProtClustDB:   PRK04870
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39230; Mature: 39230

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAGLPTMTTPQDIIRRDVLAMTSYPVPDASGFVKLDAMENPYPLPEPLAAALGERLARV
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHH
ALNRYPAPRPAALLDKLRHAMGVPGTCDVLLGNGSDEIISMISVACAKPGAKVLAPVPGF
HHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCEECCCCCH
VMYELSARFAQLDFVGVPLKADLTLDVDAMLAAIAEHRPAIVYLAYPNNPTGTLYDDADI
HHHHHHHHHHHEEEECCCEECCCEECHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHH
ERILRAATHSLIVIDEAYQPFAQHSWLPRAGEFDNVVVMRTVSKLGLAGIRLGYLVGRPA
HHHHHHHHCCEEEEEHHHCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCH
WLNEFDKVRPPYNINVLTQATADFLLDHLDVLDAQAAELRAERARLAQAVAALPGATVFP
HHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECC
SAGNFLLVRVPDAAAVFDALLTERVLVKNVSKMHPLLAECVRLTVGSPDENARLLAALKL
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ALPD
CCCC
>Mature Secondary Structure
MHAGLPTMTTPQDIIRRDVLAMTSYPVPDASGFVKLDAMENPYPLPEPLAAALGERLARV
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHH
ALNRYPAPRPAALLDKLRHAMGVPGTCDVLLGNGSDEIISMISVACAKPGAKVLAPVPGF
HHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCEECCCCCH
VMYELSARFAQLDFVGVPLKADLTLDVDAMLAAIAEHRPAIVYLAYPNNPTGTLYDDADI
HHHHHHHHHHHEEEECCCEECCCEECHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHH
ERILRAATHSLIVIDEAYQPFAQHSWLPRAGEFDNVVVMRTVSKLGLAGIRLGYLVGRPA
HHHHHHHHCCEEEEEHHHCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCH
WLNEFDKVRPPYNINVLTQATADFLLDHLDVLDAQAAELRAERARLAQAVAALPGATVFP
HHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECC
SAGNFLLVRVPDAAAVFDALLTERVLVKNVSKMHPLLAECVRLTVGSPDENARLLAALKL
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ALPD
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12754231