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The map label for this gene is caiC [C]

Identifier: 160873481

GI number: 160873481

Start: 403411

End: 405075

Strand: Reverse

Name: caiC [C]

Synonym: Sbal195_0356

Alternate gene names: 160873481

Gene position: 405075-403411 (Counterclockwise)

Preceding gene: 160873482

Following gene: 160873480

Centisome position: 7.58

GC content: 50.93

Gene sequence:

>1665_bases
ATGGATACAGCGATTAAGACGCCAATTGAAATGCTGGCGCACTGGGCTAAGACTCAGGGGGATCAAGTCTATTTACGCCA
ACCTATCAAGGGTCAATTCCTTGATTTTACTTGGGCCGAAGTTCAAGAAAAAGTGCAACAACTGGCCGGTGCCTTACAGC
ATCTAGGCCTAGAGCGCGGTGATAAGATTGCCGTACTCTCTAAAAACTGCGCCGAATGGTTTATCACCGACCTTGCGTTA
ATGCACGGCGGCTATGTCAGCGTGCCGATTTACCCAACAGCCAACACAGATACTATTCGCTATGTGCTGCAACACAGCGG
TGCAAAAGCCATTTTCCTCGGTAAGCTCGACCATTGGGCCGACCAAGAAGCCGGTGTCGGCGGCGAGCTGCTACGTCTTG
CTATGCCCTACGATACAATGCCAGCCCAATATCAATGGGAACAATTACTTAAACTAGGTTATCCCCTAGTTGATGCCCCG
CTACCGACGCCTGATCAAGTGATGACACTTATCTACACCTCTGGCTCAACGGGTCAACCTAAGGGCGCGATTCAAACCTT
CGCTAGCTATGGCTGGACTTGCCAAGCGGTAGTGCGTGATTTACGCACCGACGGCAATGACAGACTGTTATCCTATTTGC
CTTTAGCGCACATCACAGAGCGCGTCGCGATTGAAGGTTCATCCTTCTATTCCGGCAGCGTGGTCGCCTTCGTCGAGAGT
CTCGACTCCTTCGTCGCCGACGTGCAAAGGGCAAAACCGACGGTATTTTTCTCAGTGCCGCGTTTGTGGAGCCTGTTCCA
GAAAAACATCATAGACAAAATTGGTGTTAGTAAACTGAATCTATTGCTGAAGATCCCGTTAATCAGCAGCTTAGTGAAGC
ACAAAATCCATAAAGGCTTAGGTTTGAACCATTGTCGTTTGCTCGGCTCAGGCTCTGCGCCGATCCCGCCGTCGCTGATC
CACTGGTATCACAGAATTGGTCTGAATATCTGTGAAGCTTGGGGTATGACAGAAAACTGCGCCTACTCGATTATCAACTA
CCCCTTCGATGCCCGTAAAATTGGCACTGTGGGTCGCCCGGTTGAGGATTGTCAGATCCGCCAAGGGGAAGATGGTGAGC
TACTGCTTAAGAGTCCTGGGTTGATGACGGCTTATTATCTACAGCCCGAAGCCACTGCTGCAGCCTTCGACGCCGATGGT
TTCTTCCACACTGGCGATTTGTGCTCTATTGATGCCGATGGTTGCGTGACCATTACCGGCCGAGTGAAGGACAACTTCAA
AACCGCCAAGGGTAAATATGTCGCGCCCGTGCCTATCGAACGTAAATTGGCGCAGGACCCGCATGTTGAACTGATCTGCG
TGATTGGCTCAGGCCTGCCGCATCCGGTCGCATTAGTGCAATTATCCGAAGGCGCTAGTTTGCAGGCCCGCGAAGAAGTC
CGCGCTTCACTCAAGGCGACACTCGATAGCGTGAATCCGCACTTAGAATCACACGAACACGTCGATGCCATTATCGTGGT
TAACGATCCTTGGACGATTGAGAACGATGTACTGACTCCGACGCTTAAGATCAAACGCCATGTGCTTGAAAAAGCCTTTA
GCGAAAGAGTTGATGGCATTCGTGGCGCCCAAGTTCGCTGGGAAGATGAGTTAACGCAAAAATAA

Upstream 100 bases:

>100_bases
CATTCTCATATTTTACAATCCTGTAAACTATTTGCGCGGGCTCACAAAACTCGCCATACTGGGTGCAGCCAAAATAACAA
TAAAGAACAGGGAATTGCCA

Downstream 100 bases:

>100_bases
CTCGACTAAACAGAGAGATGGCCAATATGGTTATCGGCACAAATCAAGCACGCCTCGGCGTGCTTTTTTATGACATATTC
TGTCAAATTTCGATAAAACC

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 554; Mature: 554

Protein sequence:

>554_residues
MDTAIKTPIEMLAHWAKTQGDQVYLRQPIKGQFLDFTWAEVQEKVQQLAGALQHLGLERGDKIAVLSKNCAEWFITDLAL
MHGGYVSVPIYPTANTDTIRYVLQHSGAKAIFLGKLDHWADQEAGVGGELLRLAMPYDTMPAQYQWEQLLKLGYPLVDAP
LPTPDQVMTLIYTSGSTGQPKGAIQTFASYGWTCQAVVRDLRTDGNDRLLSYLPLAHITERVAIEGSSFYSGSVVAFVES
LDSFVADVQRAKPTVFFSVPRLWSLFQKNIIDKIGVSKLNLLLKIPLISSLVKHKIHKGLGLNHCRLLGSGSAPIPPSLI
HWYHRIGLNICEAWGMTENCAYSIINYPFDARKIGTVGRPVEDCQIRQGEDGELLLKSPGLMTAYYLQPEATAAAFDADG
FFHTGDLCSIDADGCVTITGRVKDNFKTAKGKYVAPVPIERKLAQDPHVELICVIGSGLPHPVALVQLSEGASLQAREEV
RASLKATLDSVNPHLESHEHVDAIIVVNDPWTIENDVLTPTLKIKRHVLEKAFSERVDGIRGAQVRWEDELTQK

Sequences:

>Translated_554_residues
MDTAIKTPIEMLAHWAKTQGDQVYLRQPIKGQFLDFTWAEVQEKVQQLAGALQHLGLERGDKIAVLSKNCAEWFITDLAL
MHGGYVSVPIYPTANTDTIRYVLQHSGAKAIFLGKLDHWADQEAGVGGELLRLAMPYDTMPAQYQWEQLLKLGYPLVDAP
LPTPDQVMTLIYTSGSTGQPKGAIQTFASYGWTCQAVVRDLRTDGNDRLLSYLPLAHITERVAIEGSSFYSGSVVAFVES
LDSFVADVQRAKPTVFFSVPRLWSLFQKNIIDKIGVSKLNLLLKIPLISSLVKHKIHKGLGLNHCRLLGSGSAPIPPSLI
HWYHRIGLNICEAWGMTENCAYSIINYPFDARKIGTVGRPVEDCQIRQGEDGELLLKSPGLMTAYYLQPEATAAAFDADG
FFHTGDLCSIDADGCVTITGRVKDNFKTAKGKYVAPVPIERKLAQDPHVELICVIGSGLPHPVALVQLSEGASLQAREEV
RASLKATLDSVNPHLESHEHVDAIIVVNDPWTIENDVLTPTLKIKRHVLEKAFSERVDGIRGAQVRWEDELTQK
>Mature_554_residues
MDTAIKTPIEMLAHWAKTQGDQVYLRQPIKGQFLDFTWAEVQEKVQQLAGALQHLGLERGDKIAVLSKNCAEWFITDLAL
MHGGYVSVPIYPTANTDTIRYVLQHSGAKAIFLGKLDHWADQEAGVGGELLRLAMPYDTMPAQYQWEQLLKLGYPLVDAP
LPTPDQVMTLIYTSGSTGQPKGAIQTFASYGWTCQAVVRDLRTDGNDRLLSYLPLAHITERVAIEGSSFYSGSVVAFVES
LDSFVADVQRAKPTVFFSVPRLWSLFQKNIIDKIGVSKLNLLLKIPLISSLVKHKIHKGLGLNHCRLLGSGSAPIPPSLI
HWYHRIGLNICEAWGMTENCAYSIINYPFDARKIGTVGRPVEDCQIRQGEDGELLLKSPGLMTAYYLQPEATAAAFDADG
FFHTGDLCSIDADGCVTITGRVKDNFKTAKGKYVAPVPIERKLAQDPHVELICVIGSGLPHPVALVQLSEGASLQAREEV
RASLKATLDSVNPHLESHEHVDAIIVVNDPWTIENDVLTPTLKIKRHVLEKAFSERVDGIRGAQVRWEDELTQK

Specific function: Could Catalyze The Transfer Of CoA To Crotonobetaine Or Carnitine. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI83745141, Length=589, Percent_Identity=24.1086587436333, Blast_Score=179, Evalue=8e-45,
Organism=Homo sapiens, GI42794756, Length=576, Percent_Identity=26.5625, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI42794760, Length=576, Percent_Identity=26.5625, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI42794758, Length=576, Percent_Identity=26.5625, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI57165412, Length=586, Percent_Identity=27.1331058020478, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI40807491, Length=575, Percent_Identity=26.4347826086956, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI57165410, Length=586, Percent_Identity=26.7918088737201, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI27477105, Length=486, Percent_Identity=25.3086419753086, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI12669909, Length=631, Percent_Identity=23.6133122028526, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI4758332, Length=631, Percent_Identity=23.6133122028526, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI42794754, Length=622, Percent_Identity=24.2765273311897, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI42794752, Length=622, Percent_Identity=24.2765273311897, Blast_Score=123, Evalue=4e-28,
Organism=Escherichia coli, GI221142682, Length=480, Percent_Identity=25.4166666666667, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1788107, Length=463, Percent_Identity=22.8941684665227, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI145693145, Length=447, Percent_Identity=23.9373601789709, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1786810, Length=448, Percent_Identity=26.5625, Blast_Score=89, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI25147511, Length=601, Percent_Identity=26.1231281198003, Blast_Score=168, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17556552, Length=581, Percent_Identity=26.6781411359725, Blast_Score=168, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI17510401, Length=573, Percent_Identity=27.5741710296684, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17541856, Length=602, Percent_Identity=26.0797342192691, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI193204819, Length=618, Percent_Identity=24.9190938511327, Blast_Score=151, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17553312, Length=624, Percent_Identity=26.1217948717949, Blast_Score=138, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17564090, Length=435, Percent_Identity=24.8275862068966, Blast_Score=125, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17558820, Length=297, Percent_Identity=32.6599326599327, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI32563687, Length=310, Percent_Identity=33.5483870967742, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17531443, Length=531, Percent_Identity=23.3521657250471, Blast_Score=102, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17560308, Length=486, Percent_Identity=24.6913580246914, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI133901848, Length=251, Percent_Identity=27.4900398406374, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17559526, Length=333, Percent_Identity=26.1261261261261, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17538037, Length=138, Percent_Identity=34.0579710144928, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320852, Length=583, Percent_Identity=27.4442538593482, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324893, Length=600, Percent_Identity=23.3333333333333, Blast_Score=131, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6323903, Length=443, Percent_Identity=27.765237020316, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6322182, Length=457, Percent_Identity=25.8205689277899, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6319699, Length=512, Percent_Identity=21.09375, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17933690, Length=616, Percent_Identity=23.8636363636364, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI281366413, Length=599, Percent_Identity=24.2070116861436, Blast_Score=155, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24666501, Length=599, Percent_Identity=24.2070116861436, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24666497, Length=599, Percent_Identity=24.2070116861436, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI19921316, Length=489, Percent_Identity=23.3128834355828, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI62471679, Length=587, Percent_Identity=24.190800681431, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI62471683, Length=587, Percent_Identity=24.190800681431, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI62471685, Length=587, Percent_Identity=24.190800681431, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24586636, Length=587, Percent_Identity=24.190800681431, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI62471681, Length=587, Percent_Identity=24.190800681431, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI62471687, Length=587, Percent_Identity=24.190800681431, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24586634, Length=587, Percent_Identity=24.190800681431, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI22026970, Length=587, Percent_Identity=24.190800681431, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI62471689, Length=587, Percent_Identity=24.3611584327087, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21358303, Length=484, Percent_Identity=24.1735537190083, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI18859661, Length=537, Percent_Identity=24.5810055865922, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21355181, Length=471, Percent_Identity=23.5668789808917, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21356947, Length=455, Percent_Identity=23.0769230769231, Blast_Score=67, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 61237; Mature: 61237

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTAIKTPIEMLAHWAKTQGDQVYLRQPIKGQFLDFTWAEVQEKVQQLAGALQHLGLERG
CCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
DKIAVLSKNCAEWFITDLALMHGGYVSVPIYPTANTDTIRYVLQHSGAKAIFLGKLDHWA
CEEEEECCHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCCC
DQEAGVGGELLRLAMPYDTMPAQYQWEQLLKLGYPLVDAPLPTPDQVMTLIYTSGSTGQP
CCCCCCCHHHHEEECCCCCCCCHHHHHHHHHCCCCEECCCCCCHHHEEEEEEECCCCCCC
KGAIQTFASYGWTCQAVVRDLRTDGNDRLLSYLPLAHITERVAIEGSSFYSGSVVAFVES
HHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHCCHHHHHHHHEECCCCCCCCHHHHHHHH
LDSFVADVQRAKPTVFFSVPRLWSLFQKNIIDKIGVSKLNLLLKIPLISSLVKHKIHKGL
HHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCHHHHHHHEECHHHHHHHHHHHHHCC
GLNHCRLLGSGSAPIPPSLIHWYHRIGLNICEAWGMTENCAYSIINYPFDARKIGTVGRP
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCHHCCCCCCC
VEDCQIRQGEDGELLLKSPGLMTAYYLQPEATAAAFDADGFFHTGDLCSIDADGCVTITG
HHHCCCCCCCCCCEEEECCCCEEEEEECCCCCEEEECCCCCEECCCEEEECCCCEEEEEE
RVKDNFKTAKGKYVAPVPIERKLAQDPHVELICVIGSGLPHPVALVQLSEGASLQAREEV
CCCCCCCCCCCCEECCCCCHHHHCCCCCEEEEEEECCCCCCCEEEEEECCCCCCHHHHHH
RASLKATLDSVNPHLESHEHVDAIIVVNDPWTIENDVLTPTLKIKRHVLEKAFSERVDGI
HHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHHHCCC
RGAQVRWEDELTQK
CCCCEEEHHHHCCC
>Mature Secondary Structure
MDTAIKTPIEMLAHWAKTQGDQVYLRQPIKGQFLDFTWAEVQEKVQQLAGALQHLGLERG
CCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
DKIAVLSKNCAEWFITDLALMHGGYVSVPIYPTANTDTIRYVLQHSGAKAIFLGKLDHWA
CEEEEECCHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCCC
DQEAGVGGELLRLAMPYDTMPAQYQWEQLLKLGYPLVDAPLPTPDQVMTLIYTSGSTGQP
CCCCCCCHHHHEEECCCCCCCCHHHHHHHHHCCCCEECCCCCCHHHEEEEEEECCCCCCC
KGAIQTFASYGWTCQAVVRDLRTDGNDRLLSYLPLAHITERVAIEGSSFYSGSVVAFVES
HHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHCCHHHHHHHHEECCCCCCCCHHHHHHHH
LDSFVADVQRAKPTVFFSVPRLWSLFQKNIIDKIGVSKLNLLLKIPLISSLVKHKIHKGL
HHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCHHHHHHHEECHHHHHHHHHHHHHCC
GLNHCRLLGSGSAPIPPSLIHWYHRIGLNICEAWGMTENCAYSIINYPFDARKIGTVGRP
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCHHCCCCCCC
VEDCQIRQGEDGELLLKSPGLMTAYYLQPEATAAAFDADGFFHTGDLCSIDADGCVTITG
HHHCCCCCCCCCCEEEECCCCEEEEEECCCCCEEEECCCCCEECCCEEEECCCCEEEEEE
RVKDNFKTAKGKYVAPVPIERKLAQDPHVELICVIGSGLPHPVALVQLSEGASLQAREEV
CCCCCCCCCCCCEECCCCCHHHHCCCCCEEEEEEECCCCCCCEEEEEECCCCCCHHHHHH
RASLKATLDSVNPHLESHEHVDAIIVVNDPWTIENDVLTPTLKIKRHVLEKAFSERVDGI
HHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHHHCCC
RGAQVRWEDELTQK
CCCCEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]