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The map label for this gene is ndhL [H]

Identifier: 160903175

GI number: 160903175

Start: 1905580

End: 1906857

Strand: Direct

Name: ndhL [H]

Synonym: Pmob_1740

Alternate gene names: 160903175

Gene position: 1905580-1906857 (Clockwise)

Preceding gene: 160903174

Following gene: 160903176

Centisome position: 87.83

GC content: 37.64

Gene sequence:

>1278_bases
TTGAAACCAAATAAATACGTTGGAGAGAATGTTTTCAAAGTTGATGCCAAAGACAAAGTATTGGGTAAAGCCATCTATCC
GGATGATATATACTTTGAGGATATGCTCTATGTGAAAGTTAAACGTGCTACGCATCCACATGCCTACATTCAAAAAATAG
ATGTCTCTAAAGCAGAATCATTACCTGGAGTAATTAAAGTTATCACTGCAAAGGATTATCCTCATTTGAATAAGTTTGGA
TTGATAGTTAAAGATCAACCTGTTTTAGTAGGAATAGGAGAAAAAACACGCTTTATGGGAGACGCTTTGGCTATAGTTGT
TGCAAAGAGTAAAGAAATCGCCACTAAAGCAATTAATTTAATAAATGTTGAGGTTAAAGAATTAGAGGTCATTACCGATC
CTTTCAGGGCAATGGAAGAAGACGCTCCAAAAATTCATGAAGGTGGAAACATAGTTGTTACTCATCAATTAAACAAAGGG
GATGTAATGAAAGGTTTTAACGAGTCTGATGTAATAATAGAAAGAGAGTACAAAACGCAGCATGTTGACCAACTCCCTTT
ACAAGTGGAGTCTGGCGTAGCTGTTTACGACGAAAAAACTGGTGTAATAACTATTTGGGCAGCTACACAATGGCTTCATG
ATACACAAGCAGATATAGCCCAATCTTTGAATCTACCCAAAGAAAAAATCAGAATAATACAACCCGTTATTGGAGGAGCG
TTTGGTAGAAAAGAAGATATATCGGTTCATATACATTTAGCGTTGGCTGCAATGGTTACTAAACACCCTGTCAAATTAAC
TTACACCAGAGAAGAATCTATGATCGCACAGTCTAAAAGGCATCCACTGTATATTAAGGCTAGAACAGGAGCCACAAAAG
ATGGAATTCTAAAGGCTTGGGAGGTTGAAGTTGTAGGGGATACCGGAGCATATGCATCCAGTGGTCCTGCTGTTGTACAT
AAAGGTATGTATCATTGTACAGGTCCATACAATGTACCTAACGTTAAGGGTATAGCTTATACCGTTTACACTAATAATAC
GTATGGTGGAGCCATGAGAGGATTTGGAACAACGCAGATGGCTTTTGCTTATGAATCTCAAATGAACATATTAGCTGAAA
AGTTGGGTATGGATCCAGCAGAGATTAGACTAAAGAACGCTTACAGAATTGGCTCAATTACTCCAAATGGTCAAAAGCTT
ACACAAAGTGTCAACGTCGTTGAAACAATACAGGAAGCTTTAAAGCTTTCAAAAGAGAAAGAAGGTGTTCGACATTGA

Upstream 100 bases:

>100_bases
TTATCTGGCAATATCTGTAGATGTACTGGATACCAAAAAATAATAGATGCGGTCAAACTCTCGGCCACTAAAATTGCTGA
GTATAAGAGAGGTGAGAAAG

Downstream 100 bases:

>100_bases
AGAAAAAAGGAAGAGGTATGGCTACAATAATGTTCGGATATGGTTACGGTGAAGGATTTCCCGATTTTTCTCATGCGACG
GTTGAATTTACGGATAATGA

Product: aldehyde oxidase and xanthine dehydrogenase a/b hammerhead

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase large molybdopterin subunit; NAH [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MKPNKYVGENVFKVDAKDKVLGKAIYPDDIYFEDMLYVKVKRATHPHAYIQKIDVSKAESLPGVIKVITAKDYPHLNKFG
LIVKDQPVLVGIGEKTRFMGDALAIVVAKSKEIATKAINLINVEVKELEVITDPFRAMEEDAPKIHEGGNIVVTHQLNKG
DVMKGFNESDVIIEREYKTQHVDQLPLQVESGVAVYDEKTGVITIWAATQWLHDTQADIAQSLNLPKEKIRIIQPVIGGA
FGRKEDISVHIHLALAAMVTKHPVKLTYTREESMIAQSKRHPLYIKARTGATKDGILKAWEVEVVGDTGAYASSGPAVVH
KGMYHCTGPYNVPNVKGIAYTVYTNNTYGGAMRGFGTTQMAFAYESQMNILAEKLGMDPAEIRLKNAYRIGSITPNGQKL
TQSVNVVETIQEALKLSKEKEGVRH

Sequences:

>Translated_425_residues
MKPNKYVGENVFKVDAKDKVLGKAIYPDDIYFEDMLYVKVKRATHPHAYIQKIDVSKAESLPGVIKVITAKDYPHLNKFG
LIVKDQPVLVGIGEKTRFMGDALAIVVAKSKEIATKAINLINVEVKELEVITDPFRAMEEDAPKIHEGGNIVVTHQLNKG
DVMKGFNESDVIIEREYKTQHVDQLPLQVESGVAVYDEKTGVITIWAATQWLHDTQADIAQSLNLPKEKIRIIQPVIGGA
FGRKEDISVHIHLALAAMVTKHPVKLTYTREESMIAQSKRHPLYIKARTGATKDGILKAWEVEVVGDTGAYASSGPAVVH
KGMYHCTGPYNVPNVKGIAYTVYTNNTYGGAMRGFGTTQMAFAYESQMNILAEKLGMDPAEIRLKNAYRIGSITPNGQKL
TQSVNVVETIQEALKLSKEKEGVRH
>Mature_425_residues
MKPNKYVGENVFKVDAKDKVLGKAIYPDDIYFEDMLYVKVKRATHPHAYIQKIDVSKAESLPGVIKVITAKDYPHLNKFG
LIVKDQPVLVGIGEKTRFMGDALAIVVAKSKEIATKAINLINVEVKELEVITDPFRAMEEDAPKIHEGGNIVVTHQLNKG
DVMKGFNESDVIIEREYKTQHVDQLPLQVESGVAVYDEKTGVITIWAATQWLHDTQADIAQSLNLPKEKIRIIQPVIGGA
FGRKEDISVHIHLALAAMVTKHPVKLTYTREESMIAQSKRHPLYIKARTGATKDGILKAWEVEVVGDTGAYASSGPAVVH
KGMYHCTGPYNVPNVKGIAYTVYTNNTYGGAMRGFGTTQMAFAYESQMNILAEKLGMDPAEIRLKNAYRIGSITPNGQKL
TQSVNVVETIQEALKLSKEKEGVRH

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=418, Percent_Identity=29.1866028708134, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI71773480, Length=418, Percent_Identity=26.3157894736842, Blast_Score=143, Evalue=3e-34,
Organism=Escherichia coli, GI1789230, Length=424, Percent_Identity=34.1981132075472, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI1789246, Length=427, Percent_Identity=31.8501170960187, Blast_Score=184, Evalue=8e-48,
Organism=Escherichia coli, GI1786478, Length=413, Percent_Identity=26.634382566586, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17540638, Length=415, Percent_Identity=26.2650602409639, Blast_Score=131, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI32566215, Length=390, Percent_Identity=24.6153846153846, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17539860, Length=394, Percent_Identity=23.3502538071066, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17737937, Length=416, Percent_Identity=28.3653846153846, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24647193, Length=422, Percent_Identity=24.6445497630332, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24647199, Length=402, Percent_Identity=22.8855721393035, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24647201, Length=400, Percent_Identity=21.75, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 47078; Mature: 47078

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPNKYVGENVFKVDAKDKVLGKAIYPDDIYFEDMLYVKVKRATHPHAYIQKIDVSKAES
CCCCCCCCCCEEEECCCHHHHCCCCCCCCCEECCEEEEEEECCCCCCHHHEEECCCHHHC
LPGVIKVITAKDYPHLNKFGLIVKDQPVLVGIGEKTRFMGDALAIVVAKSKEIATKAINL
CCCEEEEEEECCCCCCCCEEEEEECCCEEEECCCHHHHCCCEEEEEEECCHHHHHHHHEE
INVEVKELEVITDPFRAMEEDAPKIHEGGNIVVTHQLNKGDVMKGFNESDVIIEREYKTQ
EEEEEHHEEEHHHHHHHHHHCCCCEECCCCEEEEEECCCCCHHCCCCCCCEEEEECCCCC
HVDQLPLQVESGVAVYDEKTGVITIWAATQWLHDTQADIAQSLNLPKEKIRIIQPVIGGA
CHHCCCEEECCCEEEEECCCCEEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
FGRKEDISVHIHLALAAMVTKHPVKLTYTREESMIAQSKRHPLYIKARTGATKDGILKAW
CCCCCCEEEEEEEEEEHHHHCCCEEEEEECCHHHHHHCCCCCEEEEEECCCCCCCCEEEE
EVEVVGDTGAYASSGPAVVHKGMYHCTGPYNVPNVKGIAYTVYTNNTYGGAMRGFGTTQM
EEEEEECCCCCCCCCCHHEECCCEEECCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCEE
AFAYESQMNILAEKLGMDPAEIRLKNAYRIGSITPNGQKLTQSVNVVETIQEALKLSKEK
EEEHHHHHHHHHHHHCCCHHHEEEECCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EGVRH
CCCCC
>Mature Secondary Structure
MKPNKYVGENVFKVDAKDKVLGKAIYPDDIYFEDMLYVKVKRATHPHAYIQKIDVSKAES
CCCCCCCCCCEEEECCCHHHHCCCCCCCCCEECCEEEEEEECCCCCCHHHEEECCCHHHC
LPGVIKVITAKDYPHLNKFGLIVKDQPVLVGIGEKTRFMGDALAIVVAKSKEIATKAINL
CCCEEEEEEECCCCCCCCEEEEEECCCEEEECCCHHHHCCCEEEEEEECCHHHHHHHHEE
INVEVKELEVITDPFRAMEEDAPKIHEGGNIVVTHQLNKGDVMKGFNESDVIIEREYKTQ
EEEEEHHEEEHHHHHHHHHHCCCCEECCCCEEEEEECCCCCHHCCCCCCCEEEEECCCCC
HVDQLPLQVESGVAVYDEKTGVITIWAATQWLHDTQADIAQSLNLPKEKIRIIQPVIGGA
CHHCCCEEECCCEEEEECCCCEEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
FGRKEDISVHIHLALAAMVTKHPVKLTYTREESMIAQSKRHPLYIKARTGATKDGILKAW
CCCCCCEEEEEEEEEEHHHHCCCEEEEEECCHHHHHHCCCCCEEEEEECCCCCCCCEEEE
EVEVVGDTGAYASSGPAVVHKGMYHCTGPYNVPNVKGIAYTVYTNNTYGGAMRGFGTTQM
EEEEEECCCCCCCCCCHHEECCCEEECCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCEE
AFAYESQMNILAEKLGMDPAEIRLKNAYRIGSITPNGQKLTQSVNVVETIQEALKLSKEK
EEEHHHHHHHHHHHHCCCHHHEEEECCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EGVRH
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA