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The map label for this gene is ndhM [H]

Identifier: 160903176

GI number: 160903176

Start: 1906854

End: 1907849

Strand: Direct

Name: ndhM [H]

Synonym: Pmob_1741

Alternate gene names: 160903176

Gene position: 1906854-1907849 (Clockwise)

Preceding gene: 160903175

Following gene: 160903177

Centisome position: 87.89

GC content: 36.85

Gene sequence:

>996_bases
TTGAAGAAAAAAGGAAGAGGTATGGCTACAATAATGTTCGGATATGGTTACGGTGAAGGATTTCCCGATTTTTCTCATGC
GACGGTTGAATTTACGGATAATGAAAAGGTTTTAGTGGTAACCGCAGCTGCCGATGTAGGACAAGGAGTTTTAACGGTTA
TCAGTCAAATTGCAGCAGAAGTTCTTTCAGTTGGTGTTGAAAAAGTAAAAGTCATTCAGGGCGATACTCATAAAACTATG
AATTCAGGATCAACATCTGCAACTCGTCAAACCACCTTTACAGGAAATGCCGTAAAACAAGCGTGTGAGAACTTAAAGGG
AAAAATTTTCCATTATGCGAGTTTAGAGTTCAATAGTAATTATCCTGAACTAACTTTGAAAGATGGAAAAATCATCTACA
ATCCTAACCCTGAAAAAACAATTACTTACTGGGATTTAAAAAGAAAGGTAGAAGAAAAAGGTGAAACTTTGAAAGGTGAA
GCGACCTACTTTCCACCAACATATTCTCCCGATTTAATATCCGGACAGGCCCATGAAGTCTACGTTGCTTATACCTTTAT
GACTCAAATAGTCGATGTAGAGGTTGACACAACCACTGGAAAAGTTGATGTGAAAGATGTTTACACCGCACTTGATTGTG
GAAAAGCTATAAACCCTATAAATGTGGAAGGACAGATAGAGGGTGGTACAACTCAAGGAATAGGTATGGCTCTTATGGAA
GAACAAGTAATAAAAAATGGAATCACATTAAATCCAAATATGACAGGTTACTTGGTTCCAACTTCTATGGATATTCCGAA
TTTTCATTCTGTATTAATAGAAAATGAAGATTCTATCGGGCCATTTGGTGCAAAAGGTATAGGAGAACCAACAACCATTG
CAGCTTCCCCTGCCATTGCTAACGCTATATACGATGCTATAGGTATTAGATTTTATGAATTGCCTATCACCCCAGAAAAA
ATTCTTAAAGCTCTAAAAGAAAAAGAAAATGATTAA

Upstream 100 bases:

>100_bases
CAATTACTCCAAATGGTCAAAAGCTTACACAAAGTGTCAACGTCGTTGAAACAATACAGGAAGCTTTAAAGCTTTCAAAA
GAGAAAGAAGGTGTTCGACA

Downstream 100 bases:

>100_bases
AAATAACATCTTTCTTACAGGTTCTATAGGTATAGGTAAATCGACGATTATACGTAAAGTGATTAATCAACTATCATTAC
ATGTTTGTGGTTTTTCAGTT

Product: molybdopterin binding aldehyde oxidase and xanthine dehydrogenase

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase medium molybdopterin subunit; NAH [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MKKKGRGMATIMFGYGYGEGFPDFSHATVEFTDNEKVLVVTAAADVGQGVLTVISQIAAEVLSVGVEKVKVIQGDTHKTM
NSGSTSATRQTTFTGNAVKQACENLKGKIFHYASLEFNSNYPELTLKDGKIIYNPNPEKTITYWDLKRKVEEKGETLKGE
ATYFPPTYSPDLISGQAHEVYVAYTFMTQIVDVEVDTTTGKVDVKDVYTALDCGKAINPINVEGQIEGGTTQGIGMALME
EQVIKNGITLNPNMTGYLVPTSMDIPNFHSVLIENEDSIGPFGAKGIGEPTTIAASPAIANAIYDAIGIRFYELPITPEK
ILKALKEKEND

Sequences:

>Translated_331_residues
MKKKGRGMATIMFGYGYGEGFPDFSHATVEFTDNEKVLVVTAAADVGQGVLTVISQIAAEVLSVGVEKVKVIQGDTHKTM
NSGSTSATRQTTFTGNAVKQACENLKGKIFHYASLEFNSNYPELTLKDGKIIYNPNPEKTITYWDLKRKVEEKGETLKGE
ATYFPPTYSPDLISGQAHEVYVAYTFMTQIVDVEVDTTTGKVDVKDVYTALDCGKAINPINVEGQIEGGTTQGIGMALME
EQVIKNGITLNPNMTGYLVPTSMDIPNFHSVLIENEDSIGPFGAKGIGEPTTIAASPAIANAIYDAIGIRFYELPITPEK
ILKALKEKEND
>Mature_331_residues
MKKKGRGMATIMFGYGYGEGFPDFSHATVEFTDNEKVLVVTAAADVGQGVLTVISQIAAEVLSVGVEKVKVIQGDTHKTM
NSGSTSATRQTTFTGNAVKQACENLKGKIFHYASLEFNSNYPELTLKDGKIIYNPNPEKTITYWDLKRKVEEKGETLKGE
ATYFPPTYSPDLISGQAHEVYVAYTFMTQIVDVEVDTTTGKVDVKDVYTALDCGKAINPINVEGQIEGGTTQGIGMALME
EQVIKNGITLNPNMTGYLVPTSMDIPNFHSVLIENEDSIGPFGAKGIGEPTTIAASPAIANAIYDAIGIRFYELPITPEK
ILKALKEKEND

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71773480, Length=346, Percent_Identity=27.1676300578035, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI91823271, Length=357, Percent_Identity=26.0504201680672, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1789246, Length=333, Percent_Identity=33.6336336336336, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1789230, Length=326, Percent_Identity=31.2883435582822, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1786478, Length=324, Percent_Identity=32.7160493827161, Blast_Score=132, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17540638, Length=343, Percent_Identity=26.8221574344023, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008274 [H]

Pfam domain/function: PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 35928; Mature: 35928

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKGRGMATIMFGYGYGEGFPDFSHATVEFTDNEKVLVVTAAADVGQGVLTVISQIAAE
CCCCCCCEEEEEEEECCCCCCCCCCCEEEEEECCCEEEEEEECCCCCCHHHHHHHHHHHH
VLSVGVEKVKVIQGDTHKTMNSGSTSATRQTTFTGNAVKQACENLKGKIFHYASLEFNSN
HHHCCHHEEEEEECCCCCCCCCCCCCCCEEEEECCHHHHHHHHCCCCEEEEEEEEEECCC
YPELTLKDGKIIYNPNPEKTITYWDLKRKVEEKGETLKGEATYFPPTYSPDLISGQAHEV
CCEEEEECCEEEECCCCCCEEEEHHHHHHHHHCCCEECCCEEECCCCCCCCCCCCCCCEE
YVAYTFMTQIVDVEVDTTTGKVDVKDVYTALDCGKAINPINVEGQIEGGTTQGIGMALME
EEEEEEEEEEEEEEEECCCCEEEHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHH
EQVIKNGITLNPNMTGYLVPTSMDIPNFHSVLIENEDSIGPFGAKGIGEPTTIAASPAIA
HHHHHCCCEECCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEECCHHHH
NAIYDAIGIRFYELPITPEKILKALKEKEND
HHHHHHHCCEEEECCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKKGRGMATIMFGYGYGEGFPDFSHATVEFTDNEKVLVVTAAADVGQGVLTVISQIAAE
CCCCCCCEEEEEEEECCCCCCCCCCCEEEEEECCCEEEEEEECCCCCCHHHHHHHHHHHH
VLSVGVEKVKVIQGDTHKTMNSGSTSATRQTTFTGNAVKQACENLKGKIFHYASLEFNSN
HHHCCHHEEEEEECCCCCCCCCCCCCCCEEEEECCHHHHHHHHCCCCEEEEEEEEEECCC
YPELTLKDGKIIYNPNPEKTITYWDLKRKVEEKGETLKGEATYFPPTYSPDLISGQAHEV
CCEEEEECCEEEECCCCCCEEEEHHHHHHHHHCCCEECCCEEECCCCCCCCCCCCCCCEE
YVAYTFMTQIVDVEVDTTTGKVDVKDVYTALDCGKAINPINVEGQIEGGTTQGIGMALME
EEEEEEEEEEEEEEEECCCCEEEHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHH
EQVIKNGITLNPNMTGYLVPTSMDIPNFHSVLIENEDSIGPFGAKGIGEPTTIAASPAIA
HHHHHCCCEECCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEECCHHHH
NAIYDAIGIRFYELPITPEKILKALKEKEND
HHHHHHHCCEEEECCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA