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The map label for this gene is hisG [H]

Identifier: 161523507

GI number: 161523507

Start: 358749

End: 359402

Strand: Direct

Name: hisG [H]

Synonym: Bmul_0327

Alternate gene names: 161523507

Gene position: 358749-359402 (Clockwise)

Preceding gene: 161523506

Following gene: 161523508

Centisome position: 10.4

GC content: 67.28

Gene sequence:

>654_bases
ATGACCGCGCCGCTGACCCTCGCCCTGTCGAAGGGCCGCATTTTCGAGGAAACCCTGCCGCTGCTGGCCGCCGCCGGCGT
GCAGGTCGCCGAGGATCCGGAAACCTCGCGCAAGCTGATCCTGCCGACGACCGATCCGAACCTGCGCGTGATCATCGTGC
GCGCGAGCGACGTGCCGACCTACGTCGAATACGGCGCAGCCGATTTCGGCGTGGCCGGCAAGGACGTGCTCGTCGAGCAC
GGCGGCTCGGGGCTGTACCAGCCGATCGATCTGAACATTGCGCGCTGCCGGATGTCGGTCGCCGTGCCGGCCGGCTTCGA
TTACGCGAACGCGGTGCGCCAGGGCGCGCGGCTGCGCGTCGCGACGAAGTACGTCGAAACGGCGCGCGAACACTTCGCCG
CAAAGGGCGTGCACGTCGACCTGATCAAGCTGTACGGCTCGATGGAGCTCGCGCCGCTCGTCGGCCTCGCGGACGCGATC
GTCGATCTGGTCAGCTCGGGCGGCACGCTGAAGGCGAACAATCTGGTCGAGGTCGAGGAGATCATGGCGATCTCGTCGCG
TCTCGTCGTGAACCAGGCTGCGCTGAAGTTGAAGCGCGCGGCGCTCAAGCCGTTCCTCGACGCGTTCGAACGCGCGTCGC
AGAATGGCGTATGA

Upstream 100 bases:

>100_bases
GCGTCGACCGCATCTATCACCTCGATCGCGGCTACGACCGCATGGAAGCCAAACTGACCGCCGTCGGCGCGAACGTGCGC
CGCGTCTCCGGGAGCCAAGC

Downstream 100 bases:

>100_bases
GCGCATCACCGTAACGGAACTCCCATGTCCATCACCATCCGCAAACTCGATTCGACGAGCGAAGGCTTCGACGCCGCGCT
GCGTGCGGTGCTCGCGTTCG

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MTAPLTLALSKGRIFEETLPLLAAAGVQVAEDPETSRKLILPTTDPNLRVIIVRASDVPTYVEYGAADFGVAGKDVLVEH
GGSGLYQPIDLNIARCRMSVAVPAGFDYANAVRQGARLRVATKYVETAREHFAAKGVHVDLIKLYGSMELAPLVGLADAI
VDLVSSGGTLKANNLVEVEEIMAISSRLVVNQAALKLKRAALKPFLDAFERASQNGV

Sequences:

>Translated_217_residues
MTAPLTLALSKGRIFEETLPLLAAAGVQVAEDPETSRKLILPTTDPNLRVIIVRASDVPTYVEYGAADFGVAGKDVLVEH
GGSGLYQPIDLNIARCRMSVAVPAGFDYANAVRQGARLRVATKYVETAREHFAAKGVHVDLIKLYGSMELAPLVGLADAI
VDLVSSGGTLKANNLVEVEEIMAISSRLVVNQAALKLKRAALKPFLDAFERASQNGV
>Mature_216_residues
TAPLTLALSKGRIFEETLPLLAAAGVQVAEDPETSRKLILPTTDPNLRVIIVRASDVPTYVEYGAADFGVAGKDVLVEHG
GSGLYQPIDLNIARCRMSVAVPAGFDYANAVRQGARLRVATKYVETAREHFAAKGVHVDLIKLYGSMELAPLVGLADAIV
DLVSSGGTLKANNLVEVEEIMAISSRLVVNQAALKLKRAALKPFLDAFERASQNGV

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=186, Percent_Identity=34.4086021505376, Blast_Score=90, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6320896, Length=185, Percent_Identity=29.1891891891892, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 23125; Mature: 22994

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPLTLALSKGRIFEETLPLLAAAGVQVAEDPETSRKLILPTTDPNLRVIIVRASDVPT
CCCCEEEEECCCCHHHHHHHHHHHCCCEECCCCCCCCEEEEECCCCCEEEEEEECCCCCH
YVEYGAADFGVAGKDVLVEHGGSGLYQPIDLNIARCRMSVAVPAGFDYANAVRQGARLRV
HHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHEEEEEECCCCCCHHHHHHCCCEEHH
ATKYVETAREHFAAKGVHVDLIKLYGSMELAPLVGLADAIVDLVSSGGTLKANNLVEVEE
HHHHHHHHHHHHHHCCCEEEEHHHHCCCCHHHHHHHHHHHHHHHHCCCEEECCCCHHHHH
IMAISSRLVVNQAALKLKRAALKPFLDAFERASQNGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TAPLTLALSKGRIFEETLPLLAAAGVQVAEDPETSRKLILPTTDPNLRVIIVRASDVPT
CCCEEEEECCCCHHHHHHHHHHHCCCEECCCCCCCCEEEEECCCCCEEEEEEECCCCCH
YVEYGAADFGVAGKDVLVEHGGSGLYQPIDLNIARCRMSVAVPAGFDYANAVRQGARLRV
HHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHEEEEEECCCCCCHHHHHHCCCEEHH
ATKYVETAREHFAAKGVHVDLIKLYGSMELAPLVGLADAIVDLVSSGGTLKANNLVEVEE
HHHHHHHHHHHHHHCCCEEEEHHHHCCCCHHHHHHHHHHHHHHHHCCCEEECCCCHHHHH
IMAISSRLVVNQAALKLKRAALKPFLDAFERASQNGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA